Article
Medicine, Research & Experimental
Minhao Yu, Hao Wang, Wei Zhao, Xiaoxiao Ge, Wei Huang, Fengjuan Lin, Wenbo Tang, Ang Li, Sailiang Liu, Rong-Kun Li, Shu-Heng Jiang, Junli Xue
Summary: This study reveals the significant role of PIPKI?? in oxaliplatin resistance and provides a key mechanism of exosomal PD-L1 in colorectal cancer with potential therapeutic implications.
Article
Biochemistry & Molecular Biology
Sun Young Park, Ye Seo Chung, So Yeon Park, So Hee Kim
Summary: Resistance to oxaliplatin in colorectal cancer cells is associated with increased phosphorylation of AMPK, leading to cell survival. Inhibition of AMPK can induce autophagy and restore chemosensitivity to anticancer drugs.
Article
Chemistry, Multidisciplinary
Kaixuan Zeng, Weihao Li, Yue Wang, Zifei Zhang, Linjie Zhang, Weili Zhang, Yue Xing, Chi Zhou
Summary: This study identifies CDK1 as a critical contributor to oxaliplatin resistance in colorectal cancer (CRC) by suppressing ferroptosis. CDK1 is highly expressed in oxaliplatin-resistant cells and tissues due to the loss of N6-methyladenosine modification. Inhibition of CDK1 restores sensitivity to oxaliplatin in CRC cells and xenograft models. Mechanistically, CDK1 phosphorylates and promotes ubiquitination of ACSL4, leading to its degradation and subsequent inhibition of lipid peroxidation and ferroptosis. These findings suggest that CDK1 inhibition may be a promising strategy for treating oxaliplatin-resistant CRC.
Article
Biochemistry & Molecular Biology
Yaru Li, Ziru Sun, Yujun Cui, Heming Zhang, Shunjie Zhang, Xinyu Wang, Shengnan Liu, Qingzhi Gao
Summary: Oxaliplatin-based chemotherapy is the current standard of care in advanced colorectal cancer, but acquired resistance limits its efficacy. In response, researchers have designed and synthesized a novel Pt(II) complex, Ph-glu-Oxa, which shows promising in vivo therapeutic potential by targeting DNA and overcoming drug resistance mechanisms.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Chien-Hao Wang, Rathinasamy Baskaran, Shawn Shang-Chuan Ng, Tso-Fu Wang, Chi-Cheng Li, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Ming-Cheng Chen, Chih-Yang Huang
Summary: In this study, platycodin D (PD), a saponin found in Platycodon grandiflorum, was shown to inhibit the proliferation, invasion, and migration ability of LoVo and OR-LoVo cells. Combined treatment of PD with oxaliplatin dramatically reduced cellular proliferation and activated the degradation of YAP1, leading to transcriptional inhibition of downstream genes regulating cell proliferation, pro-survival, and metastasis. PD could be a promising agent for overcoming oxaliplatin-resistant colorectal cancer.
Article
Oncology
Marie Malier, Khaldoun Gharzeddine, Marie-Helene Laverriere, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet
Summary: The study reveals that macrophages specifically overexpress DPD in hypoxia, leading to macrophage-induced chemoresistance to 5-FU, while tumor cells do not express significant levels of DPD. These findings shed light on the crucial role of TAMs in promoting chemoresistance in colorectal cancers.
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Yan-yan Zhuang, Wa Zhong, Zhong-sheng Xia, Shu-zhen Lin, Man chung Chan, Ke Jiang, Wen-fei Li, Xin-yi Xu
Summary: The study reveals that miR-5000-3p may play a role in drug resistance progression of CRC by regulating the USP49 gene, resulting in cancer cells sensitized to oxaliplatin.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, General & Internal
Zhijian Zheng, Ming Wu, Hongyan Li, Wenxia Xu, Mengxiang Yang, Kailing Pan, Yuqi Ni, Ting Jiang, Hongjuan Zheng, Xiayun Jin, Yanfei Zhang, Linchao Ding, Jianfei Fu
Summary: This study identified AC092894.1 as a suppressor of oxaliplatin resistance in colorectal cancer (CRC). Mechanistically, AC092894.1 served as a scaffold molecule that mediated the de-ubiquitination of AR through USP3, thereby increasing the transcription of RASGRP3 and activating the MAPK signaling pathway to induce apoptosis in CRC cells. Targeting the AC092894.1/USP3/AR/RASGRP3 signaling axis may represent a novel option for the treatment of oxaliplatin resistance.
