Article
Microbiology
Xiaohan Wei, Mengze Ding, Xiao Liang, Baoping Zhang, Xiaomei Tan, Zezhong Zheng
Summary: This study discovered the correlation between lung microbiota and allergic rhinitis (AR), and explored the mechanism of Mahuang Fuzi Xixin decoction (MFXD), a traditional Chinese medicine, in improving AR by regulating microbiota dysbiosis. The results showed that MFXD can decrease plasma histamine and IgE levels, alleviate pathological damage, and alter the dysbiosis of lung microbiota and plasma metabolites in AR. Furthermore, MFXD can repair the damaged airway barrier. This research provides a reference for the effect of lung microbiota on AR and offers a new idea for its treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Respiratory System
Martin L. Watzenboeck, Anna-Dorothea Gorki, Federica Quattrone, Riem Gawish, Stefan Schwarz, Christopher Lambers, Peter Jaksch, Karin Lakovits, Sophie Zahalka, Nina Rahimi, Philipp Starkl, Doerte Symmank, Tyler Artner, Celine Pattaroni, Nikolaus Fortelny, Kristaps Klavins, Florian Frommlet, Benjamin J. Marsland, Konrad Hoetzenecker, Stefanie Widder, Sylvia Knapp
Summary: Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases, but the mortality rate is high due to chronic lung allograft dysfunction (CLAD). The mechanisms leading to CLAD are not well understood due to insufficient understanding of post-transplant adaptation processes. This study analyzed bronchoalveolar lavage samples from lung recipients and donors, and found that recipient-specific and environmental factors shape the long-term lung microbiome. Certain bacterial strains were found to be correlated with underlying lung diseases even after transplantation. Machine learning techniques accurately predicted future changes in lung function, with the microbial profiles showing high predictive power. The study highlights the importance of understanding lung adaptation processes and the role of microbiome in predicting allograft function.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Swetha Raghuraman, Ann-Sophie Schubert, Stephan Broeker, Alejandro Jurado, Annika Mueller, Matthias Brandt, Bart E. Vos, Arne D. Hofemeier, Fatemeh Abbasi, Martin Stehling, Raphael Wittkowski, Johanna Ivaska, Timo Betz
Summary: Collective and coordinated cellular motion is a key behavior observed during morphogenesis, wound healing, and cancer invasion. Understanding this type of migration is crucial for describing and treating cancer and other pathological defects. While individual cells exert forces to move, collective motion is coordinated by cell-cell adhesion-based forces.
Article
Biology
Jin Zhang, Qianli Ma, Qiduo Yu, Fei Xiao, Zhenrong Zhang, Hongxiang Feng, Chaoyang Liang
Summary: PSMD3 is overexpressed in lung cancer tissues and cells, promoting cell proliferation, migration, and invasion, as well as stabilizing ILF3 protein expression and deubiquitination. The ILF3 inhibitor YM155 can suppress tumor growth in the presence of PSMD3, indicating that the PSMD3/ILF3 axis may be a novel strategy for diagnosis and treatment of lung cancer.
Article
Multidisciplinary Sciences
Christopher W. Marshall, Erin S. Gloag, Christina Lim, Daniel J. Wozniak, Vaughn S. Cooper
Summary: This study illustrates how active lysogeny can drive rapid and parallel adaptations in establishing chronic infections, by repeatedly disrupting genes encoding global regulators to increase biofilm production. The implications of prophage-mediated adaptation are broad, potentially altering evolution and leading to persistent phenotypes associated with poor clinical outcomes.
Article
Microbiology
Evgenii Olekhnovich, Artem B. Ivanov, Vladimir Ulyantsev, Elena N. Ilina
Summary: Fecal microbiota transplantation (FMT) is used to treat intestinal diseases, but its therapeutic mechanism and donor bacteria colonization in the recipient's intestine remain unclear. Metagenomic analysis of FMT experiments can provide insights into the relationship between the host and gut microbiota. The enrichment of successful gut microbes with antibiotic resistance genes may play a key role in the colonization and redistribution of recipient gut microbiota during FMT.
