Article
Food Science & Technology
Pin Chen, Xiaoqian Chen, Wei Yu, Bo Zhou, Lihua Liu, Yuzhuo Yang, Peng Du, Libo Liu, Chun Li
Summary: This experiment investigated the effects of the antibiotic Ciprofloxacin on key enzymes and intracellular metabolites of Lactobacillus plantarum DNZ-4. The results showed that Ciprofloxacin significantly decreased the activity of certain enzymes and caused changes in intracellular fatty acids, carbohydrates, and amino acids. These findings are important for the development of effective probiotics preparation products.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Chao Tang, Weiwei Zhou, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu
Summary: This study found that the probiotic Lactobacillus plantarum Q16 modulates lipid and energy metabolism, improves lipid profile, and regulates colonic microbiota composition to protect against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Agriculture, Multidisciplinary
Bo Yang, He Gao, Hui Qi, Yang Chen, R. Paul Ross, Catherine Stanton, Jianxin Zhao, Hao Zhang, Haiqin Chen, Wei Chen
Summary: The linoleate isomerase complex in Lactobacillus plantarum ZS2058 plays a crucial role in CLA production and metabolism, and contributes to improving DSS-induced colitis. Knockout mutants exhibit effects similar to the DSS group, while complementation of the corresponding gene can restore anti-inflammatory activity, repairing the integrity of the mucus layer.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Neelja Singhal, Nambram Somendro Singh, Shilpa Mohanty, Manish Kumar, Jugsharan Singh Virdi
Summary: The study reported the isolation and evaluation of probiotic capabilities of Lactiplantibacillus plantarum strains from rhizospheric soil, which showed strong hypocholesterolemic potential and resistance to various environmental stresses, as well as exhibited resistance to acidic environment and multiple antibiotics. Further investigation is recommended for its potential as a potent probiotic with hypocholesterolemic biotherapeutic benefits, and the potential of exploring rhizosphere as a niche for isolating microorganisms with probiotic potential.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Yue Teng, Yu Wang, Wu-yang Guan, Chao Wang, Han-song Yu, Xia Li, Yu-hua Wang
Summary: The beneficial effects of Lactobacillus plantarum LP104 on lipid level and disordered gut microbiota in mice fed a high-fat diet were investigated in this study. The results showed that LP104 supplementation could alleviate body weight gain, liver index increase, colon length reduction, as well as improve TC, TG, LDL, TNF alpha, and LPS levels. High-throughput sequencing analysis revealed that long-term high-fat diet negatively affected microbial abundance and composition in the gut, but LP104 supplementation reduced the ratio of Firmicutes to Bacteroides and positively regulated the gut microbiota community structure. Additionally, the intake of LP104 also increased the abundance of beneficial bacteria Bifidobacterium in the cecum, which improved the intestinal flora disorder induced by a high-fat diet. These findings suggest that LP104 supplementation can improve high-fat diet-induced hyperlipidemia by positively regulating intestinal microorganisms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biotechnology & Applied Microbiology
Xianlin He, Bo Liu, Yali Xu, Ze Chen, Hao Li
Summary: The presence of Lactobacillus plantarum can increase the ethanol tolerance of Saccharomyces cerevisiae by promoting or inhibiting various metabolic processes in the yeast cells, and the maintenance of this tolerance depends on the coexistence of both organisms. The study also suggested a complex relationship between yeast and contaminating LAB, which may play a beneficial role in fermentation by promoting the ethanol tolerance of yeast.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu-Hang Fan, Yi-Lin Shen, Zhi-Wei Lin, Ying Zhou, Bang-Ce Ye
Summary: The experimental results demonstrated that exopolysaccharide and the cell wall of Lactobacillus plantarum CGMCC18980 were involved in the adsorption of di-butyl phthalate (DBP). Scanning electron microscope (SEM) and transmission electron microscope (TEM) images showed an obvious adsorption layer around the bacteria. Fourier transform infrared spectroscopy (FTIR) results indicated the presence of functional groups C=O, C-N, and C-O, which were mainly related to lipids and polysaccharides.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yu Wang, Xinyue Xing, Yuxuan Ma, Yuling Fan, Yue Zhang, Bo Nan, Xia Li, Yuhua Wang, Jingsheng Liu
Summary: This study aimed to investigate the mechanism of Lactobacillus plantarum LP104 in alleviating dyslipidemia induced by a high-fat diet. The results showed that oral administration of LP104 reduced body weight gain, body fat, and serum hepatic dyslipidemia in mice. LP104 treatment increased the concentrations of certain bile acids and suppressed specific signaling pathways, leading to the synthesis of new bile acids and cholesterol efflux. Moreover, LP104 intervention promoted the rebalance of intestinal flora and its correlation with bile acid signaling molecules. These findings suggest that LP104 has the potential to be used as a natural functional food for dyslipidemia prevention.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Ross Vermeulen, Shelly Deane, Leon Dicks, Johann Rohwer, Anton Du Preez van Staden
Summary: Plantaricin 423 is produced by Lactobacillus plantarum 423 using the biosynthetic operon located on a plasmid. The regulation of class Ila bacteriocins seems to be linked to transition metal homeostasis in the host, as shown by the upregulation of plantaricin 423 in response to manganese privation. This metalloregulatory model may have implications for bacteriocin expression and gene transfer dynamics in a given microbiome.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Taro Ko, Hiroki Murakami, Azusa Kamikouchi, Hiroshi Ishimoto
Summary: Lactic acid bacteria (LAB) have multiple influences on host brain function through the production of active metabolites in the gut. However, little is known about the biogenic effects of LAB on host brain function. In this study, we found that the Lactobacillus plantarum SBT2227 promoted sleep in Drosophila melanogaster and the involvement of neuropeptide F in this sleep-promoting action.
