Article
Biochemistry & Molecular Biology
Juliette Cholet, Caroline Decombat, Laetitia Delort, Mael Gainche, Alexandre Berry, Clemence Ogeron, Isabelle Ripoche, Marjolaine Vareille-Delarbre, Marion Vermerie, Didier Fraisse, Catherine Felgines, Adrien Rossary, Edwige Ranouille, Jean-Yves Berthon, Albert Tourrette, Julien Priam, Etienne Saunier, Yves Troin, Francois Senejoux, Pierre Chalard, Florence Caldefie-Chezet
Summary: Luzula sylvatica extract demonstrated antioxidant and anti-inflammatory properties, inhibiting reactive oxygen species production and reducing the secretion of inflammatory mediators. It also decreased PGE2 secretion in synovial fluid and protected cartilage by decreasing the expression of proteases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Danijela Petkovic Ramadza, Ivana Kuhtic, Kamelija Zarkovic, Hanns Lochmuller, Mislav Cavka, Ida Kovac, Ivo Baric, Maja Prutki
Summary: This study analyzed the skeletal muscles of three brothers with S-Adenosylhomocysteine hydrolase deficiency (SAHHD) using MRI and MRS, and found that the extent of muscle involvement increased with age, especially in the proximal skeletal muscle groups of the lower extremities. These findings demonstrate the importance of MRI and MRS in understanding muscle involvement and treatment response in SAHHD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Joyce Sweeney Gibbons, Sudip Khadka, Caroline G. Williams, Lin Wang, Stewart W. Schneller, Chong Liu, JoAnn M. Tufariello, Christopher F. Basler
Summary: 3-deazaneplanocin A (DzNep) and its 3-brominated analogs inhibit replication of several RNA viruses by targeting viral methyltransferases, impairing translation of viral transcripts. The compounds exhibit antiviral activity in nanomolar concentrations, with some enantiomers showing reduced inhibition of the target enzyme. A CL123-resistant mutant of VSV exhibited cross-resistance to neplanocin analogs, suggesting a common mechanism of action involving impairment of viral mRNA cap methylation.
ANTIVIRAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Vladimir Burmistrov, Christophe Morisseau, Denis A. Babkov, Tatiana Golubeva, Dmitry Pitushkin, Elena Sokolova, Vladimir Vasipov, Yaroslav Kuznetsov, Sergey Bazhenov, Uliana S. Novoyatlova, Nikolay A. Bondarev, Ilya Manukhov, Victoria Osipova, Nadezhda Berberova, Alexander A. Spasov, Gennady M. Butov, Bruce D. Hammock
Summary: The newly synthesized inhibitor compounds showed effective inhibitory activity against inflammation and exhibited low cytotoxicity in cell assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yiran You, Xu Chen, Yu Chen, Juan Pang, Qian Chen, Qiannan Liu, Hongliang Xue, Yupeng Zeng, Jinghe Xiao, Jiaxin Mi, Yi Tang, Wenhua Ling
Summary: This study aimed to investigate whether the inhibition of S-adenosylhomocysteine hydrolase (SAHH) accelerates vascular senescence and the development of atherosclerosis. The results showed that SAHH inhibition leads to vascular senescence and atherosclerosis by repressing DNA methylation and upregulating Drp1 expression. This identifies SAHH or SAH as potential therapeutic targets for vascular senescence and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Sara Cheleschi, Sara Tenti, Stefano Giannotti, Nicola Veronese, Jean-Yves Reginster, Antonella Fioravanti
Summary: The study showed that the combination of celecoxib and GS could significantly reduce the release of inflammatory mediators and MMPs induced by IL-1 beta, while increasing the expression of type II collagen. This combination also inhibited apoptosis and oxidative stress in OA chondrocytes through the modulation of the NF-kappa B pathway, demonstrating a synergistic effect on chondrocyte metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vengadeshprabhu Karuppagounder, William Pinamont, Natalie Yoshioka, Reyad Elbarbary, Fadia Kamal
Summary: The G-protein-coupled receptor kinase 2 (GRK2) plays an important role in inflammation and macrophage phenotype in osteoarthritis (OA). In this study, researchers investigated the therapeutic efficacy of inhibiting G beta gamma-GRK2 signaling in OA using a mouse model. They found that early inhibition of G beta gamma-GRK2 effectively attenuated OA development and reduced chondrocyte loss. In addition, inhibition of G beta gamma-GRK2 resulted in a decrease in the M1 macrophage phenotype and an increase in the M2 macrophage phenotype. Overall, this study suggests that early inhibition of G beta gamma-GRK2 has a higher therapeutic efficacy in OA by inhibiting the early inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Whasil Lee, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, Wolfgang B. Liedtke
