Article
Medicine, Research & Experimental
Ratan Sadhukhan, Utpal Ghosh
Summary: The study revealed that PARP1 controls SLX4 recruitment at telomeres by poly(ADP-ribosyl)ation reaction, thereby regulating SLX4-mediated telomere sister chromatid exchange (T-SCE) and telomere length (TL) homeostasis.
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Immunology
Daan K. J. Pieren, Noortje A. M. Smits, Rimke J. Postel, Vinitha Kandiah, Jelle de Wit, Josine van Beek, Debbie van Baarle, Teun Guichelaar
Summary: Aging leads to decreased immune responsiveness, known as immunosenescence. This study identifies novel markers associated with immunosenescence in CD8(+) T cells and shows that these features become prominent even in the earlier differentiation states of these cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laureline Roger, Kelly Miners, Louise Leonard, Julia Grimstead, David Price, Duncan Baird, Kristin Ladell
Summary: This study used specific markers to separate different subsets of CD8+ memory T cells and measured their telomere lengths. The expression of CD45RA was found to be positively correlated with telomere length, while there was a disconnect between replicative history and cellular differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hua-Song Lin, Xiao-Hong Lin, Jian-Wen Wang, Dan-Ning Wen, Jie Xiang, Yan-Qing Fan, Hua-Dong Li, Jing Wu, Yi Lin, Ya-Lan Lin, Xu-Ri Sun, Yun-Feng Chen, Chuan-Juan Chen, Ning-Fang Lian, Han-Sheng Xie, Shou-Hong Lin, Qun-Fang Xie, Chao-Wei Li, Fang-Zhan Peng, Ning Wang, Jian-Qing Lin, Wan-Jin Chen, Chao-Lin Huang, Ying Fu
Summary: In HIV/AIDS patients with COVID-19, the severity and mortality rates are lower compared to the general population, and a reduction in CD4 T-cell count is positively correlated with levels of IL-6 and CRP. This contrasts with immune responses seen in COVID-19 patients, suggesting lymphocyte redistribution as a unique immunopathology in HIV/AIDS cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu, Zhong Deng, Eun Young Yu, Yiming Cai, Caizhi Wu, Zhenbo Han, Yu-Han Huang, Xiangao Huang, Ling Zhang, Jun Yao, Neal F. Lue, Paul M. Lieberman, Haoqiang Ying, Jihye Paik, Hongwu Zheng
Summary: Through genetic screens, researchers identify histone lysine demethylase KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of ALT-specific telomere clusters via recruitment of SENP6.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Landon J. Edgar, Andrew J. Thompson, Vincent F. Vartabedian, Chika Kikuchi, Jordan L. Woehl, John R. Teijaro, James C. Paulson
Summary: Sialic acid-containing glycans on the surface of T cells and APCs are alternative ligands of CD28 that compete with CD80 for binding, resulting in attenuated costimulation. Removal of sialic acids enhances antigen-mediated activation of naive T cells and increases revival of effector T cells through synergistic mechanism with PD-1 axis antibody blockade. These findings reveal a previously unrecognized role of sialic acid ligands in attenuation of CD28-mediated costimulation of T cells.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Yunlong Zhao, Christine Caron, Ya-Yuan Chan, Calvin K. Lee, Xiaozhen Xu, Jibin Zhang, Takeya Masubuchi, Chuan Wu, Jack D. Bui, Enfu Hui
Summary: In this study, it was discovered that B7 ligands on CD8+ T cells interact with CD28 in a cis configuration at membrane invaginations of the immunological synapse, which is driven by phosphoinositide-3-kinase (PI3K) and sorting-nexin-9 (SNX9) mediated membrane remodeling. Cis-B7:CD28 interactions activate CD28 signaling through protein kinase C theta (PKCq), promoting CD8+ T cell survival, migration, and cytokine production.
Review
Cell Biology
Alex Penev, Marta Markiewicz-Potoczny, Agnel Seir, Eros Lazzerini Denchi
Summary: This review discusses the differences in telomere protection in embryonic stem cells and somatic cells, and summarizes the findings on telomerase regulation and pluripotency function.