Article
Biology
Sujuan Ding, Wenxin Yan, Jun Fang, Hongmei Jiang, Gang Liu
Summary: The study demonstrates that Lactobacillus plantarum can alleviate colitis induced by dextran sulfate sodium, with effects on the colonic microbial community and serum metabolites. This research may offer a potential therapeutic strategy for colitis.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dong Yun Kim, Jun Yong Park, Heon Yung Gee
Summary: In this study, L. plantarum treatment was found to significantly reduce liver inflammation and improve metabolic phenotypes in a mouse model of NASH. The therapeutic effect was attributed to the increase in circulating L-arginine.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Qingqing Zhou, Bingyao Xue, Rongcheng Gu, Ping Li, Qing Gu
Summary: The study found that Lactobacillus plantarum ZJ316 had significant anti-H. pylori ability, decreased IFN-gamma and IL-6 levels, increased IL-10 levels, repaired mucosal damage, and reduced the abundance of H. pylori. Different microbial families were more prevalent in the prevention and treatment groups, indicating that L. plantarum ZJ316 could be a potential candidate for the prevention and treatment of H. pylori-induced gastritis by modulating the gastric microbiota and reducing mucosal inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shuxin Tang, Yuxin Cheng, Tingting Xu, Ting Wu, Siyi Pan, Xiaoyun Xu
Summary: Mulberry pomace, rich in phytochemicals, could be utilized as a hypoglycemic food ingredient through fermentation with Lactobacillus plantarum, which enhances its protective effects and reduces glucose levels under hyperglycemic conditions.
Article
Nutrition & Dietetics
Chih-Yu Chien, Yu-Jou Chien, Yung-Hao Lin, Yung-Hsiang Lin, Shu-Ting Chan, Wei-Chun Hu, Han-Fang Wu, Chi-Fu Chiang, Chin-Lin Hsu
Summary: Lactobacillus plantarum can improve hyperuricemia and the composition of intestinal microbiota.
Article
Nutrition & Dietetics
Botao Wang, Qingmin Kong, Shumao Cui, Xiu Li, Zhennan Gu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: In this study, it was found that B. adolescentis strains isolated from the feces of elderly humans can alleviate obesity in mice, while strains isolated from newborns may increase body weight. The effects on lipid metabolism and immunity regulation varied depending on the source of the strains, indicating potential origin-specific functions being transmitted to the host.
Article
Microbiology
Jin Xing, He Yufeng, Zhou Yonghua, Chen Xiaohua, Lee Yuan-Kun, Zhao Jianxin, Zhang Hao, Chen Wei, Wang Gang
Summary: This study established a lifespan model of C. elegans to counter C. jejuni infection, revealing different abilities of LAB in protecting C. elegans against infection and identifying potential protective mechanisms of certain LAB strains. The reliability of the C. elegans lifespan model was verified using mice and chickens infected with C. jejuni.
Article
Biochemistry & Molecular Biology
Yufeng He, Liya Mei, Luyao Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: This study found that Lactiplantibacillus plantarum CCFM1019 can alleviate letrozole-induced PCOS symptoms, restore ovarian pathological changes, and improve metabolic disorders through the modulation of gut microbiota. This protective effect may be related to a butyrate-dependent gut-brain mechanism.
Article
Nutrition & Dietetics
Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Alzheimer's disease is characterized by global metabolic alterations, leading to cognitive impairment. This study found that B. breve CCFM1025 intervention can restore the metabolic changes induced by Aβ injection, particularly in amino acid metabolism.
Article
Biochemistry & Molecular Biology
Linlin Wang, Ting Jiao, Qiangqing Yu, Jialiang Wang, Luyao Wang, Gang Wang, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: The occurrence of non-alcoholic fatty liver disease (NAFLD) is closely related to intestinal microbiota disturbance. This study found that Bifidobacterium exerts species-specific effects on NAFLD, alleviating the disease by regulating the relative abundance of intestinal microbiota, increasing the levels of propionic acid and butyric acid, regulating lipid metabolism and intestinal permeability.
