Article
Microbiology
Sunil Kumar Dubey, Divya Mehta, Sakshi Chaudhary, Abdul Hasan, Sujatha Sunil
Summary: Arboviruses cause various diseases and vector control is the main strategy. The study found that AeCullin-3 plays a proviral role in CHIKV replication in Aedes aegypti.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Yusnita Mirna Anggraeni, Triwibowo Ambar Garjito, Mega Tyas Prihatin, Sri Wahyuni Handayani, Kusumaningtyas Sekar Negari, Ary Oktsari Yanti, Muhammad Choirul Hidajat, Dhian Prastowo, Tri Baskoro Tunggul Satoto, Sylvie Manguin, Laurent Gavotte, Roger Frutos
Summary: Chikungunya virus has undergone a genotype replacement in Indonesia, with the Asian-Pacific genotype replacing the Asian genotype. The study raises questions about the mechanisms behind this rapid and massive replacement.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Mario L. Novelo, Heverton L. C. F. Dutra, Hillery A. Metz, Matthew Jones, Leah Sigle, Francesca Frentiu, Scott Allen, Stephen Chenoweth, Elizabeth McGraw
Summary: Aedes aegypti is the main vector for dengue and chikungunya viruses, but they exhibit different genetic responses to the two viruses. Genetic variation in the mosquito contributes to the viral loads of both viruses, but the genetic mechanisms are distinct. The identification of genes involved in virus control provides potential targets for genetic modification to reduce the transmission of these diseases by mosquitoes.
Article
Infectious Diseases
Timothy White, Gina Mincham, Brian L. Montgomery, Cassie C. Jansen, Xiaodong Huang, Craig R. Williams, Robert L. P. Flower, Helen M. Faddy, Francesca D. Frentiu, Elvina Viennet
Summary: This study estimated the epidemic potential of CHIKV in Australia, finding that major urban centers in Northern Australia could sustain an epidemic. Future trends suggest an increase in epidemic potential towards 2029.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Virology
Khanzadi Nazneen Manzoor, Farakh Javed, Muhammad Ejaz, Mubashar Ali, Neelam Mujaddadi, Abid Ali Khan, Aamer Ali Khattak, Assad Zaib, Ibrar Ahmad, Waqar Khalid Saeed, Sobia Manzoor
Summary: Chickengunya virus (CHIKV) is a newly emerged global virus transmitted mainly by mosquito bites, with a genome containing 11,900 nucleotides. Infections lead to symptoms such as high fever, joint pain, and rashes, and there is currently no specific vaccine or treatment available for CHIKV.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Article
Medicine, General & Internal
Koen Bartholomeeusen, Matthieu Daniel, Desiree A. LaBeaud, Philippe Gasque, Rosanna W. Peeling, Kathryn E. Stephenson, Lisa F. P. Ng, Kevin K. Arien
Summary: Chikungunya virus is a widespread and recurring infectious disease that causes severe joint and muscle pain. It is transmitted by Aedes mosquitoes and has been causing outbreaks in various regions due to climate change and globalization. With no specific treatment or vaccines available, surveillance and vector control measures are crucial in preventing further re-emergence and epidemics.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Parasitology
Maria C. Carrasquilla, Mario I. Ortiz, Cielo Leon, Silvia Rondon, Manisha A. Kulkarni, Benoit Talbot, Beate Sander, Heriberto Vasquez, Juan M. Cordovez, Camila Gonzalez
Summary: A study conducted in Ibague, Colombia found that Aedes aegypti and Aedes albopictus mosquitoes are vectors for dengue, Zika, and chikungunya viruses, with dengue and chikungunya circulating in the area but Zika virus remaining undetected. The research results showed that mosquitoes were mainly found in low socioeconomic areas and indoors, with a higher number of female mosquitoes that have fed on human blood, indicating a high risk of arbovirus transmission in Ibague.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Igor Andrade Santos, Jacqueline Farinha Shimizu, Debora Moraes de Oliveira, Daniel Oliveira Silva Martins, Leia Cardoso-Sousa, Adelia Cristina Oliveira Cintra, Victor Hugo Aquino, Suely Vilela Sampaio, Nilson Nicolau-Junior, Robinson Sabino-Silva, Andres Merits, Mark Harris, Ana Carolina Gomes Jardim
