期刊
RSC ADVANCES
卷 7, 期 84, 页码 53385-53395出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra11036g
关键词
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资金
- Special Fund Project of Application-oriented for Science and Technology, Research and Development of Guangdong Province [2015B020230001]
- Major Special Project of Industry-University-Research Collaborative Innovation of Guangzhou City [201508020086]
- Project of Technology Research Center for Lingnan Characteristic Fruits & Vegetables Processing and Application Engineering of Guangdong Province [[2015]1487]
- Project of Food Science Innovation Team of Guangdong Higher Education Institutes [2016KCXTD020]
The present study aims to improve the biological activities of luteolin by complexation with manganese(II). UV-visible spectroscopy, infrared spectroscopy, thermogravimetric analysis and elemental analysis were adopted to assess the relevant interaction of luteolin and manganese(II) ions and the chelation sites. The antioxidant activity, hypoglycemic effect and antimicrobial activity of luteolin-manganese(II) complex with respect to its parent luteolin and the inhibition effect of which on xanthine oxidase were investigated and compared. The spectroscopic data indicated that luteolin reacts with manganese(II) cations through the chelation sites of 5-hydroxy and 4-carbonyl in two luteolin molecules. Antioxidant and antibacterial activity were enhanced after the complexation of manganese(II) cations with luteolin. An inhibition effect assay found that luteolin and luteolin-manganese(II) complex reversibly inhibited xanthine oxidase in a competitive manner. Luteolin-manganese(II) complex had a more remarkable hypoglycemic effect than luteolin by increasing the glucose consumption in liver tissue.
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