Article
Microbiology
Andrea Laconi, Ilenia Drigo, Nicola Palmieri, Lisa Carraro, Elena Tonon, Raffaela Franch, Luca Bano, Alessandra Piccirillo
Summary: The study revealed that Campylobacter isolates from chicken livers possessed a higher number of virulence-associated genes, which might contribute to the development of pathological lesions in these isolates within the host.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Ying-Shu Liao, Bo-Han Chen, Ru-Hsiou Teng, You-Wun Wang, Jui-Hsien Chang, Shiu-Yun Liang, Chi-Sen Tsao, Yu-Ping Hong, Hui-Yung Sung, Chien-Shun Chiou
Summary: Research in Taiwan has shown that C. coli and C. jejuni are highly resistant to most therapeutic antimicrobials. Whole-genome sequencing was used to analyze genetic diversity among isolates and genetic resistance determinants associated with antimicrobial resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Si-Hyeon Kim, Yong-Kuk Kwon, Choi-Kyu Park, Hye-Ryoung Kim
Summary: In this study, metagenomic analysis revealed the presence of C. jejuni and C. psittaci in cockatiels in Korea, which could cause symptoms such as diarrhea. Three de novo assembly tools were compared to obtain accurate contigs, with genetic analysis being performed using sequences generated by metaSPAdes.
Article
Immunology
Morgane Nennig, Ann-Katrin Llarena, Malte Herold, Joel Mossong, Christian Penny, Serge Losch, Odile Tresse, Catherine Ragimbeau
Summary: A study on Campylobacter jejuni in Luxembourg revealed an unexpected endemic pattern in the genetic profiles, and tested the hypothesis of stable lineages occurrence by implementing whole genome sequencing (WGS). Results showed that regardless of the typing scheme used, epidemic or endemic signals were detected in the lineages, supporting the clonal expansion of stable genomes in the Campylobacter population.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Cecilia Johansson, Christian Kampmann, Anna Nilsson, Johan Dicksved, Lars Engstrand, Hilpi Rautelin
Summary: This study characterized Campylobacter jejuni fecal isolates from international travelers and analyzed the relationship between bacterial traits and clinical symptoms. It found that isolates from Bangladesh had higher pathogenic potential but led to milder symptoms compared to isolates from other regions with lower pathogenic potential but more severe symptoms. The study also examined the fecal microbiota composition prior to travel and found individual variation but no direct association with symptom development. Further research is needed to confirm the potential relationship between gut microbiota characteristics and the severity of Campylobacter infections.
Article
Immunology
Shiho Fukushima, Takaaki Shimohata, Yuri Inoue, Junko Kido, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi
Summary: Campylobacter jejuni infection activates the Rac1 signaling pathway to promote bacterial internalization, and LC3 plays a role in regulating the invasion signaling of C. jejuni, thereby participating in autophagy-mediated host immune response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Husheem Michael, Ayako Miyazaki, Stephanie N. Langel, Joshua O. Amimo, Maryssa K. Kick, Juliet Chepngeno, Francine C. Paim, David D. Fischer, Gireesh Rajashekara, Linda J. Saif, Anastasia N. Vlasova
Summary: This study evaluates the effects of colonization with Escherichia coli Nissle and Lacticaseibacillus rhamnosus GG probiotics on the efficacy of oral rotavirus vaccine, and finds that colonization with Escherichia coli Nissle enhances the immunogenicity and protective efficacy to a greater extent than Lacticaseibacillus rhamnosus GG.
