Article
Public, Environmental & Occupational Health
Yunping Zhang, Xueping Zhao, Beibei Zhao, Lu Xu, Xiaofang Chen, Aichao Ruan
Summary: This study highlights the importance of increasing the number and level of nursing staff and improving facility characteristics in nursing homes to reduce readmission rates and length of stay for elderly residents.
Article
Geriatrics & Gerontology
Connie S. S. Cole, Janet S. S. Carpenter, Justin Blackburn, Chen X. X. Chen, Bobby L. L. Jones, Susan E. E. Hickman
Summary: By conducting a retrospective longitudinal analysis of nursing home resident pain scores, researchers identified and characterized four pain trajectories, including persistent pain presence, decreasing-increasing pain presence, increasing-decreasing pain presence, and consistent pain absence. Demographic characteristics such as younger age, female gender, living in a rural area, as well as clinical factors like obesity and intact cognition, were associated with specific pain trajectories. Residents diagnosed with Alzheimer's disease or dementia were less likely to be in trajectories with pain, highlighting the challenges of evaluating pain in this population. Staff in nursing homes should understand and respond to these factors to improve pain management and assessment for residents.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Psychology, Multidisciplinary
Xiaoqi Wu, Jie Li, Chun Zhang, Xing Zhou, Xiaoqian Dong, Huan Cao, Yinglong Duan, Sha Wang, Min Liu, Qiuxiang Zhang, Jianfei Xie
Summary: This study aimed to evaluate the effects of modified problem-solving therapy (MPST) on depression, coping and self-efficacy in elderly nursing home residents. The results showed that MPST could reduce depressive symptoms and improve positive coping and self-efficacy levels in older adults.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Nicole Huberfeld
Summary: This Viewpoint discusses the potential risks faced by Medicaid beneficiaries if the Supreme Court allows states to deny benefits and prevents beneficiaries from holding states accountable in federal court.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Joshua D. Niznik, Meredith A. Gilliam, Cathleen Colon-Emeric, Carolyn T. Thorpe, Jennifer L. Lund, Sarah D. Berry, Laura C. Hanson
Summary: Osteoporotic fractures are a common and serious health problem for older adults in nursing homes. There are controversies regarding when to start and stop treatment for osteoporosis in nursing home residents, especially those with high fracture risk but limited life expectancy. Current guidelines and research provide some basis for clinical decisions, but there is still a lack of strong evidence for the treatment of nursing home residents with advanced dementia, multimorbidity, or severe mobility impairment. Future research should focus on risk stratification and prevention strategies for nursing home residents, as well as evaluating the risk-benefit profile of pharmacologic treatments for osteoporosis.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Food Science & Technology
Yibing Liu, Dequn Wu, Kang Wang, Heng Chen, Hao Xu, Wencheng Zong, Nan Zhang, Luan Zhao, Zheguang Lin, Ting Ji
Summary: Royal jelly has a therapeutic effect on mammary gland hyperplasia by improving breast tissue structure and regulating endocrine dyscrasia, with the most significant effects observed at a dosage of 100 and 800 mg kg(-1) d(-1). It also increases the expression of estrogen receptor and inhibits the secretion of estrogen and prolactin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Geriatrics & Gerontology
Sin Yee Chew
Summary: This study aimed to investigate the prevalence of loneliness among nursing home residents in Singapore and its associations with variables such as health statuses and social contacts. The results showed that approximately 60% of nursing home residents experienced loneliness, with significant associations found between frailty and loneliness, and history of falls and loneliness.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Psychology, Multidisciplinary
Ashild Slettebo, Ragnhild Skaar, Kari Brodtkorb
Summary: The study demonstrates that social innovation within working practices in nursing homes, including phenomena that contribute to a meaningful everyday life for the residents, mainly include opening the nursing home to the surroundings, expanding and strengthening the community of practice, facilitating customized activities, ensuring sufficient nutrition and facilitating enjoyable mealtimes, as well as preventing unrest and disturbing behavior.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Health Care Sciences & Services
Klara Komici, Germano Guerra, Franco Addona, Carlo Fantini
Summary: This narrative review aims to provide the latest evidence on delirium screening tools, epidemiology characteristics, outcomes, risk factors, and prevention strategies in nursing homes.
