Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Pharmacology & Pharmacy
Junying Lu, Yuanyuan Huang, Xiaohao Zhang, Yang Xu, Shu Nie
Summary: Diabetes, a metabolic disorder, leads to vascular complications, accelerated by mechanisms such as oxidative stress and inflammation caused by high blood glucose. Epigenetic modifications and non-coding RNAs play important roles in the pathogenesis of diabetic vascular complications.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Ye Cheng, Yanna Chen, Guodong Wang, Pei Liu, Guiling Xie, Huan Jing, Hongtao Chen, Youlin Fan, Min Wang, Jun Zhou
Summary: This review discusses the relationship between chronic kidney disease (CKD) and diabetic kidney disease (DKD), with a focus on the role of protein methylation. It summarizes the current clinical research status and explores the potential application of protein methyltransferase (PMT) inhibitors in DKD treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Kristyna Kupkova, Savera J. Shetty, Marilyn G. Pray-Grant, Patrick A. Grant, Rashidul Haque, William A. Petri Jr, David T. Auble
Summary: This study found a global association between elevated levels of H3K9me3 and poor linear growth in children. The findings have the potential to be used for the development of new therapeutic interventions for preventing and treating stunting.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Shang, Xue-Wei Cai, Yin-Na Su, Zhao-Chen Zhang, Xin Wang, Nan Zhao, Xin-Jian He
Summary: This study reveals a previously unknown mechanism for the regulation of DNA methylation, showing that ATX1-5 proteins play a crucial role in plant development, survival, and the regulation of DNA methylation. The redundant ATX paralogues promote the expression and H3K4me3 levels of both RNA-directed DNA methylation genes and active DNA demethylation genes to regulate DNA methylation.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Samarth Dwivedi, Atharva Chavan, Atish T. Paul
Summary: This review focuses on the role of SET7 in the onset and progression of diabetic nephropathy (DN), and its potential as a therapeutic target to combat renal disorders.
DRUG DISCOVERY TODAY
(2023)
Review
Physiology
Bao-Yi Shao, Shao-Fei Zhang, Hai-Di Li, Xiao-Ming Meng, Hai-Yong Chen
Summary: Diabetic nephropathy (DN) is a disease that leads to high morbidity and disability, with inflammation playing a critical role in its pathogenesis. Epigenetic modifications regulate gene expression without altering the DNA sequence, and recent studies have revealed the mechanisms behind this regulation in DN's inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biology
Rui Cao, Jun Xie, Li Zhang
Summary: Neural tube closure disorders, such as anencephaly, spina bifida, and encephalocele, are complex diseases caused by multiple etiologies and mechanisms, including genetic and environmental factors. Folic acid deficiency can lead to methylation modification disorders, which play an important role in the pathogenesis of NTDs. Understanding the relationship between folic acid metabolism and methylation is crucial for effective prevention and treatment of NTDs.
OPEN LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Feng-Chih Kuo, Chia-Ter Chao, Shih-Hua Lin
Summary: Chronic kidney disease (CKD) is characterized by a gradual decline in glomerular filtration rate, resulting in adverse consequences such as fluid retention, electrolyte imbalance, and increased cardiovascular risk. Diabetes mellitus is a major contributor to the development of CKD, particularly diabetic kidney disease (DKD), which is influenced by epigenetic dysregulation triggered by metabolic disturbances, oxidative stress, and inflammation. This review provides an overview of the major epigenetic molecular mechanisms and summarizes current knowledge about epigenetic alterations in DKD. It highlights the importance of epigenetic regulation in various renal cell types and explores potential epigenetic biomarkers and therapeutic agents for early detection and management of DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Eman A. Al Abdulsalam, Rowyda N. Al Harithy
Summary: The study found significantly higher expression levels of visfatin and global H3K9me in colon cancerous tissue compared to adjacent non-cancerous tissue. This indicates a potential role of visfatin in colon cancer development through the mechanism of H3K9me.
