Article
Obstetrics & Gynecology
Lizhen Lin, Guan Lin, Huixin Lian, Qingshan Chen, Penghui Huang, Shunhe Lin, Zhenhong Wang, Jun Shi, Chaobin Liu, Xi Xie
Summary: Preoperative NLR levels are significantly associated with natural pregnancy outcomes in infertile OMA patients after laparoscopic cystectomy. A predictive model combining NLR, LF score, and age could assist in the clinical decision-making process.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, General & Internal
Jin Seo Yang, Jae Jun Lee, Young-Suk Kwon, Jong-Ho Kim, Jong-Hee Sohn
Summary: This study investigated the association between preoperative inflammatory markers and postoperative delirium (POD) in patients undergoing lumbar spinal fusion surgery (LSFS). The analysis of 11 years' worth of data showed that increased levels of inflammatory markers, particularly the neutrophil-to-lymphocyte ratio (NLR), were associated with the development of POD. These findings suggest that a proinflammatory state may be a potential pathological mechanism of POD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Zilong Xiao, Xinxin Wang, Xiaoxiao Chen, Jiawei Zhou, Haitao Zhu, Jiangnan Zhang, Wensheng Deng
Summary: This study retrospectively analyzed clinical and survival data of 448 patients with colorectal cancer who underwent surgical resection, and found that the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were negatively correlated with overall survival, while lymphocyte-to-monocyte ratio (LMR) was positively correlated with overall survival. Multivariate analysis showed that an increase in NLR was associated with increased risk of death, while a decrease in LMR was associated with reduced risk of death. Therefore, preoperative inflammatory markers NLR, PLR, and LMR are associated with the overall survival of postoperative colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Hongni Tian, Xuetao Jiang, Guangyou Duan, Jie Chen, Qi Liu, Yamei Zhang, Shiqi Li, Xiaohang Bao, He Huang
Summary: This study aimed to explore the role and predictive effects of preoperative inflammation on the primary outcomes after valvular cardiac surgery. The results showed that there was a significant association between preoperative inflammation and adverse outcomes after heart valve surgery. CRP level >5 mg/L effectively predicted postoperative heart failure, and NLR >3.5 had a good predictive effect on all-cause mortality within 30 days after surgery.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Alessandro Coppola, Vincenzo La Vaccara, Lorenza Caggiati, Ludovico Carbone, Silvia Spoto, Massimo Ciccozzi, Silvia Angeletti, Roberto Coppola, Damiano Caputo
Summary: Preoperative inflammatory biomarkers may serve as predictors of postoperative complications after pancreaticoduodenectomy (PD). CRP levels were significantly associated with postoperative complications and abdominal collections, while preoperative derived neutrophil-to-lymphocyte ratio (dNLR) was a strong predictor of abdominal collection. The combination of CRP and dNLR further increased the predictive positive value.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Yingchao Zhu, Yaodan Bi, Bin Liu, Tao Zhu
Summary: This study aimed to assess the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR) for morbidity and mortality after surgery and determine the optimal threshold for NLR. The results showed that elevated preoperative NLR was significantly associated with higher in-hospital mortality and ICU admission after surgery. The predictive value of high NLR was confirmed in multiple surgical subgroups, and a NLR threshold of 3.6 provided good prognostic value.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yao-Yu Wu, Kai-Ping Chang, Tsung-Ying Ho, Wen-Chi Chou, Sheng-Ping Hung, Kang-Hsing Fan, Yin-Yin Chiang, Yung-Chih Chou, Ngan-Ming Tsang
Summary: In patients with oral cavity squamous cell carcinoma treated with surgery and postoperative radiotherapy, a low neutrophil-to-lymphocyte ratio (NLR) was the only independently favorable marker for overall survival (OS) and distant control (DC). Other preoperative complete blood count parameters and cell ratios did not show prognostic significance. High NLR was identified as a significant adverse risk factor in high-risk patients.
Article
Immunology
Meilong Wu, Shizhong Yang, Xiaobin Feng, Chengquan Li, Xiangchen Liu, Zhenyu Zhang, Ying Xiao, Chuchu Liu, Jiahong Dong
Summary: This study investigated the prognostic value of postoperative inflammatory indicators and the potential improvement of predictive performance by combining preoperative and postoperative indicators. The results showed that the combined model had higher prognostic efficacy than individual models and traditional clinical staging systems at 2 and 3 years, suggesting the importance of postoperative inflammatory indicators in predicting prognosis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
Gulay Ulger, Ramazan Baldemir, Musa Zengin, Hilal Sazak, Ali Alagoz
Summary: This study aimed to investigate the effectiveness of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in evaluating postoperative pain in patients undergoing video-assisted thoracoscopic surgery (VATS). The results showed a positive correlation between postoperative monocyte, neutrophils, and visual analog scale (VAS) resting and cough levels in the early postoperative period. There was no significant correlation between preoperative and postoperative NLR, PLR, and LMR values and VAS rest and cough values. A negative correlation was found between the change in postoperative LMR value and the VAS rest and cough values in the early postoperative period compared to the preoperative period. The researchers believe that further comprehensive studies on this topic will greatly contribute to the objective criteria in postoperative pain evaluation.
