Article
Plant Sciences
Jianyun Zhang, Ziyi Zhao, Wenyu Liang, Jingyi Bi, Yuguang Zheng, Xian Gu, Huiyong Fang
Summary: This study evaluated the chemical composition and antifungal activity of Sabina chinensis essential oil (EO) against plant pathogenic fungi. The results showed that S. chinensis EO exhibited high and long-term antifungal activity against Fusarium oxysporum and Fusarium incarnatum. The EO's antifungal activity varied among different harvest periods, and five compounds were strongly correlated with the mycelial inhibition rate. This study provides valuable information for developing potential fungicides from natural agents.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Atia, Yasser K. Abdel-Monem, A. H. Salama, Salah M. El-kousy, Wael H. Eisa
Summary: A clean and high-throughput synthesis of gold@chitosan nanocomposite using nontoxic oxalic acid as a reducing agent was developed. The gold nanoparticles were bound with chitosan through the hydroxyl and amino groups, and scanning and transmission electron microscopy imaging confirmed the formation of semi-spherical gold particles with an average size of 8-15 nm. The catalytic performance of the synthesized gold nanoparticles for the reduction of chromium(IV) in the presence of formic acid was evaluated, and the film-forming ability of chitosan enabled the design of separable/reusable heterogeneous catalyst which is convenient for real industrial applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Parinaz Jabbari, Gholam Reza Mahdavinia, Parisa Fathi Rezaei, Bagher Kazemi Heragh, Parisa Labib, Hessam Jafari, Shahrzad Javanshir
Summary: A nanocomposite carrier with double-responsive features was developed by integrating magnetic montmorillonite into a chitosan matrix and crosslinking it with citric acid. The carrier showed high sustained release and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Maryam Payandeh, Mehdi Ahmadyousefi, Hamidreza Alizadeh, Mahboobeh Zahedifar
Summary: This study reports the design, synthesis, and characterization of nanoencapsulated Satureja kermanica essential oil/extract using chitosan biopolymer as a carrier for antifungal efficacy. The results show that the nanoencapsulated Satureja kermanica essential oil/extract effectively inhibits fungal growth and can be used as a green strategy to protect plants from fungal infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Sheril Ann Mathew, Stephen Arumainathan
Summary: The study successfully crosslinked chitosan and gelatin without the use of a crosslinking agent, resulting in the synthesis of nanocomposites in three different ratios. The nanocomposites exhibited excellent biodegradability, biocompatibility, adhesion, and absorption properties, making them suitable for drug delivery applications. Of particular significance is the sustained release of dopamine in a neutral medium achieved using the crosslinked chitosan and gelatin, without the presence of a crosslinker. The nanocomposites also demonstrated favorable antioxidant and antibacterial activity.
Article
Chemistry, Applied
Onur Bulut, M. Deniz Yilmaz
Summary: This study evaluated the catalytic activity of biocompatible chitosan-stabilized gold nanoparticles on the oxidation reaction, demonstrating high efficiency and long-term stability with low toxicity to cells. The nanoparticles showed positive correlation with concentrations of catalyst and oxidant, while negative correlation with substrate concentration. The results suggest the potential of CH-AuNPs as effective and reusable nanocatalysts for oxidation reactions.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Awad Shala, Shweta Singh, Saif Hameed, M. P. Paul Khurana
Summary: This article summarizes the potential of several major essential oils in combating Candida albicans and provides recommendations for further research.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Morvarid Hatamiazar, Javad Mohammadnejad, Sepideh Khaleghi
Summary: Currently, the high incidence of fungal infections among females is a significant problem. Chitosan-albumin derivatives with more stability have innate antifungal and antibacterial effects that enhance drug activity without causing inflammation. Encapsulating Fluconazole in protein/polysaccharide nanocomposites ensures its stability and sustained release in mucosal tissues. Therefore, chitosan-albumin nanocomposites loaded with Fluconazole could be a promising candidate against vaginal candidiasis.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Infectious Diseases
Alice Kit Ying Chan, Yiu Cheung Tsang, Chun Hung Chu, Chiu Shun Peter Tsang
Summary: The study aimed to evaluate the anti-biofilm effect of aspirin on Candida biofilms and found that C. albicans was the most sensitive species towards aspirin, which could effectively eradicate the biofilm at a concentration of 40 mg/mL in 4 hours. Aspirin at the same concentration could eradicate biofilms of other tested species in 24 hours. These results suggest that aspirin may be used as an anti-fungal agent in lock therapy for the treatment of catheter-related candidemia.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Polymer Science
Abdul Mukheem, Syed Shahabuddin, Noor Akbar, Irfan Ahmad, Kumar Sudesh, Nanthini Sridewi
Summary: The unique structures and multifunctionalities of two-dimensional nanomaterials have attracted increasing interest for constructing novel scaffolds in biomedical applications. In this study, a biocompatible nanocomposite PHA/Ch-WS2 was synthesized and characterized. The results showed significant bactericidal effects of the nanocomposite and no cytotoxicity to human cells, suggesting its potential for biomedical and sanitizing applications.
