Article
Biophysics
Lingyi Kong, Shuzhen Lv, Zhenjie Qiao, Yongcun Yan, Jian Zhang, Sai Bi
Summary: In this study, a label-free electrochemical biosensing platform equipped with metal-organic frameworks (MOFs)-based nanoreactors has been developed for amplification detection of miRNA. The proposed biosensor exhibits excellent performance for miRNA-21 amplification detection, opening a new way for clinical analysis of miRNAs and early diagnosis of cancers.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Chemical
Mohammad Mehmandoust, Erknaz Ecehan Erk, Mustafa Soylak, Nevin Erk, Fatemeh Karimi
Summary: A label-free electrochemical detection system based on zeolitic imidazolate frameworks and reduced graphene oxide anchored with gold nanoparticles (Au@ZIF-8@rGO) was developed for glial fibrillary acidic protein (GFAP) detection in urine samples. The system utilizes the change in charge transfer resistance of the electrode to detect the binding of the protein. It has a low detection limit and a wide linear concentration range, and has been successfully applied to GFAP detection in urine samples.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Analytical
Elham Karimi, Maryam Nikkhah, Saman Hosseinkhani
Summary: Using gold nanoparticles as an enzyme immobilizer can increase the activity of luciferases and improve signal stability in the presence of nanoparticles. The application of ATP in the firefly luciferase reaction increases luciferase activity and enhances detection limits.
Article
Materials Science, Biomaterials
Muhammad Rezki, Ni Luh Wulan Septiani, Muhammad Iqbal, Suksmandhira Harimurti, Poetro Sambegoro, Damar Rastri Adhika, Brian Yuliarto
Summary: Amine-functionalized Cu-MOF nanospheres were successfully synthesized and optimized for HBsAg detection. The immobilization of a bioreceptor allowed for accurate detection of the hepatitis B infection biomarker.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Xiangyu Ma, Kun Qian, Onome Ejeromedoghene, Martha Kandawa-Schulz, Wei Song, Yihong Wang
Summary: A label-free electrochemical platform for the determination of microRNA-21 was developed using a thionine functionalized Fe-N-C nanocomposite. The high sensitivity and specificity of the biosensor were achieved through differential pulse voltammetry (DPV) testing of the strong electrochemical reduction signal of thionine. The sensitivity of the biosensor was further enhanced by utilizing a catalytic hairpin assembly (CHA) reaction.
Article
Chemistry, Analytical
Yuxin Lin, Beibei Nie, Xinyu Qu, Minghui Wang, Jie Yang, Genxi Li
Summary: Covalent organic frameworks (COFs) have attracted much attention for their unique physical-chemical characteristics and potential applications in biosensing. In this study, spherical COFs with regular shape and good dispersion were synthesized, and a novel nanoprobe was developed by modifying Histostar on the COFs surface. The nanoprobe was then applied to fabricate an electrochemical biosensor for exosomes detection, achieving a low detection limit and wide linear detection range. This work offers a promising platform for ultrasensitive detection of exosomes.
Article
Chemistry, Applied
Yuanyuan Hui, Ding Yang, Weizhe Wang, Yingying Liu, Chao He, Bini Wang
Summary: In this study, a novel electrochemical aptasensor was developed for sensitive and specific detection of STR in milk samples. The sensor utilized a composite material of gold nanoparticles, poly(diallyldimethylammonium chloride) nitrogen-doped carbon nanotube, and polyethyleneimine-functionalized metal-organic framework as the platform, enabling immobilization of STR aptamers and signal amplification.
Article
Nanoscience & Nanotechnology
Sudip Biswas, Qingchun Lan, Yao Xie, Xin Sun, Yang Wang
Summary: A high-performance nanocomposite of Zr-trimesic acid MOF (MOF-808) with carbon nanotube (CNT) was synthesized through in situ formation on activated CNT, showing excellent electrochemical properties and selectivity for ultra-low-level ovarian cancer biomarker detection.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Yun Ling, Ya-ru Chu, Feng Gao, Qing-yun Feng, Hui-qi Xie, Yong Shao, Qing-xiang Wang
Summary: Metal-organic frameworks (MOFs) have promising applications in electrochemical sensing, and this study developed a novel label-free electrochemical sensing strategy for detecting cardiac troponin I (cTnI) using Cu-MOF-74. The electrochemical assay demonstrated that the immunoaffinity reaction between cTnI and anticTnI effectively inhibited the electrochemical signal of Cu-MOF-74, indicating the potential of Cu-MOF-74-based interface in label-free cTnI analysis.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Analytical
Juan Liu, Siyi Yang, Jinhui Shen, Huanbao Fa, Changjun Hou, Mei Yang
Summary: An ultrasensitive electrochemical biosensor was developed for label-free detection of circulating tumor DNA. The biosensor exhibited excellent linear response to ctDNA with a detection limit in the femtomolar range. This simple and efficient method is suitable for liquid biopsy of ctDNA.
