Article
Agronomy
Tianrun Zheng, Junyi Zhan, Maojia Wang, Wenjun Sun, Jun Yan, Zhi Shan, Hui Chen
Summary: Under ferrous iron stimulation, the terpenoid content in C. blinii was found to be different, and the metabolic pathways of MVA and MEP were periodically regulated.
Review
Biochemistry & Molecular Biology
Ujjwala Karmacharya, Jong-Wha Jung
Summary: Autophagy is a cellular process that removes damaged components of cells and recycles them as biochemical building blocks. Dysregulation of autophagy has been linked to various diseases, including cancer. In recent years, targeting Unc-51-like autophagy-activating kinase (ULK) inhibitors has emerged as a promising strategy for cancer treatment. This review highlights the recent discoveries and developments in small-molecule ULK inhibitors and their potential as anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ganesh Pai Bellare, Birija Sankar Patro
Summary: This study proposes the usage of resveratrol as a chemosensitizer in combination with talazoparib for targeting HR proficient breast cancers. Resveratrol effectively enhances talazoparib-induced cell death in breast cancer cells and shows minimal cytotoxicity in normal cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Qian Zuo, Long Liao, Zi-Ting Yao, Ya-Ping Liu, Ding-Kang Wang, Shu-Jun Li, Xing-Feng Yin, Qing-Yu He, Wen-Wen Xu
Summary: This study demonstrates that the lipid-lowering agent lomitapide exhibits antitumor properties against colorectal cancer by activating autophagy and AMPK phosphorylation, making it a potential therapeutic drug for CRC treatment. The anticancer effect of lomitapide is found to be dependent on PP2A, as its bioactivity is attenuated in PP2A-deficient cells.
Article
Chemistry, Medicinal
Giuseppe Campiani, Tuhina Khan, Cristina Ulivieri, Leopoldo Staiano, Chiara Papulino, Stefania Magnano, Seema Nathwani, Anna Ramunno, Daniel Lucena-Agell, Nicola Relitti, Stefano Federico, Luca Pozzetti, Gabriele Carullo, Alice Casagni, Simone Brogi, Francesca Vanni, Paola Galatello, Magda Ghanim, Niamh McCabe, Stefania Lamponi, Massimo Valoti, Ola Ibrahim, Jeffrey O'Sullivan, Richard Turkington, Vincent P. Kelly, Ruben VanWemmel, J. Fernando Diaz, Sandra Gemma, Daniela Zisterer, Lucia Altucci, Antonella De Matteis, Stefania Butini, Rosaria Benedetti
Summary: Autophagy, a crucial mechanism for maintaining organismal homeostasis, has become a focus in cancer therapy. In this study, new multifunctional agents with both pro-apoptotic and autophagy-inhibiting effects were designed and their therapeutic potential was demonstrated through experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Chul Won Yun, Juhee Jeon, Gyeongyun Go, Jun Hee Lee, Sang Hun Lee
Summary: Autophagy is a cellular degradation process that plays a role in regulating tumorigenesis, metastasis, cancer stem cells, and resistance to anticancer agents. While modulating autophagy may be a promising approach in anticancer therapy, its dual roles present limitations in its application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jiaxin Yong, Songqing Cai, Zhaolei Zeng
Summary: This article summarizes the detrimental effects of increased NAD(+) production, the functions of NAD(+) metabolic enzymes in creating an immunosuppressive tumor microenvironment, and discusses the progress and clinical translational potential of inhibitors for NAD(+) synthesis and therapies targeting NADase.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lucile Hoch, Nathalie Bourg, Fanny Degrugillier, Celine Bruge, Manon Benabides, Emilie Pellier, Johana Tournois, Gurvan Mahe, Nicolas Maignan, Jack Dawe, Maxime Georges, David Papazian, Nik Subramanian, Stephanie Simon, Pascale Fanen, Cedric Delevoye, Isabelle Richard, Xavier Nissan
Summary: This study investigates the protein degradation defect in LGMD R3 and identifies the HDAC inhibitor givinostat as a potential therapeutic option. The findings provide new treatment strategies for LGMD R3 patients and offer insights for the treatment of other genetic diseases with similar protein degradation defects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Masahiro Ohara, Kengo Saito, Ken Kageyama, Mizue Terai, Hanyin Cheng, Andrew E. Aplin, Takami Sato
Summary: Uveal melanoma (UM) is a common eye cancer in adults, with up to 50% of patients developing metastases. A preclinical study showed that combining CDK4/6 inhibitor with cMET inhibitor could provide significant clinical benefit to patients with metastatic uveal melanoma by suppressing tumor growth.