Article
Polymer Science
Shangru Cheng, Yaokai Tang, Qiangmin Gao, Xincheng Wang, Anqi Li, Yingxin Yuan, Shanshan Guan
Summary: This study presents a critical material design concept for fabricating high-performance flexible dielectric nanocomposites with high dielectric constant and suppressed loss. By utilizing a 3D conductive network and a chitosan insulating barrier layer, a balance between dielectric constant and loss is achieved. The resulting composites are employed as a dielectric interlayer in capacitive sensors, exhibiting high sensitivity and a wide working range.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Mondejar-Lopez, Alberto Jose Lopez-Jimenez, Oussama Ahrazem, Lourdes Gomez-Gomez, Enrique Niza
Summary: In this study, chitosan-coated biogenic silver nanoparticles (AgNP-CH) were obtained through green chemistry by recycling wheat crop leaf residues. The nanoparticles were characterized and confirmed by various spectroscopy techniques, and their antifungal properties were evaluated. The results showed that AgNP-CH exhibited high antimicrobial activity against certain fungal strains, making it a potential alternative for preventing fungal infections in the early stages of wheat crop development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Chiravoot Pechyen, Khanittha Ponsanti, Benchamaporn Tangnorawich, Nipaporn Ngernyuang
Summary: Gold nanoparticles synthesized using waste fruit peel extracts exhibit biocompatibility and non-cytotoxicity, with the green synthesis method showing potential for biomedical applications. The use of pineapple and passion fruit peel extracts as reducing and stabilizing agents provides a cost-effective and environmentally friendly approach to AuNP synthesis. The synthesized AuNPs showed characteristic red coloration and UV-visible absorption peak, along with spherical morphology and face-centered cubic structure, demonstrating their potential utility in biomedical science.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Pharmacology & Pharmacy
Obaid Afzal, Md Habban Akhter, Irfan Ahmad, Khursheed Muzammil, Adam Dawria, Mohammad Zeyaullah, Abdulmalik S. A. Altamimi, Habibullah Khalilullah, Shehla Nasar Mir Najib Ullah, Mohammad Akhlaquer Rahman, Abuzer Ali, Naiyer Shahzad, Mariusz Jaremko, Abdul-Hamid Emwas, Ibrahim Abdel Aziz Ibrahim
Summary: This study focuses on synthesizing and characterizing beta-sitosterol encapsulated Alginate/Chitosan nanoparticles for breast cancer treatment, evaluating their effectiveness in vitro and in vivo. The nanoparticles demonstrated higher cytotoxicity and oral bioavailability compared to conventional suspension, showing potential as a promising treatment option.
