Article
Nanoscience & Nanotechnology
Juan Du, Lanlan Zong, Mengmeng Li, Keke Yu, Yonghui Qiao, Qi Yuan, Xiaohui Pu
Summary: This study develops a reduction-sensitive polymer prodrug micelle, PDSP, as a carrier to overcome tumor multidrug resistance and improve the anti-tumor effect of PTX. The PDSP micelles exhibit good stability, double-responsive drug release, and excellent biocompatibility. Both in vitro and in vivo experiments demonstrate the potential of PDSP micelles in enhancing the sensitivity of tumor cells and reducing systemic toxicity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Anand Gupta, Antonio P. Costa, Xiaoming Xu, Diane J. Burgess
Summary: A continuous polymeric micelle processing platform was developed to eliminate batch-to-batch variation in critical quality attributes. By controlling polymer molecular weight and concentration, precise particle size and low polydispersity were achieved. The optimized conditions produced paclitaxel polymeric micelles equivalent to commercial Genexol PM, with similar quality attributes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Yun-qiu Miao, Ming-shu Chen, Xin Zhou, Lin-miao Guo, Jing-jing Zhu, Rui Wang, Xin-xin Zhang, Yong Gan
Summary: Introduction of chitosan oligosaccharide (CSO) modification on liposomes enhances the delivery of chemotherapeutics to lung tumors, leading to improved therapeutic outcomes for lung cancer treatment.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Polymer Science
Meirong Zhao, Weiwei Jiang, Xinrong Xie, Yogini Jaiswal, Leonard Williams, Mei Wei, Ying Mo, Yifu Guan, Hua Yang
Summary: In this paper, a new drug carrier was synthesized using self-assembled polymeric micelles to load paclitaxel. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The results indicate that the developed carrier has good pH sensitivity and potential for increased solubility and clinical efficacy of paclitaxel.
Article
Engineering, Biomedical
Jiamao Luo, Xinxian Zhong, Yingming Peng, Chenyuan Hao, Xiaomei Liang, Yulu Yang, Xiubo Shi, Xuncai Chen, Xiao Yi, Xiaoxuan Li, Jianhua Wu, Jinheng Li, Qian Xiao, Chentian Wu, Ruojing Lu, Yao Pan, Xuejiao Wang, Jun-Bing Fan, Yifeng Wang, Ying Wang
Summary: In this study, a self-assembled nanoparticle (VE-DDP-Pro) was developed to enhance the treatment efficacy of cisplatin against ovarian cancer. The nanoparticle exhibited self-anti-angiogenesis and anti-vascular mimicry capacity, inhibiting tumor growth and metastasis. The findings highlight the importance of integrating anti-angiogenesis strategies to improve the effectiveness of chemotherapeutics for malignant metastatic tumors.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Raju Lunkad, Philip Biehl, Anastasiia Murmiliuk, Pablo M. Blanco, Peter Mons, Miroslav Stepanek, Felix H. Schacher, Peter Kosovan
Summary: We synthesized three different polyzwitterions and investigated their ionization states in response to changes in solution pH. By using molecular simulations and experimental measurements, we predicted and explained the differences in ionization behavior and effectively obtained pK(a) values.