Article
Engineering, Biomedical
Song Xue, Xiaojun Zhou, Weilin Sang, Cong Wang, Haiming Lu, Yiming Xu, Yiming Zhong, Libo Zhu, Chuanglong He, Jinzhong Ma
Summary: A novel cartilage-targeting dual-drug delivery system was designed to effectively treat osteoarthritis by sequentially releasing two agents. The system demonstrated excellent ROS scavenging ability and anti-apoptotic effects, while also enhancing autophagy activity and chondrocyte protection. It has the potential to be a promising therapy for osteoarthritis.
BIOACTIVE MATERIALS
(2021)
Article
Plant Sciences
Naibedya Dutta, Deepak Bharadwaj Pemmaraju, Suvranil Ghosh, Asif Ali, Ayan Mondal, Chirantan Majumder, Vinod K. Nelson, Subhash C. Mandal, Anup K. Misra, Aravind K. Rengan, Velyutham Ravichandiran, Chun-Tao Che, Katerina Gurova, Andrei Gudkov, Mahadeb Pal
Summary: The study showed that an alkaloid-rich fraction of Ervatamia coronaria leaf extracts (AFE) exhibited high toxicity to colorectal cancer cells by inducing cell cycle arrest and activating both apoptotic and autophagy pathways. It targeted key genes and signaling pathways involved in cancer cell survival and proliferation, offering a potential alternative therapy for colorectal cancer with minimal side effects on normal cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Min Ju Lee, Jae-Sung Park, Seong Bin Jo, Young Ae Joe
Summary: Autophagy is a process that maintains intracellular homeostasis by eliminating damaged or unnecessary proteins and organelles. Deregulation of autophagy is associated with various diseases, including cancer. The cytoprotective mechanism of autophagy has been extensively studied for overcoming resistance to cancer therapies, leading to the development of selective autophagy inhibitors for cancer treatment.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Chemistry, Medicinal
Zhaoping Pan, Yi Chen, Haiying Pang, Xiaoyun Wang, Yuehua Zhang, Xin Xie, Gu He
Summary: A novel class of thieno [2,3-d] pyrimidine derivatives containing resorcinol and morpholine fragments as Hsp90/mTOR dual inhibitors were designed, synthesized, and evaluated. The most potent compound 17o showed remarkable inhibitory activities on Hsp90, mTOR, and SW780 cancer cell, both in vitro and in vivo. Mechanism studies revealed that 17o suppressed cell proliferation through the over-activation of the PI3K/AKT/mTOR pathway regulated by mTOR inhibition and apoptosis regulated by the mitochondrial pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jihyeon Song, Heesun Jung, Gayeon You, Hyejung Mok
Summary: In this study, hybrid vesicles developed from two types of cancer cells showed enhanced intracellular uptake and promising anticancer activities against both MCF-7 and HeLa cells. The dual-targeting activity of these hybrid vesicles may offer a potential strategy for specific delivery of anticancer drugs with reduced toxicity.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Thomas Whitmarsh-Everiss, Luca Laraia
Summary: Autophagy plays a key role in maintaining cellular homeostasis, neurodegenerative disorders, aging, and cancer. The development of small molecule autophagy modulators faces challenges but also provides opportunities for better understanding the autophagy process and potential therapeutic development.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Mathematics, Applied
Jing Zhao, Zhenhai Liu, Yongjian Liu
Summary: This paper aims to address the approximate controllability of control systems described by non-autonomous second-order evolution hemivariational inequalities with nonlocal conditions in Hilbert spaces. A concept of mild solution is first defined based on the existence of an evolution operator for the corresponding linear equation and the property of Clarke subdifferential. Then, the solvability and approximate controllability are investigated using a fixed-point strategy. Finally, two examples are provided to illustrate the main results.