Article
Biochemistry & Molecular Biology
Joonho Shin, Atanu Naskar, Dongjoon Ko, Semi Kim, Kwang-sun Kim
Summary: This study reports the bioconjugation of thymol with zinc oxide nanoparticle to form TZ nanocomposite, which exhibits potent and selective antibacterial activity against Staphylococcus species. By improving the antibacterial effect of thymol, this nanocomposite could serve as an effective alternative to antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
E. H. T. Thulshan Jayathilaka, Dinusha C. Rajapaksha, Chamilani Nikapitiya, Mahanama De Zoysa, Ilson Whang
Summary: Octominin exhibits significant antibacterial and antibiofilm activities against multidrug-resistant Acinetobacter baumannii, increasing membrane permeability and ROS generation, and successfully controlling bacteria in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Chamilani Nikapitiya, Amal Senevirathne, S. H. S. Dananjaya, Nipuna Tennakoon, Hyun-Jin Shin, Jehee Lee, Mahanama De Zoysa
Summary: Aeromonas phage AHP-1 is a phage that can infect both Aeromonas hydrophila and A. salmonicida. Its genome is 218,317 base pairs long and contains 67 unique open reading frames.
ARCHIVES OF VIROLOGY
(2022)
Article
Chemistry, Medicinal
E. H. T. Thulshan Jayathilaka, Dinusha C. Rajapaksha, Chamilani Nikapitiya, Joeun Lee, Mahanama De Zoysa, Ilson Whang
Summary: Octoprohibitin, a synthetic antimicrobial peptide derived from the prohibitin-2 gene of Octopus minor, showed significant activity against multidrug resistant Acinetobacter baumannii, inhibiting both bacterial growth and biofilm formation.
Article
Fisheries
E. H. T. Thulshan Jayathilaka, Shan Lakmal Edirisinghe, Jehee Lee, Chamilani Nikapitiya, Mahanama De Zoysa
Summary: This study isolated exosomes from plasma of olive flounder and investigated their characteristics, wound healing and regeneration activities. The exosomes exhibited typical characteristics and were found to have no toxicity. They showed enhanced wound healing and tissue regeneration activities. These findings are important for the development of exosomes as an efficient therapeutic carrier system for fish medicine.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Withanage Prasadini Wasana, Amal Senevirathne, Chamilani Nikapitiya, Jong-Soo Lee, Do-Hyung Kang, Kae Kyoung Kwon, Chulhong Oh, Mahanama De Zoysa
Summary: This study characterizes and evaluates the probiotic properties of a newly isolated marine bacterium, Pseudoalteromonas ruthenica. The results show that P. ruthenica enhances disease tolerance and thermal stress resistance in larval and adult zebrafish, and modulates the gut microbiota and immune-stress response. The findings suggest that P. ruthenica has potential as a probiotic for enhancing host defense mechanisms.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shan Lakmal Edirisinghe, Chamilani Nikapitiya, S. H. S. Dananjaya, Jungho Park, Dukgyu Kim, Dongrack Choi, Mahanama De Zoysa
Summary: This study aimed to develop a corneal epithelial injury model in zebrafish and investigate the effectiveness of PDRN treatment on in vivo corneal epithelial regeneration and wound healing. The results showed that PDRN treatment significantly reduced the wounded area of the zebrafish eye, indicating its potential to accelerate corneal re-epithelialization. Transcriptional analysis results revealed that PDRN treatment induced the expression of several genes related to corneal healing. Overall, this study provides important insights into corneal epithelial healing and the potential application of PDRN treatment in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
E. H. T. Thulshan Jayathilaka, Chamilani Nikapitiya, Mahanama De Zoysa, Ilson Whang
Summary: This study successfully encapsulated Octominin into chitosan nanoparticles, resulting in Octominin-CNPs. Octominin-CNPs showed lower toxicity and greater antimicrobial activity against Candida albicans and Acinetobacter baumannii, demonstrating their potential as an effective solution for combating multi-drug-resistant pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Amal Senevirathne, Jehee Lee, Mahanama De Zoysa, Chamilani Nikapitiya
Summary: Bacteriophage KPP-1 is highly effective against multidrug-resistant K. variicola and can significantly suppress its growth, working synergistically with ampicillin. Further research is needed to develop a strategy for controlling the emerging pathogen K. variicola using bacteriophages such as KPP-1.
