Article
Physiology
Sian-Tai Liu, Jiun-Lin Horng, Li-Yih Lin
Summary: This study investigates the subcellular localization and function of NHE2 in ionocytes of seawater fishes, showing its crucial role in acid-base regulation and salt secretion.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Chia-Hao Lin, Huei-Jyun Hu, Hsin-Ju Chuang, Yi-Ling Tsou, Pung-Pung Hwang
Summary: The study revealed that mRNA levels of acid secretion transporters and cortisol-synthesis enzymes increased in medaka larvae after treatment in acidic freshwater. Exogenous cortisol treatment promoted the expression of nhe3 and rhcg1 genes, as well as acid secretion in medaka larvae. Loss-of-function experiments showed that glucocorticoid receptor 2 plays a conserved role in regulating fish body fluid acid-base balance.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Article
Environmental Sciences
Naveen Ranasinghe, Chia-Hao Lin, Tsung-Han Lee
Summary: This study revealed the relationship between cholesterol metabolism and SIRT1, LXR alpha, and SREBP-1 in fish, as well as the effects of salinity on hepatic cholesterol metabolism in euryhaline teleosts. The results showed that SREBP-1 is involved in cholesterol biosynthesis in fish, and knockdown of SREBP-1 has differential effects on the expression of key enzymes involved in cholesterol biosynthesis.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cell Biology
Ke Lu, Jiaqi Wu, Shulin Tang, Yuye Wang, Lixin Zhang, Farui Chai, Xu-Fang Liang
Summary: Depletion of sws1 in medaka larvae impairs visual function, leading to retinal cell apoptosis, which may be associated with the downregulation of photoconduction expression and oxidative stress.
Article
Marine & Freshwater Biology
Abraham J. Fischer, Leslie Kerr, Tamanna Sultana, Chris D. Metcalfe
Summary: The study found that exposure to codeine reduced reproductive capacity and altered hormone levels in fish. However, exposure to fentanyl did not affect fish reproduction or hormone levels. Monitoring in southern Ontario, Canada showed that concentrations of fentanyl and codeine in surface waters were environmentally relevant. These findings contribute to understanding the impacts of opioids and other drugs released into surface waters.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Anitha Myla, Asok K. Dasmahapatra, Paul B. Tchounwou
Summary: The study focused on the sex development and sex reversal of Japanese medaka under exposure to different concentrations of GO. Results showed that exposure to GO had an impact on the sex development of medaka, but had minimal effects on the histopathology/histochemistry of liver and kidneys.
Article
Environmental Sciences
Yangqing Liu, Xuchun Qiu, Xinning Xu, Yuki Takai, Hijiri Ogawa, Yohei Shimasaki, Yuji Oshima
Summary: The study revealed the distribution and concentration of fluorescent-labeled MPs of different diameters in the bodies of Japanese medaka, indicating that 2 μm diameter PS-MPs may pose risks of long-term persistence in aquatic species.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ruichao Chen, Jianwu He, Yu Li, Lihui An, Jianying Hu
Summary: Tricresyl phosphate (TCrP), a commonly found compound in global water sources, has been found to have potential reproductive toxicity to fish. Exposure to TCrP resulted in significant fertilization inhibition and induced intersex in Japanese medaka larvae. The compound also caused dilation of the efferent duct in the testes. Metabolites of TCrP exhibited higher androgen receptor antagonistic activity and anti-estrogenic activities, which may contribute to the observed adverse outcomes. These adverse effects occurred at environmentally relevant concentrations, indicating considerable ecological risk to wild fish.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Xi Li, Xinwen Li, Wenhao Li, Yingqing Zhang, Haiyan Guo, Guangxing Wang, Yayuan Li, Xiaowen Wu, Ruiqin Hu, Siyu Wang, Xiaomiao Zhao, Liangbiao Chen, Guijun Guan
Summary: The study reveals the important role of gsdf in meiotic entry in medaka by analyzing gametogenesis in gsdf-deficient gonads. The deficiency of gsdf leads to abnormal expression of genes like Sycp3, causing disruption of normal gametogenesis processes. This finding is supported by immunofluorescence analysis and transmission electron microscope observations.
Article
Ophthalmology
Megumi Matsuo, Makoto Matsuyama, Tomoe Kobayashi, Shinji Kanda, Satoshi Ansai, Taichi Kawakami, Erika Hosokawa, Yutaka Daido, Takehiro G. Kusakabe, Kiyoshi Naruse, Shoji Fukamachi
Summary: The study aimed to assess the effects of SWS1 deficiency on retinal structure using sws1-mutant medaka. The results showed that the deletion of SWS1 did not cause retinal degeneration and had no impact on the expression of long wavelength sensitive opsin.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Environmental Sciences
Miguel Gonzalez-Doncel, Jose Enrique Garcia-Maurino, Eulalia Maria Beltran, Carlos Fernandez Torija, Oscar Andreu-Sanchez, Maria Victoria Pablos
Summary: The number of studies evaluating the effects of microplastics on fish has increased, but few studies have explored the long-term effects. This study found that a 150-day exposure to polystyrene microplastics did not affect overall fish growth and development, but did have mild effects on certain organs and reproduction.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Hsin-Ju Chuang, Ling Chiu, Jia-Jiun Yan, Chun-Yung Chang, Yu-Hsin Tang, Ming-Yi Chou, Hon-Tsen Yu, Pung-Pung Hwang
Summary: Anthropogenic acidification of water is devastating for freshwater fishes. In this study, medaka fish were used to investigate the effects of acidic stress on ammonia production and excretion. The researchers discovered a previously unknown type of ammonia-producing cell in the gills of the fish, which works in coordination with ammonia-excreting cells. This finding sheds light on a novel physiological mechanism for mitigating the harmful effects of acidification.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Endocrinology & Metabolism
Muhammad Rahmad Royan, Khadeeja Siddique, Gergely Csucs, Maja A. Puchades, Rasoul Nourizadeh-Lillabadi, Jan G. Bjaalie, Christiaan Henkel, Finn-Arne Weltzien, Romain Fontaine
Summary: This study utilized medaka as a model to reveal the gland-wide distribution of seven endocrine cell populations in the anterior pituitary using multi-color fluorescence in situ hybridization. The research also demonstrated sexual dimorphism and the presence of bi-hormonal cells within these populations, offering a basis for future comparative studies on the teleost pituitary and its functional plasticity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tapas Chakraborty, Sipra Mohapatra, Michiya Matsuyama, Yoshitaka Nagahama, Kohei Ohta
Summary: This study investigated the role of sxl in vertebrate gonadogenesis and sexuality using medaka, and identified two Sxl homologues, Sxl1a and Sxl1b. It was found that sxl1a specifically expressed in primordial germ cells (PGC) and played a role in germ cell numbers and sexual identity assignment through its association with estrogenic signaling and er beta 2. This study highlights the novel role of sxl1a in germ cell maintenance and sexual identity determination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Melissa Chernick, Alan Kennedy, Treye Thomas, Keana C. K. Scott, Christine Ogilvie Hendren, Mark R. Wiesner, David E. Hinton
Summary: Polymer nanocomposites combine the characteristics of polymers and nanomaterials, but ingestion of these materials may pose health risks. Particularly, multi-walled carbon nanotubes (MWCNTs) may contribute to toxicity and unique effects.