Article
Biotechnology & Applied Microbiology
Jianquan He, Xingxiang He, Yonghui Ma, Luxi Yang, Haiming Fang, Shu Shang, Huping Xia, Guanghui Lian, Hailing Tang, Qizhi Wang, Junping Wang, Zhihui Lin, Jianbo Wen, Yuedong Liu, Chunbao Zhai, Wen Wang, Xueliang Jiang, Ji Xuan, Morong Liu, Shiyun Lu, Xuejun Li, Han Wang, Cong Ouyang, Man Cao, Aiqiang Lin, Bangzhou Zhang, Depei Wu, Ye Chen, Chuanxing Xiao
Summary: This study in China conducted screening for FMT donors, selecting 66 donors through online surveys, clinical assessments, etc. The research found that the gut microbiota of the same donor was typically more stable, providing a potential reference index for regular donor re-evaluation.
MICROBIAL CELL FACTORIES
(2021)
Article
Immunology
Yifan Zhong, Jiahong Cao, Yanfei Ma, Yu Zhang, Jianxin Liu, Haifeng Wang
Summary: Transforming the gut microbiota through fecal microbiota transplantation (FMT) has become an intriguing intervention for various gastrointestinal and non-gastrointestinal disorders. This study investigated the effects of different diets on the gut microbiota post-FMT from donors with different diets. The results showed that different dietary fiber contents paired with FMT from different donors led to distinct patterns of gut microbiota and metabolites, highlighting the importance of precise dietary interventions post-FMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jesus Antonio Lopez-Carvallo, Roberto Cruz-Flores, Arun K. Dhar
Summary: The study assessed the modulation of microbiome in shrimp experimentally challenged with EHP, showing that EHP infection can lead to alterations in gut microbiota and impact the health and disease progression of shrimp.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Nia Paddison Rees, Walaa Shaheen, Christopher Quince, Chris Tselepis, Richard D. Horniblow, Naveen Sharma, Andrew D. Beggs, Tariq H. Iqbal, Mohammed Nabil Quraishi
Summary: This systematic review aims to identify clinical, microbial, and metabolomic biomarkers in donors and recipients that predict the response to FMT in UC. The results suggest that distinct changes in gut microbiota profiles, along with specific baseline characteristics and microbial and metabolomic alterations, may predispose patients towards a successful therapeutic outcome.
Article
Surgery
Hiromi Oda, Satona Tanaka, Toyofumi F. Chen-Yoshikawa, Yuki Morimura, Yoshito Yamada, Yojiro Yutaka, Daisuke Nakajima, Masatsugu Hamaji, Akihiro Ohsumi, Toshi Menju, Miki Nagao, Hiroshi Date
Summary: This study aimed to evaluate the impact of postoperative pathogenic organism (PO) positivity on transplant outcomes. It was found that postoperative PO positivity in the airway was associated with prolonged ventilation time and significantly lower 5-year overall survival compared to PO-negative group.
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Yifan Zhong, Jiahong Cao, Zhaoxi Deng, Yanfei Ma, Jianxin Liu, Haifeng Wang
Summary: The combination of FMT from different donors with dietary fiber intervention can result in varied patterns of gut microbiota composition, with dietary fiber potentially playing a more critical role in shaping gut microbiota compared to the FMT donor. Strategies based on dietary fiber can influence the effectiveness of FMT in the recipient.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Zilin Wang, Bo Zhao, Mingming Deng, Run Tong, Yiding Bian, Qin Zhang, Gang Hou
Summary: This study critically evaluated the efficacy and safety of airway stents in treating airway stenosis after lung transplantation. It showed that airway stenting is a safe and effective method for immediate symptom palliation, but further investigations are needed to determine its long-term efficacy on survival rate.
FRONTIERS IN MEDICINE
(2023)
Article
Microbiology
Efthymia Iliana Matthaiou, Wayland Chiu, Carol Conrad, Joe Hsu
Summary: Cystic fibrosis lung transplant recipients are at a higher risk of life-threatening invasive aspergillosis. Alkalization of macrophages lacking the CFTR gene is associated with this increased risk, and the presence of iron in the post-transplant microenvironment exacerbates this alkalization. The alkalization impairs the ability of macrophages to clear Aspergillus fumigatus conidia. pH modulation after transplantation may be a therapeutic strategy to reduce the risk of invasive aspergillosis.