Article
Geriatrics & Gerontology
Hemalkumar B. Mehta, Yong-Fang Kuo, Mukaila A. Raji, Jordan Westra, Cynthia Boyd, G. Caleb Alexander, James S. Goodwin
Summary: The study found that from 2014 to 2018, chronic opioid use among nursing home residents decreased from 14.1% to 11.4%, with a decline in variation among states but an increase in variation among nursing homes.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Andrew R. R. Zullo, Melissa R. R. Riester, Kaleen N. N. Hayes, Medha N. N. Munshi, Sarah D. D. Berry
Summary: We compared the effects of three sulfonylureas (SUs) and initial SUs doses on adverse glycemic and cardiovascular events among nursing home residents. Our findings suggest that new use of glimepiride and standard SU doses may increase the risk of severe hypoglycemic events, while cardiovascular outcomes may not be affected by the choice of SU medication or dose.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jennifer L. Carnahan, Kristi M. Lieb, Lauren Albert, Kamal Wagle, Ellen Kaehr, Kathleen T. Unroe
Summary: This study described the disease course of nursing home residents infected with COVID-19, with common symptoms including fever, hypoxia, anorexia, and fatigue. Some residents experienced a rapidly progressive, fatal course.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Selvedina Osmancevic, Silvia Bauer
Summary: This study examined the associated factors of pain in nursing home residents in Austria. The results showed that diseases of the musculoskeletal system, diseases of the skin and subcutaneous tissue, diseases of the circulatory system, pressure injuries, and a risk of malnutrition were statistically associated with pain. Healthcare professionals in nursing homes need to be aware of these associated factors when treating pain in residents.
Letter
Medicine, General & Internal
Elizabeth M. White, Xiaofei Yang, Carolyn Blackman, Richard A. Feifer, Stefan Gravenstein, Vincent Mor
Summary: The study found that incident SARS-CoV-2 infections decreased significantly after mRNA vaccination in nursing homes, with most infections being asymptomatic.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Hideto Okamoto, Akio Ohkuma, Mitsuhiko Kawaguchi, Norihiro Shigematsu, Nobuaki Okumura
Summary: This study investigated the effects of protease-treated royal jelly (RJ) on stem cells in 90 healthy subjects. Results showed that there were no significant differences in peripheral hematopoietic stem cell count between the RJ and placebo groups, but diastolic blood pressure was significantly improved in the RJ group. The subgroup analysis also revealed that the changes in HSC populations were higher in the RJ group. These findings suggest that RJ administration may have an impact on stem cell functions.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Review
Food Science & Technology
Qi Cui, Yang Xia, Qijun Wu, Qing Chang, Kaijun Niu, Yuhong Zhao
Summary: Food frequency questionnaires (FFQs) are commonly used tools for assessing dietary intake. This study comprehensively evaluated the validity of FFQs and found that they are suitable for assessing overall dietary intake in nutritional epidemiological studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Geriatrics & Gerontology
Yeqing Gu, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Qiang Liu, Kaijun Niu
Summary: This study found that longitudinal trends in thyroid function were associated with the development of carotid atherosclerosis in middle-aged and older euthyroid subjects.
Article
Nutrition & Dietetics
Huiping Li, Xiaoxi Zheng, Rayamajhi Sabina, Thapa Amrish, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Jun Dong, Zhixia Cao, Xu Zhang, Xinrong Dong, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This prospective cohort study aimed to investigate the association between organ meat consumption and risk of non-alcoholic fatty liver disease (NAFLD) in a general Chinese adult population. The study found that organ meat consumption was related to a modestly higher risk of NAFLD among Chinese adults.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Sport Sciences
Yoshiko Tsutsumi, Haruki Momma, Satoru Ebihara, Ryoichi Nagatomi
Summary: This study aimed to investigate the effects of L-menthol on endurance exercise capacity. The results showed that L-menthol administration can prolong running time and improve breathing comfort. Additionally, L-menthol can prevent the decrease in dyspnea threshold after running.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
David Horvath, Janos Negyesi, Tamas Gyori, Botond Szucs, Peter Janos Toth, Zsolt Matics, Csaba Okros, Sandor Safar, Nikolett Szabo, Beata Takacs, Robert Kathy, Klara Toth, David P. Ferguson, Ryoichi Nagatomi, Levente Racz
Summary: The study examines the effects of a 6-week reactive agility training program using light-based stimuli on the physiological and cognitive abilities of car racing drivers. The results show that the training program improves participants' cognitive performance, reaction time, peak heart rate, ventilation, and relative maximal oxygen consumption. It also suggests that the program has the potential to contribute to the physical and mental performance of car racing drivers.