Article
Pharmacology & Pharmacy
Chengzhi Huang, Minjia Wang, Junjiang Wang, Deqing Wu, Yuan Gao, Kaihong Huang, Xueqing Yao
Summary: The study revealed that overexpression of MGP in colorectal cancer may contribute to oxaliplatin resistance and be associated with cancer stage and patient prognosis. Inhibition of MGP expression can increase sensitivity of CRC cells to OXA, potentially reversing resistance and reducing tumor growth.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Elham Fakhr, Fatemeh Zare, Kayhan Azadmanesh, Ladan Teimoori-Toolabi
Summary: LEF1 plays an important role in the chemo-resistance of colorectal cancer cells, with downregulation of the long isoform making cells more sensitive to chemotherapy through reduced proliferation, increased apoptosis, or cell cycle arrest. Balancing the expression of long and short isoforms of LEF1 is crucial in overcoming chemo-resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yiqiang Liu, Hong Wu, Tao Luo, Qiyu Luo, Ziyu Meng, Ying Shi, Feifei Li, Mingxin Liu, Xinhao Peng, Junjie Liu, Chuan Xu, Weizhong Tang
Summary: In colorectal cancer, the activation of the SOX9-MMS22L-dependent DNA damage pathway is a core mechanism regulating sensitivity to oxaliplatin. Targeting this pathway in oxaliplatin-resistant CRC cells shows promise as a therapeutic option in CRC treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Xiao-Lan Qian, Fang Zhou, Song Xu, Jian Jiang, Zhi-Peng Chen, Shao-Kai Wang, Yun Zuo, Chen Ni
Summary: The study identified that miR-454-3p is up-regulated in oxaliplatin-resistant colorectal cancer cells, promoting resistance by targeting PTEN and activating the AKT pathway. Inhibition of miR-454-3p restored sensitivity to oxaliplatin in resistant cells and enhanced apoptosis. Furthermore, overexpression of miR-454-3p correlated with decreased responsiveness to oxaliplatin-based chemotherapy and shorter progression-free survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shota Tanaka, Mika Hosokawa, Ai Tatsumi, Shiho Asaumi, Ryoji Imai, Ken-ichi Ogawara
Summary: This study found that pre-treatment with the histone deacetylase inhibitor Vorinostat (SAHA) can improve the resistance of colorectal cancer cells to oxaliplatin. SAHA significantly increased the sensitivity of resistant cells to oxaliplatin, but had no effect on other platinum-based drugs. Further investigation revealed that SAHA improved oxaliplatin resistance by inhibiting the activation of the Nrf2-Keap1 pathway. These findings contribute to a better understanding of drug resistance mechanisms and the development of more effective treatment strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xinyi Wang, Haiyang Zhang, Shengjie Yin, Yuchong Yang, Haiou Yang, Jiayu Yang, Zhengyang Zhou, Shuang Li, Guoguang Ying, Yi Ba
Summary: Oxaliplatin is a standard treatment for colorectal cancer, but chemoresistance is a challenge. A study found that a short peptide, pep-AP, can increase cancer cell sensitivity to L-OHP, offering a potential treatment option for L-OHP resistant CRC.
