Article
Pharmacology & Pharmacy
Luan K. M. Souza, Kerolayne M. Nogueira, Thiago S. L. Araujo, Nayara A. Sousa, Francisca B. M. Sousa, Ana P. Oliveira, Thiago Sales, Karine Silva, Talita M. Rocha, Luzia K. A. M. Leal, Pedro J. C. Magalhaes, Marcellus H. L. P. Souza, Jand V. R. Medeiros
Summary: Activation of the ACE II pathway can reduce diarrhea by increasing Na+/K+-ATPase activity, decreasing gastrointestinal transit, and inhibiting contractions of intestinal smooth muscle, among other mechanisms. Therefore, activation of the ACE II/Ang-(1-7)/MasR axis may serve as an important pharmacological target for the treatment of diarrheal diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: The study found that the water extract of Piper longum Linn (WEPL) can inhibit osteoclast differentiation and alleviate bone loss in ovariectomized mice. Additionally, phytochemicals in WEPL were identified to have inhibitory effects on osteoclastogenesis and bone loss.
Article
Medicine, Research & Experimental
Seon-A Jang, Youn-Hwan Hwang, Hyun Yang, Jin Ah Ryuk, Dong Ryun Gu, Hyunil Ha
Summary: The study found that the extract of Pyrrosia lingua has anti-osteoporotic effects by suppressing the differentiation of osteoclasts and preventing trabecular bone loss in mice. The researchers also identified phytochemicals in the extract that have known anti-osteoclastogenic or anti-osteoporotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Priya Tiwari, Virendra Tiwari, Shivangi Gupta, Shubha Shukla, Kashif Hanif
Summary: This study reveals the important role of ACE2/Ang (1-7)/MasR axis in neuroinflammation. It decreases glial activation, neuroinflammation, and cell apoptosis, while improving mitochondrial health, thus providing neuroprotection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ki-Shuk Shim, Youn-Hwan Hwang, Seon-A Jang, Taesoo Kim, Hyunil Ha
Summary: The study found that ethanol extract of Amomum tsao-ko (EEAT) significantly reduced body weight gain and fat accumulation, prevented bone density deterioration, and inhibited osteoclast differentiation. EEAT may be an effective nutraceutical candidate for menopausal osteoporosis and obesity prevention by suppressing fat accumulation and osteoclastogenesis.
Article
Endocrinology & Metabolism
Tero Puolakkainen, Petri Rummukainen, Vappu Pihala-Nieminen, Olli Ritvos, Eriika Savontaus, Riku Kiviranta
Summary: ActRIIB-Fc treatment improves bone and muscle mass, inhibits fat accumulation, and restores metabolic alterations in postmenopausal osteoporosis.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Feng Zhang, Aidong Chen, Yan Pan, Xingxing Wang, Yu Xu, Ankit A. Desai, Haiyang Tang, Ying Han
Summary: PAH is a progressive disease with high mortality and complex etiology, leading to right heart failure. The renin-angiotensin system plays a critical role in maintaining cardiovascular homeostasis, with the ACE2-Ang-(1-7)-Mas axis potentially representing a novel target for PAH treatment.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Hesham Farouk Hasan, Heba Karam Mohmed, Shereen Mohamed Galal
Summary: This research explores the potential of BPF in mitigating radiation-induced lung damage by inhibiting ACE and regulating the RAS system, leading to a decrease in Ang II levels and an increase in Ang (1-7) production. These mechanisms alleviate oxidative stress and reduce apoptosis in irradiated lungs.
Article
Biotechnology & Applied Microbiology
Zhiqi Zhao, Haibiao Sun, Yongliang Fu, Xingyu Liang, Tao Fan, Xiaoqiong Li, Liying Zhu, Liubei Xu, Xin Wang, Jinjun Li, Xiaoqiang Han
Summary: This study explored the effects of fucoidan on the gut-bone axis in ovariectomized mice with osteoporosis and demonstrated its efficacy in treating osteoporosis. Fucoidan improves bone health by regulating gut microbiota, protecting the intestinal barrier, and altering lipid metabolism.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Medicine, Research & Experimental
Ra-Yeong Choi, In-Woo Kim, Moongi Ji, Man-Jeong Paik, Eu-Jin Ban, Joon Ha Lee, Jae Sam Hwang, HaeYong Kweon, Minchul Seo
Summary: The ethanol extract of P. brevitarsis larvae (PBE) can inhibit RANKL-induced osteoclast formation and prevent bone loss. PBE decreases tartrate-resistant acid phosphatase activity and the expression of osteoclastogenesis-associated genes and proteins. It also inhibits the phosphorylation of p38 and NF-κB.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physiology
Gustavo B. Lamy, Eduardo M. Cafarchio, Barbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Artur F. Silva Neto, Lila M. Oyama, Patrik Aronsson, Monica A. Sato
Summary: This study found that Angiotensin-(1-7) has the ability to increase intravesical pressure in the urinary bladder, and the expression of related receptors and enzymes were detected in the bladder.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Virendra Tiwari, Jitendra Singh, Priya Tiwari, Swati Chaturvedi, Shivangi Gupta, Akanksha Mishra, Sonu Singh, Muhammad Wahajuddin, Kashif Hanif, Shubha Shukla
Summary: In this study, the role of the ACE2/Ang-(1-7)/Mas receptor axis in Alzheimer's disease (AD) was investigated using various methods. The results showed that activation of this axis could improve cognitive impairment and amyloid deposition in an AD-like rat model. These findings suggest the potential involvement of the ACE2/Ang-(1-7)/Mas axis in the pathophysiology of AD by regulating inflammation and cognitive functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Priyavathi Sureshkumar, Robson Augusto Souza dos Santos, Natalia Alenina, Stefan Mergler, Michael Bader
Summary: The G protein-coupled receptor MAS is the receptor for the endogenous ligand Angiotensin (Ang)-(1-7). This paper demonstrates the importance of MAS signaling in developing novel therapeutics for cardiovascular diseases. Ang-(1-7) induces calcium influx in MAS-transfected HEK293 cells, which is dependent on plasma membrane Ca2+ channels, phospholipase C, and protein kinase C. The study also reveals that MAS utilizes non-selective transient receptor potential channels (TRPs) for calcium entry.
