Article
Engineering, Multidisciplinary
Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi
Summary: This study used culturomics to isolate Escherichia coli strains from colorectal cancer (CRC) mucosal samples and investigated their genomic and functional differences. The strains were divided into five phylogroups based on genomic comparison and were found to induce different levels of cytokine secretion. The analysis also revealed distinct profiles of single-nucleotide polymorphisms, genes, and metabolic pathways in the different phylogroups, highlighting the importance of studying microbiota function at the strain level for understanding host-bacteria interactions.
Article
Virology
Sarah Brendle, Jingwei J. Li, Nancy M. Cladel, Debra A. Shearer, Lynn R. Budgeon, Karla K. Balogh, Hannah Atkins, Marina Costa-Fujishima, Paul Lopez, Neil D. Christensen, John Doorbar, Thomas T. Murooka, Jiafen Hu
Summary: In this study using a mouse papillomavirus infection model, the impact of L1 and L2 on viral life cycle and tumor growth was investigated. The results showed that L1 is not essential for tumor growth induced by MmuPV1, and the L2 gene influences the expression and localization of the L1 protein in vivo.
Article
Microbiology
Simon Blaine-Sauer, Myeong-Kyun Shin, Kristina A. Matkowskyj, Ella Ward-Shaw, Paul F. Lambert
Summary: This study demonstrates that MmuPV1 infection alone can efficiently mediate high-grade squamous intraepithelial lesions in the anal tract of mice using the NSG immunocompromised strain. We also show that MmuPV1, in combination with the chemical carcinogen DMBA, has carcinogenic potential. Furthermore, MmuPV1 is able to persist for up to 6 months in the anal tract of UVB-irradiated FVB/NJ mice and contributes to high-grade disease and cancer in an immunocompetent strain.
Article
Biology
Vural Yilmaz, Panayiota Louca, Louiza Potamiti, Mihalis Panayiotidis, Katerina Strati
Summary: This study successfully generated an in vivo lineage-tracing model to track papillomavirus-harboring cells and their progeny. By observing MmuPV1-treated tissues, increased proliferation dynamics and decreased MHC-I cell surface expression were found, which may have implications in tissue regenerative capacity and virus clearance. This model provides a novel tool to study the biology of MmuPV1 host-pathogen interactions.
Article
Virology
Sarah A. Brendle, Jingwei Li, Nancy M. Cladel, Karla K. Balogh, Jennifer Booth, Debra A. Shearer, Vonn Walter, Song Lu, Neil D. Christensen, Danielle Covington, Jake DeBroff, Janice Milici, Yusheng Zhu, Raphael Viscidi, Jiafen Hu
Summary: We established a mouse papillomavirus (MmuPV1) model and tested passive immunization using a single neutralizing monoclonal antibody to protect both cutaneous and mucosal infections in mice. Results showed that MPV.A4 antibody provided protection against MmuPV1 infections at both skin and mucosal sites, with partial protection observed at 6 hours post-viral inoculation in female mice. The study also demonstrated the presence of MPV.A4 antibody in the blood for up to 8 weeks postadministration.
JOURNAL OF VIROLOGY
(2022)
Article
Infectious Diseases
Subash Chapagain, Prince Pal Singh, Khanh Le, David Safronetz, Heidi Wood, Uladzimir Karniychuk
Summary: This study investigates the infection phenotypes and host transcriptional responses of Japanese encephalitis virus (JEV) in human and pig reproductive epithelial cells. The results show that JEV can cause persistent infection and cytopathology in the vaginal epithelium, endometrial epithelium, and trophoblast. The study also confirms JEV tropism in the female reproductive tracts of pigs. These findings contribute to a better understanding of the interactions between JEV and reproductive tissues, the impact of persistent infection on female reproductive functions, and the risks of non-mosquito transmission.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This nationwide population-based study aimed to investigate the association between nasopharyngeal carcinoma and human papillomavirus infections. The results indicated a significant difference in the rates of previous human papillomavirus infections between nasopharyngeal carcinoma patients and controls. The adjusted odds ratio showed a significantly higher risk of prior human papillomavirus infections in nasopharyngeal carcinoma cases compared to controls.
Article
Biochemistry & Molecular Biology
Jolyn Fernandes, Katelyn Dunigan-Russell, Hua Zhong, Vivian Lin, Mary Silverberg, Stephanie B. Moore, ViLinh Tran, Dean P. Jones, Peter F. Vitiello, Lynette K. Rogers, Trent E. Tipple
Summary: Utilizing a multi-omics integrated approach, this study found that murine strain disproportionately impacts baseline expression of antioxidant systems in lung tissues, potentially leading to discrepant pulmonary responses in preclinical mouse models.
Article
Immunology
Nadine M. Weisel, Stephen M. Joachim, Shuchi Smita, Derrick Callahan, Rebecca A. Elsner, Laura J. Conter, Maria Chikina, Donna L. Farber, Florian J. Weisel, Mark J. Shlomchik
Summary: The study conducted a large-scale screening of memory B cells in humans and mice, identifying numerous surface proteins that are differentially expressed between MBCs and NBCs, providing insight into their functional differences.
Article
Multidisciplinary Sciences
Kathryn L. Hopkins, Maya Jaffer, Khuthadzo E. Hlongwane, Kennedy Otwombe, Janan Dietrich, Mireille Cheyip, Jacobus Olivier, Tanya Doherty, Glenda E. Gray
Summary: A screening center in Soweto, South Africa investigated high-risk HPV, HIV, and cervical cancer risk among women. The study found high prevalence of HR-HPV infection in South African women, low coverage of cervical cancer screening, and that younger women are more susceptible to LSIL and other HR-HPV infections. It suggests implementing HPV-based primary screening starting from age 25.
Article
Immunology
Cecilia Svanberg, Rada Ellegard, Elisa Crisci, Mohammad Khalid, Ninnie Borendal Wodlin, Maria Svenvik, Sofia Nystrom, Kenzie Birse, Adam Burgener, Esaki M. Shankar, Marie Larsson
Summary: Exposure of cervical biopsies to complement-opsonized HIV increased the rate of infection, with enhanced expression of genes and proteins associated with viral replication. The findings suggest that HIV opsonization alters signaling pathways in cervical mucosa to promote viral establishment and infection, laying a foundation for further studies on early HIV-induced events in pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Annika Antonsson, Marjorie M. A. de Souza, Benedict J. Panizza, David C. Whiteman
Summary: Oropharyngeal cancer is increasingly caused by HPV, possibly due to changing sexual behavior. Sexual intercourse elicits a stronger immune response to HPV compared to oral sex, potentially leading to a weaker immune response in individuals who have their oral sex debut before or at the same time as sexual intercourse, increasing their risk of developing persistent oral HPV infection and oropharyngeal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Sandrine Nugteren, Janneke N. Samsom
Summary: SLPI is a protein expressed mainly by epithelial cells at mucosal surfaces, with functions including inhibition of proteases, antimicrobial activity, and suppression of inflammatory responses. It maintains homeostasis at barrier tissues, regulates the threshold of inflammatory immune responses, and protects the host from infection.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Microbiology
Yubing Zhu, Ling Ma, Wenting Wei, Xiang Li, Yuxiao Chang, Zhiyuan Pan, Hong Gao, Ruifu Yang, Yujing Bi, Lei Ding
Summary: The gut microbiota plays a significant role in the development of colorectal cancer, but research on mucosal microbiota is limited. In this study, a culture-based method was used to analyze mucosal bacteria from colorectal cancer and normal tissues, revealing tissue-specific bacteria that may be associated with tumor occurrence and development.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Olivera Lijeskic, Tijana Stajner, Jelena Srbljanovic, Aleksandra Radosavljevic, Branko Bobic, Ivana Klun, Anka Stanojevic-Paovic, Olgica Djurkovic-Djakovic
Summary: This study reported the clinical evolution of ocular toxoplasmosis in immunocompetent patients of conclusively proven postnatal origin. The cases were diagnosed based on clinical diagnosis and laboratory investigation, including genotyping of the parasite strain.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Oncology
Edward J. Wyluda, Jihua Cheng, Todd D. Schell, Jeremy S. Haley, Carol Mallon, Rogerio I. Neves, Gavin Robertson, Jeffrey Sivik, Heath Mackley, Giampaolo Talamo, Joseph J. Drabick
CANCER BIOLOGY & THERAPY
(2015)
Article
Biochemical Research Methods
Balazs Koscso, Kavitha Gowda, Todd D. Schell, Milena Bogunovic
JOURNAL OF IMMUNOLOGICAL METHODS
(2015)
Article
Oncology
Y. Kong, J. Zhang, D. F. Claxton, W. C. Ehmann, W. B. Rybka, L. Zhu, H. Zeng, T. D. Schell, H. Zheng
BLOOD CANCER JOURNAL
(2015)
Article
Oncology
Kristian M. Koller, Heath B. Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D. Schell, Colette Pameijer, Rogerio I. Neves, Bryan Anderson, Kathleen M. Kokolus, Carol A. Mallon, Joseph J. Drabick
CANCER BIOLOGY & THERAPY
(2017)
Article
Oncology
Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng
CLINICAL CANCER RESEARCH
(2016)
Review
Oncology
Kristian M. Koller, Wenge Wanga, Todd D. Schell, Eugene M. Cozza, Kathleen M. Kokolus, Rogerio I. Neves, Heath B. Mackley, Colette Pameijer, Anna Leung, Bryan Anderson, Carol A. Mallon, Gavin Robertson, Joseph J. Drabick
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2016)
Article
Immunology
Andrea Schietinger, Mary Philip, Varintra E. Krisnawan, Edison Y. Chiu, Jeffrey J. Delrow, Ryan S. Basom, Peter Lauer, Dirk G. Brockstedt, Sue E. Knoblaugh, Guenter J. Haemmerling, Todd D. Schell, Natalio Garbi, Philip D. Greenberg
Review
Oncology
Kun-Ming Chen, Todd D. Schell, John P. Richie, Yuan-Wan Sun, Shang-Min Zhang, Ana Calcagnotto, Cesar Aliaga, Krishne Gowda, Shantu Amin, Karam El-Bayoumy
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS
(2017)
Article
Oncology
Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2017)
Article
Gastroenterology & Hepatology
Guangfu Li, Dai Liu, Timothy K. Cooper, Eric T. Kimchi, Xiaoqiang Qi, Diego M. Avella, Ningfei Li, Qing X. Yang, Mark Kester, C. Bart Rountree, Jussuf T. Kaifi, David J. Cole, Don C. Rockey, Todd D. Schell, Kevin F. Staveley-O'Carroll
JOURNAL OF HEPATOLOGY
(2017)
Article
Immunology
Arash Memarnejadian, Courtney E. Meilleur, Christopher R. Shaler, Khashayarsha Khazaie, Jack R. Bennink, Todd D. Schell, S. M. Mansour Haeryfar
JOURNAL OF IMMUNOLOGY
(2017)
Article
Microbiology
Saumya Maru, Ge Jin, Todd D. Schell, Aron E. Lukacher
Editorial Material
Oncology
Dai Liu, Guangfu Li, Diego M. Avella, Eric T. Kimchi, Jussuf T. Kaifi, Mark P. Rubinstein, E. Ramsay Camp, Don C. Rockey, Todd D. Schell, Kevin F. Staveley-O'Carroll
Article
Oncology
Eugene M. Cozza, Timothy K. Cooper, Lynn R. Budgeon, Neil D. Christensen, Todd D. Schell
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2015)