ANNALS OF MEDICINE
(2021)
Review
Endocrinology & Metabolism
Heng-Cheng Lu, Wen-Ni Dai, Li-Yu He
Summary: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus, affecting a significant percentage of patients with type 1 and type 2 diabetes. Current treatments can alleviate but not prevent the progression of DKD into end-stage renal disease (ESRD). The disease is influenced by both genetic and environmental factors, with emerging research suggesting a role for epigenetic mechanisms such as histone post-translational modifications.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Bing Song, Yujie Chen, Chao Wang, Guanjian Li, Zhaolian Wei, Xiaojin He, Yunxia Cao
Summary: This study suggests that abnormal DNA methylation of certain CpG sites of imprinted genes is associated with poor sperm quality and severe sperm DNA damage.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xueyan Wei, Prabin Dhungana, Cheolho Sim
Summary: By comparing histone methylation levels, we found that the levels of H3K27me2 decrease in the fat body of diapausing mosquitoes, suggesting its potential role in the initial activation of the diapause program.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Genetics & Heredity
Zelha Nil, Ashish R. Deshwar, Yan Huang, Scott Barish, Xi Zhang, Sanaa Choufani, Polona Le Quesne Stabej, Ian Hayes, Patrick Yap, Chad Haldeman-Englert, Carolyn Wilson, Trine Prescott, Kristian Tveten, Arve Vollo, Devon Haynes, Patricia G. Wheeler, Jessica Zon, Cheryl Cytrynbaum, Rebekah Jobling, Moira Blyth, Siddharth Banka, Alexandra Afenjar, Cyril Mignot, Florence Robin-Renaldo, Boris Keren, Oguz Kanca, Xiao Mao, Daniel J. Wegner, Kathleen Sisco, Marwan Shinawi, Michael F. Wangler, Rosanna Weksberg, Shinya Yamamoto, Gregory Costain, Hugo J. Bellen
Summary: Misregulation of histone lysine methylation, particularly caused by mutations in the DOT1L gene, is associated with human developmental disorders. This study identified seven different de novo heterozygous missense variants in DOT1L in nine unrelated individuals, leading to elevated levels of histone methylation and developmental delays in humans. Functional studies performed in fruit flies and human cells confirmed the pathogenicity of these variants. The findings highlight the importance of DOT1L in human development and its association with Mendelian diseases.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Marta Ignasiak-Kciuk, Karolina Nowicka-Bauer, Marta Grzechowiak, Tina Ravnsborg, Kamil Frackowiak, Ole N. Jensen, Mariusz Jaskolski, Bronislaw Marciniak
Summary: This study investigates the sensitized photo-oxidation reaction using carboxybenzophenone (CB) as a sensitizer and a PR-10 protein (MtN13) as a quencher. It reveals the specific binding of CB in the protein's hydrophobic cavity and the amino acid residues creating adducts with the sensitizer. The study also elucidates the mechanisms of CB quenching and the influence of neighboring groups on the oxidation process.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Gronbaek, Kim Theilgaard-Moench, Ole N. N. Jensen, Kristian Helin, Bo T. T. Porse
Summary: This study identifies the Histone 3 Lysine 4 (H3K4) demethylase KDM5C as a tumor suppressor in acute myeloid leukemia (AML). Decreased KDM5C expression leads to increased cell growth in AML cell lines and mouse models. Mechanistically, KDM5C acts as a transcriptional repressor through its demethylase activity, resulting in upregulation of immature genes marked by H3K4me3. The association of KDM5C levels with long-term disease-free survival in female AML patients highlights the clinical relevance of this finding.