Summary: The study reveals that interleukin-1 affects the expression and function of Piezo1 gene in osteoarthritis, leading to a detrimental calcium-driven feed-forward mechanism that can be targeted for intervention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ching-Hou Ma, Wan-Ching Chou, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Pei-Ling Hsieh, Kun-Ling Tsai
Summary: This study demonstrated that ginsenoside Rg3 reversed the TNF-α-inhibited SIRT1 expression, and suppressed TNF-α-induced CypD acetylation by activating the SIRT1/PGC-1 alpha/SIRT3 pathway, leading to reduced mitochondrial dysfunction and ROS accumulation. Additionally, Rg3 reduced ROS levels, ameliorated TNF-α-induced apoptosis, and mediated the downregulation of p38 MAPK to inhibit NF-kappa B translocation. Overall, Rg3 may serve as an adjunct therapy for arthritis patients by regulating the SIRT1/PGC-1 alpha/SIRT3/p38 MAPK/NF-kappa B signaling pathway.
Article
Geriatrics & Gerontology
Yu Cai, Zhengchao Wang, Bokai Liao, Zhenxing Sun, Pengfei Zhu
Summary: This article explores the effects of platelet-derived growth factor (PDGF)-BB on osteoarthritis (OA) and finds that PDGF-BB can attenuate OA development by inhibiting inflammation and enhancing cell proliferation through various signaling pathways. This is the first study to report the role of PDGF-BB in regulating OA development via PKA-mediated regulation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Masayuki Nakanishi, Mami Hino, Hiroshi Nomoto
Summary: In this study, a null mutant of the SAH hydrolase gene was created in Trypanosoma brucei and surprisingly, despite the observed SAH accumulation, the mutant exhibited normal cell proliferation. This suggests that inhibiting SAH hydrolase may not be an effective approach to suppressing T. brucei proliferation, making the enzyme a less promising target for antitrypanosome drug development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Saraswati Patel, Jyoti Shukla, Smita Jain, Vartika Paliwal, Neetika Tripathi, Sarvesh Paliwal, Swapnil Sharma
Summary: This study evaluates the analgesic and anti-inflammatory activity of Tubocurarine (d-TC) and suggests its repositioning in the treatment of pain and inflammation-related issues. The results showed significant inhibitory effects of d-TC on pain and inflammation in both in vitro and in vivo models, as well as good oral absorption capability.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Katsutaka Mitachi, Kyohei Ariake, Hiroki Shima, Satoko Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Hideo Ohtsuka, Takashi Kamei, Kazuhiko Igarashi, Michiaki Unno
Summary: The study identified C1TC and SAHH as novel biomarkers for predicting the sensitivity of PDAC patients to 5-FU chemotherapy based on CD-DST results. These proteins significantly improved recurrence-free survival in patients and showed potential for use as substitutes for CD-DST in adjuvant chemotherapy for PDAC.
SCIENTIFIC REPORTS
(2021)
Article
Anatomy & Morphology
Yusuke Kubo, Olga Lang, Lavin Amin, Felix Waldmann, Andreas Bayer, Sebastian Lippross, Thomas Pufe, Mersedeh Tohidnezhad
Summary: The study showed that PRGF treatment could enhance chondrocyte proliferation and viability as well as chondrogenic markers, particularly exerting anti-inflammatory effects under inflammatory conditions, which may protect articular cartilage from degeneration.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Biochemistry & Molecular Biology
Monica Paesa, Carmen Ancin-Azpilicueta, Gustavo Velderrain-Rodriguez, Olga Martin-Belloso, Oreste Gualillo, Jesus Osada, Maria Jesus Rodriguez-Yoldi, Gracia Mendoza
Summary: This study investigated the potential of onion waste products in inhibiting molecular events involved in osteoarthritis. Onion extracts showed high content of phenolic compounds and antioxidant properties, demonstrated cytocompatibility with chondrogenic cell line ATDC-5, and effectively inhibited molecular markers related to inflammation and cartilage degradation.