Article
Immunology
Blake W. Stamps, Janelle Kuroiwa, Sandra D. Isidean, Megan A. Schilling, Clayton Harro, Kawsar R. Talaat, David A. Sack, David R. Tribble, Alexander C. Maue, Joanna E. Rimmer, Renee M. Laird, Chad K. Porter, Michael S. Goodson, Frederic Poly
Summary: The study showed that there were statistically significant but minor differences in beta diversity among study participants during the challenge period, and pre-challenge alpha diversity was higher in participants who did not develop campylobacteriosis compared to those who did. However, alpha diversity decreased in all participants after infection. Future studies could explore CHIM studies with inocula more closely resembling natural exposure and field studies involving naturally-occurring enteric infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Food Science & Technology
Malgorzata Emanowicz, Joseph Meade, Catherine Burgess, Declan Bolton, John Egan, Helen Lynch, Lisa O'Connor, Aidan Coffey, Brigid Lucey, Montserrat Gutierrez, William Byrne, Rosemarie Slowey, Paul Whyte
Summary: Phenotypic antimicrobial resistance testing was conducted on 160 Campylobacter jejuni isolates from broiler samples to determine prevalence and distribution of resistance profiles. Whole genome sequencing of 132 isolates revealed a high correlation between resistant phenotypes and genotypes, with identified resistance determinants including tet(O) genes and gyrA p. T86I mutation. Multiple sequence types (ST) were identified, with ST-257 being prevalent, and virulence genes associated with human infection and broiler colonization were detected.
Article
Infectious Diseases
Eriko Mori, Takehiro Hashimoto, Takaaki Yahiro, Masakazu Miura, Toshinobu Ishihara, Masashi Miyazaki, Kosaku Komiya, Naohiko Takahashi, Akira Nishizono, Kazufumi Hiramatsu
Summary: We report the first case of vertebral osteomyelitis caused by C. lari, identified from a vertebral biopsy sample collected using CT-guided percutaneous needle biopsy in a patient without obvious episodes of immunodeficiency. Pathogen identification was aided by cultureing using the HK semisolid medium. It is crucial to identify the causative pathogen in vertebral osteomyelitis.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Amber Hameed, Julian M. Ketley, Alexandra Woodacre, Lee R. Machado, Gemma L. Marsden
Summary: This study conducted a classification and frequency analysis of LOS genotypes in C. jejuni and C. coli. The results showed that class B is the most abundant LOS class in C. jejuni, while class III is the most abundant LOS locus type in C. coli.
Article
Biotechnology & Applied Microbiology
Lucia Rivas, Pierre-Yves Dupont, Brent Gilpin, Helen Withers
Summary: A pilot survey in New Zealand showed that the prevalence of Campylobacter in ovine carcass trim was 33% based on PCR detection, with hogget carcasses having the highest prevalence at 56%. Twenty-five MLST sequence types were identified among isolates, indicating genetic diversity among ovine isolates collected. Whole genome sequencing analysis discriminated isolates within a single sequence type.
JOURNAL OF FOOD PROTECTION
(2021)
Article
Genetics & Heredity
Jessica K. Calland, Ben Pascoe, Sion C. Bayliss, Evangelos Mourkas, Elvire Berthenet, Harry A. Thorpe, Matthew D. Hitchings, Edward J. Feil, Jukka Corander, Martin J. Blaser, Daniel Falush, Samuel K. Sheppard
Summary: This study presents a new approach to estimate the molecular clock rate in Campylobacter, drawing on the 'birthday problem'. By analyzing large genomic datasets, the synonymous rates of nucleotide change for the common pathogenic bacteria Campylobacter colt and Campylobacter jejuni were estimated. The study also inferred the number of effective lineages within the sample time frame and assessed the rate of turnover of lineages over short evolutionary timescales.