Article
Neurosciences
Ting Yang, Xueping Li, Peng Xia, Xiaoju Wang, Jianqiang Lu, Lin Wang
Summary: This study evaluated the effect of rTMS combined with rPMS on stroke patients with arm paralysis after CSCNTS. The results showed that this combined treatment significantly reduced muscle tone and increased grip and pinch strength.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Junjun Ma, Xiaoju Wang, Yonghuan Bian, Changyong Zhang, Chun Liu, Jianrui Niu, Jing Zhang, Ge Shen, Jie Liu
Summary: A spiral mosquito-repellent incense-shaped channel was designed and used in a flow electrode capacitive deionization system. Computational fluid dynamics analysis was conducted to study its hydrodynamic performance. The newly designed channel showed low flow resistance and minimal stagnant regions. The effects of flow rate and mass loading on desalination performance were investigated and compared to traditional runway and snake-shaped channels. The MR-shaped channel exhibited a higher salt removal rate. Vortices in the corners of the traditional channels aided in charge transfer.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Correction
Cell & Tissue Engineering
Xinwei Wang, Danbi Wang, Peng Xia, Kai Cheng, Qi Wang, Xiaoju Wang, Qiang Lin, Jiulong Song, Anliang Chen, Xueping Li
BONE & JOINT RESEARCH
(2022)
Article
Orthopedics
Peng Xia, Qi Wang, Jiulong Song, Xiaoju Wang, Xinwei Wang, Qiang Lin, Kai Cheng, Anliang Chen, Xueping Li
Summary: The study showed that LIPUS can promote MSC exosome release by activating autophagy, enhancing the positive effects of MSCs on OA cartilage repair. In vivo results demonstrated that LIPUS significantly improved the therapeutic efficacy of MSCs in OA cartilage repair, possibly through increasing autophagy-mediated exosome release.
Article
Psychology, Multidisciplinary
Jun Lei, Yaoyue Luo, Yude Xie, Xiaoju Wang
Summary: This study examined the association between VAI and depression in the American population using NHANES data. The results showed that for every 1 unit increase in VAI, the clinical depression increased by 14%. Patients with high VAI scores had the highest risk of developing depression.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Construction & Building Technology
Jianwei Zhang, XiaoJu Wang, Lei Shi, Yue Yin
Summary: A novel method combining enzyme-induced carbonate precipitation (EICP) and lignin was proposed to enhance the mechanical properties of silt in the Yellow River flood area. Laboratory experiments were conducted to investigate the effect of EICP-lignin treatment on the unconfined compressive strength (UCS), elasticity modulus, cohesion, internal friction angle, and microstructure of silt. The results showed that the strength parameters of silt increased and then decreased with increasing lignin content, with an optimum value at approximately 5%. The EICP-lignin treatment significantly improved the strength of silt obtained from the Yellow River flood area.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Behavioral Sciences
Xiaoju Wang, Peng Xia, Jiulong Song, Ting Yang, Changjun Yu, Kai Cheng, Anliang Chen, Xueping Li
Summary: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Engineering, Environmental
Jie Liu, Junjun Ma, Weizhang Zhong, Jianrui Niu, Zaixing Li, Xiaoju Wang, Ge Shen, Chun Liu
Summary: Membrane capacitive deionization (MCDI) is an efficient desalination technology. In this study, penicillin fermentation residue biochar (PFRB) was used as an electrode in the MCDI system, showing a high-capacity desalination performance. The PFRB electrode exhibited excellent electrochemical properties and stability.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Engineering, Environmental
Ge Shen, Junjun Ma, Jianrui Niu, Ruina Zhang, Jing Zhang, Xiaoju Wang, Jie Liu, Jiarong Gu, Ruicheng Chen, Xiqing Li, Chun Liu