Article
Immunology
Carlos Mejia-Chew, Peggy L. Carver, Sasinuch Rutjanawech, Luis F. Aranha Camargo, Ruan Fernandes, Sara Belga, Shay Anne Daniels, Nicolas J. Mueller, Sara Burkhard, Nicole M. Theodoropoulos, Douwe F. Postma, Pleun J. van Duijn, Maria Carmen Farinas, Claudia Gonzalez-Rico, Jonathan Hand, Adam Lowe, Marta Bodro, Elisa Vanino, Ana Fernandez Cruz, Antonio Ramos, Mateja Jankovic Makek, Ribal Bou Mjahed, Oriol Manuel, Nassim Kamar, Antonia Calvo-Cano, Laura Rueda Carrasco, Patricia Munoz, Sara Rodriguez, Sandra Perez-Recio, Nuria Sabe, Regino Rodriguez Alvarez, Jose Tiago Silva, Alessandra Mularoni, Elisa Vidal, Juana Alonso-Titos, Teresa del Rosal, Annika Y. Classen, Charles W. Goss, Mansi Agarwal, Francisco Lopez-Medrano
Summary: This study aimed to describe the risk factors for nontuberculous mycobacteria (NTM) infections after solid organ transplant (SOT). The results showed that older age, prior hospital admission, receipt of antifungals, and lymphocyte-specific antibodies were associated with NTM infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Biophysics
Mihaela Sava, Veronika Battig, Sabine Gerull, Jakob R. Passweg, Nina Khanna, Christian Garzoni, Bernhard Gerber, Nicolas J. Mueller, Urs Schanz, Christoph Berger, Yves Chalandon, Christian van Delden, Dionysios Neofytos, Susanne Stampf, Fabian C. Franzeck, Maja Weisser
BONE MARROW TRANSPLANTATION
(2023)
Article
Surgery
Pouya Iranmanesh, Shinil K. Shah, Mickael Chevallay, Christian Toso, Stefan P. Monig, Monika E. Hagen, Erik B. Wilson, Minoa K. Jung
Summary: This study retrospectively analyzed patient data from two databases at two high-volume bariatric centers to identify predictors of early postoperative complications after RRYGB. The results showed that male sex and ASA score > 2 were independent predictors of early postoperative complications after RRYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Jeremy Meyer, Elin Roos, Richard Justin Davies, Nicolas Christian Buchs, Frederic Ris, Christian Toso
Summary: An updated systematic review and meta-analysis of 11 randomized controlled trials (RCTs) confirms that prophylactic negative-pressure wound therapy (pNPWT) reduces the incidence of surgical site infection (SSI) after laparotomy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Dermatology
Colin Morton, Samira Baharlou, Nicole Basset-Seguin, Piergiacomo Calzavara-Pinton, Thomas Dirschka, Yolanda Gilaberte, Merete Haedersdal, Gunther Hofbauer, Sheetal Sapra, Rick Waalboer-Spuij, Leona Yip, Rolf-Markus Szeimies
Summary: Actinic keratoses are pre-malignant skin lesions that require personalized care. Lack of personalized care may lead to poor treatment adherence and suboptimal outcomes. The Personalizing Actinic Keratosis Treatment panel developed recommendations to support personalized, long-term management of actinic keratoses lesions, including tailoring treatment to patient priorities and goals and supporting shared decision-making.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Pharmacology & Pharmacy
Catia Marzolini, Matthias L. Cavassini, Dominique L. Braun, Anna Hachfeld, Enos Bernasconi, Alexandra Calmy, Patrick Schmid, Manuel Battegay, Luigia Elzi
Summary: This study aimed to investigate whether a common single polymorphism could explain the phenomenon of some HIV patients not achieving their lipid targets despite elevated statin concentrations. The study found that individuals carrying the SLCO1B1 c.521T>C polymorphism had smaller changes in lipid levels after statin initiation compared to those without this polymorphism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Paul Thoueille, Susana Alves Saldanha, Vincent Desfontaine, Katharina Kusejko, Perrine Courlet, Pascal Andre, Matthias Cavassini, Laurent A. Decosterd, Thierry Buclin, Monia Guidi
Summary: This study investigated the pharmacokinetics of tenofovir alafenamide (TAF) in people living with HIV (PLWH), and found that renal function significantly affects TAF exposure. The study suggests cautious adjustment of TAF dosage intervals in case of moderate or severe chronic kidney disease (CKD).
