Article
Multidisciplinary Sciences
Dong Sun, Zhi-Bing Tan, Xiang-Dong Sun, Zhi-Peng Liu, Wen -Bing Chen, Leena Milibari, Xiao Ren, Ling-Ling Yao, Daehoon Lee, Chen Shen, Jin-Xiu Pan, Zhi-Hui Huang, Lin Mei, Wen-Cheng Xiong
Summary: The loss of NEO1 is associated with the development of epilepsy, as evidenced by reduced NEO1 expression in the hippocampi of epilepsy patients and elevated seizure susceptibility in Neo1 knockout mice. The interaction between NEO1 and GLAST in astrocytes plays a crucial role in regulating the epileptic phenotype by affecting GABAergic transmission and extracellular glutamate clearance. The findings suggest that NEO1 could be a potential therapeutic target for protecting the brain from epilepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Surya P. Aryal, Xu Fu, Joree N. Sandin, Khaga R. Neupane, Jourdan E. Lakes, Martha E. Grady, Christopher Richards
Summary: Nicotine exposure induces morphological and functional changes in astrocytes mediated by nAChRs. Functional studies demonstrate increased calcium activity in both cell soma and processes following nicotine treatment. Nicotine does not induce reactive astrocytosis.
Article
Endocrinology & Metabolism
Nan Wang, Yan Sun, Hao Yang, Yongxia Xu, Yaojun Cai, Tiantian Liu, Qin Xia, Defa Zhu, Fen Wang
Summary: This study established a euthyroid HT mouse model and found that HT can cause abnormalities in synaptic plasticity in the hippocampal Schaffer collateral-CA1 synapse, affecting learning and memory function. Additionally, HT also leads to impairment of astrocytes, which may underlie the deleterious effects of HT on hippocampal-dependent learning and memory function.
Article
Neurosciences
Xiao-Hui Tang, Yu-Gang Diao, Zhuo-Yu Ren, Yan-Yu Zang, Guang-Fen Zhang, Xing-Ming Wang, Gui-Fang Duan, Jin-Chun Shen, Kenji Hashimoto, Zhi-Qiang Zhou, Jian-Jun Yang
Summary: Mouse models of depression-like behavior showed decreased levels of GABA and increased levels of glutamate in the hippocampus. Ketamine treatment reversed these alterations by increasing GABA levels and decreasing glutamate levels. These effects were mediated by changes in enzymes and transporters on GABAergic neurons and astrocytes.
Article
Neurosciences
Olga Tyurikova, Pei-Yu Shih, Yulia Dembitskaya, Leonid P. Savtchenko, Thomas J. McHugh, Dmitri A. Rusakov, Alexey Semyanov
Summary: Glutamatergic transmission through postsynaptic NMDA receptors induces K+ efflux, which enhances glutamate release in astrocytes and reduces glutamate uptake, forming a feedback loop.
Article
Biochemistry & Molecular Biology
Rafael S. Ferreira, Jessica Teles-Souza, Cleide dos Santos Souza, Erica P. L. Pereira, Fillipe M. de Araujo, Alessandra Bispo da Silva, Juliana H. Castro e Silva, Yasmine Nonose, Yanier Nunez-Figueredo, Adriano M. de Assis, Diogo O. Souza, Maria de Fatima D. Costa, Jose Claudio F. Moreira, Silvia L. Costa, Victor D. A. da Silva
Summary: Rutin is considered as a neuroprotective agent that prevents glutamate excitotoxicity, and its mechanism may involve the regulation of astrocytic metabolism.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Wong
Summary: This article reviews how glutamate handling and glutamatergic function are affected by neuroinflammation and their contribution to cognitive impairment. The authors summarize the current data regarding glutamate in neurotransmission, including its receptors and regulation. They also examine the impact of inflammation on glutamate handling and neurotransmission, focusing on changes in glial cells and the effect of cytokines. Finally, they discuss the implications of these changes for perioperative neuroinflammation and perioperative neurocognitive disorders.
Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Allison R. Peterson, Terese A. Garcia, Kyle Cullion, Seema K. Tiwari-Woodruff, Ernest Pedapati, Devin K. Binder
Summary: Astrocytic glutamate transporters play a crucial role in maintaining glutamate homeostasis in the brain, and targeting glutamate uptake may be a promising therapeutic strategy for epilepsy. Upregulation of GLT-1 in astrocytes has shown to be neuroprotective, reducing seizure frequency and eliminating large behavioral seizures in epilepsy models.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Karin Schwarz, Frank Schmitz
Summary: Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting nearly three million humans worldwide and causing cells of an auto-reactive immune system to invade the brain and trigger a harmful neuroinflammatory process in both white and grey matter. Synapse dysfunctions in MS occur early and are likely associated with cognitive and mental symptoms, with disturbed synapse/glia communication playing a central role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michele Malaguarnera, Tiziano Balzano, Mari Carmen Castro, Marta Llansola, Vicente Felipo
Summary: The study suggests that GABA(A) receptor modulation may be a suitable target for improving neuroinflammation in MHE, as evidenced by the effects of the GABA(A) antagonist bicuculline in reducing inflammation in hyperammonemic rats while possibly inducing inflammation in control rats. This indicates a complex interaction between the GABAergic system and the immune system in the development of neuroinflammation in MHE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeier
Summary: Tauopathies are neurodegenerative diseases characterized by tau accumulation. This study investigates the interactions between astrocytes and tau, and the effect of apoE genotype on these processes. The findings suggest that apoE4 disrupts the elimination of extracellular tau by astrocytes, leading to tau accumulation and mitochondrial dysfunction. These results provide insights into the early stages of neurodegenerative diseases such as traumatic brain injury.
Review
Neurosciences
Kyle J. Brymer, Jocelyn R. Barnes, Matthew P. Parsons
Summary: Glutamate transporter proteins play a crucial role in regulating neuronal activity, with dysfunction implicated in various CNS diseases. Rapid glutamate uptake is essential for preventing toxic accumulation and ensuring efficient excitatory network activity.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Environmental Sciences
Wenjie Ding, Zixuan Zhao, Yudan Zheng, Rui Wang, Zeyao Zhang, Ziyang Zhang, Xiangdong Wang, Shali Yu, Lei Liu, Rongrong Huang, Xinyuan Zhao, Qiyun Wu
Summary: In this study, SCCP exposure was shown to induce astrocyte proliferation and activation via the JAK2/STAT3 signaling pathway. These findings contribute to the understanding of the molecular mechanism underlying SCCP-induced neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Nitin Goyal, Vijaya Kumar Bulasara, Gang Li, Liying Liu
Summary: This study synthesized and modified MCM-41 adsorbent for the effective removal of AZN from aqueous phase. The optimized conditions for maximum removal of AZN were found to be a pH of 6 and a temperature of 313 K. The pseudo-first-order kinetic model provided the best fit, while the adsorption equilibrium isotherm models showed strong correlation with the removal process of AZN.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Physical
Luiza L. Knittel, Huaying Zhao, Ai Nguyen, Antonio Miranda, Peter Schuck, Alioscka A. Sousa
JOURNAL OF PHYSICAL CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Andre L. Lira, Rodrigo S. Ferreira, Maria Luiza Oliva, Alioscka A. Sousa
Article
Cell Biology
John P. McCauley, Maurice A. Petroccione, Lianna Y. D'Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rose M. De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Damian G. Zuloaga, Michele Migliore, Annalisa Scimemi
Review
Neurosciences
Renae M. Ryan, Susan L. Ingram, Annalisa Scimemi
Summary: Neurotransmitter transporters play a crucial role in regulating neurotransmitter concentration and can be dynamically regulated through redistribution and stabilization. This allows for adjustments in uptake capacity for different neurotransmitters in response to changes in neuronal activity, blood flow, and cell-to-cell interactions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Corinne S. Wilson, Preeti Dohare, Shaina Orbeta, Julia W. Nalwalk, Yunfei Huang, Russell J. Ferland, Rajan Sah, Annalisa Scimemi, Alexander A. Mongin
Summary: The knockout of the LRRC8A gene in mice leads to seizures in adolescence, as well as abnormalities in neurons and astrocytes in the brain. These abnormalities are associated with reactive astrogliosis, as well as dysregulation of amino acid neurotransmitter uptake and supply by astrocytes.