Article
Immunology
Yasser H. Habib, Eman Sheta, Mahmoud Khattab, Mennatallah A. Gowayed
Summary: This study evaluated the therapeutic potential of combining the angiotensin-converting enzyme 2 activator diminazen aceturate (DIZE) with hyaluronic acid (HYAL) for osteoarthritis (OA) treatment. The results showed that the combination of HYAL and DIZE had a significant effect in relieving knee joint deformities, improving inflammation, and reducing oxidative stress in rats. It suggests that HYAL and DIZE may be a possible therapeutic option for OA.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
J-X Xie, J. Hu, J. Cheng, C. Liu, X. Wei
Summary: This article reviews the role of the ACE2/Ang(1-7)/MasR axis in myocardial ischemia reperfusion injury and highlights its therapeutic potential.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marwa Abdelgwad, Manal Ewaiss, Dina Sabry, Warda A. Khalifa, Zeinab M. Altaib, Maha Alhelf
Summary: This study examined the effects of BM-MSCs and UC-EPCs on the reversal of CCl4-induced hepatic injury. The results showed that the groups treated with BM-MSCs and UC-EPCs had increased albumin concentration and decreased ALT concentration compared to the untreated groups. The UC-EPCs treated group had significantly higher expression of MMP-2 and VEGF genes compared to the BM-MSCs treated group. Additionally, UC-EPCs were more effective than BM-MSCs in increasing HGF gene expression and immunohistochemistry of alpha-SMA and Ki-67. BM-MSCs had significantly lower TGF-beta expression compared to UC-EPCs.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Marwa Madi, Hatem M. Abuohashish, Dina Attia, Norah AlQahtani, Nabras Alrayes, Verica Pavlic, Subraya G. Bhat
Summary: The study found that the risk of alveolar bone loss in periodontitis patients increases with diabetes in the presence of other comorbidities, regardless of smoking habits or gender.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Nehal S. Wahba, Rasha H. Abdel-Ghany, Salah A. Ghareib, Mohamed Abdel-Aal, Amira E. Alsemeh, Dina Sabry
Summary: The study investigates the nephroprotective effects of vildagliptin-metformin combination in an experimental model of fructose/salt-induced metabolic syndrome. It confirms the antioxidant, anti-inflammatory, and antifibrotic effects of the treatment, highlighting the potential of dipeptidyl peptidase-4 inhibition and sirtuin-1/5' adenosine monophosphate-activated protein kinase activation as therapeutic targets for renoprotection.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Omar Omar, Hatem M. Abuohashish, Taleb Alkhamis, Faisal Al-Qarni
Summary: The study evaluated the effect of habitual caffeine intake on stability, bone regeneration, and bone markers at the bone-implant interface. The results showed a positive promoting effect on long-term osseointegration with increased stability and bone formation, remodeling, and vascularization genes expression.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Hatem M. Abuohashish, Abdullah F. AlAsmari, Mohamed Mohany, Mohammed M. Ahmed, Salim S. Al-Rejaie
Summary: This study finds that morin can protect against altered bone histomorphometry in diabetic rats by modulating the insulin/IGF-1 pathway, restoring bone density and histomorphology, and alleviating systemic oxidative stress.
Article
Dentistry, Oral Surgery & Medicine
Abir Tarek Mansour El-Mouelhy, Sherine Adel Nasry, Omnia Abou El-Dahab, Dina Sabry, Karim Fawzy El-Sayed
Summary: Cannabis and cigarettes smoke were found to induce DNA damage and cellular dedifferentiation in GF/G-MSCs of never smokers, negatively affecting cellular proliferation and viability; meanwhile, EC aerosol showed significantly lower impact on these properties.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Clinical Neurology
Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish
Summary: This study investigates the influence of habitual caffeine intake on lidocaine action and reveals that chronic caffeine consumption can potentiate the local anesthetic effect of lidocaine. The study results also suggest that this enhancement may be related to the upregulation of voltage-gated sodium channels in the dorsal root ganglia by caffeine.
