Article
Food Science & Technology
Chuanqi Wang, Yang Liu, Huiting Wang, Feng Gao, Xin Guan, Baoming Shi
Summary: This study found that oxidized soybean oil can affect placental injury in gestational rats, leading to a decrease in placental and embryonic weights, and changes in the expression of apoptosis-related genes. Additionally, oxidized soybean oil also affects the levels of nutrient transporters and cytokines.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Food Science & Technology
Mengling Liu, Siying Lu, Chuanzhen Yang, Dalei Zhang, Jun Zhu, Jiting Yin, Hongru Zhao, Bei Yang, Haibin Kuang
Summary: This study aimed to investigate the effects and mechanisms of glyphosate-based herbicides (GBHs) exposure on placental development in vivo during pregnancy in mice. The results showed that GBHs administration led to increased resorption of fetuses, decreased fetal and placental weight, inhibited placental growth, and altered expression of related proteins and genes. Further study revealed that GBHs exposure induced oxidative stress in placental tissue. In conclusion, maternal exposure to GBHs can impair placental development through the activation of endoplasmic reticulum stress-mediated signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Caiyun Ge, Ting Geng, Lin Cheng, Yuanzhen Zhang
Summary: Maternal exposure to PCB118 was found to have adverse effects on placental angiogenesis and fetal growth. PCB118 exposure caused decreased fetal body and placental weights, increased rates of intrauterine growth retardation (IUGR), impaired placental histology, decreased number of blood vessels, and anomalous mRNA expression of genes related to angiogenesis in the placenta.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Wensi Ni, Haoxuan Gao, Bing Wu, Ji Zhao, Jian Sun, Yanan Song, Yiping Sun, Huifang Yang
Summary: This study evaluated the effect of cyfluthrin exposure during pregnancy on placenta development and found that exposure to cyfluthrin leads to placental developmental disorder, which might be associated with ER stress-mediated PERK signaling pathway.
Article
Developmental Biology
Nykola L. Kent, Sharat C. Atluri, Karen M. Moritz, James S. M. Cuffe
Summary: Maternal hypothyroidism affects placental nutrient transporter expression, placental morphology, and placental metabolism, thereby leading to fetal growth restriction. It reduces fetal weight, impairs placental efficiency, and alters the ratio of the junctional zone to the labyrinth zone. Additionally, it induces changes in lipid and carbohydrate metabolism in the placenta, with sex-specific effects on mitochondria and nutrient transporters.
Article
Environmental Sciences
Paulina Jedynak, Lucile Broseus, Jorg Tost, Florence Busato, Stephan Gabet, Cathrine Thomsen, Amrit K. Sakhi, Isabelle Pin, Remy Slama, Johanna Lepeule, Claire Philippat
Summary: A previous study found positive associations between maternal urinary concentrations of triclosan and placental DNA methylation in male fetuses. This study aimed to validate and expand on these findings by examining triclosan exposure and placental DNA methylation in a cohort of male and female fetuses. The results confirmed associations between triclosan and certain genes in both sexes, with the majority of associations being positive and mapping to imprinted genes. The study also identified mediation effects of placental tissue heterogeneity on the associations. In conclusion, triclosan exposure is associated with placental DNA methylation, particularly in imprinted genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Qiuling Li, Yulong Qiao, Feifei Wang, Jian Zhao, Lijun Wu, Honghua Ge, Shengmin Xu
Summary: Triclosan (TCS), commonly found in personal care and household products, has been recently associated with children's health and gestational TCS exposure. However, its effects on embryonic lung development remain unclear. This study found that prenatal TCS exposure resulted in impaired lung development and altered airway patterning. The dysplasias were accompanied by reduced proliferation and increased apoptosis, mediated by activated Bmp4 signaling. Inhibiting Bmp4 signaling partially rescued the defects. In vivo evidence showed that administering TCS during gestation compromised branching formation and enlarged airspace in the offspring's lungs. This study provides novel toxicological insights into TCS and suggests a strong/possible association between TCS exposure during pregnancy and lung dysplasia in offspring.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Na Zhu, Xiaotong Ji, Xilin Geng, Huifeng Yue, Guangke Li, Nan Sang