TRENDS IN CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengjie Shan, Hao Liu, Yan Hao, Kexin Song, Cheng Feng, Youbin Wang
Summary: This study found that patients with keloids have higher expression levels of costimulatory molecules and a larger number of CD8(+) T cells in their skin tissue. CD8(+) T cells may drive the development of keloids by promoting immunosuppression in keloid-associated fibroblasts. The expression of CD28 and CD8(+) T cells may serve as predictors of keloid severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Valentina Buemi, Odessa Schillaci, Mariangela Santorsola, Deborah Bonazza, Pamela Veneziano Broccia, Annie Zappone, Cristina Bottin, Giulia Dell'Omo, Sylvie Kengne, Stefano Cacchione, Grazia Daniela Raffa, Silvano Piazza, Fabrizio D'Adda di Fagagna, Roberta Benetti, Maurizio Cortale, Fabrizio Zanconati, Giannino Del Sal, Stefan Schoeftner
Summary: Researchers have found that the trimethylguanosine capping of the RNA component of the human telomerase complex plays an important role in directing telomere maintenance and suppressing the ALT pathway in cancer cells.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Mark E. Snyder, Michaela R. Anderson, Luke J. Benvenuto, Rachel M. Sutton, Anna Bondonese, Ritchie Koshy, Robin Burke, Sarah Clifford, Andrew Craig, Carlo J. Iasella, Stefanie J. Hannan, Iulia Popescu, Yingze Zhang, Pablo G. Sanchez, Jonathan K. Alder, John F. Mcdyer
Summary: IPF-LTRs with short telomeres exhibit premature aging of their circulating T cell compartment and a decline in ACR burden with increasing age.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Oncology
Gaia Zuccolotto, Alessandro Penna, Giulio Fracasso, Debora Carpanese, Isabella Monia Montagner, Silvia Dalla Santa, Antonio Rosato
Summary: Prostate cancer is the second leading cause of malignancy-related mortality in males in the Western world. Although treatments like prostatectomy and radiotherapy are effective for localized cancer, new methods are urgently needed for aggressive and metastatic forms of the disease. A study on third generation CAR-T cells showed that the addition of extra costimulatory elements may lead to increased activation-induced cell death and decreased efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Saadiya Zia, Netasha Khan, Komal Tehreem, Nazia Rehman, Rokayya Sami, Roua S. Baty, Faris J. Tayeb, Majed N. Almashjary, Nouf H. Alsubhi, Ghadeer Alrefaei, Ramla Shahid
Summary: This study found that the expression levels of the CTC1 gene were significantly upregulated in pediatric and adult ALL patients, showing a significant association with ALL occurrence. This suggests that CTC1 has the potential to be used as a risk biomarker for the diagnosis of ALL in both pediatric and adult populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Luke Vistain, Hoang Van Phan, Bijentimala Keisham, Christian Jordi, Mengjie Chen, Sai T. Reddy, Savas Tay
Summary: We present Proximity Sequencing (Prox-seq), a method that allows simultaneous measurement of proteins, protein complexes, and mRNAs in thousands of single cells. Prox-seq combines proximity ligation assay with single-cell sequencing and enables the measurement of protein interactions and complexes. Validation experiments on T cells and B cells show that Prox-seq accurately identifies different cell types and detects known protein complexes. Further analysis on human peripheral blood mononuclear cells reveals new protein complexes and interactions, providing insights into cell signaling processes.
Article
Biochemistry & Molecular Biology
Jerome D. Robin, Andrew T. Ludlow, Kimberly Batten, Marie-Cecile Gaillard, Guido Stadler, Frederique Magdinier, Woodring E. Wright, Jerry W. Shay
Article
Multidisciplinary Sciences
Tsung-Po Lai, Ning Zhang, Jungsik Noh, Ilgen Mender, Enzo Tedone, Ejun Huang, Woodring E. Wright, Gaudenz Danuser, Jerry W. Shay
NATURE COMMUNICATIONS
(2017)
Article
Cell Biology
Enzo Tedone, Ejun Huang, Ryan O'Hara, Kimberly Batten, Andrew T. Ludlow, Tsung-Po Lai, Beatrice Arosio, Daniela Mari, Woodring E. Wright, Jerry W. Shay
Article
Biochemistry & Molecular Biology
Mohammed E. Sayed, Laura Yuan, Jerome D. Robin, Enzo Tedone, Kimberly Batten, Nicole Dahlson, Woodring E. Wright, Jerry W. Shay, Andrew T. Ludlow
Review
Genetics & Heredity
Jerry W. Shay, Woodring E. Wright
NATURE REVIEWS GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Ryan O'Hara, Enzo Tedone, Andrew Ludlow, Ejun Huang, Beatrice Arosio, Daniela Mari, Jerry W. Shay
Article
Multidisciplinary Sciences
Yu-Ching Teng, Aishwarya Sundaresan, Ryan O'Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski
Summary: The study reveals that ATRX protects genomic integrity at G4-containing regions by maintaining these regions in a closed heterochromatic state.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Amanuel Tafessu, Ryan O'Hara, Sara Martire, Altair L. Dube, Purbita Saha, Vincent U. Gant, Laura A. Banaszynski
Summary: H3.3 plays a crucial role in the chromatin state and cellular differentiation of ESCs by facilitating DNA accessibility, transcription factor binding, and histone post-translational modification at active promoters.