Article
Chemistry, Analytical
Xian-Na Wang, Bin Li
Summary: Gold nanoparticles/thiol-beta-cyclodextrin-functionalized TiO2 nanowires were prepared to enhance the performance of SALDI MS and MSI, showing superior detection sensitivity and repeatability.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xufang Hu, Zongping Wang, Haolin Chen, An Zhao, Nianrong Sun, Chunhui Deng
Summary: An advanced metabolic analysis tool based on highly porous metal oxides derived from metal-organic frameworks (MOFs) is developed in this study. The tool successfully differentiates and stages renal cell carcinoma (RCC), as well as identifies the size of tumors. This achievement shows promising prospects for designer matrix-based analytical tools in disease diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Lanaia Itala Louzeiro Maciel, Ricardo Alves Bernardo, Rafael Oliveira Martins, Almir Custodio Batista Jr, Joao Victor Ataide Oliveira, Andrea Rodrigues Chaves, Boniek Gontijo Vaz
Summary: The imaging of biological tissues using mass spectrometry imaging (MSI) techniques allows for the visualization of the distribution of various metabolites, drugs, lipids, and glycans in complex samples. MSI methods like DESI-MSI and MALDI-MSI provide high sensitivity and the ability to evaluate/visualize multiple analytes in a single sample, overcoming limitations of classical microscopy techniques. This review discusses the application of DESI-MSI and MALDI-MSI in evaluating exogenous and endogenous molecules in biological samples, providing technical insights and recent research findings.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ouyang Dan, Chuanzhe Wang, Chao Zhong, Juan Lin, Gang Xu, Guane Wang, Zian Lin
Summary: In this study, novel LDI-MS substrates were designed to enhance the sensitivity of mass signals and achieve high accuracy diagnosis of different saccharides and central precocious puberty (CPP).
Article
Chemistry, Physical
Dong Chen, Mingyi Du, Yudi Huang, Yizhu Xu, Yingying Chen, Lianlian Ma, Qingrong Xie, Xinhai Zhu, Zilong Chen, Hanhong Xu, Xinzhou Wu, Zhibin Yin
Summary: Mass spectrometry imaging (MSI) enables the characterization of small-molecule metabolites within biological tissues. However, current matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has limitations. Surface-assisted LDI-MS (SALDI-MS) using the AuNP-hPDA-TDNT substrate shows superior performance for the detection and imaging of small biomolecules. The substrate has reduced background interference and allows visualization of various metabolites and lipids.
Article
Chemistry, Physical
Dong Chen, Mingyi Du, Yudi Huang, Yizhu Xu, Yingying Chen, Lianlian Ma, Qingrong Xie, Xinhai Zhu, Zilong Chen, Hanhong Xu, Xinzhou Wu, Zhibin Yin
Summary: Mass spectrometry imaging (MSI) enables the characterization of small-molecule metabolites in biological tissues. However, existing techniques suffer from background interference and inhomogeneous matrix deposition. This study presents a new composite substrate that overcomes these limitations and demonstrates superior performance for the detection and imaging of small biomolecules.
Article
Chemistry, Analytical
Frederic Fournelle, Nidia Lauzon, Ethan Yang, Pierre Chaurand
Summary: Traditionally, MALDI IMS requires the deposition of an organic matrix, which often generates high background noise in the low mass range. LDI offers selective ionization with low background in the low mass range. This article discusses the advantages and disadvantages of solvent free and wet deposition of metals as LDI matrices and demonstrates the power of metal-assisted LDI for analyzing low molecular weight molecules in tissue sections.
MICROCHEMICAL JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Norihiro Mizoshita, Yuri Yamada, Masakazu Murase, Yasutomo Goto, Shinji Inagaki
Summary: In this study, a nanostructured organosilica substrate was designed and synthesized for efficient and rapid detection of peptides and small proteins. The surface functionality of the substrate was tuned at a molecular level, enabling both lowering surface free energy and introducing weak anchoring sites for biomolecules. The organosilica substrate showed great potential in detecting various compounds, including drugs and biomarkers for Alzheimer's disease.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Norihiro Mizoshita, Yuri Yamada, Masakazu Murase, Yasutomo Goto, Shinji Inagaki
Summary: A nanostructured organosilica substrate is designed and synthesized for efficient and rapid detection of peptides and small proteins using laser desorption/ionization mass spectrometry. Surface functionality of the substrate is tuned to lower surface free energy and introduce weak anchoring sites for analyte molecules, enabling homogenous distribution and easy desorption upon laser irradiation. The substrate shows potential for easy detection of a wide range of biomolecules, including amyloid beta protein fragments as a biomarker for Alzheimer's disease.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Enhui Wu, Jia Yi, Baohong Liu, Liang Qiao
Summary: A rapid bacterial viability assessment and antimicrobial susceptibility testing method using LDI-MS technology was developed, showing higher efficiency than traditional methods. This method demonstrated high efficiency with different bacterial species and antibiotic drugs, and can be applied to human body fluid samples for antibiotic drug screening.