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Olivier de Rougemont, Yun Deng, Lukas Frischknecht, Caroline Wehmeier, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. However, there are no large studies comparing the impact of pre-transplant donor specific antibody (DSA) stratified on donation type in a cohort with long-term follow-up. This study compared the effect of pre-transplant DSA on rejection risk, graft loss, and eGFR decline in DBD, DCD, and LD transplants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Oriol Manuel, Mirjam Laager, Cedric Hirzel, Dionysios Neofytos, Laura N. Walti, Gideon Hoenger, Isabelle Binet, Aurelia Schnyder, Susanne Stampf, Michael Koller, Matteo Mombelli, Min Jeong Kim, Matthias Hoffmann, Katrin Koenig, Christoph Hess, Anne-Valerie Burgener, Pietro E. Cippa, Kerstin Huebel, Thomas F. Mueller, Daniel Sidler, Suzan Dahdal, Franziska Suter-Riniker, Jean Villard, Andrea Zbinden, Giuseppe Pantaleo, Nasser Semmo, Karine Hadaya, Natalia Enriquez, Pascal R. Meylan, Marc Froissart, Dela Golshayan, Thomas Fehr, Uyen Huynh-Do, Manuel Pascual, Christian van Delden, Hans H. Hirsch, Peter Jueni, Nicolas J. Mueller, Swiss Transplant Cohort Study STCS
Summary: This study examined the use of immune monitoring to individualize the duration of antiviral prophylaxis after transplantation. The results showed that immune monitoring led to a significant reduction in prophylaxis duration, but did not establish noninferiority in terms of the primary outcome of CMV infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Matteo Mombelli, Dionysios Neofytos, Uyen Huynh-Do, Javier Sanchez-Cespedes, Susanne Stampf, Dela Golshayan, Suzan Dahdal, Guido Stirnimann, Aurelia Schnyder, Christian Garzoni, Reto M. Venzin, Lorenzo Magenta, Melanie Schonenberger, Laura Walti, Cedric Hirzel, Aline Munting, Michael Dickenmann, Michael Koller, John-David Aubert, Jurg Steiger, Manuel Pascual, Thomas F. Mueller, Mace Schuurmans, Christoph Berger, Isabelle Binet, Jean Villard, Nicolas J. Mueller, Adrian Egli, Elisa Cordero, Christian van Delden, Oriol Manuel
Summary: The use of MF59-adjuvanted or high-dose influenza vaccine in solid-organ transplant recipients was safe and resulted in a higher vaccine response rate.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Bashkim Jaha, Corinne D. Schenkel, Lisa Jorimann, Michael Huber, Maryam Zaheri, Kathrin Neumann, Christine Leemann, Alexandra Calmy, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner, Swiss HIV Cohort Study
Summary: A new method was used to analyze HIV-1 DNA, including the detection of drug resistance. The results showed varying levels of drug resistance mutations, which were associated with the duration of antiretroviral therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Oncology
Charles-Henri Wassmer, Sofia El Hajji, Xenofon Papazarkadas, Philippe Compagnon, Parissa Tabrizian, Stephanie Lacotte, Christian Toso
Summary: ICI therapy has improved the management of HCC patients and made liver transplantation possible for some of them. However, acute rejection after ICI therapy challenges its safety in transplant settings. A three-month washout period is desirable to reduce the risk of acute rejection, and the use of ICIs after liver transplantation should be avoided whenever possible.
Article
Medicine, General & Internal
Alix T. Coste, Adrian Egli, Jacques Schrenzel, Beatrice Nickel, Andrea Zbinden, Reto Lienhard, Alexis Dumoulin, Martin Risch, Gilbert Greub
Summary: The IVDR regulation poses a major challenge for diagnostic microbiology laboratories due to its complexity and risks. The emergence of new pathogens further complicates the regulation, negatively impacting the development of new diagnostic tests. Additionally, the regulation affects the availability and costs of diagnostic tests, posing a risk to public health.
Meeting Abstract
Dermatology
B. Meier-Schiesser, D. Jankovic, C. Surber, G. Hofbauer, E. Contassot, L. E. French
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Parasitology
Bastian Marquis, Florent Demonmerot, Carine Richou, Gerard Thiefin, Laurence Millon, Martine Wallon, Dominique Angele Vuitton, Anne Grall-Jezequel, Frederic Grenouillet, Olivier Epaulard, Philippe Gervais, Oriol Manuel, Solange Bresson-Hadni
Summary: This study aimed to investigate the occurrence of alveolar echinococcosis (AE) in transplant patients. The research found that AE had a higher mortality and faster clinical progression in transplant patients, possibly due to the reactivation of latent liver lesions through immunosuppression, and suggested the use of Western blot serology as the preferred diagnostic method. Surgery had a low success rate and high mortality, while conservative treatment with albendazole was well tolerated.