Summary: Capacitive deionization (CDI) is a novel electrochemical water-treatment technology that utilizes activated carbon (AC) as an electrode material. This study adopted ball milling to produce ball milled AC (BAC) with improved physical and electrochemical properties. BAC exhibited excellent pore structures and favorable surfaces for ion adsorption, leading to reduced electron transfer resistance and ion migration resistance. The average salt adsorption rates and energy-normalized removal salt were significantly enhanced in both membrane capacitive deionization (MCDI) and flow-electrode capacitive deionization (FCDI) using BAC as the electrode material.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Inorganic & Nuclear
Xinxin Hang, Xiaoju Wang, Meilin Wang, Mengwei Chen, Yanfeng Bi
Summary: The integration of heterometallic units into coordination clusters can enhance their electrocatalytic performance. In this study, a series of coordination clusters were synthesized using different metal precursors and ligands, and they showed improved activity in the oxygen evolution reaction.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Environmental Sciences
Xiaoju Wang, Shanshan Hu, Haitao Mao, Xueyu Wei, Saraschandra Naraginti
Summary: Recently, there has been increasing attention on the development of efficient materials for degradation and detoxification of antibiotics in wastewater treatment. AgVO3, as a visible light active material, has been widely studied for environmental remediation. In this research, a novel heterojunction of AgVO3/rGO/BiVO4 was prepared through a hydrothermal method to improve its efficiency and stability. The results showed that the degradation efficiency of AgVO3/rGO/BiVO4 towards Norfloxacin (NFC) antibiotic was significantly higher compared to pure AgVO3 and BiVO4. The enhanced efficiency can be attributed to the formation of heterojunction and faster charge separation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Luyao Wang, Qingbo Wang, Emil Rosqvist, Jan-Henrik Smatt, Qiwen Yong, Lippo Lassila, Jouko Peltonen, Thomas Rosenau, Martti Toivakka, Stefan Willfoer, Patrik Eklund, Chunlin Xu, Xiaoju Wang
Summary: Fabricating bio-latex colloids with core-shell nanostructure is an effective method for obtaining films with enhanced mechanical characteristics. Nano-sized lignin is rising as a class of sustainable nanomaterials that can be incorporated into latex colloids. The correlation between surface chemistry of lignin nanoparticles (LNPs) and integration efficiency in latex colloids and from it thermally processed latex films is explored.
Article
Engineering, Biomedical
Qingbo Wang, Ozge Karadas, Oskar Backman, Luyao Wang, Tuomas Nareoja, Jessica M. Rosenholm, Chunlin Xu, Xiaoju Wang
Summary: In this study, a ternary-component aqueous emulsion was used to fabricate microgel assembly for 3D bioprinting. The emulsion consisted of methacrylated gelatin (GelMA) microgels, methacrylated galactoglucomannan (GGMMA), and dextran (Dex). The GGMMA and Dex provided stability to the emulsion, while GGMMA also facilitated the adhesion of GelMA microgels to form a porous hydrogel construct that supported cell growth and colonization.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, General & Internal
Pei Zhang, Jing Liao, Xiaoju Wang, Zhengping Feng
Summary: The present study compared the effects of high glucose and glucose fluctuation on apoptosis and autophagy in MC3T3-E1 osteoblasts. The results showed that high glucose and glucose fluctuation decreased cell proliferation and activated autophagy. They also induced oxidative stress, mitochondrial damage, and apoptosis, with more significant differences observed in the glucose fluctuation group. Antioxidant treatment eliminated reactive oxygen species, inhibited autophagy and apoptosis, while autophagy inhibition enhanced apoptosis in the osteoblasts.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Meeting Abstract
Oncology
Lanbo Xiao, Abhijit Parolia, Yuanyuan Qiao, Pushpinder Bawa Pushpinder, Sanjana Eyunni, Rahul Mannan, Sandra E. Carson, Yu Chang, Xiaoju Wang, Yuping Zhang, Josh Vo, Steven Kregel, Stephanie A. Simko, Andrew D. Delekta, Mustapha Jaber, Heng Zheng, Ingrid Apel, Lisa McMurry, Fengyun Su, Rui Wang, Sylvia Wang, Sanjita Sasmal, Leena K. Satyam, Subhendu Mukherjee, Chandrasekhar Abbinen, Kiran Aithal, Mital S. Bhakta, Jay Ghurye, Xuhong Cao, Nora M. Navone, Alexey Nesvizhskii, Rohit Mehra, Ulka Vaishampayan, Marco Blanchette, Yuzhuo Wang, Susanta Samajdar, Murali Ramachandra, Arul M. Chinnaiyan
