Synthesis and biological evaluation of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimidin-2-amine derivatives as PLK4 inhibitors for the treatment of breast cancer

Solubility determination and correlation for o -phenylenediamine in (methanol, ethanol, acetonitrile and water) and their binary solvents from T = (283.15–318.15) K

(2017) Ganbing Yao et al.   JOURNAL OF CHEMICAL THERMODYNAMICS

Design and optimization of (3-aryl-1 H -indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

(2016) Sze-Wan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Dynamic BRG1 Recruitment during T Helper Differentiation and Activation Reveals Distal Regulatory Elements

(2011) S. De et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Viability Profiles of Breast Cancer

(2011) R. Brough et al.   Cancer Discovery

Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

(2010) Christian Tovar et al.   CELL CYCLE

Polo-like kinase 4: the odd one out of the family

(2010) James E Sillibourne et al.   Cell Division

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL