Review
Pharmacology & Pharmacy
Lisna Meylina, Muchtaridi Muchtaridi, I. Made Joni, Ahmed Fouad Abdelwahab Mohammed, Nasrul Wathoni
Summary: Natural compounds, such as alpha-mangostin, are being explored for their potential in cancer treatment, with nanoformulations showing promise in enhancing their efficacy through improved cellular uptake and accumulation in tumors. Specifically, polymeric nanoparticles and nanomicelles have demonstrated the ability to increase the accumulation of alpha-mangostin in tumors and inhibit tumor growth in vivo.
Review
Chemistry, Multidisciplinary
Rajeev Taliyan, Violina Kakoty, K. C. Sarathlal, Sanskruti Santosh Kharavtekar, Chandrashekar R. Karennanavar, Yogendra Kumar Choudhary, Gautam Singhvi, Yassine Riadi, Sunil Kumar Dubey, Prashant Kesharwani
Summary: Dementia is a progressive memory-related neurodegenerative disease observed in the geriatric population. The current therapeutics for Alzheimer's disease primarily target symptomatic management and face challenges in crossing the blood-brain barrier and blood-cerebrospinal fluid barrier. Nanocarriers show promise in facilitating targeted drug delivery for the management of Alzheimer's disease.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Environmental
Thi Hien Nguyen, Thuy Chinh Nguyen, Thi Minh Tu Nguyen, Dinh Hoa Hoang, Do Mai Trang Tran, Dinh Thang Tran, Phuong Thai Hoang, Van Tan Le, Thi Kim Ngan Tran, Hoang Thai
Summary: The study developed microparticles loaded with alpha-mangostin extracted from Vietnamese mangosteen skin using carrageenan and chitosan. The microparticles exhibited improved release ability of alpha-mangostin into solutions, maintained its bioactivities, reduced vero cell toxicity, and showed antibacterial and antioxidant activities. The combination of chitosan and carrageenan in the microparticles enhanced the controlled release of alpha-mangostin.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Environmental Sciences
Nargis Jamila, Naeem Khan, Nousheen Bibi, Muhammad Waqas, Sadiq Noor Khan, Amir Atlas, Farhat Amin, Faryal Khan, Malka Saba
Summary: The study successfully synthesized silver nanoparticles (AgNPs) using Garcinia mangostana fruit pericarp extracts and alpha-mangostin. These AgNPs showed excellent performance in Hg(II) detection, as well as demonstrated potential applications in dye degradation and anticancer research.
Review
Veterinary Sciences
Chun Wang, Cuiting Yang, Yutian Zeng, Ming Zhang
Summary: Traditional methods of castration in animals have welfare issues, while GnRH immunocastration, as an animal-friendly alternative, effectively addresses these issues. This review systematically summarizes the principles, development, current applications, and challenges of GnRH immunocastration, offering insights into its role in promoting animal welfare.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Tojofaniry Fabien Rakotondrabe, Min-Xia Fan, Felix Wambua Muema, Ming-Quan Guo
Summary: The global increase and prevalence of inflammatory-mediated diseases have posed a significant threat to human welfare. Natural polyphenolic compounds, such as flavonoid derivatives and phenolic acids, have shown promising anti-inflammatory potentials. To enhance their stability and bioavailability, nanocarrier technologies, including organic and inorganic carriers, have been employed. These nanocarrier systems not only improve the stability and bioavailability of natural polyphenolic compounds, but also enhance their target delivery and reduce drug toxicity and adverse effects.
Review
Chemistry, Physical
Ana S. Macedo, Francisca Mendes, Patricia Filipe, Salette Reis, Pedro Fonte
Summary: This review discusses a promising therapeutic strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers, which can accelerate re-epithelialization and stimulate angiogenesis.
Article
Nutrition & Dietetics
Yu-Hsien Lee, Pei-Ling Hsieh, Shih-Chi Chao, Yi-Wen Liao, Chia-Ming Liu, Cheng-Chia Yu
Summary: This study found that alpha-mangostin can inhibit the development of oral submucous fibrosis and also reduce the expression of long non-coding RNA LincROR. The results suggest that alpha-mangostin has anti-fibrosis effects, which may be achieved through the downregulation of LincROR.