Article
Fisheries
E. H. T. Thulshan Jayathilaka, S. L. Edirisinghe, Chulhong Oh, Chamilani Nikapitiya, Mahanama De Zoysa
Summary: This study investigates the isolation, physicochemical and molecular characteristics, toxicity, wound healing, and regeneration properties of exosomes derived from olive flounder. The study reveals the presence of specific surface markers and differentially expressed miRNAs in these exosomes, which are involved in various physiological and immunological functions, including wound healing and fin regeneration. The results demonstrate the potential therapeutic applications of these exosomes in wound healing.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Virology
Amal Senevirathne, E. H. T. Thulshan Jayathilaka, D. K. Haluwana, Kiramage Chathuranga, Mahinda Senevirathne, Ji-Soo Jeong, Tae-Won Kim, Jong-Soo Lee, Mahanama De Zoysa
Summary: This study investigated the antiviral activity of aqueous leaf extract of Costus speciosus (TB100) against influenza A. Pretreatment of TB100 enhanced antiviral activity and inhibited viral replication in murine and human cells. TB100 induced the phosphorylation of transcriptional activators associated with interferon pathways, indicating the activation of antiviral defenses. Safety and efficacy tests confirmed that TB100 was effective against different strains of influenza A. Potential antiviral chemicals, including cinnamic, caffeic, and chlorogenic acids, were identified through high-performance liquid chromatography.
Article
Infectious Diseases
Dinusha Chathurangi Rajapaksha, Shan Lakmal Edirisinghe, Chamilani Nikapitiya, Ilson Whang, Mahanama De Zoysa
Summary: In this study, it was found that the antimicrobial peptide octopromycin can inhibit the biofilm and quorum-sensing of Acinetobacter baumannii. Octopromycin reduced biofilm mass, caused a collapse in biofilm architecture, and successfully killed antibiotic-resistant persister cells. It also inhibited violacein production in Chromobacterium violaceum and alginate production, surface movements, and twitching motility of A. baumannii.
Article
Microbiology
Chamilani Nikapitiya, H. P. S. U. Chandrarathna, Mawalle Kankanamge Hasitha Madhawa Dias, Jehee Lee, Mahanama De Zoysa
Summary: A novel phage (KPP-1) infecting Klebsiella variicola was isolated and characterized from a natural water stream. The phage showed inhibitory effects on the growth of K. variicola both in vitro and in vivo. The study suggests that KPP-1 has the potential to be developed as a biocontrol agent against multidrug-resistant K. variicola.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Fisheries
Mawalle Kankanamge Hasitha Madhawa Dias, E. H. T. Thulshan Jayathilaka, Shan Lakmal Edirisinghe, Jae-Woong Lim, Chamilani Nikapitiya, So Young Kang, Ilson Whang, Mahanama De Zoysa
Summary: In this study, octominin, an antimicrobial peptide derived from Octopus minor, was preliminarily tested for its antiviral activity and immune response in fish cells. The results suggest that octominin has potential as an antiviral agent, but further research is needed to understand its mechanism of action.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
J. N. C. Jayasinghe, Ilson Whang, Mahanama De Zoysa
Summary: In this study, Octominin was modified into Octominin II, which showed inhibitory effects on drug-resistant Candida albicans by employing different modes of action and reducing its pathogenicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Chamilani Nikapitiya, Eriyawala Hewage Thimira Thulshan Jayathilaka, Shan Lakmal Edirisinghe, Dinusha C. Rajapaksha, Withanage Prasadini Wasana, Jayasinghage Nirmani Chathurangika Jayasinghe, Mahanama De Zoysa
Summary: This study isolated exosomes from the plasma of rock bream using differential ultracentrifugation and a commercial membrane affinity spin column technique. The kit-based method was found to be more suitable for isolating high-purity exosomes, while UC method showed higher safety in terms of yielding exosomes with low toxicity.