Article
Nanoscience & Nanotechnology
Xin Ting Zheng, Yingying Zhong, Huan Enn Chu, Yong Yu, Yu Zhang, Jiah Shin Chin, David Lawrence Becker, Xiaodi Su, Xian Jun Loh
Summary: Effective wound care requires a comprehensive assessment of healing status. Researchers have developed a carbon dot-doped hydrogel sensor array for the simultaneous colorimetric detection of five wound biomarkers, enabling a holistic assessment of inflammation and infection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Ankita Deb, Gaurav Raghunath Nalkar, Devasish Chowdhury
Summary: The dynamic interplay between nanotechnology and immunoassay has led to the development of a novel immunosensor using carbon dots for the detection of the disease biomarker VEGF. Carbon dots synthesized from a biogenic source were conjugated with a detection antibody and used as fluorescent labels. The immunosensor showed a wide linear range and low detection limit, demonstrating the potential of carbon dots as fluorescent labels in immunoassay techniques.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Nitzan Shauloff, Noa Prishkolnik, Seema Singh, Rajendran Manikandan, Uri Ben Nun, Raz Jelinek
Summary: In this study, a wavelength-specific capacitive photodetector was constructed using carbon dots (C-dots) and thermo-responsive polymer poly-(N-isopropylacrylamide) (PNIPAM). When the C-dot/PNIPAM composite is illuminated, the absorbed light by C-dots is released as heat, causing a rapid temperature increase and resulting in the structural transformation of PNIPAM host and change in capacitance. The wavelength sensitivity of the photodetector is determined by the excitation wavelength of the embedded C-dots, which can be easily tuned by selecting different C-dot species. The C-dot/PNIPAM photodetector exhibits reversible and rapid light response, and it is synthesized from inexpensive and recyclable building blocks. This technology has potential applications in photo-switching, photoinduced capacitors, smart windows, and other photo-electronic devices.
Article
Engineering, Environmental
Wei-Rong Wang, Pei-Yao Chen, Jie Deng, Yu Chen, Hua-Ji Liu
Summary: This study successfully prepared CD hydrogels that efficiently adsorb PFOS through their CD moieties, demonstrating excellent adsorption performance and cycling stability. In practical wastewater treatment, CD hydrogels can effectively remove PFOS and meet environmental protection standards.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Suman Nayak, Prakash Kumar, Ravi Shankar, Asish Kumar Mukhopadhyay, Debabrata Mandal, Prolay Das
Summary: In this study, onion derived biomass DNA was transformed into DNA-dots and used as crosslinkers to create a DNA hydrogel. The hydrogel can sustainably release antibiotics and produce reactive oxygen species with visible light, showing remarkable antibacterial effects against drug-resistant strains.
Article
Engineering, Environmental
Yuhao Weng, Xiaoqian Chen, Huihong Chen, Huilin Yang, Zhigang Gong, Hongliang Tan
Summary: This study developed a hydrogel microreactor GHAP that generates •OH and NO sequentially for synergistic bacterial inactivation, offering a promising solution to combat bacterial infections and antibiotic resistance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Luxuan Yao, Shan He, Yiyu Chen, Huiting Lian, Bin Liu, Chengcai Lai, Xiaofeng Wei
Summary: Abnormal expression of alkaline phosphatase (ALP) in serum is important for health monitoring and disease diagnosis. A ratiometric approach using a carbon dot/cobalt-metal organic framework nanocoral mediated fluorescence-scattering sensor has been developed for simple and highly sensitive detection of ALP. The sensor effectively converted ALP into a ratio signal of fluorescence-scattering dual emission with a wide linear range of detection and improved sensitivity in serum.
Article
Nanoscience & Nanotechnology
Xue-Chun Yang, Yun-Ling Yang, Meng-Meng Xu, Shan-Shan Liang, Xiao-Long Pu, Jian-Feng Hu, Qian-Li Li, Jing-Tai Zhao, Zhi-Jun Zhang
Summary: Nitrogen-doped carbon dots (NCDs) synthesized by low-temperature sintering show electronegativity rich in -COO-, -CO-NH-, -NH-, and -OH, and can effectively remove heavy metal ions from water, particularly Pb2+, with a removal rate of up to 94.8%.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Jingxin Zhou, Ran Wang, Weiwei Su, Lexin Zhang, Adan Li, Tifeng Jiao
Summary: In this study, phenylboronic acid functionalized reduced graphene oxide and polyhydroxy modified carbon dot fluorescent probe were designed for the rapid and sensitive detection of small molecule glucose.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Srikrishna Tummala, Rajkumar Bandi, Yen-Peng Ho
Summary: A nanozyme composite prepared by crosslinking Cu-doped carbon dots with chitosan shows promise for detecting H2O2 and glucose, with good linear range and detection limits. It also possesses biodegradability and ease of handling.