Article
Materials Science, Ceramics
Xiaoping Guo, Qiwen Pan, Xiaoqian Song, Qianyi Guo, Shangxiong Zhou, Jianrong Qiu, Guoping Dong
Summary: A dual-emission Eu3+: CDs@ZIF-8 has been rationally designed for constructing a ratiometric fluorescent sensor with self-calibrating ability for Fe(3+) determination, showing high selectivity, low detection limit, good aqueous dispersibility, and low cytotoxicity.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Article
Electrochemistry
Shamim Ahmed Hira, Saravanan Nagappan, Dicky Annas, Yedluri Anil Kumar, Kang Hyun Park
Summary: A novel method using a metal-organic framework incorporating bimetallic alloy nanoparticles has been developed for sensitive detection of dopamine. The fabricated sensor demonstrates excellent sensing abilities and shows potential for detecting other neurotransmitters in the future.
ELECTROCHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Wenxing Lv, Ziwei Han, Yike Li, Yanjuan Huang, Jiashu Sun, Xiaoquan Lu, Chao Liu
Summary: The use of cancer cell-derived exosome membrane-coated zeolitic imidazolate framework-8 (EM-ZIF-8) nanoparticles enhances cellular uptake efficiency and phagocytosis evasion. Additionally, EM-ZIF-8 can be employed for in situ imaging of cellular adenosine triphosphate (ATP) and restoration of Rhodamine B (RhB) fluorescence through competitive coordination with ATP and Zn2+. These biomimetic EM-ZIF-8 nanoparticles provide an efficient platform for intracellular drug delivery and ATP sensing.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Niannian Hu, Youlie Cai, Lan Li, Xusheng Wang, Junkuo Gao
Summary: This study synthesized a new amino-functionalized Ti-MOFs called NH2-ZSTU-2 for photocatalytic hydrogen production under visible light. The structure and photoelectrochemical properties of NH2-ZSTU-2 were fully investigated, indicating its favorable characteristics for photocatalytic hydrogen production. NH2-ZSTU-2 exhibited a stable hydrogen production rate under visible light irradiation, surpassing its counterpart ZSTU-2.
Article
Chemistry, Analytical
Haoyang Yan, Baoshan He, Lingling Xie, Xiaoyu Cao
Summary: This study developed a simple, specific, and ultrasensitive electrochemical aptasensor for detecting citrinin. The sensor utilized NH2-Fe-MOF nanomaterial as a loading platform, and demonstrated excellent selectivity, stability, and significant potential for ultrasensitive detection of citrinin in practical applications.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Multidisciplinary
Tao Yan, Linlin Ren, Fengyan Li, Feng Tian, Chengfang Jiang, Qi Wang, Xinyue Song, Shusheng Zhang
Summary: This sequentially responsive nanocarrier integrates bio-imaging, tumor microenvironment responsive chemotherapy, and cascade activation of upconversion photodynamic therapy. It shows site-specific degradation in the designed DNA outer nanoshell, leading to high cell apoptosis ratios and significant tumor inhibition.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Yilin Wang, Xuefan Xiong, Yanxi Zhu, Xinyue Song, Qiong Li, Shusheng Zhang
Summary: In this study, a pH-responsive nanoplatform was developed to combine gene therapy and chemotherapy for cancer treatment. Results showed that the combination therapy achieved better therapeutic efficacy in tumor inhibition compared to monotherapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Huimin Zhou, Yao Jiang, Wenjing Zhao, Shusheng Zhang
Summary: In this study, a light-activated nanodevice based on DNA nanotechnology was constructed for high precision detection of low-abundance miRNA. The nanodevice enabled on-demand imaging of miRNA in living cells with high spatial and temporal control.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Feifei Xu, Qing Wang, Ling Jiang, Fawei Zhu, Lei Yang, Shusheng Zhang, Xiangzhi Song
Summary: IPF is a chronic and fatal lung disease. The DCM-NO probe can quickly detect IPF by monitoring changes in NO concentration, showing good response properties in vitro and ability to evaluate treatment effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yao Jiang, Huimin Zhou, Wenjing Zhao, Shusheng Zhang