Article
Multidisciplinary Sciences
Yuli Melisa Sierra-Arguello, Gustavo Perdoncini, Laura Beatriz Rodrigues, Luciana Ruschel dos Santos, Karen Apellanis Borges, Thales Quedi Furian, Carlos Tadeu Pippi Salle, Hamilton Luiz de Souza Moraes, Marcos Jose Pereira Gomes, Vladimir Pinheiro do Nascimento
Summary: Campylobacter jejuni is a common cause of foodborne illnesses worldwide, with limited research on strains isolated from Latin-American countries. This study in Southern Brazil identified 140 C. jejuni strains from various poultry sources and analyzed their virulence markers, providing insight into factors related to the occurrence of this pathogen and their epidemiology. The PCR analysis revealed 25 different virulence profiles, with certain combinations of virulence genes being more common among the strains.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jamieson B. McDonald, Nichollas E. Scott, Greg J. Underwood, Daniel M. Andrews, Thi Thu Hao Van, Robert J. Moore
Summary: Campylobacter hepaticus is a significant pathogen causing Spotty Liver Disease in layer chickens, leading to increased mortality and reduced egg production. This study confirms the functionality of the N-glycosylation system in C. hepaticus through glycoproteomic analysis, which showed the modification of over 35 proteins with an N-linked heptasaccharide glycan. C. hepaticus shares conserved glycoproteins with Campylobacter jejuni involved in host colonization and possesses unique glycoproteins that may contribute to its survival in challenging host environments.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Kevin Mclean, Javier Palarea-Albaladejo, Carol G. Currie, Lisa H. J. Imrie, Erin D. T. Manson, Douglas Fraser-Pitt, Frank Wright, Colin J. Alexander, Kevin G. J. Pollock, Lesley Allison, Mary Hanson, David G. E. Smith
Article
Microbiology
Shlomo E. Blum, Robert J. Goldstone, James P. R. Connolly, Maryline Reperant-Ferter, Pierre Germon, Neil F. Inglis, Oleg Krifucks, Shubham Mathur, Erin Manson, Kevin Mclean, Pascal Rainard, Andrew J. Roe, Gabriel Leitner, David G. E. Smith
Article
Immunology
Koen Breyne, Jonas Steenbrugge, Kristel Demeyere, Chun Geun Lee, Jack A. Elias, Wolfram Petzl, David G. E. Smith, Pierre Germon, Evelyne Meyer
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Vincent Herry, Christophe Gitton, Guillaume Tabouret, Maryline Reperant, Laurine Forge, Christian Tasca, Florence B. Gilbert, Edouard Guitton, Celine Barc, Christophe Staub, David G. E. Smith, Pierre Germon, Gilles Foucras, Pascal Rainard
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Stefan P. W. de Vries, Srishti Gupta, Abiyad Baig, Elli Wright, Amy Wedley, Annette Nygaard Jensen, Lizeth LaCharme Lora, Suzanne Humphrey, Henrik Skovgard, Kareen Macleod, Elsa Pont, Dominika P. Wolanska, Joanna L'Heureux, Fredrick M. Mobegi, David G. E. Smith, Paul Everest, Aldert Zomer, Nicola Williams, Paul Wigley, Thomas Humphrey, Duncan J. Maskell, Andrew J. Grant
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Amin Tahoun, Kirsty Jensen, Yolanda Corripio-Miyar, Sean McAteer, David G. E. Smith, Tom N. McNeilly, David L. Gally, Elizabeth J. Glass
SCIENTIFIC REPORTS
(2017)
Article
Immunology
T. V. Riley, D. Lyras, G. R. Douce
Article
Microbiology
Kate E. Dingle, Xavier Didelot, T. Phuong Quan, David W. Eyre, Nicole Stoesser, Charis A. Marwick, John Coia, Derek Brown, Sarah Buchanan, Umer Z. Ijaz, Cosmika Goswami, Gill Douce, Warren N. Fawley, Mark H. Wilcox, Timothy E. A. Peto, A. Sarah Walker, Derrick W. Crook
Article
Immunology
Annie Aubry, Wei Zou, Evguenii Vinogradov, Dean Williams, Wangxue Chen, Greg Harris, Hongyan Zhou, Melissa J. Schur, Michel Gilbert, Gillian R. Douce, Susan M. Logan
Article
Cell Biology
Abdi Elmi, Amber Dorey, Eleanor Watson, Heena Jagatia, Neil F. Inglis, Ozan Gundogdu, Mona Bajaj-Elliott, Brendan W. Wren, David G. E. Smith, Nick Dorrell
CELLULAR MICROBIOLOGY
(2018)
Article
Biochemical Research Methods
Javier Palarea-Albaladejo, Kevin Mclean, Frank Wright, David G. E. Smith
Article
Genetics & Heredity
Robert J. Goldstone, David G. E. Smith
MICROBIAL GENOMICS
(2017)