Article
Geriatrics & Gerontology
Yanli Zhao, Jirong Yue, Peng Lei, Taiping Lin, Xuchao Peng, Dongmei Xie, Langli Gao, Xiaoyu Shu, Chenkai Wu
Summary: The study found that NLR is a simple and practical marker that can predict the development of delirium in older internal medicine patients.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Surgery
Carlos Delgado-Miguel, Miriam Miguel-Ferrero, Antonella Garcia, Bonifacio Delgado, Juan Camps, Leopoldo Martinez
Summary: This study aimed to analyze the role of neutrophil-to-lymphocyte ratio (NLR) in predicting postoperative complications and readmission in children after appendectomy. The results showed that NLR at admission is a reliable indicator for identifying high-risk surgical patients and predicting postoperative complications and readmission in children with acute appendicitis
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Keisuke Toya, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the healing time and potential factors associated with the healing time of postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The study found that the neutrophil-to-lymphocyte ratio was the only factor independently associated with the healing time of POPF. Patients with a lower neutrophil-to-lymphocyte ratio had significantly shorter healing times for POPF after DP.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Oncology
Myung-Hoon Han, Kyueng-Whan Min, Yung-Kyun Noh, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Seong-Ho Koh, Jae Kyung Myung, Ji Young Park, Mi Jung Kwon
Summary: This study found that high expression of DKK3 in patients with GBM is associated with increased immunosuppressive response and decreased antitumoral immunity. High DKK3 expression is also correlated with poor prognosis and disease progression in GBM patients. The identification of navitoclax as an agent with potent activity against GBM cell lines with high DKK3 expression suggests that DKK3 could be a therapeutic target in GBM.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Medicine, General & Internal
Dongwook Oh, Jung-Soo Pyo, Kwang Hyun Chung, Byoung Kwan Son
Summary: This study explored the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in pancreatic neuroendocrine tumors (PNETs) through meta-analysis, revealing that high NLRs are associated with worse overall and recurrence-free survivals. It can also be useful in predicting tumor grade and prognosis in PNETs.
Article
Gastroenterology & Hepatology
Yoon Jin Choi, Yong Chan Lee, Jung Mogg Kim, Jin Il Kim, Jeong Seop Moon, Yun Jeong Lim, Gwang Ho Baik, Byoung Kwan Son, Hang Lak Lee, Kyoung Oh Kim, Nayoung Kim, Kwang Hyun Ko, Hye-Kyung Jung, Ki -Nam Shim, Hoon Jai Chun, Byung-Wook Kim, Hyuk Lee, Jie-Hyun Kim, Hyunsoo Chung, Sang Gyun Kim, Jae Young Jiang
Summary: This study evaluated the efficacy and safety of tegoprazan compared to lansoprazole as a first-line triple therapy for Helicobacter pylori eradication. The results showed that tegoprazan was as effective as lansoprazole in eradicating H. pylori and both treatment regimens were well-tolerated. However, tegoprazan did not overcome clarithromycin resistance in H. pylori.
Article
Gastroenterology & Hepatology
Yoon Suk Lee, Tae Joo Jeon, Woo Hyun Paik, Dong-Won Ahn, Kwang Hyun Chung, Byoung Kwan Son, Tae Jun Song, Sung-Hoon Moon, Eaum Seok Lee, Jae Min Lee, Seung Bae Yoon, Chang Nyol Paik, Yun Nah Lee, Jin-Seok Park, Dong Wook Lee, Sang Wook Park, Hyung Ku Chon, Kwang Bum Cho, Chang Hwan Park
Summary: This study investigated the preferred types and techniques of endoscopic procedures for managing difficult common bile duct (CBD) stones in South Korea. The majority of respondents showed unified trends in the management of difficult CBD stones. These findings can serve as basic data for clinical quality improvements.
Article
Gastroenterology & Hepatology
Kwang Hyun Chung, Jeong Don Chae, Wonho Choe, Hyo Young Lee, Il Hwan Oh, Byoung Kwan Son
Summary: This study compared the effectiveness of a newly developed channel-cleaning ball brush (BB) with a conventional brush (CB) in the cleaning process of endoscopic channels, and found that the efficacy of the BB was similar to that of the CB.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Dong -Won Ahn, Hyung Ku Chon, Sung-Hoon Moon, Sang Wook Park, Woo Hyun Paik, Chang Nyol Paik, Byoung Kwan Son, Tae Jun Song, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Jae Min Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Hong Ja Kim, Seung Bae Yoon, Kwang Hyun Chung, Jin-Seok Park
Summary: According to a nationwide survey conducted by the Korean Pancreatobiliary Association, the practice patterns of EUS-FNA/FNB for pancreatic solid mass vary substantially, some of which differ considerably from the recommendations present in existing guidelines. These results suggest that the development of evidence-based quality guidelines fitting Korean clinical practice is needed to establish the optimal strategy for this procedure.