PAIN RESEARCH & MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
Nesrine Ebrahim, Hajir A. Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman Abd El Aziz M. El Gebaly, Nashwa Hassan Abo-Rayah, Dina Sabry, Mohamed El-Sherbiny, Abdelmonem G. Madboly, Noha Ibrahim Hussien, Raja El Hasnaoui Saadani, Hasnaa Ali Ebrahim, Omnia A. M. Badr, Nehal M. Elsherbiny, Rabab F. Salim
Summary: This study aimed to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz-mediated cardiotoxicity model and elucidate the underlying mechanisms. The results showed that MSCs-derived exosomes could protect from and attenuate DOX/Trz-induced cardiotoxicity by modulating the NRG-1/HER2, MAPK, PI3K/AKT, PJNK/JNK, and PSTAT/STAT signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tasneem Soliman, Zoba Ali, Mohamed Zayed, Dina Sabry, Nermeen AbuBakr
Summary: This study demonstrated the potential effectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in treating osteoporosis.
DENTAL AND MEDICAL PROBLEMS
(2022)
Review
Biochemistry & Molecular Biology
Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Woelfle, Yasir Siddiqui, Dalia Kaisarly
Summary: This review article discusses the roles of Matrix metalloproteinases (MMPs) in dental and periodontal tissues, as well as their potential as biomarkers for diagnosis and treatment. The article provides insights into the involvement of MMPs in development, remodeling, degradation, and turnover of dental and periodontal tissues, and their signals in the pathogenesis and wound healing. The review identified 119 published papers, two textbooks, and two doctoral theses as the basis for the discussion. MMPs are seen as significant proteases with potential diagnostic and prognostic value. Understanding their role in dental and periodontal lesions and dentine-pulp wound healing is crucial for future diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Fatma Y. Meligy, Hanan Sharaf El-Deen Mohammed, Tarek M. Mostafa, Mohamed M. Elfiky, Israa El-Sayed Mohamed Ashry, Ahmed M. Abd-Eldayem, Nermin Rizk, Dina Sabry, Eman S. H. Abd Allah, Salwa Fares Ahmed
Summary: This study compared the cardioprotective effects of mesenchymal stem cells (MSCs) and PUFAs in a rat model of gentamicin-induced cardiac degeneration. The results showed that both MSCs and PUFAs improved cardiac pathology, with MSCs showing higher efficacy compared to PUFAs. The protective effects were mediated through mechanisms involving cell proliferation and apoptosis.
Article
Chemistry, Medicinal
Heba F. F. Salem, Marwa Mohamed Abd El-Maboud, Amira S. A. Said, Mohamed Nabil Salem, Dina Sabry, Nadia Hussain, Omnia A. M. Abd El-Ghafar, Raghda R. S. Hussein
Summary: Nanomedicine is an important approach for targeting RA medication. The combination of methotrexate with gold nanoparticles can overcome the restrictions of methotrexate and improve its anti-arthritic effects.
Article
Chemistry, Multidisciplinary
Doaa M. AlEraky, Ahmed M. Rahoma, Hatem M. Abuohashish, Abdullh AlQasser, Abbas AlHamali, Hussain M. AlHussain, Hussain M. AlShoalah, Zakrya AlSaghah, Abdulrahman Khattar, Shimaa Rifaat
Summary: The long-term success of root canal treatment relies on preventing bacterial leakage. This study compared the leakage of Enterococcus faecalis in single-rooted mandibular premolars using different obturation techniques and sealers. The results showed comparable sealing efficiency against Enterococcus faecalis between bio-ceramic sealers with single-cone obturation and a resin-based sealer with lateral condensation technique. MTA Fillapex demonstrated better sealing ability than CeraSeal bio-ceramic sealer.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hatem Abuohashish, Suliman Shahin, Abdulaziz Alamri, Zainah Salloot, Hussain Alhawaj, Omar Omar
Summary: The activation of the Ang(1-7)/Mas receptor axis inhibits tooth movement and regulates alveolar bone remodeling in response to mechanical force, with potential effects on osteoclastogenesis and osteoblast activity.
PROGRESS IN ORTHODONTICS
(2023)
Article
Biotechnology & Applied Microbiology
Hatem M. Abuohashish, Amany S. El Sharkawy
Summary: This study successfully isolated a characteristic blue pyocyanin compound from a marine pseudomonas strain and characterized its antimicrobial activity. The marine-isolated P. otitidis represents a promising new source of marine-derived pyocyanin, which has antimicrobial efficacy mainly against Gram-positive pathogens.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2023)
