Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

Chemotherapy for advanced non-small cell lung cancer with a focus on squamous cell carcinoma

(2016) Kozo Kuribayashi et al.   Journal of Cancer Research and Therapeutics

Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis

(2016) Shu-Ming Tsao et al.   Scientific Reports

A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo

(2016) Ge Liu et al.   Scientific Reports

Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling

(2015) Yong-seok Han et al.   Biomolecules & Therapeutics

Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer

(2015) Chee-Seng Tan et al.   LANCET ONCOLOGY

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

(2015) Akihiro Kasai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Sulfated Polysaccharide Fucoidan Rescues Senescence of Endothelial Colony-Forming Cells for Ischemic Repair

(2015) Jun Hee Lee et al.   STEM CELLS

NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer

(2015) Xiyu Liu et al.   TUMOR BIOLOGY

ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer

(2015) Peng Zou et al.   Oncotarget

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

(2015) Hsien-Yeh Hsu et al.   Oncotarget

Biological activities of novel pyrazolyl hydroxamic acid derivatives against human lung cancer cell line A549

(2014) Jin-Feng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

Fucoidan as a Marine Anticancer Agent in Preclinical Development

(2014) Jong-Young Kwak   Marine Drugs

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

(2014) Hye Park et al.   MOLECULES

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

(2014) Shaohua Chen et al.   PLoS One

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

(2013) Lili Yang et al.   Marine Drugs

Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling

(2013) Yunliang Chen et al.   THROMBOSIS AND HAEMOSTASIS

Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production

(2013) X Yuan et al.   Cell Death & Disease

Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages

(2012) Honghui Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Tollip, an Intracellular Trafficking Protein, Is a Novel Modulator of the Transforming Growth Factor-β Signaling Pathway

(2012) Lu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways

(2012) Hyunkyoung Lee et al.   PLoS One

Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway

(2011) Chien-Ting Wu et al.   CARCINOGENESIS

Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions

(2011) Kyoung Min Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways

(2011) Zhongyuan Zhang et al.   PLoS One

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells

(2009) Yumi Yamasaki-Miyamoto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA