Article
Chemistry, Multidisciplinary
Takaaki Miyamoto, Kousuke Tsuchiya, Keiji Numata
Summary: A strategy utilizing endosome-escaping micelles with dual peptide modification has been developed for efficient intracellular DNA delivery to plants, overcoming vacuolar degradation and enhancing transfection efficiency with minimal cytotoxicity, which could facilitate diverse biotechnological applications in plant bioengineering.
Article
Nanoscience & Nanotechnology
Huiying Xu, Chong Liao, Shifu Liang, Bang-Ce Ye
Summary: Exosomes are natural delivery vehicles with features like low immunogenicity, excellent biocompatibility, and migration capability. This study developed a novel peptide-equipped exosomes platform that can improve cellular uptake efficiency and deliver nucleic acids effectively, showing potential for personalized cancer medicine.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Nadjib Kihal, Ali Nazemi, Steve Bourgault
Summary: Research has shown that supramolecular bio-assemblies based on PDI have unique structures and functionalities. By conjugating PDI derivatives with biological molecules, nanoassemblies with tailored functional properties can be constructed.
Article
Physics, Applied
Jiajia Sun, Zongqian Shi, Mingjia Li, Shuang Chen, Mingjie Zhong, Xiaofeng Liu, Jingjie Sha, Shenli Jia
Summary: The use of microfluidic and magnetic field-assisted self-assembly allows for the patterning of colloidal magnetic-plasmonic nanoparticles in a controlled environment, opening up new possibilities for assembling complex structures.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Biotechnology & Applied Microbiology
Karidia Konate, Emilie Josse, Milana Tasic, Karima Redjatti, Gudrun Aldrian, Sebastien Deshayes, Prisca Boisguerin, Eric Vives
Summary: Novel amphipathic cell-penetrating peptides WRAP efficiently deliver siRNA molecules into cells. Through a structural-activity relationship study comparing different peptides and synthesizing new analogues, it was determined that the amino acid composition of WRAP peptides plays a crucial role in nanoparticle formation, cellular internalization, and gene silencing efficiency, with lower cell toxicity compared to other transfection agents.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Abhijit Biswas, Maria Maloverjan, Kart Padari, Aare Abroi, Margus Ratsep, Sebastian K. T. S. Warmlander, Juri Jarvet, Astrid Graslund, Vambola Kisand, Runno Lohmus, Margus Pooga
Summary: Cell-penetrating peptides (CPPs) are promising transfection agents for delivering compounds into living cells. The properties of the resulting CPP particles in an aqueous solution depend on the solvent used for dissolving the CPP. Using different methods, such as dynamic light scattering and microscopy, it was found that CPPs dissolved in organic solvents form uniform particles, while those dissolved in water tend to form aggregates and micelles.
Article
Biochemistry & Molecular Biology
Safa Bazaz, Tonis Lehto, Rahel Tops, Olof Gissberg, Dhanu Gupta, Burcu Bestas, Jeremy Bost, Oscar P. B. Wiklander, Helena Sork, Eman M. Zaghloul, Doste R. Mamand, Mattias Hallbrink, Rannar Sillard, Osama Saher, Kariem Ezzat, C. I. Edvard Smith, Samir El Andaloussi, Taavi Lehto
Summary: Splice-switching therapy with SSOs has shown promise for treating mis-splice disorders, but limited by poor bioavailability. Cell-penetrating peptides have gained attention for improving delivery of oligonucleotide compounds. By introducing hydrophobic modifications using hydrocarbon-modified amino acids, CPPs can effectively formulate SSOs into NPs for improved delivery efficacy in vitro and in vivo.
Article
Biotechnology & Applied Microbiology
Zhen Zhang, Amy E. E. Baxter, Diqiu Ren, Kunhua Qin, Zeyu Chen, Sierra M. M. Collins, Hua Huang, Chad A. A. Komar, Peter F. F. Bailer, Jared B. B. Parker, Gerd A. A. Blobel, Rahul M. M. Kohli, E. John Wherry, Shelley L. L. Berger, Junwei Shi
Summary: Peptide-assisted genome editing allows efficient editing of single and multiple genes in hematopoietic cells. This system enables simple and well-tolerated delivery of CRISPR-Cas system into primary cells with minimal toxicity. It achieves rapid and robust genome editing in primary cells, including T cells and hematopoietic progenitor cells, with editing efficiencies exceeding 98%. The Peptide-Assisted Genome Editing (PAGE) provides a versatile platform for next-generation genome engineering in primary cells.
NATURE BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Prisca Boisguerin, Karidia Konate, Emilie Josse, Eric Vives, Sebastien Deshayes
Summary: Gene therapy offers the potential to address faulty genes by delivering therapeutic nucleic acids or stimulating the immune system, but the delivery of these exogenous nucleic acids remains a challenge. Cell-penetrating peptides are gaining interest as delivery systems for their ability to form a variety of nanocomplexes, with common features including defined formulation conditions for optimal delivery.
Review
Cell Biology
Umme Sabrina Haque, Toshifumi Yokota
Summary: Antisense oligonucleotide-based therapeutics have great potential for treating human disorders, while the efficient delivery to target cells remains a challenge. Cell-penetrating peptides (CPPs), especially DG9 peptide, show promise in enhancing the cellular uptake and intracellular delivery of oligonucleotide-based drugs. Several studies have demonstrated the potential of DG9-conjugated PMOs in treating DMD and SMA in animal models.
Review
Chemistry, Medicinal
So Hee Nam, Joonhyuck Park, Heebeom Koo
Summary: Cell-penetrating peptides (CPPs) have been used to enhance the delivery of bioactive and therapeutic agents by increasing interaction with the cell membrane. However, their non-specific targeting limits their medical applications.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hanhua Wang, Ziyi Wang, Weiwei Chen, Wencai Wang, Woda Shi, Jinzhong Chen, Ye Hang, Jin Song, Xiao Xiao, Zhenyu Dai
Summary: The study successfully prepared and characterized Ce6-R9-I-125-RGD-MNPs, which demonstrated excellent tumor targeting and the therapeutic effects of combined photodynamic therapy and radiotherapy in experiments.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Valentina Del Genio, Annarita Falanga, Emilie Allard-Vannier, Katel Herve-Aubert, Marilisa Leone, Rosa Bellavita, Rustem Uzbekov, Igor Chourpa, Stefania Galdiero
Summary: Self-assembled peptides have great potential as targeted drug delivery systems. In this study, self-assembled peptide-based nanofibers were developed with the inclusion of a cell-penetrating peptide and a matrix metalloproteinase-9 responsive sequence, enhancing the penetration and tumor-triggered cleavage to release Doxorubicin in Triple Negative Breast Cancer cells. The formulation was optimized and characterized. The loading and release kinetics of Doxo were studied in situ, and the cytotoxicity profiles were evaluated. The results confirm the promising potential of these nanofibers as novel nanovectors for Doxo delivery in Triple Negative Breast Cancer treatment.
Article
Biochemistry & Molecular Biology
Tanja Sack, Piriththiv Dhavarasa, Daniel Szames, Siobhan O'Brien, Stephane Angers, Shana O. Kelley
Summary: Comparing to nuclear DNA repair mechanisms, the characterization of mtDNA repair mechanisms is difficult due to the challenge of specifically addressing mitochondrial damage. This study uses an mtDNA-damaging agent in combination with CRISPR/Cas9 screening to identify genes essential for mtDNA damage response and confirms the responsiveness of WRNIP1 to mtDNA damage for the first time. The study also reveals the mitochondrial role of WRNIP1 in innate immune signaling and nuclear genome maintenance.
ACS CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Na Song, Zhifei Zhou, Yanqiu Song, Mingming Li, Xiunan Yu, Binbin Hu, Zhilin Yu
Summary: The study demonstrates the oxidation-regulated self assembly of peptides into transformable scaffolds for cascade cancer therapy via in situ ROS generation. The scaffolds with combinatorial therapeutic effect promoted by photo-induced in situ ROS generation and morphological transition due to methionine oxidation enhance tumor accumulation and penetration of therapeutics, leading to effective tumor eradication. The findings provide a new and versatile strategy for ROS-associated disease treatment in the future.
Article
Chemistry, Applied
Ahmed R. Abdellah, Abu-Bakr AAM. El-Adasy, Ahmed A. Atalla, Kamal I. Aly, Hani Nasser Abdelhamid
Summary: In this study, COFs synthesized via the solvothermal method were used as supports for in-situ growth of Pd NCs, resulting in catalysts with small particle sizes. The materials were characterized using various techniques, and the Pd NCs@COFs exhibited excellent catalytic performance and stability in C-C formation reactions.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Faisal K. Algethami, Ilyes Saidi, Hichem Ben Jannet, M. Khairy, Babiker Y. Abdulkhair, Youssef O. Al-Ghamdi, Hani Nasser Abdelhamid
Summary: Cadmium sulfide quantum dots were successfully embedded into chitosan using an in situ hydrothermal method. The resulting CdS@CTS quantum dots showed high selectivity towards copper ions and can be used for naked-eye detection of heavy metals.
Article
Engineering, Environmental
Hani Nasser Abdelhamid, Dimitrios Georgouvelas, Ulrica Edlund, Aji P. Mathew
Summary: This article reports a method of processing hierarchical porous zeolitic imidazolate frameworks (ZIF-8) into a cellulose paper using a sheet former. This method shows promise in overcoming the bottleneck in applying metal-organic frameworks (MOFs) in commercial products, and the resulting materials have high adsorption and electrochemical detection performance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Mahmoud R. Saleh, Haitham M. El-Bery, Hani Nasser Abdelhamid
Summary: A wet-incipient impregnation method was used to synthesize hierarchical porous bimetallic (Co, Zn)-zeolitic imidazolate frameworks (ZIF-8)/TiO2 for efficient photocatalytic water splitting. Co@ZIF-8/TiO2 exhibited significantly higher photocatalytic efficiency than TiO2, with a hydrogen generation rate of 13 mmol·h(-1)·g(-1) and a 151-fold increase in catalytic performance. The hierarchical porous structure of Co@ZIF-8 facilitated charge transfer and provided efficient transport channels. This study demonstrates the potential of hierarchical porous metal-organic frameworks (MOFs) as support and promoter in photocatalytic applications of TiO2.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Ghada Abd-Elmonsef Mahmoud
Summary: In this study, copper-based metal-organic frameworks (MOFs) were used to synthesize copper oxide (CuO) embedded into carbon (CuO@C), which displayed high antifungal activity against four economic postharvest plant pathogens. The CuO@C nanoparticles inhibited the growth of the fungal species and decreased their enzyme activity, reducing the potentiality of fruit disease. The successful formation of CuO@C nanoparticles was confirmed using various characterization techniques.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid
Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Walid Sharmoukh, Hani Nasser Abdelhamid
Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: Metal-organic frameworks (MOFs) have shown great potential for industrial applications but current synthesis processes limit their use due to the powder form. A solvothermal method was used to grow copper-based MOFs onto a cotton textile, creating a material called CuBDC@Textile. CuBDC@Textile demonstrated excellent vapor sensing properties and high adsorption capacity for pyridine. This dual-functional material holds promise for further research on MOFs in textile applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Numa A. A. Althubiti, T. A. Taha, A. A. Azab, Hani Nasser Abdelhamid
Summary: The use of solid-state materials such as sodium borohydride for hydrogen storage and release can meet the requirements of the "Hydrogen Economy". This study investigated ZnO-based materials as catalysts for hydrogen release through the hydrolysis of NaBH4. The synthesis method produced nanocomposites consisting of ZnO-xTiO(2) and ZnO-xCeO(2) (x = 5 wt.% or 10 wt.%). Characterization techniques confirmed the phase purity and optical properties of the materials. The materials exhibited a high hydrogen generation rate and different activation energies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Mahmoud M. Abdelnaby, Mansur Aliyu, Medhat A. Nemitallah, Ahmed M. Alloush, El-Hassan M. Mahmoud, Khaled M. Ossoss, Mostafa Zeama, Moataz Dowaidar
Summary: The synthesis of nitrogen-rich porous organic polymers (POPs) through crosslinking melamine and pyrrole monomers followed by pyrolysis at different temperatures resulted in high surface area nitrogen-doped porous carbons (NPCs) with excellent CO2 uptake capacities and selectivity. The method developed in this work highlights the potential of POPs as precursors for synthesizing nitrogen-doped porous carbons with high nitrogen content and yield.
Article
Chemistry, Physical
Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber
Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.
MOLECULAR CATALYSIS
(2023)
Article
Energy & Fuels
Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery
Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew
Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew
Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.
NANOSCALE ADVANCES
(2023)
Review
Biochemistry & Molecular Biology
Moataz Dowaidar
Summary: This paper discusses the impact of gene-environment interactions on various diseases, emphasizing the role of genetic variations and environmental factors in determining disease risk. Through the study of cardiovascular disease, lipid metabolism, obesity, diabetes, and hypertension, the importance of gene-environment interactions in disease development is revealed.
MOLECULAR ASPECTS OF MEDICINE
(2023)