Article
Pharmacology & Pharmacy
Tian-Tian Jiang, Chao-Fan Ji, Xiu-Ping Cheng, Shao-Fei Gu, Rui Wang, Yan Li, Jian Zuo, Jun Han
Summary: MAN treatment inhibits aerobic glycolysis in AIA rats, which consequently eases inflammation-related hypoxia, and hampers pathological neovascularization. MAN has inhibitory effects on the migration and tube formation capability of both AIA rats and human umbilical vein endothelial cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song
Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Shogo Nishida, Yuuki Takashima, Ryotaro Udagawa, Hisako Ibaraki, Yasuo Seta, Hiroshi Ishihara
Summary: This study aimed to develop a nanocarrier for the non-invasive delivery of siRNA to the retina by eyedrops. A hybrid nanocarrier based on a multifunctional peptide and liposomes was prepared and optimized. The results showed that the nanocarrier significantly enhanced siRNA transfection efficiency and effectively suppressed vascular endothelial growth factor expression in rat retinal pigment epithelium cells.
Article
Pharmacology & Pharmacy
Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu, Siyu Chen
Summary: The study successfully developed a nanoparticle system based on biomaterials for co-delivery of MET and DOX into melanoma tumors, resulting in the inhibition of melanoma progression.
Article
Cell & Tissue Engineering
Shengsen Yang, Fei Zhou, Yi Dong, Fei Ren
Summary: Alpha-mangostin inhibits the growth of osteosarcoma cells while having little effect on normal human osteoblast cells. It induces apoptosis in osteosarcoma cells by activating the caspase-3/8 cascade and inducing endoplasmic reticulum stress, while also suppressing the Wnt/beta-catenin pathway. The apoptosis triggered by alpha-mangostin is mediated by reactive oxygen species-induced ER stress, dependent on Wnt/beta-catenin signaling inactivation.
CELL TRANSPLANTATION
(2021)
Article
Pharmacology & Pharmacy
Xiaolin Yu, Lu Xue, Jing Zhao, Shuhua Zhao, Daqing Wu, Hong Yan Liu
Summary: In this study, a genetically engineered non-cationic non-viral tumor-targeted universal siRNA nanocarrier was developed, which showed great potential for tumor-targeted siRNA delivery with low toxicity and high efficiency. This multifunctional and biomimetic siRNA carrier is biodegradable, suitable for mass production, and holds promise for widespread application in vivo.
Article
Pharmacology & Pharmacy
Negar Bidar, Majid Darroudi, Ailin Ebrahimzadeh, Mohammadreza Safdari, Miguel de la Guardia, Behzad Baradaran, Vahabodin Goodarzi, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: RNA interference (RNAi) has been found to have a great potential in reducing cancer burden by downregulating genes. Small interfering RNA (siRNA) is a more attractive molecule for this purpose, as it can silence a pathological pathway and promote mRNA degradation, resulting in changes in protein function. Nanocarrier-mediated delivery of siRNA using inorganic nanoparticles, polymers, and lipids has been developed as a biocompatible approach to overcome the limitations of siRNA delivery.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Kanokwan Sansanaphongpricha, Pacharapan Sonthithai, Pakkanun Kaewkong, Boonlom Thavornyutikarn, Suwussa Bamrungsap, Wasana Kosorn, Tapanee Thinbanmai, Nattika Saengkrit
Article
Biophysics
Warut Kengkittipat, Somrudee Kaewmalun, Mattaka Khongkow, Tawin Iempridee, Angkana Jantimaporn, Phichaporn Bunwatcharaphansakun, Jakarwan Yostawonkul, Teerapong Yata, Waranyoo Phoolcharoen, Katawut Namdee
Summary: A hybrid nanocarrier system comprising biloniosome-core/chitosan-shell was developed to enhance the bioavailability of cordycepin. The system showed enhanced mucoadhesive characteristics, stability in gastric fluid, and increased permeability across the intestinal barrier. Cordycepin-loaded HNCs demonstrated effective anti-cancer activity in both 2D cell cultures and 3D multi-cellular spheroids of colon cancer cells. Quantitative real time PCR analysis revealed the mechanism by which cordycepin HNCs induce apoptosis in cancer cells. This study suggests that hybrid nanocarrier systems could be a promising strategy for improving the bio-characteristics of cordycepin as a potential anti-cancer agent for colorectal cancer chemotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Paweena Dana, Suphawadee Bunthot, Kunat Suktham, Suvimol Surassmo, Teerapong Yata, Katawut Namdee, Werayut Yingmema, Thunyatorn Yimsoo, Uracha Rungsardthong Ruktanonchai, Sith Sathornsumetee, Nattika Saengkrit