APPLICABLE ANALYSIS
(2023)
Article
Nanoscience & Nanotechnology
Zhenzhen Liu, Chongwen Wang, Shuai Zheng, Xingsheng Yang, Han Han, Yuwei Dai, Rui Xiao
Summary: In this study, a portable immunoassay based on SERS technology was proposed for simultaneous detection of multiple respiratory viruses. The method utilizes magnetic SERS tags for direct enrichment and capture of target viruses, eliminating the need for sample pretreatment and improving detection sensitivity. Experimental verification on throat swab samples demonstrated the potential of the method for early and rapid differential diagnosis of respiratory viruses.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Biology
Minghui Jin, Bo Liu, Weigang Zheng, Conghui Liu, Zhenxing Liu, Yuan He, Xiaokang Li, Chao Wu, Ping Wang, Kaiyu Liu, Shigang Wu, Hangwei Liu, Swapan Chakrabarty, Haibin Yuan, Kenneth Wilson, Kongming Wu, Wei Fan, Yutao Xiao
Summary: This study generated a high-quality chromosome-level assembly of Agrotis ipsilon and found that detoxification-associated gene families were highly expanded and induced after feeding on specific host plants. Knockout of genes encoding induced ABC transporters significantly reduced larval growth rate, indicating their contribution to host adaptation. Comparative transcriptomic analysis also revealed expression differences between tethered-flight moths and migrating moths, involving genes related to sensing photoperiod variations, magnetic fields, and migration processes.
Article
Chemistry, Physical
Qin Liu, Shibo Xi, Xinnan Peng, Lei Feng, Guangyuan Xu, Zhendong Liu, Yuan Kong, Xiaoxu Zhao, Huan Yan
Summary: This study proposes a new strategy for investigating the coordination environment of catalytic centers and its effect on reactivity. By altering the surrounding atoms instead of the catalytic metal center, a clear relationship between coordination environment and catalytic activity was observed. DFT calculations provided a comprehensive map of the relationship between coordination environments and catalytic performances. This coordination environment engineering method can be widely applied to screen new catalysts and offers a novel way to investigate the fundamental chemistry of active sites in catalysis.
Article
Cell Biology
Mingxi Shao, Shiyun Wang, Yani Wan, Zhenzhen Liu, Yi Ma, Wenjun Cao, Shengjie Li
Summary: This study investigated the relationship between peripheral blood total bilirubin (TBIL) levels and the risk of primary open-angle glaucoma (POAG). The results showed that high levels of TBIL may be related to the pathogenesis of POAG and that the severity of the disease is positively correlated, especially in male patients.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2023)
Review
Cell Biology
Hong-Jiao Liu, Hua Miao, Jun-Zheng Yang, Fei Liu, Gang Cao, Ying-Yong Zhao
Summary: Fibrosis is a common feature of chronic diseases, and ageing is a major risk factor for fibrotic diseases. However, current therapies are limited and new treatments that specifically target the pathogenesis of fibrosis are urgently needed. This review discusses the role of lipids and lipidomics in the development of renal ageing and fibrosis, as well as the potential use of dyslipidaemia as a therapeutic target. The review also highlights the progress in research on small molecule therapeutic agents that modulate lipid metabolism to prevent and treat ageing and ageing-associated renal fibrosis.