Article
Chemistry, Multidisciplinary
Tiantian Guo, Haiping Zhong, Xingwei Li, Jingqing Mu, Tao Liu, Na Yu, Yang Zhao, Xing-Jie Liang, Shutao Guo
Summary: In this study, we synthesized four dextran-paclitaxel (PTX) conjugates with different drug contents and used them to construct self-assembled nanoparticles. We investigated how PTX content influenced the performance and antitumor efficacy of the nanoparticles. The results showed that nanoparticles with lower PTX content exhibited faster drug release, increased tumor accumulation, and enhanced antitumor efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Wei Zhang, Dongdong Li, Xiaodan Xu, Yong Chen, Xueying Shi, Yixuan Pan, Shasha Yao, Ying Piao, Zhuxian Zhou, Nigel K. H. Slater, Youqing Shen, Jianbin Tang
Summary: Peptide-based immune checkpoint inhibitors have therapeutic benefits, but their application is hindered by quick blood clearance and low affinity with receptors. Conjugation of peptides with a polymer is an ideal platform to solve these problems, and the bridging effect mediated by bispecific artificial antibodies promotes the interaction of cancer cells and T cells for cancer immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Fernanda Lapa Campos, Janaina de Alcantara Lemos, Caroline Mari Ramos Oda, Juliana de Oliveira Silva, Renata Salgado Fernandes, Sued Eustaquio Mendes Miranda, Carolina Henriques Cavalcante, Geovanni Dantas Cassali, Danyelle M. Townsend, Elaine Amaral Leite, Andre Luis Branco de Barros
Summary: Colorectal cancer is a significant global public health issue due to the ineffectiveness of current treatments. This study proposes micellar formulations as a novel targeted drug delivery system for colorectal cancer therapy. The micelles showed promising characteristics such as small size, neutral charge, and high encapsulation efficiency. Animal experiments demonstrated that the micellar formulations effectively inhibited tumor growth with low toxicity at an appropriate dosage.
Article
Engineering, Biomedical
Shixian Lv, Meilyn Sylvestre, Kefan Song, Suzie H. Pun
Summary: Melittin, the primary peptide component in bee venom, has anti-tumor activity but its practical application is hindered by hemolytic activity and instability. Use of D-amino acids in place of L-amino acids reduces immunogenicity of melittin, allowing for safer delivery and maintaining cytolytic potential. D-melittin micelles show cytotoxicity in a pH-dependent manner, inducing immunogenic cell death and demonstrating potential for cancer immunotherapy. The study presents a new strategy for systemic delivery of cytotoxic peptides in cancer treatment.
Article
Chemistry, Applied
Haohui Shi, Na Liang, Jiyang Liu, Siyi Li, Xianfeng Gong, Pengfei Yan, Shaoping Sun
Summary: A novel polymer TPE-bi(SS-CS-Bio) was synthesized for encapsulating PTX with excellent AIE feature and enhanced cellular uptake due to biotin modification. The drug-loaded micelles showed remarkable cytotoxicity against MCF-7 cells and demonstrated potential as a carrier for PTX.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Yue Wang, Jingyi Han, Dongdong Wang, Menghua Cai, Yi Xu, Yu Hu, Hui Chen, Wei He, Jianmin Zhang
Summary: This study constructed novel armored gamma delta T cells capable of secreting humanized anti-PD-1 antibodies, referred to as Lv-PD1-gamma delta T cells. These cells showed improved proliferation and enhanced cytotoxicity against tumor cells, resulting in augmented therapeutic effects and survival benefits in ovarian tumor-bearing mice. The engineered cells demonstrated a prolonged in vivo survival without any potential for tumorigenicity, and exhibited excellent tolerance and safety in humanized mice.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Pharmacology & Pharmacy
Xinran Wang, Jieyi Pan, Haohui Shi, Na Liang, Shaoping Sun
Summary: This study aimed to develop tumor-targeting and acid-responsive micelles as carriers for paclitaxel (PTX). An amphipathic polymer TOS-Ace-PEG-Bio was designed and synthesized and proved to self-assemble into nanosized micelles capable of encapsulating PTX. The PTX-loaded micelles showed pH-dependent drug release behavior and were selectively internalized by MCF-7 cells. In vivo studies confirmed their excellent antitumor activity and reduced side effects, making the TOS-Ace-PEG-Bio micelles promising carriers for PTX delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hyun Jin Kim, Su Kyoung Seo, Ha Yeon Park
Summary: This article introduces the significance and mechanism of successful translation of mRNA vaccines and discusses the development of next generation delivery vehicles for future mRNA vaccines.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Runan Zuo, Jingjing Zhang, Xinhao Song, Shiheng Hu, Xiuge Gao, Junqi Wang, Hui Ji, Chunlei Ji, Lin Peng, Hongbin Si, Gonghe Li, Kun Fang, Junren Zhang, Shanxiang Jiang, Dawei Guo
Summary: HF-loaded TPGS polymeric micelles exhibit excellent drug release, inhibitory effects, and biocompatibility in cancer therapy, enhancing the treatment efficacy against MDA-MB-231 triple-negative breast cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)