Summary: Research has shown that the snake venom protein PLA2(CB) has strong anti-CHIKV activity, interfering with various stages of the CHIKV replicative cycle. Additionally, PLA2(CB) interacts with CHIKV glycoproteins, blocking virus entry into host cells.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Daniel Nunez-Avellaneda, Chandra Tangudu, Jacqueline Barrios-Palacios, Ma. Isabel Salazar, Carlos Machain-Williams, Jonathan Cisneros-Pano, Lauren A. McKeen, Bradley J. Blitvich
Summary: The local public health authorities reported nine cases of chikungunya in Mexico in 2019 with none in Guerrero, a coastal state. Testing in Guerrero revealed a significant number of cases that met the WHO definition, indicating a severe underestimation of chikungunya cases in Mexico.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biochemistry & Molecular Biology
Ayman Ahmed, Mustafa Abubakr, Hamza Sami, Isam Mahdi, Nouh S. Mohamed, Jakob Zinsstag
Summary: This study investigated the mosquito species in four Sudanese states and found an invasive vector mosquito, Aedes albopictus, originating from Southeast Asia. Its presence was associated with an increase in outbreaks of chikungunya and dengue, posing a serious threat to public health. The study highlights the need for enhanced vector surveillance and control systems and the implementation of the One Health strategy for the prevention and control of future pandemics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Maria Angelica Carrillo, Rocio Cardenas, Johanna Yanez, Max Petzold, Axel Kroeger
Summary: This study conducted a baseline survey in Colombia to collect basic information on arbovirus transmission risk and assess the requirements for a large intervention trial. The production of Ae. aegypti mosquitoes was found to occur mainly in concrete ground tanks, providing necessary evidence for the design and implementation of a cluster randomized intervention trial in Colombia.
Article
Microbiology
Elodie Calvez, Elliott F. Miot, Sitsana Keosenhom, Vaekey Vungkyly, Souksakhone Viengphouthong, Phaithong Bounmany, Paul T. Brey, Sebastien Marcombe, Marc Grandadam
Summary: Between 2014 and 2020, only a few cases of the chikungunya virus (CHIKV) were imported to Lao PDR, with isolates from different lineages recorded in the capital city of Vientiane. In 2020, a few autochthonous cases of the ECSA-IOL lineage were detected in the southern part of the country. The study aimed to assess the ability of local Aedes aegypti mosquitoes from Vientiane to transmit the Asian and ECSA-IOL lineages of CHIKV. Results showed low infection rates but high dissemination rates, indicating a low vector competence for the tested CHIKV strains. Factors such as mosquito longevity and density may influence arbovirus emergence in the region.
Article
Biochemistry & Molecular Biology
Julian Roos, Meike Dahlhaus, Jan-Bernd Funcke, Monika Kustermann, Gudrun Strauss, Daniel Halbgebauer, Elena Boldrin, Karlheinz Holzmann, Peter Moeller, Bernadette M. Trojanowski, Bernd Baumann, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
Summary: The study revealed that miR-146a regulates adipose tissue inflammation by suppressing the NPR3 gene, thereby impacting the development of obesity and insulin resistance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Infectious Diseases
Ana Paula Razal Dalvi, Gerusa Gibson, Alberto Novaes Ramos Jr, Katia V. Bloch, Geziel dos Santos de Sousa, Thiago Luiz Nogueira da Silva, Jose Ueleres Braga, Marcia C. Castro, Guilherme Loureiro Werneck
Summary: This study aimed to identify sociodemographic and environmental risk factors for the occurrence of Zika, dengue, and chikungunya in adolescents. The study found that adolescents with better socioeconomic conditions had a lower risk of infection. Additionally, a higher risk of arboviral diseases was associated with a high mosquito infestation index in the school's region. These findings can contribute to the implementation of control measures in population groups and priority locations.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biology
Xinyi Liu, Shuzhen Yang, Yuan Yao, Si Wu, Pa Wu, Zongzhao Zhai
Summary: This study reveals that mosquitoes consistently prefer darker environments and identifies the first example of a visual molecule that modulates mosquito photobehavior.
Article
Biochemical Research Methods
Hukam Chand Rawal, Shakir Ali, Tapan Kumar Mondal
Summary: In recent years, the identification and analysis of miRNAs and tRFs have been extensively studied. Using benchmarking methodologies, researchers have developed accurate methods for predicting and identifying these molecules, which is important for studying both model and non-model organisms.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Panagiota Agrafioti, Joshua Morin-Baxter, Kranthi K. K. Tanagala, Sunil Dubey, Peter Sims, Evanthia Lalla, Fatemeh Momen-Heravi
Summary: By using single-cell RNA-sequencing, this study revealed the heterogeneity and transcriptional heterogeneity of macrophages in periodontitis. The study found that macrophages in periodontitis express both pro-inflammatory and anti-inflammatory markers, and their polarization is closely associated with the inflammatory response.
Article
Immunology
M. Ratheesh, Sujatha Sunil, S. Sheethal, Svenia P. Jose, S. Sandya, Oriparambil Sivaraman Nirmal Ghosh, Sony Rajan, Tariq Jagmag, Jayesh Tilwani
Summary: The study aims to demonstrate the anti-viral and anti-inflammatory effects of a novel polyherbal formulation called Imusil. Chemical characterizations of Imusil were conducted, and the results showed that Imusil significantly inhibited the replication of SARS-CoV-2 and reduced the production of inflammatory mediators.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cell Biology
Divyaa Srinivasan, Tarak Shisode, Jatin Shrinet, Peter Fraser
Summary: Genome organization and the folding of chromosomes play significant roles in nuclear functions, such as gene regulation, replication, and repair. Chromosomes undergo continuous conformational changes throughout the cell cycle, with differential dynamics in various structures. Understanding these changes is crucial for interpreting genome conformation data and identifying the driving molecules and mechanisms behind chromosomal conformational changes.
JOURNAL OF CELL SCIENCE
(2022)
Article
Microbiology
Sheetal Kaul, Vivek Nair, Shweta Birla, Shikha Dhawan, Sumit Rathore, Vishal Khanna, Sheelu Lohiya, Shakir Ali, Shamim Mannan, Kirankumar Rade, Pawan Malhotra, Dinesh Gupta, Ashwani Khanna, Asif Mohmmed
Summary: This study compares the potential of transcript signatures and IGRA in diagnosing LTBI. A transcript signature (FCGR1B, GBP1, & GBP5) is identified as a potential biomarker for LTBI. These results can lead to the development of a point-of-care (POC)-like device for screening LTBI in high TB burden areas.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Sunil Kumar Dubey, Divya Mehta, Sakshi Chaudhary, Abdul Hasan, Sujatha Sunil
Summary: Arboviruses cause various diseases and vector control is the main strategy. The study found that AeCullin-3 plays a proviral role in CHIKV replication in Aedes aegypti.
MICROBIOLOGY SPECTRUM
(2022)
Article
Genetics & Heredity
Shanshan Zhang, Dylan Plummer, Leina Lu, Jian Cui, Wanying Xu, Miao Wang, Xiaoxiao Liu, Nachiketh Prabhakar, Jatin Shrinet, Divyaa Srinivasan, Peter Fraser, Yan Li, Jing Li, Fulai Jin
Summary: DeepLoop is a modular Hi-C processing workflow that enables robust chromatin interaction mapping from low-depth Hi-C data through deep-learning-based signal enhancement. It can identify allele-specific chromatin loops and structural variants, providing loop-resolution insights into the genetics of the three-dimensional genome.
Article
Nutrition & Dietetics
Anubhuti Gupta, Kunal Singh, Sameen Fatima, Saira Ambreen, Silke Zimmermann, Ruaa Younis, Shruthi Krishnan, Rajiv Rana, Ihsan Gadi, Constantin Schwab, Ronald Biemann, Khurrum Shahzad, Vibha Rani, Shakir Ali, Peter Rene Mertens, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a major metabolic disease with limited treatment options. This study discovers that sterile inflammation caused by neutrophil extracellular traps (NETs) may play a significant role in DKD. Inhibiting NETs may provide a promising therapeutic strategy for DKD.
