Article
Agriculture, Dairy & Animal Science
Katarzyna Piorkowska, Julia Sroka, Kacper Zukowski, Karolina Zygmunt, Katarzyna Ropka-Molik, Miroslaw Tyra
Summary: This study evaluated the effects of BSCL2 variants on slaughter and fattening characteristics and meat quality traits. The selection of mutations was based on variant calling analysis and chi test results using subcutaneous fat RNA-seq data. Significant genotype/allele distribution variations between high- and low-fat pigs were observed. The study suggests that variant calling from RNA-seq data may help develop genetic markers for complex pig traits, and the BSCL2 G allele (rs341493267) was found to increase backfat thickness in pigs.
Article
Endocrinology & Metabolism
Radwan Kassir, Pierre Gimet, David Hupin, Claire Boutet, Jean-Claude Barthelemy, Frederic Roche, Sebastien Celle
Summary: This study aims to explore the relationship between the brain and obesity, using two different measures of obesity (BMI and BFI). The results show that in the elderly population, the relationship between the brain and obesity may differ from that in younger subjects. Higher BMI and BFI are associated with increased grey matter volume in the left cerebellum and increased white matter volume in the cerebellum and near the right medial orbital gyrus. This suggests that the cerebellum may be one of the key structures related to obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Yuka Kawate, Takuro Okamura, Hiroshi Okada, Noriyuki Kitagawa, Naoko Nakanishi, Saori Majima, Takafumi Osaka, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Michiaki Fukui
Summary: This study investigated the relationship between dietary fiber intake and skeletal muscle mass, body fat mass, and muscle-to-fat ratio in individuals with type 2 diabetes. The results showed that dietary fiber intake was positively correlated with these measures in women, but not in men.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Genetics & Heredity
Geyu Zhou, Tianqi Chen, Hongyu Zhao
Summary: Polygenic risk score (PRS) has been proven highly useful in biomedical research for identifying high-risk individuals based on their genotypes. However, the limited transferability of PRS developed in Europeans to non-European populations has hindered its broader application. To address this, a statistical method called SDPRX is developed, which effectively integrates genome-wide association study data from different populations. SDPRX adjusts for linkage disequilibrium differences and characterizes the joint distribution of variant effect sizes in different populations. Simulation and real trait applications demonstrate that SDPRX improves prediction accuracy in non-European populations compared to existing methods.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Liwan Fu, Hong Cheng, Xiaoyuan Zhao, Dongqing Hou, Xianghui Xie, Jie Mi
Summary: The study explored the causal relationships of general obesity, adipose obesity, and central obesity with cardiometabolic traits among children, finding that general obesity and adipose obesity may have stronger effects on blood pressure and blood lipids compared to central obesity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
V Deru, A. Bouquet, O. Zemb, B. Blanchet, M. L. De Almeida, L. Cauquil, C. Carillier-Jacquin, H. Gilbert
Summary: The composition of gut microbiota in pigs is influenced by diet and plays an important role in digestion. This study investigated the genetic correlations between microbiota traits and feed efficiency and digestive efficiency traits in pigs fed conventional or high-fiber diets. The results showed limited genetic by diet interactions on gut microbiota composition, suggesting that microbiota-based traits could be used as proxies to improve feed and digestive efficiency in pigs.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Y. Xue, C. Li, D. Duan, M. Wang, X. Han, K. Wang, R. Qiao, X. -J. Li, X. -L. Li
Summary: Through genome-wide association studies, this research identified 14 SNPs associated with growth traits (backfat thickness and loin muscle depth) in Chuying-black pigs and selected candidate genes, providing insights into the genetic architecture of BF and LMD traits.
Article
Medicine, General & Internal
Navin Suthahar, Kan Wang, Victor W. Zwartkruis, Stephan J. L. Bakker, Silvio E. Inzucchi, Tim R. Eijgenraam, Fariba Ahmadizar, Eric G. Sijbrands, Ron T. Gansevoort, Lyanne M. Kieneker, Dirk J. van Veldhuisen, Maryam Kavousi, Rudolf A. de Boer
Summary: Relative fat mass (RFM), a novel anthropometric equation based on height and waist measurements, is strongly associated with incident type-2 diabetes (T2D) and shows potential as a predictor of future diabetes risk in the general population, outperforming BMI, waist circumference, and waist-to-hip ratio.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Xinglong Gong, Min Zheng, Jian Zhang, Yourong Ye, Mengqi Duan, Yangzom Chamba, Zhongbin Wang, Peng Shang
Summary: Fat deposition traits play a crucial role in pig production and breeding. This study analyzed the differential expression of mRNA levels in dorsal adipose tissue of Tibetan and York pigs at different growth stages and identified key genes involved in regulating fat deposition in pigs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Nutrition & Dietetics
Anja M. Sedlmeier, Sebastian E. Baumeister, Andrea Weber, Beate Fischer, Barbara Thorand, Till Ittermann, Marcus Doerr, Stephan B. Felix, Henry Voelzke, Annette Peters, Michael F. Leitzmann
Summary: The study indicates that fat mass and fat-free mass show opposing associations with mortality risk. Excess fat mass is related to increased mortality risk, while fat-free mass is protective against mortality risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Oscar Coltell, Carolina Ortega-Azorin, Jose Sorli, Olga Portoles, Eva M. Asensio, Carmen Saiz, Rocio Barragan, Ramon Estruch, Dolores Corella
Summary: In a high-cardiovascular risk Mediterranean population, plasma adiponectin levels are strongly associated with metabolic traits and lower type 2 diabetes. However, the gene variants most associated with adiponectin may be population-specific, and some suggestive gene-Mediterranean diet interactions were detected.