Article
Food Science & Technology
Shaohua Yang, Wenjun Wang, Shuang Ni
Summary: In this study, the role of G0S2 in regulating chicken meat quality traits through modulation of fatty acid synthesis and intramuscular fat content was investigated. The results showed that reduced expression of G0S2 led to decreased lipid accumulation and lower levels of unsaturated fatty acids. The regulation network of G0S2 in thigh tissues of Huangshan Black chickens was also confirmed. This study highlights the potential of using G0S2 as a genetic approach to improving meat quality.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Mechanical
Ji Lin, Jin Qian, Yu Xie, Ji Wang, Rui Xiao
Summary: In this study, a micromechanical mean-field shear transformation zone (STZ) model is developed to systematically describe the stress responses of amorphous polymers. The model captures the behaviors of amorphous polymers in various loading conditions and successfully reproduces the Bauschinger effect. The deformation-induced material polarization, in the form of an anisotropic distribution of STZs, is identified as the governing mechanism of the Bauschinger effect.
INTERNATIONAL JOURNAL OF PLASTICITY
(2023)
Article
Environmental Sciences
Wenjun Wang, Nina Khanna, Jiang Lin, Xu Liu
Summary: Black carbon is a harmful byproduct of incomplete combustion and China plays a significant role in global black carbon emissions. This study provides an inventory of black carbon emissions in China for 2015 and projects emissions for 2016-2050 under different scenarios. Residential use is the largest contributor to black carbon emissions in China, followed by coke production, industry, agricultural waste burning, and transportation. The study shows that an accelerated reduction scenario could result in much faster and deeper reductions in black carbon emissions across all sectors.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Materials Science, Multidisciplinary
Yumei Chen, Xiang Fang, Ji Wang, Matteo Filippi, Erasmo Carrera
Summary: By using a microstructure with an antisymmetric dual helix, we designed a metamaterial plate with wide band gaps for phononic crystals. The band structure and displacement transmission curves of the metamaterial plates were calculated and compared with and without considering the mass in the center of the dual helix. The results show excellent consistency in the band gaps, and the effects of various parameters on the band gaps were examined for further evaluation of potential applications.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Review
Environmental Sciences
Siyuan Wang, Jianchen Li, Wenjun Wang, Chengyun Zhou, Yanfeng Chi, Jianhui Wang, Youcai Li, Qingbo Zhang
Summary: Three-dimensional biofilm electrode reactors (3D-BERs) have gained extensive attention due to their wide application range, high efficiency, and energy saving. This paper reviews the constitution, advantages, and basic principles of 3D-BERs, as well as recent research progress. It also discusses electrode materials selection, reactor constructions, and the degradation of various contaminants. The shortcomings of this technology and future research directions are analyzed.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Materials Science, Multidisciplinary
Yangyang Zhang, Qi Lai, He Zhang, Yingwu Yang, Ji Wang, Chaofeng Lu
Summary: In this study, an electromechanical model is established to consider the wheel-path distribution under actual traffic conditions. The optimal lateral embedded locations for PEH units should be adjusted according to the prescribed traffic speed of the roads, and these mathematical results serve as guidelines for selecting the optimal lateral embedded locations for PEH units.