Review
Medicine, General & Internal
Chi Hyuk Oh, Byoung Kwan Son
Summary: Fluoroscopy is frequently used in endoscopic procedures like ERCP, but radiation exposure is a significant concern for the health of both patients and staff. Understanding how to measure radiation doses and methods to minimize exposure is crucial, although comprehensive guidelines are currently lacking.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Oncology
Jinah Chu, Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Hyung Suk Kim, Un Suk Jung, Mi Jung Kwon, Sung-Im Do
Summary: This study found that high PPFIA1 expression is associated with poor prognosis and decreased anticancer immune response in breast cancer patients. Additionally, erlotinib may be a promising drug for treating tumors overexpressing PPFIA1.
Article
Clinical Neurology
Myung-Hoon Han, Jeong Min Baek, Kyueng-Whan Min, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Mi Jung Kwon, Seong-Ho Koh
Summary: This study compared the association of DKK3 with other Wnt/β-catenin pathway-related genes and immune responses between LGG and GBM. The results showed that DKK3 was significantly associated with immunosuppression and poor prognosis in GBM, but had a weaker effect in LGG. Therefore, DKK3 plays different roles in the Wnt/β-catenin pathway between LGG and GBM.
Article
Biochemistry & Molecular Biology
Mi Jung Kwon, Young Rim Song, Joo-Hee Kim, Ji Hee Kim, Ho Suk Kang, Hyun Lim, Min-Jeong Kim, Nan Young Kim, Sangkyoon Hong, Younghee Choi, Kyueng-Whan Min, Hyo Geun Choi, Eun Soo Kim
Summary: Chronic kidney disease (CKD) is associated with an increased risk of Alzheimer's disease (AD) in the Korean adult population, regardless of demographic or lifestyle conditions. This longitudinal follow-up study included 15,756 individuals with CKD and 63,024 matched controls aged ≥40 years. After adjusting for various factors, CKD was significantly associated with a 1.14-fold increased likelihood of developing AD. This highlights the importance of frequent AD screening and management for patients with CKD.
Article
Oncology
Ho Suk Kang, Ji Hee Kim, Hyun Lim, Joo-Hee Kim, Hye-Mi Noh, Hyo Geun Choi, Kyueng-Whan Min, Nan Young Kim, Mi Jung Kwon
Summary: This study found that patients with Alzheimer's disease (AD) have a lower likelihood of developing cancer, especially pancreatic cancer. The protective effect against specific organ-specific cancers persists over a long follow-up period, particularly in individuals aged 60 years and above.
Article
Medicine, General & Internal
Jung-Soo Pyo, Nae Yu Kim, Kyueng-Whan Min, Il Hwan Oh, Dae Hyun Lim, Byoung Kwan Son
Summary: This study compared the diagnostic accuracy of the Ki-67 labeling index (LI) in endoscopic ultrasonography-fine-needle aspiration cytology/biopsy (EUS-FNAC/FNB) and surgical specimens of pancreatic neuroendocrine neoplasms (PanNENs). The concordance rate of tumor grade based on Ki-67 LI was higher between EUS-FNAC/FNB and surgical specimens, indicating the potential usefulness of Ki-67 LI in predicting PanNEN tumor grade in EUS-FNAC/FNB.
Article
Oncology
Hyung Suk Kim, Yung-Kyun Noh, Kyueng-Whan Min, Dong-Hoon Kim, Mi Jung Kwon, Jung Soo Pyo, Jeong-Yeon Lee
Summary: This study highlights the significant role of cancer-associated fibroblasts (CAFs) in breast cancer biology and provides compelling evidence of their impact on patient outcomes and treatment response. The presence of CAFs is correlated with young age, lymphatic invasion, and perineural invasion, and is associated with critical processes such as the epithelial-mesenchymal transition and immune modulation. CAF-targeted therapies have the potential to enhance the efficacy of certain anticancer drugs, including ARRY-520, ispinesib-mesylate, paclitaxel, and docetaxel. Integrating CAF presence with machine-learning improves survival prediction, and CAFs are independent prognostic markers for worse disease-specific survival and disease-free survival in breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Daeseon Yoo, Kyueng-Whan Min, Jung-Soo Pyo, Nae Yu Kim
Summary: This study evaluated the diagnostic and prognostic roles of GATA-binding protein 3 (GATA3) immunohistochemistry in urothelial carcinoma (UC) through a meta-analysis. The results showed that GATA3 expression significantly correlated with low-stage and better prognosis in UC, while also exhibiting high variability across histological subtypes.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Daeyoung So, Kyueng-Whan Min, Woon Yong Jung, Sang-Woong Han, Mi-Yeon Yu
Summary: This article reports the first case of microscopic polyangiitis (MPA) following BNT162b2 vaccination in Korea. The patient experienced renal dysfunction, proteinuria, and hematuria after vaccination, but showed improvement after induction therapy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