Article
Endocrinology & Metabolism
Satoshi Yoshiji, Daisuke Tanaka, Hiroto Minamino, Tianyuan Lu, Guillaume Butler-Laporte, Takaaki Murakami, Yoshihito Fujita, J. Brent Richards, Nobuya Inagaki
Summary: This study used Mendelian randomization to compare the independent causal relationships of body fat mass and fat-free mass with COVID-19 severity. The results showed that an increase in body fat mass was associated with severe COVID-19, while fat-free mass did not have an independent association with COVID-19. This suggests that body fat mass plays a mediating role in the biological pathways between COVID-19 and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Critical Care Medicine
Asja Kunoe, Astrid Sevelsted, Bo L. Chawes, Jakob Stokholm, Anders Eliasen, Martin Krakauer, Klaus Bonnelykke, Hans Bisgaard
Summary: The study found that children who received ICS treatment during the ages of 0-6 had an increased BMI z-score, an earlier adiposity rebound age, and a trend of increased android body fat percentage at age 6.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Nutrition & Dietetics
Maobin Kuang, Song Lu, Ruijuan Yang, Huaigang Chen, Shuhua Zhang, Guotai Sheng, Yang Zou
Summary: This study examined the association between body composition (fat mass and lean body mass) and diabetes risk. The results showed that in women, an increase in lean body mass reduced the risk of diabetes, while an increase in fat mass increased the risk. In men, the relationship between body composition and diabetes risk was non-linear. It is recommended that Asian men maintain a lean body mass above 45.4 kg and a fat mass around 13.76 kg to reduce the risk of diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Genetics & Heredity
Marua Abu Risha, Puntita Siengdee, Dirk Dannenberger, Klaus Wimmers, Siriluck Ponsuksili
Summary: The study found that PUFAs have an impact on the transition of C2C12 cells from proliferation to differentiation phase, prolonging proliferation and preventing differentiation.
Article
Genetics & Heredity
Frieder Hadlich, Henry Reyer, Michael Oster, Nares Trakooljul, Eduard Murani, Siriluck Ponsuksili, Klaus Wimmers
Summary: Commercial and customized microarrays are valuable tools for analyzing holistic expression patterns, but require integration of the latest genomic information. This study presents a comprehensive workflow using the rePROBE R package to assign probes and annotate probe sets based on up-to-date genomic and transcriptomic data. The workflow reveals updated probe assignments and annotations for various livestock species and human, with a focus on providing a detailed basis for comprehensive analyses such as eQTL studies.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Spectroscopy
Kay Sowoidnich, Michael Oster, Klaus Wimmers, Martin Maiwald, Bernd Sumpf
Summary: The study demonstrates the potential of shifted excitation Raman difference spectroscopy (SERDS) for inspecting intact feed pellets and their constituents, with the ability to efficiently analyze various components and promising prospects for future development.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Cell Biology
Christina Walz, Julia Brenmoehl, Nares Trakooljul, Antonia Noce, Caroline Caffier, Daniela Ohde, Martina Langhammer, Klaus Wimmers, Siriluck Ponsuksili, Andreas Hoeflich
Summary: The study investigated the effects of training and genetic predisposition on mRNA expression in the pituitary gland of a marathon mouse model, revealing a strong impact of genetic selection for enhanced running performance on gene expression in the pituitary gland. Training induced differential expression of genes in both mouse lines, but DUhTP mice showed resistance to the positive effects of training on protein and energy metabolism in the pituitary gland.
Article
Agronomy
Dario Fornara, Elizabeth M. E. Ball, Christina Mulvenna, Henry Reyer, Michael Oster, Klaus Wimmers, Hanne Damgaard Poulsen, Arno Rosemarin
Summary: The over-supplementation of animal feeds with phosphorus leads to high rates of P excretion and negative environmental impacts. Adding phytase to pig and poultry diets can reduce P excretion, but the effects on plant-soil systems are poorly understood. This study found that phytase supplementation significantly influenced P content of animal waste and plant P dynamics, with intermediate phytase levels contributing to higher P use efficiency and lower soil P availability. The effects of dietary P content on P losses from soils varied depending on the type of organic amendment.