Article
Biochemical Research Methods
Anca R. Radulescu, Gabrielle C. Todd, Cassandra L. Williams, Benjamin A. Bennink, Alex A. Lemus, Haley E. Chesbro, Justin R. Bourgeois, Ashley M. Kopec, Damian G. Zuloaga, Annalisa Scimemi
Summary: Glutamate transporters play a crucial role in maintaining the spatial specificity of synaptic transmission by limiting glutamate diffusion and preventing excitotoxicity. This study conducted quantitative dot blot analysis to determine the surface density of astrocytic glutamate transporters in mice of different ages. The findings indicate that the density of glial glutamate transporters is similar in 7-8 week old mice and rats, but increases until about 6 months of age in mice and then slowly declines. Moreover, the study reveals heterogeneity in the expression of glutamate transporters across different sub-cellular compartments, suggesting that the extent of astrocyte-mediated limitation of extrasynaptic glutamate diffusion depends on both synaptic coverage and the specific astrocyte compartment in contact with the synapse.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Behavioral Sciences
P. Ortinski, K. J. Reissner, J. Turner, T. A. Anderson, A. Scimemi
Summary: Glial cells, specifically astrocytes and microglia, have been found to influence behavior and reflect behavioral history and circuit-specific computations. Regional diversity of glial cell phenotypes may contribute to behavioral outcomes, with a focus on higher cognitive control, reward-seeking, and circadian regulation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Editorial Material
Neurosciences
Daniela Tropea, Annalisa Scimemi, Abhishek Banerjee
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Andre L. Lira, Natasha Mina, Camila R. Bonturi, Ruben S. Nogueira, Ricardo J. S. Torquato, Maria Luiza V. Oliva, Alioscka A. Sousa
Summary: Ultrasmall gold nanoparticles (usNPs) and nanoclusters are a type of emerging nanomaterials with unique physicochemical properties and in vivo behaviors. This study found that anionic usNPs can bind to and activate factor XII (FXII), leading to the promotion of coagulation cascade. This suggests that anionic usNPs may disrupt the normal hemostatic balance.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Andre F. Lima, Vinicius S. Guido, Natasha Mina, Ricardo J. S. Torquato, Alioscka A. Sousa
Summary: This study investigated the interactions between ultrasmall gold nanoparticles (usGNPs) and six different proteins. The results showed that prolonged interactions between proteins and usGNPs permanently altered protein function, while both short and long-term interactions yielded short-lived complexes. This study enhances our understanding of nano-bio interactions in the ultrasmall size regime.
Meeting Abstract
Critical Care Medicine
David Priemer, Mayumi Yagi, Cheryl Stimpson, Abigail Schindler, Suhjung Janet Lee, Rita De Gasperi, Miguel Gama Sosa, Gregory Elder, Annalisa Scimemi, David Cook, Daniel Perl
JOURNAL OF NEUROTRAUMA
(2022)
Article
Chemistry, Multidisciplinary
Paulo H. Jr Jr Olivieri, Marcelo B. Jesus, Helena B. Nader, Giselle Z. Justo, Alioscka A. Sousa
Summary: This study reveals that surface glycosaminoglycans (GAGs) can regulate the cellular internalization of nanoparticles. Anionic nanoparticles are hindered by the charged surface GAGs, while cationic nanoparticles interact favorably with GAGs. Further investigation shows that the interaction of nanoparticles with GAGs is different, and heparan sulfate plays a crucial role in the cellular internalization of cationic nanoparticles.
Review
Chemistry, Multidisciplinary
Alioscka A. Sousa, Peter Schuck, Sergio A. Hassan
Summary: The use of nanoparticles in biomedicine has transitioned from concept to clinical trials, with ultrasmall nanoparticles showing potential applications in diagnosis and therapy. The ability to control the behavior of these nanoparticles is limited, and further advances are needed in nanoengineering and chemical synthesis to fully understand their interactions in biological environments.
NANOSCALE ADVANCES
(2021)
Article
Clinical Neurology
Kimberly Goodspeed, Eduardo Perez-Palma, Sumaiya Iqbal, Dominique Cooper, Annalisa Scimemi, Katrine M. Johannesen, Arthur Stefanski, Scott Demarest, Katherine L. Helbig, Jingqiong Kang, Frances C. Shaffo, Brandon Prentice, Catherine A. Brownstein, Byungchan Lim, Ingo Helbig, Emily De Los Reyes, Dianalee McKnight, Vincenzo Crunelli, Arthur J. Campbell, Rikke S. Moller, Amber Freed, Dennis Lal
BRAIN COMMUNICATIONS
(2020)