Article
Chemistry, Multidisciplinary
Moon-Ju Kim, Tae Gyeong Yun, Joo-Yoon Noh, Zhiquan Song, Hong-Rae Kim, Min-Jung Kang, Jae-Chul Pyun
Summary: The study developed a hybrid matrix of nanoporous Au-modified TiO2 nanowires for enhanced LDI-MS performance. The improvement in the hybrid matrix was attributed to the laser-induced surface restructuring/melting phenomenon, promoting internal energy transfer and enhancing the ionization process through structural changes on the surface.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Yuri Yamada, Kenichi Yatsugi, Masakazu Murase, Norihiro Mizoshita
Summary: This paper reports on the use of TiN nanopillars as a robust analytical substrate for laser desorption/ionization mass spectrometry (LDI-MS), which showed promising results in various analyte detection with low noise interference and no fragmentation. The development of nanostructured TiN substrates is expected to contribute to the widespread implementation of nanostructured solid substrates for biomedical and clinical applications.
Article
Biochemical Research Methods
Ari Chae, Gwanwon Lee, Dong-Yeun Koh, Cheol-Min Yang, Sungho Lee, Young-Kwan Kim
Summary: Carbon fiber (CNF), prepared from electrospun PAN fibers, shows high salt tolerance, sensitivity, and resolution for matrix-free LDI-MS analysis, making it a promising material for developing an efficient and universal platform for analyte analysis regardless of ionization modes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Hua Zhang, Lin Zhao, Jingjing Jiang, Jie Zheng, Li Yang, Yanyan Li, Jian Zhou, Tianshu Liu, Jianmin Xu, Wenhui Lou, Weige Yang, Lijie Tan, Weiren Liu, Yiyi Yu, Meiling Ji, Yaolin Xu, Yan Lu, Xiaomu Li, Zhen Liu, Rong Tian, Cheng Hu, Shumang Zhang, Qinsheng Hu, Yangdong Deng, Hao Ying, Sheng Zhong, Xingdong Zhang, Yunbing Wang, Hua Wang, Jingwei Bai, Xiaoying Li, Xiangfeng Duan
Summary: As cancer is increasingly seen as a metabolic disorder, serum metabolite profiling is proposed as a viable method for detecting cancer. In this study, a machine learning model using mass spectrometry-based liquid biopsy data is reported for pan-cancer screening and classification. The Multiplexed Nanomaterial-Assisted LDI for Cancer Identification (MNALCI) achieves high sensitivity and specificity for distinguishing cancers from healthy controls and accurately identifying the tissue of origin of tumors. This high throughput assay shows promising potential for non-invasive cancer diagnosis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Wei Chen, Haojun Yu, Yong Hao, Wanshan Liu, Ruimin Wang, Yida Huang, Jiao Wu, Lei Feng, Yangtai Guan, Lin Huang, Kun Qian
Summary: Timely screening and differential diagnosis of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein associated disorder (MOGAD) are crucial for improving patients' quality of life. This study developed a fast metabolic fingerprint analysis method using nanoparticle-enhanced laser desorption/ionization mass spectrometry, which achieved high accuracy in diagnosing NMOSD and revealed comprehensive information about metabolic dysregulation. By combining metabolic fingerprints from plasma and cerebrospinal fluid, NMOSD and MOGAD could be effectively differentiated. This approach outperformed human experts, especially in regions with limited antibody testing.
