期刊
SCIENTIFIC REPORTS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep44921
关键词
-
资金
- National Research Foundation of Korea (NRF)-Ministry of Science, ICT & Future Planning [NRF-2013R1A1A2064434, NRF-2016M3C7A1913845]
- Korean Government (MSIP) [2010-0028684]
- Korea Institute of Science and Technology [2E26820]
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga(+/-)mice which have an increased level of O-GlcNAcylation, and found that Oga(+/-)mice exhibited impaired spatial learning and memory. Consistent with this result, Oga(+/-)mice showed a defect in hippocampal synaptic plasticity. Oga heterozygosity causes impairment of both long-term potentiation and long-term depression due to dysregulation of AMPA receptor phosphorylation. These results demonstrate a role for hyper-OGlcNAcylation in learning and memory.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据