Article
Anthropology
Kiran Meena, Anoop Misra, Naval Vikram, Shakir Ali, Ashish Datt Upadhyay, Kalpana Luthra
Summary: This study evaluated the distribution of FABP-2 Ala54Thr polymorphism and its association with lipid levels in hyperlipidemic Asian Indians. The results showed that the heterozygous genotype FABP-2 Ala/Thr was significantly associated with higher triglycerides and very low-density lipoproteins.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2023)
Article
Oncology
Nadia Mezghani, Alexandria Yao, Daria Vasilyeva, Nicole Kaplan, Austin Shackelford, Angela Yoon, Elizabeth Phillipone, Sunil Dubey, Gary K. Schwartz, Alison M. Taylor, Fatemeh Momen-Heravi
Summary: The purpose of this study was to understand the molecular biomarkers and signatures of head and neck cancer (HNC) among Black patients and identify molecular changes associated with HNC disparities. The study identified molecular subtypes and genomic changes in HNC samples from Black and White patients, as well as their clinical outcomes. The findings showed that Black patients had more aggressive tumor types, higher frequencies of certain gene mutations, and poorer survival outcomes. The study suggests that these molecular features could be used for more targeted screening, diagnosis, and treatment to improve health outcomes.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Medicinal
Shweta Sharma, Mohd. Hafizur Rehman Ansari, Kalicharan Sharma, Rajesh K. Singh, Shakir Ali, Mohd. Mumtaz Alam, Mohd. Shaqiquzamman Zaman, Prawez Alam, Mymoona Akhter
Summary: In this study, a series of analogues were synthesized and evaluated, and KB-23, KB-22, and KB-06 showed promising antihyperglycemic potential in both in vitro and in vivo studies, making them potential starting points for the development of antidiabetic agents.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Kranthi Kiran Kishore Tanagala, Joshua Morin-Baxter, Richard Carvajal, Maryum Cheema, Sunil Dubey, Hiroshi Nakagawa, Angela Yoon, Yi-Shing L. Cheng, Alison Taylor, Jeffrey Nickerson, Akiva Mintz, Fatemeh Momen-Heravi
Summary: Understanding the role of SP140 in tumor-associated macrophages (TAMs) is crucial for cancer immunotherapies. Our study found that higher expression of SP140 in tumors was associated with improved survival and a favorable response to immunotherapy. SP140 negatively regulated STAT1 transcription and phosphorylation and induced IFN-gamma signaling, leading to increased antitumor activity of macrophages. SP140 expression also predicted the response to immunotherapy in HNSCCs and melanoma. These findings suggest that SP140 could be a potential therapeutic target and biomarker in cancer immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Infectious Diseases
Ankit Kumar, Jatin Shrinet, Sujatha Sunil
Summary: This study evaluates the impact of CHIKV infection on the redox biology of Aedes mosquitoes. The findings suggest that by providing dietary supplements of L-cysteine and reducing the expression of specific genes, oxidative damage during CHIKV infection can be regulated through protein carbonylation and GST activity.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Priya Bhatnagar, Prashant Bajpai, Jatin Shrinet, Murali Krishna Kaja, Anmol Chandele, Ramakrishnan Sitaraman
Summary: NS5, the most conserved protein among flaviviruses, functions as an RNA-dependent RNA polymerase and an RNA-methyltransferase and is essential for viral RNA replication. This study used computational approaches to predict host proteins that interact with DENV-NS5, and identified 34 novel interactions. The predicted human proteins are involved in key cellular processes related to cell cycle regulation, proliferation, protein degradation, apoptosis, and immune responses.
Article
Biochemistry & Molecular Biology
Pavan Kumar Kakumani, Yunkoo Ko, Sushmitha Ramakrishna, Grace Christopher, Maria Dodgson, Jatin Shrinet, Louis-Mathieu Harvey, Chanseok Shin, Martin J. Simard
Summary: This study found that the RNA binding protein CSDE1 controls the expression of miR-451 in erythroleukemia cells by binding to it. CSDE1 regulates the processing of pre-miR-451 by AGO2 through its N-terminal domains. CSDE1 also interacts with PARN to promote the trimming of intermediate miR-451 to its mature length. These results demonstrate that CSDE1 promotes the biogenesis of miR-451 in erythroid progenitors.
NUCLEIC ACIDS RESEARCH
(2023)