Article
Chemistry, Applied
Xu Yang, Peili Li, Wentao Tang, Shoukang Du, Meizhe Yu, Haojie Lu, Huaping Tan, Xiaodong Xing
Summary: An injectable self-healing carbon dot hydrogel was prepared using c-poly(L-lysine) carbon dot and oxidized dextran, exhibiting outstanding antibacterial properties with the ability to rapidly kill S. aureus and achieve complete healing within seconds after severe damage.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Analytical
Tong Bu, Feier Bai, Shuang Zhao, Xinyu Sun, Pei Jia, Kunyi He, Ying Wang, Qing Li, Li Wang
Summary: The rapid detection of toxins is crucial for food security and human health. In this study, a dual-modality immunochromatographic test using Staphylococcus aureus-biosynthesized polymer dots was developed for sensitive monitoring of zearalenone in agro products. The results showed that this method has high sensitivity and feasibility, making it suitable for on-site testing in real-life scenarios.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Composites
Yiying Yue, Jiamin Gu, Wanli Cheng, Guangping Han, Jingquan Han, Jianchun Jiang
Summary: A portable, sensitive, rapid, specific, and environment-friendly PB hydrogel fluorescence probe was synthesized for the sequential sensing of Cu2+ and OTC in wastewater.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Rongzhen Li, Lian Li, Bin Wang, Liping Yu
Summary: In this study, a photonic crystal structure was utilized to enhance the luminescence performance of fluorescent hydrogel, allowing it to be used as a fluorescence sensor for detecting nitrite in water with good selectivity. The hydrogel was endowed with fluorescence properties by PEI-CdS QDs, while the photonic crystal structure significantly enhanced the fluorescence emission capability, with a detection limit lower than the maximum limit for nitrite in drinking water.
Article
Chemistry, Analytical
Hyeong Jun Jo, Akhmad Irhas Robby, Seul Gi Kim, Gibaek Lee, Byung Chan Lee, Sung Young Park
Summary: A smartphone-based electrochemical biosensor using boronic acid-modified polymer dot coated electrode was developed for detecting bacterial contamination. It showed high sensitivity, low LOD, and reusability, with good selectivity towards bacteria in real environmental samples. The biosensor offers a simple approach for bacteria monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Shani Ben Zichri, Sofiya Kolusheva, Alexander Shames, Elina Abaev Schneiderman, Juan L. Poggio, David E. Stein, Elena Doubijensky, Dan Levy, Zulfiya Orynbayeva, Raz Jelinek
Summary: The study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells to normal mitochondria, revealing significant cancer-induced membrane changes that may be targeted by anti-cancer molecules. The findings highlight the relationship between cancer and mitochondrial membrane transformations, suggesting a potential therapeutic significance of mitochondrial membrane targeting in cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Materials Science, Multidisciplinary
Rajesh Bisht, Vartika Dhyani, Raz Jelinek
Summary: Polydiacetylenes, specifically aminoanthraquinone-substituted ones, exhibit aggregation-dependent chromatic properties influenced by the alignment of headgroups and sidechains; film organization and optical properties are determined by solvent polarity and intermolecular interactions, allowing for solvochromic, thermochromic, and mechanochromic effects.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ashim Paul, Guru KrishnaKumar Viswanathan, Adi Huber, Elad Arad, Hamutal Engel, Raz Jelinek, Ehud Gazit, Daniel Segal
Summary: The dopamine-based hybrid molecule NQDA effectively inhibits the aggregation of key tau-derived amyloidogenic fragments PHF6 and PHF6*, as well as full-length tau protein, in in vitro experiments. It disassembles preformed fibrils and demonstrates significant binding efficiency with tau fibrils through entropic and enthalpic processes. NQDA shows comparable or lower IC50 values for inhibiting fibril formation compared to other amyloid inhibitors, suggesting its potential as a scaffold for developing therapeutics for Alzheimer's disease and other tauopathies.
Article
Chemistry, Multidisciplinary
Sathish Rajendran, Shani Ben Zichri, Varsha Usha Vipinachandran, Raz Jelinek, Susanta Kumar Bhunia
Summary: This research presents a novel type of carbon dots that can serve as both mitochondrial labeling agents and tetracycline sensors, exhibiting a high quantum yield of fluorescence. These carbon dots have the ability to recognize cellular mitochondria and rapidly detect tetracycline in a quenching response.
Article
Biochemistry & Molecular Biology
Segev Naveh Tassa, Shani Ben Zichri, Shiran Lacham-Hartman, Ofek Oren, Zeev Slobodnik, Ekaterina Eremenko, Debra Toiber, Raz Jelinek, Niv Papo
Summary: This study demonstrates that a nonaggregating A beta 42 double mutant can act as a multispecific binder to inhibit the function of AD-associated molecules and protect neuronal cells from toxic damage.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Nitzan Shauloff, Ahiud Morag, Karin Yaniv, Seema Singh, Ravit Malishev, Ofra Paz-Tal, Lior Rokach, Raz Jelinek
Summary: This study presents a method for continuous, real-time monitoring and identification of bacteria by detecting microbially emitted volatile molecules using the principle of capacitance changes. By utilizing interdigitated electrodes coated with carbon dots, the artificial nose is able to sense and distinguish volatile molecules of different polarities, showing excellent selectivity and accuracy.
