Article
Cell & Tissue Engineering
Hewei Xiong, Sen Ren, Jing Chen, Xiaofan Yang, Yutian Liu, Zhao Xu, Jiahe Guo, Tao Jiang, Meng Yuan, Yang Liu, Guolei Zhang, Wenqing Li, Hans-Guenther Machens, Zhenbing Chen
Summary: The lncRNA SAN mediates ASC senescence by regulating the miR-143-3p/ADD3 pathway, providing a potential target for rejuvenation of senescent ASCs and enhancement of wound repair.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Vu Anh Truong, Ya-Hui Lin, Nuong Thi Kieu Nguyen, Mu-Nung Hsu, Nam Ngoc Pham, Yi-Hao Chang, Chin-Wei Chang, Chih-Che Shen, Hsiang-Sheng Lee, Po-Liang Lai, Yelena Parfyonova, Mikhail Menshikov, Jaw-Ching Wu, Yu-Han Chang, Yu-Chen Hu
Summary: This study demonstrates the potential of the CRISPR-BiD system in bi-directional regulation of cell fate, particularly in transforming adipogenic differentiation into chondrogenic differentiation, thus improving calvarial bone healing. The findings suggest the application of this system in regenerative medicine.
Article
Endocrinology & Metabolism
Chao Gu, Quan Zhou, Xiayu Hu, Xiaoyang Ge, Mingzhuang Hou, Wenhao Wang, Hao Liu, Qin Shi, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Tao Liu, Fan He
Summary: Osteoporotic bone defects are a severe complication of osteoporosis. This study found that melatonin has the potential to enhance the repair of osteoporotic bone defects by restoring the mitochondrial function of bone marrow-derived mesenchymal stem cells (BMMSCs). In vitro experiments showed that melatonin improved the mitochondrial function of BMMSCs and reduced the level of mitochondrial superoxide. In animal experiments, silk fibroin scaffolds loaded with melatonin partially restored the mitochondrial energy metabolism and osteogenic differentiation of BMMSCs.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Oncology
Jinlong Chen, Yishan Yang
Summary: HAGLR regulates BMP2 by absorbing miR-214-3p to play a protective role in tibial fracture, promoting osteoblast proliferation, inhibiting apoptosis, and up-regulating serum ALP and OPG levels to accelerate bone healing.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Zhitao Yao, Wei An, Adili Moming, Maimaitituxun Tuerdi
Summary: This study investigated the effect of long non-coding RNA (lncRNA) TUG1 on maxillofacial fracture development. The results demonstrated that TUG1 expression was decreased in patients with maxillary fractures and TUG1 knockdown repressed the biological process of osteoblasts by sponging miR-214.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yuan Zhou, Li Chen, Deping Ding, Ziheng Li, Li Cheng, Qiuyun You, Shunbo Zhang
Summary: Our research revealed the potential mechanism by which C3G mediates the suppression of temozolomide resistance in LN-18/TR cells through upregulating miR-214-5p, which may help in the treatment of MGMT-induced resistance in glioma cells.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jiawei Wang, Xiaolin Li, Chao Duan, Yifei Jia
Summary: This study found that circFNDC3B is highly expressed in esophageal squamous cell carcinoma (ESCC) and is closely associated with poor prognosis in patients. Acting as a sponge for miR-214-3p, circFNDC3B upregulates the expression of its target gene CDC25A. Silencing of circFNDC3B inhibits the in vitro and in vivo growth, migration, and invasion of ESCC. Therefore, circFNDC3B may serve as a potential therapeutic target for ESCC.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Zhaoyang Ran, Yan Wang, Jiaxin Li, Wenyu Xu, Jia Tan, Bojun Cao, Dinghao Luo, Yiwen Ding, Junxiang Wu, Lei Wang, Kai Xie, Liang Deng, Penghuai Fu, Xiaoying Sun, Liyi Shi, Yongqiang Hao
Summary: Osteoporotic fracture, a serious complication of osteoporosis, is difficult to repair due to the imbalance between osteogenesis and bone destruction. This study successfully fabricated 3D-printed biodegradable magnesium alloy scaffolds with a zoledronic acid-loaded ceramic composite coating. The coating reduced the degradation rate of the scaffolds and achieved a slow release of drugs. The degradation products of the drug-loaded coating promoted osteogenic differentiation and inhibited bone resorption. Compared to uncoated scaffolds, the drug-coated scaffolds showed improved healing rates and quality of osteoporotic bone defects. This study provides a new method for repairing osteoporotic bone defects using functional materials.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biochemistry & Molecular Biology
Huali Xiang, Binfeng Tu, Ming Luo, Ping Hou, Jiakun Wang, Rongguiyi Zhang, Linquan Wu
Summary: This study focused on the role of long noncoding RNA UCA1 in alcoholic fatty liver (AFL) and explored the potential mechanism of this disease. The researchers found that UCA1 expression was up-regulated in AFL patients and ethanol-induced L02 cells. Knockdown of UCA1 reversed the inhibiting effect of ethanol on L02 cell behavior, including cell proliferation, migration, and apoptosis. Additionally, UCA1 regulated the expression of KLF5 by sponging miR-214. These findings may provide novel therapeutic strategies for alcoholic fatty liver.