Summary: The study found that maternal exposure to fine particulate matters during pregnancy disrupted cell proliferation and impaired nutrient transport in the placenta, with significant changes observed at E18.5. This included altered mRNA expression of nutrient transporters and changes in glycogen and triglyceride content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Xue-Ting Shi, Hua-Long Zhu, Xiao-Feng Xu, Yong-Wei Xiong, Li-Min Dai, Guo-Xiang Zhou, Wei-Bo Liu, Yu-Feng Zhang, De-Xiang Xu, Hua Wang
Summary: This study found that melatonin treatment significantly alleviated environmental cadmium-induced placental angiogenesis disorder and reduction of VEGF-A level. Mechanistically, melatonin reversed the downregulation of VEGF-A protein expression induced by environmental cadmium by inhibiting glucocorticoid receptor (GR) activation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Ying Hao, Li Meng, Yan Zhang, Aixin Chen, Ye Zhao, Kaoqi Lian, Xiangfei Guo, Xinhao Wang, Yuru Du, Xi Wang, Xuzi Li, Li Song, Yun Shi, Xi Yin, Miao Gong, Haishui Shi
Summary: The study revealed that chronic exposure to TCS can reduce social dominance in mice, decrease social interaction, impair memory formation, alter the relative abundance of gut microbiota, and induce ultrastructural damage to hippocampal neurons and synapses. These findings suggest that TCS exposure may impact social behaviors through changes in gut microbiota and impaired plasticity of hippocampal neurons and synapses.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Ran Li, Jing Peng, Wenhui Zhang, Yunlu Wu, Renjie Hu, Rucheng Chen, Weijia Gu, Lu Zhang, Li Qin, Mianhua Zhong, Lung-Chi Chen, Qinghua Sun, Cuiqing Liu
Summary: Recent studies have found that gestational exposure to ambient fine particulate matter (PM2.5) is associated with adverse pregnancy outcomes, particularly intrauterine growth restriction (IUGR). However, the underlying mechanism is still unclear. In this study, pregnant mice were exposed to either filtered air or ambient PM2.5, and it was found that PM2.5 exposure during gestation resulted in reduced fetal body weight and crown-rump length. Moreover, the placental blood sinusoid and expression of placental nutrient transporters and growth hormone were also affected by PM2.5 exposure. Additional tests revealed that PM2.5 exposure inhibited autophagy and activated the AMPK/mTOR signaling pathway in the placenta. These findings suggest that autophagy inhibition leading to placental developmental disorder might be an important mechanism for PM2.5-induced growth restriction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Guangdong Bai, Xu Jiang, Jianwei Qin, Yingbin Zou, Wentao Zhang, Teng Teng, Baoming Shi, Haoyang Sun
Summary: Glyphosate-based herbicides (GBHs) can damage placental angiogenesis and function, leading to impaired health in postnatal progeny. Betaine treatment provides modest relief.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Environmental
Chiang-Wen Lee, Lee-Fen Hsu, I-Lin Wu, Yung-Li Wang, Wei-Chen Chen, Yan-Jun Liu, Lu-Tang Yang, Chong-Lun Tan, Yueh-Hsia Luo, Chia-Ching Wang, Hui-Wen Chiu, Thomas Chung-Kuang Yang, Yen-Yue Lin, Hsin-An Chang, Yao-Chang Chiang, Ching-Hsiang Chen, Ming-Hsueh Lee, Kuo-Ti Peng, Cathy Chia-Yu Huang
Summary: Exposure to polystyrene microplastics impairs learning and memory in mice, especially in the hippocampus, and the memory function can be improved by ablation of the vagus nerve.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Yong-Wei Xiong, Xiao-Feng Xu, Hua-Long Zhu, Xue-Lin Cao, Song-Jia Yi, Xue-Ting Shi, Kai-Heng Zhu, Yuan Nan, Ling-Li Zhao, Chen Zhang, Lan Gao, Yuan-Hua Chen, De-Xiang Xu, Hua Wang
Summary: Cadmium exposure can negatively affect placental angiogenesis and progesterone levels, potentially impairing fetal growth through a mechanism involving GCN-2-mediated mitochondrial stress.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Chenlu Xu, Jia Zhang, Qinfeng Zhou, Juling Wang, Chenyang Liu, Yu Tian, Danni Huang, Huaizhuang Ye, Yongtang Jin
Summary: Traffic-related air pollution impairs memory function and enhances neuroinflammation and oxidative stress responses, which may be associated with altered expression and DNA methylation levels of ABCA7 and PYK2.
ENVIRONMENTAL RESEARCH
(2022)