Summary: This study presents a self-assembled three-dimensional (3D) DNA nanostructure drug delivery system that utilizes ATP-triggered drug release for tumor fluorescence imaging and targeted therapy. The Dox@3D DNA nanostructures are assembled through a simple annealing reaction and can release drugs rapidly in tumor cells induced by high concentrations of ATP, providing efficient accumulation of drugs in tumors and minimizing damage to normal tissues.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: In this study, stable Janus nanoparticles (JNPs) were successfully prepared and used for in situ SERS detection and imaging analysis of cancer cells. The results showed that this method can improve the accuracy and sensitivity of cancer diagnosis and achieve a synergistic antitumor effect of chemotherapy and photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Jiaju Shi, Chunqin Zhao, Meiqi Shen, Zichao Chen, Jinhua Liu, Shusheng Zhang, Zhen Zhang
Summary: This article discusses the advantages and disadvantages of label-free and label-based methods commonly used in the isolation of CTCs, and systematically reviews the most recent advances in the combination of microfluidic chips and biosensing for the enrichment of circulating tumor cells, proposing the current barriers and developmental trends in CTCs research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Cheng Tian, Lei Zhao, Jin Zhu, Shusheng Zhang
Summary: In this study, a new SERS aptasensor was developed to simultaneously detect Hg2+ and Ag+ using cascade nucleic acid amplification strategy, which greatly improved the sensitivity. It can be widely applied for the detection of multiple heavy metal ions or other toxic substances in environmental water.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Yingnan Sun, Yuhan Song, Haohan Sun, Qingqing Tian, Qian Wang, Yongshu Liu, Shusheng Zhang
Summary: This study develops a strategy to transform superhydrophobic surfaces into large label-free SERS substrates with uniform and dense hot spots, enabling sensitive and high-throughput detection.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wenxiu Han, Zizhen Wei, Lu Feng, Mei Yao, Huairong Zhang, Shusheng Zhang
Summary: The study developed a therapeutic platform by wrapping doxorubicin in mesoporous CNTs/Fe-N-C with the cell membrane, showing high antitumor activity due to efficient catalytic ability, increased drug release rates, and significant photothermal effect.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Cheng Tian, Lei Zhao, Guoliang Qi, Jin Zhu, Shusheng Zhang
Summary: In this study, a SERS aptasensor was developed for fast and sensitive detection of SARS-CoV-2 virus. The sensor has the advantages of convenience, speed, sensitivity, and selectivity, making it a promising tool for analyzing viral particles in the environment and monitoring virus sources.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xiaoru Zhang, Yonghao Ge, Minghui Liu, Yujiao Pei, Peng He, Weiling Song, Shusheng Zhang
Summary: This study developed stable Janus nanoparticles for in situ SERS detection and imaging analysis of cancer cells, which can improve the accuracy and sensitivity of diagnosis by monitoring ATP and acid conditions. Additionally, these nanoparticles can also achieve a synergistic antitumor effect through chemotherapy/photodynamic therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenjing Zhao, Yao Jiang, Huimin Zhou, Shusheng Zhang
Summary: DNA self-assembling nanoprobes with self-transferability and resistance to nuclease degradation have been developed and applied in live cell bio-imaging. A hairpin-functionalized DNA tetrahedron (HFDT) intramolecular catalytic self-assembly platform was designed to detect low-abundance miRNAs using catalyzed hairpin assembly (CHA). This innovative strategy effectively changes the distribution and properties of biomaterials, increases accumulation of nanomaterials at the tumor site, and has promising applications in tumor imaging.
Article
Chemistry, Multidisciplinary
Chao Wang, Kexiao Zhu, Pengfei Shi, Xilai Ding, Shusheng Zhang
Summary: We present a simple aptamer assay for rapid analysis of the carcinogenic fungal metabolite AFB1. By rationally truncating the original anti-AFB1 aptamer, a short aptamer with improved performance was obtained. Different concentrations of AFB1 were detected by measuring the circular dichroism spectra of this short aptamer. The detection limit reached 0.6 nM, which was lower than that of the original aptamer (80 nM).
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xinran Sun, Guoda Zhang, Xilai Ding, Yingyan Liu, Kaixiu Chen, Pengfei Shi, Shusheng Zhang
Summary: This study presents a metal-organic framework combined with magnesium peroxide nanoparticles, functionalized with an aptamer, for enhanced photodynamic therapy. The platform generates sufficient oxygen to address tumor hypoxia and performs targeted therapy.
MATERIALS CHEMISTRY FRONTIERS
(2022)