SPORTS MEDICINE-OPEN
(2022)
Article
Biochemistry & Molecular Biology
Shion Osana, Yasuo Kitajima, Suzuki Naoki, Hiroaki Takada, Kazutaka Murayama, Yutaka Kano, Ryoichi Nagatomi
Summary: The proteasome and aminopeptidases are thought to be involved in protein synthesis through intracellular energy production by recycled-amino acid metabolism, thereby maintaining myoblast integrity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Shunming Zhang, Yan Yan, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yan Borne, Lu Qi, Yu-Ming Chen, Kaijun Niu
Summary: This study suggests that replacing animal protein foods with plant protein foods significantly reduces the risk of NAFLD, with whole grains showing the strongest benefit.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Peerada Ngamsnae, Tatsuma Okazaki, Yuzhou Ren, Yunxiang Xia, Hikaru Hashimoto, Ryoukichi Ikeda, Yohei Honkura, Yukio Katori, Shin-Ichi Izumi
Summary: Lymphatic vessels in the parietal pleura drain fluids, but impaired drainage function can lead to fluid accumulation. Inflammation can alter the structure of lymphatics and blood vessels, affecting drainage function. Inhibiting vascular endothelial growth factor receptor (VEGFR) under inflammation can maintain vascular structures and lymphatic endothelial junctions.
MICROVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Honghao Yang, Yeqing Gu, Bei Zhang, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yaogang Wang, Tao Huang, Kaijun Niu
Summary: The habitual consumption of onions is associated with a lower risk of depressive symptoms, according to the findings of two cohort studies.
Article
Nutrition & Dietetics
Hongmei Wu, Jing Quan, Xuena Wang, Yeqing Gu, Shunming Zhang, Ge Meng, Qing Zhang, Li Liu, Xing Wang, Shaomei Sun, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
Summary: Habitual soy food consumption is associated with muscle strength decline among Chinese adults, suggesting that soy foods may have beneficial effects on muscle health.
Article
Nutrition & Dietetics
Yawen Wang, Yeqing Gu, Jian Huang, Hongmei Wu, Ge Meng, Qing Zhang, Li Liu, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Junsheng Huo, Bing Zhang, Gangqiang Ding, Peng Du, Kaijun Niu
Summary: This study found that a higher level of serum vitamin D is independently related to the increment of irisin in sarcopenia females, but not in males.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Juanjuan Zhang, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population, especially in obese individuals.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Junchul Shin, Aki Nunomiya, Kohsuke Gonda, Ryoichi Nagatomi
Summary: The skeletal muscle fiber type can be changed during muscle regeneration after cardiotoxin injection, but the mechanism of fiber type transition is still unclear. Previous studies have shown that CTX-induced muscle damage leads to temporary hypoxia, suggesting the involvement of HIF-1a in the transition. This study demonstrates that CTX-induced muscle injury causes transient ischemia and stabilizes HIF-1a, leading to an increase in oxidative muscle fibers through the calcineurin/NFATc1 signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi
Summary: Impaired %FVC is associated with higher all-cause mortality in aged adults, and strong leg force may improve this relationship. Among the three major leading causes of death, impaired %FVC is specifically related to higher pneumonia mortality. Weak leg force might indicate sarcopenia, and its prevention may reduce the risk of higher pneumonia mortality associated with impaired %FVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Shion Osana, Yasuo Kitajima, Suzuki Naoki, Kazutaka Murayama, Hiroaki Takada, Ayaka Tabuchi, Yutaka Kano, Ryoichi Nagatomi
Summary: Skeletal muscle maintenance relies on muscle stem cells that provide myoblasts for muscle regeneration and growth. Proteasome dysfunction in skeletal muscle impairs muscle growth and development. Aminopeptidase inhibition affects the proliferation and differentiation ability of C2C12 myoblasts. Knockdown of different aminopeptidases in C2C12 myoblasts results in defective myogenic differentiation, except for leucine aminopeptidase 3 (LAP3) which promotes myogenic differentiation. Knockdown of LAP3 inhibits proteasomal proteolysis, decreases branched-chain amino acid levels, and enhances mTORC2-mediated AKT phosphorylation to promote myogenic differentiation through increased expression of myogenin.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)