Article
Agriculture, Dairy & Animal Science
Christina C. Mulvenna, Ursula M. McCormack, Elizabeth Magowan, John McKillen, Mike R. Bedford, Carrie L. Walk, Michael Oster, Henry Reyer, Klaus Wimmers, Dario A. Fornara, M. Elizabeth E. Ball
Summary: Phytase has been a common addition to poultry diets for over 20 years, showing benefits in growth performance, nutrient digestibility, and bone parameters. This study found that superdosing phytase in rapeseed meal and maize dried distiller grains with solubles diets can improve performance, increase digestibility, and reduce P excretion by 15% compared to birds without phytase.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Michael Oster, Henry Reyer, Siriluck Ponsuksili, Eduard Murani, Petra Wolf, Dagmar-Christiane Fischer, Klaus Wimmers
Summary: This study investigated the tissue-wide expression patterns of key genes related to vitamin D metabolism and FGF23 signaling in pigs fed different phosphorus diets. The results showed that non-renal tissues and cells have specific requirements for active vitamin D formation. Low phosphorus diet suppressed vitamin D signaling locally, while high phosphorus diet stimulated local vitamin D synthesis and regulation of FGF23 signaling in bone.
Article
Agriculture, Dairy & Animal Science
Adewunmi O. Omotoso, Henry Reyer, Michael Oster, Steffen Maak, Siriluck Ponsuksili, Klaus Wimmers
Summary: Phosphorus inclusion in broiler diets needs to be tailored to their physiological demands at different developmental stages. A timed nutritional conditioning strategy, such as P depletion, may enhance mineral homeostasis mechanisms and reduce dietary P supply. This study investigated the effects of dietary P depletion on broiler chickens at different developmental stages, revealing marked responses early on, but indications of compensatory mechanisms later. Endocrine control mediated by calcitriol, intestinal P uptake, and mineral mobilization from bones were identified as potential mechanisms for maintaining mineral homeostasis. Precise timing, duration, and extent of P depletion should be considered for optimized nutrient utilization in broiler husbandry.
Article
Chemistry, Analytical
Mohd. Rahil Hasan, Pradakshina Sharma, Shifa Shaikh, Saumitra Singh, Roberto Pilloton, Jagriti Narang
Summary: We have developed a paper-based experimental platform for analyzing dengue virus, which incorporates screen-printing technology and black carbon conductive ink. The platform utilizes both two-electrode and three-electrode systems, with an LOD of 0.1 μg/mL for detecting the virus. The three-electrode system exhibits a significantly higher current range and amplification compared to the two-electrode system, making it a viable option for sensitive detection of dengue virus and other diseases.
Article
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
Summary: Vitamin D-3 (Vit D-3) and 25(OH)D-3 are used as dietary sources of active vitamin D in pig husbandry, and while their primary effects are on the intestine, kidney, and bone, they also have wide-ranging effects on peripheral tissues. The use of Vit D-3 and 25(OH)D-3 in pig nutrition has been shown to have different outcomes in terms of reproductive capacities, growth performance, immunity, and bone development.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Hanne Honerlagen, Henry Reyer, Ibrahim Abou-Soliman, Dierck Segelke, Siriluck Ponsuksili, Nares Trakooljul, Norbert Reinsch, Bjoern Kuhla, Klaus Wimmers
Summary: Improving the nitrogen-utilization efficiency (NUE) of dairy cows through breeding selection has benefits in terms of nutrition, environment, and economics. The individual milk urea concentration (MU) of cows has been proposed as an indicator trait for NUE. This study aimed to identify different microbial genera in the rumen of Holstein cows with divergent genomic breeding values for MU (GBVMU). The identified microbial genera were further investigated for their correlations with MU and other NUE-associated traits, providing insight into genetically determined N-utilization in Holstein cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Julia Brenmoehl, Elli Brosig, Nares Trakooljul, Christina Walz, Daniela Ohde, Antonia Noce, Michael Walz, Martina Langhammer, Stefan Petkov, Monika Roentgen, Steffen Maak, Christina E. E. Galuska, Beate Fuchs, Bjoern Kuhla, Siriluck Ponsuksili, Klaus Wimmers, Andreas Hoeflich
Summary: This study investigated the contribution of non-mitochondrial and mitochondrial metabolic pathways in contracting muscles during repeated training. The results showed that marathon mice displayed increased glucose and fatty acid oxidation, reduced lactate dehydrogenase activity, and inhibited lactate formation compared to trained control mice. This suggests that marathon mice have enhanced metabolic flexibility towards lipid catabolism regulated by lactate dehydrogenase.
Review
Agriculture, Dairy & Animal Science
Benjamin Diehl, Michael Oster, Andreas Vernunft, Klaus Wimmers, Hartwig Bostedt
Summary: The losses of piglets in commercial pig farming remain a concern and sustainable breeding and management strategies are needed. This review systematically presents the three phases of neonatal adaptation in piglets and highlights the key developments and influencing factors in each phase.
ARCHIVES ANIMAL BREEDING
(2022)
Review
Biochemistry & Molecular Biology
Fabio Sarais, Alvaro Perdomo-Sabogal, Klaus Wimmers, Siriluck Ponsuksili
Summary: This review focuses on the latest discoveries of tsRNAs, with special attention to molecules initially thought to be associated with tiRNAs. The paper outlines their biological functions, provides a collection of useful databases, and discusses future research perspectives and applications in livestock basic and applied research.