Article
Chemistry, Applied
Mahmoud R. Saleh, Haitham M. El-Bery, Hani Nasser Abdelhamid
Summary: A wet-incipient impregnation method was used to synthesize hierarchical porous bimetallic (Co, Zn)-zeolitic imidazolate frameworks (ZIF-8)/TiO2 for efficient photocatalytic water splitting. Co@ZIF-8/TiO2 exhibited significantly higher photocatalytic efficiency than TiO2, with a hydrogen generation rate of 13 mmol·h(-1)·g(-1) and a 151-fold increase in catalytic performance. The hierarchical porous structure of Co@ZIF-8 facilitated charge transfer and provided efficient transport channels. This study demonstrates the potential of hierarchical porous metal-organic frameworks (MOFs) as support and promoter in photocatalytic applications of TiO2.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid
Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Walid Sharmoukh, Hani Nasser Abdelhamid
Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid
Summary: Metal-organic frameworks (MOFs) have shown great potential for industrial applications but current synthesis processes limit their use due to the powder form. A solvothermal method was used to grow copper-based MOFs onto a cotton textile, creating a material called CuBDC@Textile. CuBDC@Textile demonstrated excellent vapor sensing properties and high adsorption capacity for pyridine. This dual-functional material holds promise for further research on MOFs in textile applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Numa A. A. Althubiti, T. A. Taha, A. A. Azab, Hani Nasser Abdelhamid
Summary: The use of solid-state materials such as sodium borohydride for hydrogen storage and release can meet the requirements of the "Hydrogen Economy". This study investigated ZnO-based materials as catalysts for hydrogen release through the hydrolysis of NaBH4. The synthesis method produced nanocomposites consisting of ZnO-xTiO(2) and ZnO-xCeO(2) (x = 5 wt.% or 10 wt.%). Characterization techniques confirmed the phase purity and optical properties of the materials. The materials exhibited a high hydrogen generation rate and different activation energies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Shamsa Kizhepat, Akash S. Rasal, Jia-Yaw Chang, Hui-Fen Wu
Summary: The recent progress in functional nanomaterials and nanostructure engineering has opened up new possibilities for the development of field-ready biosensors. Two-dimensional (2D) nanomaterials, with their ultra-thin structures, exhibit exceptional physical, chemical, anisotropic, chemically active, and mechanical properties. The surface characteristics of 2D nanomaterials can be engineered to enable targeted identification, thus improving the reliability, selectivity, and sensitivity of biosensing platforms. This review summarizes various approaches to using 2D nanomaterials for biomolecule detection, discusses the advantages and disadvantages of their use in biosensing, and explores the opportunities and challenges in this promising field.
Article
Green & Sustainable Science & Technology
Raju Gurung, Nallin Sharma, Chia Hung Chi, C. Srivastava, Hui-Fen Wu
Summary: A recent surge in the study of a room temperature afterglow nanomaterial has revealed its potential for multidisciplinary applications due to its wide emission spectrum coverage and long afterglow with single light excitation. The synthesis of nanosheets with white light phosphorescence at room temperature is challenging. This study focuses on the photoelectrochemical response of boron carbon nitride nanosheets (BCNs) with room temperature proximate white light phosphorescence, synthesized by varying the overall boron dopant.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Nanoscience & Nanotechnology
Hemal Weerasinghe, Maheshika Kumarihamy, Hui-Fen Wu
Summary: In this study, a dual optical sensor method (DOSM) using 2D VO2 nanosheets was developed for quantitative analysis of epinephrine (EP) and dopamine (DA). The newly synthesized 2D VO2 nanosheet sensor showed promising results in detecting and quantifying EP and DA with high selectivity and sensitivity using both colorimetry and fluorometry simultaneously. The sensor was successfully applied to real urine samples, achieving satisfactory recovery rates. This study has introduced a new platform for biosensing using the DOSM and vanadium oxidation spectrum.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hemal Weerasinghe, Hui-Fen Wu
Summary: Vanadium dioxide exhibits excellent absorbance in near-infrared (NIR) wavelengths, making it a promising candidate for solar energy-based photothermal applications. This study demonstrates the synthesis of VO2-based nanomaterials with superior photothermal capability for solar steam generation and water purification from seawater and wastewater. The synthesized nanosheets, when coated on cellulose fabric, achieved a high steady state temperature of 87 degrees C under one sun illumination, resulting in a competitive evaporation rate and efficiency for water purification.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Polymer Science
Tzu-Chi Chiang, Jia-Yaw Chang, Tzung-Han Chou
Summary: This study successfully prepared stable nanoemulsions of curcumin by adjusting the HLBt using Tween 60. The addition of Tween 60 reduced the size of the nanoemulsions and improved their storage stability. Higher HLBt values resulted in higher encapsulation efficiency and enhanced remaining activity of curcumin.
Article
Chemistry, Physical
Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber
Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.
MOLECULAR CATALYSIS
(2023)
Article
Energy & Fuels
Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery
Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article
Materials Science, Biomaterials
Deepak Dabur, Nallin Sharma, Hui-Fen Wu
Summary: This article presents a novel synthesis methodology for bimetallic aluminum-tungsten (Al-W) nanosheets, which exhibit high selectivity for the detection of serotonin neurotransmitters. Photoluminescent behavior of the nanosheets with serotonin was observed, with a significant enhancement in emission wavelength (lambda(em)) at 335 nm. The Al-W nanosheets enabled nanomolar quantification of serotonin, with a detection limit of 0.05 nm and high linearity (R-2 = 0.9906). Real-world quantification studies on urine and serum samples demonstrated good correlation coefficients (R-2 of 0.9938 and 0.9801, respectively).
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew
Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew
Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.
NANOSCALE ADVANCES
(2023)