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Inorganic & Nuclear
Nuttaporn Pimpha, Noppawan Woramongkolchai, Panya Sunintaboon, Nattika Saengkrit
Summary: This study proposed a novel nanoparticle-based antimicrobial agent with recycle ability, showing effective antibacterial and antiviral properties against infectious pathogens in contaminated water, especially demonstrating strong antibacterial activity against waterborne pathogens.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Multidisciplinary Sciences
Chutchai Piewbang, Sabrina Wahyu Wardhani, Jira Chanseanroj, Jakarwan Yostawonkul, Suwimon Boonrungsiman, Nattika Saengkrit, Piyaporn Kongmakee, Wijit Banlunara, Yong Poovorawan, Tanit Kasantikul, Somporn Techangamsuwan
Summary: CPPV-1 infection in fishing cats leads to systemic fatal diseases, with lesions observed in the intestine, spleen, and kidney. The virus was localized in the kidneys for the first time. Genetic analysis showed clustering with FPV genomes from domestic cats in Thailand, indicating potential harm to other vulnerable wild carnivores from fatal CPPV-1 infections.
Article
Pharmacology & Pharmacy
Paweena Dana, Jakarwan Yostawonkul, Walailuk Chonniyom, Onuma Unger, Sakhiran Sakulwech, Sith Sathornsumetee, Nattika Saengkrit
Summary: Glioblastoma (GBM) is a primary malignant brain tumor that is difficult to treat; using nanostructured lipid carriers (NLC) as a carrier for garlic oil can improve its bioavailability and inhibit glioma cell viability more efficiently.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Waleewan Eaknai, Phichaporn Bunwatcharaphansakun, Chutikorn Phungbun, Angkana Jantimaporn, Sasikan Chaisri, Suwimon Boonrungsiman, Ubonthip Nimmannit, Mattaka Khongkow
Summary: This research demonstrates that fenugreek extract has inhibitory activity against collagenase and nanoencapsulation can enhance its bioactivities. The formulated liponiosome encapsulating fenugreek extract (LNF) exhibits sustained release, improved skin penetration, and molecular mechanisms against skin aging. It could potentially be used as an innovative ingredient for the prevention of skin aging.
Article
Medicine, Research & Experimental
Nutthanit Thumrongsiri, Paweena Dana, Rand Bawab, Prattana Tanyapanyachon, Chaichana Treetidnipa, Nattika Saengkrit, Sith Sathornsumetee
Summary: The study demonstrated that liposomes conjugated with RTX and modified with tween-80 can effectively penetrate the blood-brain barrier, targeting lymphoma cells in the CNS. The Lip/RTX showed comparable antitumor activity to free RTX and inhibited tumor aggressiveness. Systemic administration of Lip/RTX significantly prolonged the survival of mice with intracranial lymphoma xenografts.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Pornthida Riangjanapatee, Mattaka Khongkow, Alongkot Treetong, Onuma Unger, Chutikorn Phungbun, Supatchaya Jaemsai, Chatchaya Bootsiri, Siriporn Okonogi
Summary: This study developed nanostructured lipid carriers loaded with tea seed oil, which showed better nontoxicity and growth-stimulating effect on human follicle dermal papilla cells compared to the intact oil. The nanoformulations exhibited excellent stability and improved spreadability in a hair serum formulation, reducing the sticky and greasy feeling after use.
Article
Infectious Diseases
Mariusz Skwarczynski, Sahra Bashiri, Ye Yuan, Zyta M. Ziora, Osama Nabil, Keita Masuda, Mattaka Khongkow, Natchanon Rimsueb, Horacio Cabral, Uracha Ruktanonchai, Mark A. T. Blaskovich, Istvan Toth
Summary: The development of effective treatments against infectious diseases requires overcoming bacteria's rapid adaptation to antibiotics. Appropriately designed activity enhancers can increase the effectiveness of current antibiotics, reduce antibiotic resistance, improve drug delivery and penetration, and decrease side effects.