Article
Oncology
Chao Gao, Yi Zhang, Yanming Tian, Chun Han, Lan Wang, Boyue Ding, Hua Tian, Chaoxi Zhou, Yingchao Ju, Ale Peng, Qiyao Yu
Summary: The study revealed that circ_0055625 inhibited the progression and radioresistance of colon cancer by regulating MSI1 through sponging miR-338-3p.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Materials Science, Biomaterials
Jihong Li, Jinlin Song, Di Meng, Yin Yi, Ting Zhang, Yu Shu, Xiaohong Wu
Summary: Repairing osteoporotic bone defects is a major challenge in clinical practice. Recent studies have shown that immune response plays a crucial role in osteogenesis. This study constructed an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate (Ng-m-SAIB) system to investigate its effect on macrophage polarization and osteoporotic bone defects. The results demonstrated that Ng-m-SAIB promoted macrophage polarization towards M2 and created a favorable microenvironment for osteogenesis. In animal experiments, Ng-m-SAIB also effectively promoted osteogenesis in critical size defects in the skull of a mouse model. These findings suggest that Ng-m-SAIB is a promising biomaterial for treating osteoporotic bone defects with osteo-immunomodulatory effects.
REGENERATIVE BIOMATERIALS
(2023)
Article
Reproductive Biology
Jun Zhu, Jun-e Luo, Yurong Chen, Qiong Wu
Summary: The study revealed that circ_0061140 plays a role in PTX sensitivity and malignant progression of ovarian cancer by regulating the expressions of miR-136 and CBX2.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Nilanjan Ghosh, Sonya Fenton, Isabelle van Hout, Gregory T. Jones, Sean Coffey, Michael J. A. Williams, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Daryl O. Schwenke, Anirudha Chatterjee, Rajesh Katare
Summary: The study demonstrates that miR-320 plays a pathological role in diabetic heart disease by promoting apoptosis and cardiac dysfunction, and therapeutic knockdown of miR-320 can partially restore cardiac function.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Pharmacology & Pharmacy
Tao Li, Peiyang Tu, Jianbo Bi, Yanling Sun, Dejun Yu, Jinghao Wang, Baoshan Zhao
Summary: The study revealed that lncRNA Miat is upregulated in atherosclerosis and its suppression protects against ox-LDL-induced endothelial cell injury. Miat has binding sites with miR-214, and it exerts its effects by regulating the miR-214-3p/Caspase-1 signaling pathway.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hui Yuan, Hsiu-Wei Cheng, Laura L. E. Mears, Renliang Huang, Rongxin Su, Wei Qi, Zhimin He, Markus Valtiner
Summary: The study found that a DPPC layer formed on COL I has good lubricating properties and can reduce the coefficient of friction. In contrast, albumin and gamma-globulin exhibit poor lubrication effects but still provide protection to COL I from wear.