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES
(2023)
Article
Materials Science, Ceramics
Qingzhen Zheng, Xuesong Mei, Gedong Jiang, Jianlei Cui, Zhengjie Fan, Wenjun Wang, Zhaoxuan Yan, Hang Guo, Aifei Pan
Summary: This paper proposes a novel ultrasonic vibration-assisted femtosecond laser polishing method for C/SiC composites. The near-field convection enhancement of ultrasonic vibration improves cooling and reduces bonding of ablated particles to the material surface, resulting in reduced oxidation, improved surface quality, removal depth, and material removal rate. By optimizing defocusing distance and scanning speed, a specific relationship between ultrasonic amplitude, pulse energy density, and spot overlap rate was established, achieving a smooth and defect-free surface. The coupling effect of ultrasonic and laser energy fields enhances the residual compressive stress of carbon fibers, explaining the formation of typical features such as fiber fracture and pulling-out, banded pits, voids, and deposition. This paper presents new research ideas for understanding the removal mechanism of C/SiC composites using ultrasonic vibration-assisted femtosecond laser.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
J. H. Wu, J. Wang, E. Carrera, R. Augello
Summary: This work analyzes the wave propagation of Rayleigh type through a periodic elastic element covered with a T-plate. Viscous-spring artificial boundaries are used to satisfy the boundary conditions of the periodic structure. The Carrera Unified Formulation (CUF) is used to consistently express the various kinematics of the structure and obtain the wave propagation within the model. The numerical evaluation and comparison with analytical methods and COMSOL show that the results of this study are reliable and the developed model provides accurate analysis of T-plate periodic elastic structures.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Hematology
Chuanyang Lu, Qiuni Chen, Jiaxin Li, Chunling Wang, Liang Yu
Summary: This study investigated the correlation between lymphocyte to monocyte ratio (LMR) and Myelodysplastic Neoplasms (MDS), and found that LMR could serve as a potential prognostic indicator in MDS patients.
Article
Materials Science, Multidisciplinary
Qianqian Du, Zhifeng Wang Du, Mengru Li Du, Yuquan Gan, Shuhong Li, Yunlong Liu, Wenjun Wang, Fengqiu Wang, Shuchao Qin
Summary: Organic single crystals (OSCs) have shown great potential for advanced optoelectronic devices, especially for flexible and wearable devices, due to their high carrier mobility and intrinsic mechanical flexibility. However, the optimization of photoelectronic performances and response speed still needs to be addressed. In this study, we demonstrate a high-performance organic phototransistor based on pentacene single crystals grown by a simple in-air sublimation method. The device exhibits competitive rise and decay times in the field of organic phototransistors. Furthermore, the device shows remarkable mechanical flexibility, maintaining excellent electrical conductivity and stable light detection after 500 bending cycles.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Spectroscopy
Wang Wen-jun, Sha Yun-fei, Wang Yang-zhong, Yu Jie, Liu Tai-ang, Zhang Xu-feng, Meng Xiang-zhou, Ge Jiong
Summary: In this study, a qualitative discrimination model based on NIR and EN was established to distinguish the flavors of tobacco leaves. The combined model showed higher prediction accuracy for intermediate and strong flavors compared to NIR and EN alone. The study also compared different data mining algorithms and found that artificial neural network had higher modeling accuracy but lower prediction accuracy compared to support vector machine. This study can support the rapid identification of tobacco flavor style and provide an auxiliary identification method for professional tobacco evaluators.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2023)
Article
Hematology
Lijuan Zhang, Kankan Chen, Yingying Li, Qiuni Chen, Wenting Shi, Tingting Ji, Hong Tao, Zhengmei He, Chunling Wang, Liang Yu
Summary: This study explored the clinical outcomes and characteristics of TP53-mutated primary myelodysplastic syndromes (MDS). The results showed that TP53-mutated patients had a higher frequency of cytogenetic abnormalities, with 5q- karyotype, complex karyotype, high-risk MDS, and acute myelogenous leukemia transformation. Moreover, TP53-mutated patients had lower mean corpuscular volume (MCV) and were more sensitive to HMA treatment. However, they had worse overall survival and leukemia-free survival compared to TP53 wild-type patients, and TP53 mutation was identified as an independent adverse prognostic factor.
Article
Hematology
Yue Chen, Junhui Wang, Jingjing Ma, Linrong Fei, Qiuni Chen, Shandong Tao, Zhengmei He, Chunling Wang, Liang Yu
Summary: This study aimed to assess the value of nutritional status in predicting the prognosis of myelodysplastic syndromes (MDS) patients. The results showed that a better nutritional status was associated with improved overall survival (OS) in MDS patients, while there were no statistical differences in progression-free survival (PFS) between the two groups. Furthermore, the prognostic nutritional index (PNI) was found to be a useful tool for evaluating the OS of MDS patients.