Article
Medicine, Research & Experimental
Lyess Allas, Quitterie Rochoux, Sylvain Leclercq, Karim Boumediene, Catherine Bauge
LABORATORY INVESTIGATION
(2020)
Article
Oncology
Nicolas Girard, Eva Lhuissier, Juliette Aury-Landas, Olivier Cauvard, Marion Lente, Martine Boittin, Catherine Bauge, Karim Boumediene
JOURNAL OF BONE ONCOLOGY
(2020)
Article
Physics, Applied
M. Khokhlova, M. Hammad, E. Lhuissier, R. Retoux, D. Goux, A. Fouchet, A. David, U. Luders, K. Boumediene, W. Prellier
Summary: Metal oxide thin films can be used as bio-surfaces for stem cell growth and can influence cell differentiation pathways, showing potential as novel biocompatible materials.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc do Rego, Jean-Claude do Rego, Frederic Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltete, Abdelhamid Benazzouz, Catherine Bauge, Jerome Leprince, Abdel G. Elkahloun, Lee E. Eiden, Youssef Anouar
Summary: PSELT, derived from SELENOT, shows promise as a therapeutic candidate for Parkinson's disease by targeting oxidative stress at multiple intracellular levels.
Article
Oncology
Eva Lhuissier, Juliette Aury-Landas, Marion Lente, Karim Boumediene, Catherine Bauge
Summary: Chondrosarcoma, a rare bone tumor resistant to chemotherapy and radiotherapy, has been primarily treated with surgical resection. Combining the epigenetic drug DZNep with conventional antitumor agents shows promising results in reducing chondrosarcoma viability and inducing apoptosis, suggesting a potential new approach for future treatment of the disease.
Review
Biochemistry & Molecular Biology
Quitterie Rochoux, Jana Sopkova-de Oliveira Santos, Christian Marcelli, Anne Rovelet-Lecrux, Virginie Chevallier, Jean-Jacques Dutheil, Sylvain Leclercq, Karim Boumediene, Catherine Bauge, Juliette Aury-Landas
Summary: A family carrying a germline mutation in COMP was described, associated with three distinct phenotypes including early-onset osteoarthritis, severe multiple epiphyseal dysplasia (MED), and peripheral inflammatory arthritis. The mutation of COMP was found to be causal for a broad phenotypic variability with joint alterations.
Article
Biology
O. C. Koumar, T. Martin, A. Bataille, J. Bulla, V. Crunel, V. Bouet, T. Freret, K. Boumediene, C. Bauge, S. Moussay, F. Dauphin, N. Bessot
Summary: Physical exercise increases body temperature differently depending on the time of day, indicating the significance of circadian rhythm in thermal regulation. Orexin A, which is involved in central pathways related to thermoregulation, may play a role in regulating core body temperature during and after exercise. However, our study found that the level of orexin A in the dorsal hypothalamus was not affected by physical activity or time of day. The thermoregulatory response to acute physical exercise in male rats was influenced by the time of day.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Chemistry, Applied
Sara Bouhout, Arnaud Aubert, Francis Vial, Benjamin Choquenet
Summary: This study aimed to demonstrate the specific nature of well-being induced by facial skincare by deciphering its physiological and psychological impacts out of a therapeutic context. The results showed that facial skincare led to higher levels of physiological and psychological relaxation compared to resting conditions. This research contributes to a better understanding of the specific profile of well-being associated with facial skincare.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Multidisciplinary Sciences
Lyess Allas, Sybille Brochard, Quitterie Rochoux, Jules Ribet, Cleo Dujarrier, Alexis Veyssiere, Juliette Aury-Landas, Ophelie Grard, Sylvain Leclercq, Denis Vivien, Hang-Korng Ea, Eric Maubert, Martine Cohen-Solal, Karim Boumediene, Veronique Agin, Catherine Bauge
SCIENTIFIC REPORTS
(2020)