Review
Food Science & Technology
Xin Qian, Peijun Tian, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: The presence of lactic acid bacteria (LAB) as probiotics in the harsh intestinal environment is usually temporary. Quorum sensing (QS), a form of bacterial communication based on signaling molecules, has gained attention for its important role in regulating LAB properties that support colonization in the intestines. QS is also involved in autolysis and bacteriocin production by LAB, which are essential processes for the application of these species as probiotics or starter cultures. This review discusses LAB's QS systems, the factors that may affect QS, the impact of QS on LAB's intestinal colonization, and the possible interactions mediated by QS between probiotics and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Qingmin Kong, Qian Chen, Xuhua Mao, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: The kynurenine pathway (KP) is abnormal in autistic patients and model animals. A study found that Bifidobacterium longum (B. longum) CCFM077 can enhance the gut microbiome and KP metabolism, regulate neurotransmitter levels and neuroinflammation, and alleviate autistic-like behaviors. This suggests that B. longum CCFM077 has the potential to be used as a therapeutic treatment for autism through the intestinal and neural pathways.
Review
Nutrition & Dietetics
Chunxiu Lin, Yugui Lin, Heng Zhang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This review discusses the role of gut microbiota in educating the neonatal immune system, focusing on the importance of infant-type bifidobacteria during the first 1000 days of life. It highlights the immune tolerance and intestinal inflammation suppression induced by infant-type bifidobacteria, as well as the potential underlying mechanisms. Recent research suggesting the administration of infant-type bifidobacteria for modifying the intestinal microecology and preventing immune-mediated disorders is also summarized.
Article
Nutrition & Dietetics
Qianqian Wang, Yufeng He, Xiu Li, Ting Zhang, Ming Liang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: Cardiovascular disease, mainly caused by atherosclerosis, is one of the leading causes of morbidity and mortality worldwide. Hypercholesterolemia and hyperlipidemia are the major risk factors for the development of atherosclerosis. Lowering serum cholesterol and triglyceride levels is considered an effective strategy in preventing atherosclerotic cardiovascular disease. The gut microbiota dysbiosis has been associated with various diseases, and probiotic intervention has shown potential in preventing or treating certain diseases. This study demonstrated that treatment with Lactobacillus reuteri CCFM8631 reduced cholesterol levels and improved gut microbiota composition, leading to the alleviation of hypercholesterolemia.
Article
Nutrition & Dietetics
Mengshu Xu, Peijun Tian, Huiyue Zhu, Renying Zou, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Supplementation with certain Lactobacillus strains has been found to have positive effects in reducing depressive and anxiety behaviors, increasing concentrations of serotonin and brain-derived neurotrophic factor in the brain, and regulating purine metabolism. These findings suggest a potential role of Lactobacillus in alleviating symptoms of depression and anxiety.
Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Article
Environmental Sciences
Qian Chen, Qingmin Kong, Peijun Tian, Yufeng He, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study demonstrates that LAB strains with outstanding DEHP/MEHP binding capacities can facilitate the elimination of DEHP and its metabolite MEHP, decrease DEHP and MEHP levels in serum, and alleviate DEHP-induced liver and testicular injuries. Furthermore, these LAB strains modulate the gut microbiota and increase the concentrations of faecal propionate and butyrate, thus regulating host metabolism-related pathways. LAB with powerful bio-binding capacity of DEHP and MEHP can be considered as a potential therapeutic dietary strategy against DEHP exposure.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Linlin Wang, Mao Chai, Jialiang Wang, Qiangqing Yu, Gang Wang, Hao Zhang, Jianxin Zhao, Wei Chen
Summary: This study found that Bifidobacterium longum can relieve constipation by regulating the intestinal barrier, enhancing intestinal motility, improving water and electrolyte metabolism, inhibiting inflammation, and preventing loperamide-induced intestinal barrier damage.
Article
Biochemistry & Molecular Biology
Peijun Tian, Ying Chen, Xin Qian, Renying Zou, Huiyue Zhu, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: The Pediococcus acidilactici strain CCFM6432 has shown psychobiotic potential by improving gut microbial composition, regulating anxiety-like behaviors, and reducing HPA axis hyperactivity. Its key compound for antimicrobial activity was confirmed to be lactic acid, paving the way for potential mental health management during daily life, especially amid the COVID-19 pandemic.
Article
Biochemistry & Molecular Biology
Caixin Ni, Xin Li, Linlin Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study demonstrated the therapeutic effects of several LAB strains on a mouse model of hyperuricaemia by promoting the production of short-chain fatty acids, leading to reduced uric acid levels. Importantly, this effect was independent of purine degradation, providing a novel therapeutic approach for hyperuricaemia.