NANO-MICRO LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Amrita De Adhikari, Nitzan Shauloff, Yury Turkulets, Ilan Shalish, Raz Jelinek
Summary: Transition metal dichalcogenides, specifically the WS2-PANI composite electrodes, have been found to exhibit excellent electrochemical properties and high frequency response in supercapacitors. The highly porous structure of the WS2-PANI device enables rapid ion transport and surface access, contributing to the rapid reversible redox reactions and high frequency pseudocapacitive profile of the device. The symmetric WS2-PANI supercapacitor demonstrates significantly higher capacitance at a frequency of 120 Hz, showing potential for high frequency applications like AC line filtering and energy storage.
ADVANCED ELECTRONIC MATERIALS
(2021)
Article
Microbiology
Orit Malka, Dorin Kalson, Karin Yaniv, Reut Shafir, Manikandan Rajendran, Oshrit Ben-David, Ariel Kushmaro, Michael M. Meijler, Raz Jelinek
Summary: A study revealed a new fungus-secreted metabolite that can inhibit bacterial communication and virulence, shedding light on the potential benefits of probiotic foods and maintenance of a healthy gut microbiome. The discovery of cross-kingdom interference in quorum sensing may play important roles in enabling microorganism co-existence in multi-population environments, such as probiotic foods and the gut microbiome. This finding may contribute to understanding the health benefits of probiotic products against bacterially associated diseases.
Article
Chemistry, Physical
Seema Singh, Nitzan Shauloff, Chetan Prakash Sharma, Ran Shimoni, Christopher J. Arnusch, Raz Jelinek
Summary: Facemasks are essential in preventing infection and viral spread, highlighting the need for recyclable masks to reduce environmental damage and health risks from disposable masks. A study showed nanoporous membranes made of carbon dots and PVDF could potentially be used for recyclable, self-sterilized facemasks. The composite films have a hydrophobic surface, a compact nanopore network, and can self-sterilize upon short solar irradiation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Reut Israeli, Sofiya Kolusheva, Pablo Mateos-Gil, Electra Gizeli, Raz Jelinek
Summary: The study introduced composite nanoparticles comprising PDA and a dendritic amphiphilic polymer, showing potential applications in diverse biological and chemical diagnostic fields.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Linoy Dery, Nitzan Shauloff, Yury Turkulets, Ilan Shalish, Raz Jelinek, Daniel Mandler
Summary: Monitoring nanoparticles in air and aquatic environments is a challenge, and current technologies are not ideal. However, a method called nanoparticle-imprinted matrices shows promise for size-selective detection.
Article
Biophysics
Elad Arad, Raz Jelinek, Hanna Rapaport
Summary: This study demonstrates the potential application of functionalized titania nanoparticles for labeling and separating mature amyloid fibrils from solution.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Rajendran Manikandan, Nitzan Shauloff, Ashim Nandi, Alexander Pevzner, Sharon Marx, Raz Jelinek
Summary: This study demonstrates a donor/acceptor dibenzylidine derivative that enables rapid and specific visual detection of organophosphate gas molecules through internal charge transfer and aggregation-induced emission effects. By tuning the electron donating/withdrawing capacities of the pendant residues, both positive and negative solvatochromism and distinct aggregation-induced emission behavior were observed. The release of halogens facilitated chemical reactions with specific organophosphate molecules, leading to visible color changes.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Biochemistry & Molecular Biology
Ravit Malishev, Nir Salinas, James Gibson, Angela Bailey Eden, Joel Mieres-Perez, Yasser B. Ruiz-Blanco, Orit Malka, Sofiya Kolusheva, Frank-Gerrit Klaemer, Thomas Schrader, Elsa Sanchez-Garcia, Chunyu Wang, Meytal Landau, Gal Bitan, Raz Jelinek
Summary: This study demonstrates that molecular tweezers can modulate biofilm formation of Staphylococcus aureus, with CLR01 significantly inhibiting biofilm formation and disrupting PSM alpha 1 assembly, while CLR05, containing methylenecarboxylate units, disrupts biofilm more strongly despite lower lysine residues affinity. Molecular tweezers may serve as potent biofilm inhibitors and antibacterial agents against bacteria producing biofilms and PSM.
CELL CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satabdee Mohapatra, Guru Krishna Kumar Viswanathan, Lukas Wettstein, Elad Arad, Ashim Paul, Vijay Kumar, Raz Jelinek, Jan Munch, Daniel Segal
Summary: Human semen contains amyloidogenic peptides that can enhance HIV-1 infection. Vitamin C has a concentration-dependent effect on the formation of amyloid fibrils derived from PAP(248-286). Low molar ratios of vitamin C promote fibril formation while high molar ratios inhibit it.
RSC CHEMICAL BIOLOGY
(2021)