Article
Biochemistry & Molecular Biology
Sasiwimon Nukulkit, Angkana Jantimaporn, Preeyaporn Poldorn, Mattaka Khongkow, Thanyada Rungrotmongkol, Hsun-Shuo Chang, Rutt Suttisri, Chaisak Chansriniyom
Summary: Eight new indole alkaloids were isolated from Maerua siamensis roots, showing anti-inflammatory activity, with maeruabisindole B exhibiting the most significant inhibition of nitric oxide production.
Article
Immunology
Jieru Yang, Jennifer C. Boer, Mattaka Khongkow, Sarunya Phunpee, Zeinab G. Khalil, Sahra Bashiri, Cyril Deceneux, Georgia Goodchild, Waleed M. Hussein, Robert J. Capon, Uracha Ruktanonchai, Magdalena Plebanski, Istvan Toth, Mariusz Skwarczynski
Summary: Intranasal vaccine administration has advantages in mass immunization. A new liposomal system using lipidated chitosan derivative (OTMC) showed promising results in stimulating high systemic antibody titers against group A Streptococcus (GAS) in mice. OTMC was more effective than the traditional trimethyl chitosan formulation and could enhance the immune responses of the vaccine without the need for a liposome delivery system. Importantly, OTMC also stimulated cytokine production by dendritic cells, indicating its potential for mucosal vaccine development.
Article
Pharmacology & Pharmacy
Farrhana Z. Z. Firdaus, Stacey Bartlett, Waleed M. M. Hussein, Lantian Lu, Quentin Wright, Wenbin Huang, Ummey J. J. Nahar, Jieru Yang, Mattaka Khongkow, Margaret Veitch, Prashamsa Koirala, Uracha R. R. Ruktanonchai, Michael J. J. Monteiro, Jazmina L. Gonzalez L. Cruz, Rachel J. J. Stephenson, James W. W. Wells, Istvan Toth, Mariusz Skwarczynski
Summary: Human papilloma virus (HPV) is responsible for all cases of cervical cancer. Peptide-based vaccines, such as 8Qm conjugated to polyleucine, show promise as a therapeutic option with fewer side effects compared to chemotherapy and surgery. Liposomes incorporating the 8Qm conjugate demonstrated efficacy in tumor eradication, while the introduction of DC-targeting moieties did not significantly improve vaccine efficacy.
Article
Biochemistry & Molecular Biology
Sasikarn Kongsompong, Teerasak E-Kobon, Weerasak Taengphan, Mattanun Sangkhawasi, Mattaka Khongkow, Pramote Chumnanpuen
Summary: This study investigated the anti-tyrosinase properties of Haliotis diversicolor tyrosinase inhibitory peptides (hdTIPs) and found that the peptide KNN1 exhibited high inhibitory activity against mushroom tyrosinase. Additionally, hdTIPs peptides could reduce tyrosinase activity and reactive oxygen species levels, leading to a decrease in melanin content. Therefore, these selected peptides have great potential for medical cosmetology applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Phitsanu Pinmanee, Kamonwan Sompinit, Jantima Arnthong, Surisa Suwannarangsee, Angkana Jantimaporn, Mattaka Khongkow, Thidarat Nimchua, Prakit Sukyai
Summary: Superoxide dismutase (SOD), an antioxidant enzyme, plays a crucial role in protecting cells against reactive oxygen species (ROS). In this study, the high SOD production of Saccharomyces cerevisiae TBRC657 was utilized. By optimizing the culture medium, molasses and yeast extract were identified as the major components that significantly increased SOD production. The optimized medium did not require induction, making it suitable for large-scale production. The SOD formulation, with trehalose as the best additive, exhibited enhanced stability and maintained activity after storage. The obtained SOD demonstrated cytotoxicity and ROS elimination properties in fibroblast cells. Therefore, S. cerevisiae TBRC657-derived SOD in the optimized medium could be a potential ROS scavenger for various industries.
FERMENTATION-BASEL
(2022)