AGEING RESEARCH REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Peixin Guan, Zhanchen Guo, Shuxin Xu, Haifeng Lu, Lisheng Wang, Zikuan Gu, Zhen Liu
Summary: In this study, a new strategy called molecularly imprinted nanobeacons (MINBs) was developed to redirect innate immune killing towards triple-negative breast cancer (TNBC). The MINBs tagged TNBC cells by binding with glycoprotein nonmetastatic B (GPNMB) and recruited hapten-specific antibodies to trigger effective immune killing. In vivo experiments showed significant inhibition of TNBC growth after MINBs treatment. This research not only provides a new approach for redirecting innate immunity towards TNBC, but also paves the way for innate immunity-based therapy of other diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Juntao Zhou, Xianhui Cheng, Zhanchen Guo, Muhammad Mujahid Ali, Guiyuan Zhang, W. Andy Tao, Lianghai Hu, Zhen Liu
Summary: Phospholipids are key components of cell membranes with important functions in molecule transportation and cell recognition. However, methods for specific recognition of lipids are limited compared to proteins and glycans due to their structural diversity and amphipathic nature. In this study, a molecular imprinting strategy was developed for controllable imprinting of the polar head of phospholipid on the surface of cellular membranes. Phosphatidylserine, a unique lipid on the outer membrane leaflet of exosomes and a hallmark for cell apoptosis, was successfully imprinted using this method. The resulting phosphatidylserine imprinted materials exhibited high efficiency and specific targeting capability for apoptotic cell imaging and exosome isolation. These molecularly imprinted materials have great potential for selective plasma membrane recognition in targeted drug delivery and biomarker discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Mathematics
Zhenhai Liu, Nikolaos S. S. Papageorgiou
Summary: This paper discusses a Dirichlet problem driven by the anisotropic p-Laplacian, with a reaction that has the competing effects of a singular term and a parametric superlinear perturbation. A bifurcation-type theorem describing the changes of the set of positive solutions as the parameter varies is proven. The existence of minimal positive solutions is also proven.
MATHEMATISCHE NACHRICHTEN
(2023)
Article
Cell Biology
Zhendong Liu, Zhehao Fan, Rui Wang, Xiaolei Li, Hui Chen, Jingcheng Wang
Summary: This study investigated the effect of IFN-alpha-2b on preventing postoperative arthrofibrosis in rats and its antiproliferation effect on fibroblasts in vitro, as well as its molecular mechanism. The results showed that IFN-alpha-2b significantly reduced arthrofibrosis by inhibiting fibroblast proliferation and migration, possibly through the regulation of STAT1/p21 signaling pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Geochemistry & Geophysics
Yanbo Liang, Yuanfang Cheng, Zhongying Han, Chuanliang Yan, Zhenhai Liu, Xiufeng Zhang, Chao Wang
Summary: This paper proposes the ground fracturing technology to pre-split the high-level roof, aiming to address the frequent occurrence of mine dynamic disasters such as mine earthquake and rock burst. The FLAC numerical model is used to study the dynamic response of the roof before and after fracturing. The simulation results show that the presence of hydraulic fracture can effectively reduce the first breaking span of the roof and slow down the stress and deformation energy concentration of coal and rock mass on both sides of the goaf.
Article
Environmental Sciences
Jian Xue, Zongxing Li, Qi Feng, Zongjie Li, Juan Gui, Yuchen Li
Summary: The Qilian Mountains in western China are an important ecological security barrier and water conservation area with a significant ecological status. Research on ecosystem services in the Qilian Mountains can help explore green development pathways. This paper quantifies the ecosystem services of the Qilian Mountains and proposes an ecological conservation pattern. The results show that the ecosystem services of the Qilian Mountains have been gradually improving, with increases in habitat quality, soil retention, and water conservation. Precipitation, NDVI, and NPP are significant contributors to ecosystem services. The proposed conservation pattern based on double E + G provides new ideas and approaches for ecological management in alpine regions.
ENVIRONMENTAL DEVELOPMENT
(2023)
Article
Materials Science, Multidisciplinary
Zhenzhen Liu, Haibo Li
Summary: The study prepared CMO microspheres with porous core-shell structure and investigated their properties. As an electrode for capacitive deionization, the optimized AC || CMO device exhibited high salt removal capacity and current efficiency, with a relatively high capacity retention rate. It was found that the intercalation/de-intercalation of sodium ions in CMO were governed by the (103) and (221) crystal planes, which had higher adsorption energies for Na+.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Psychology, Multidisciplinary
Zhenzhen Liu, Xiaomin Sun, Yarong Guo, Shuting Yang
Summary: This study shows that mindful parenting has a positive impact on adolescents' life satisfaction, and this relationship is mediated by adolescents' coping self-efficacy. These findings highlight the importance of mindful parenting for adolescents' healthy development.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Zhenzhen Liu, Xiaomin Sun, Yarong Guo, Fang Luo
Summary: This study aimed to explore whether mindful parenting could prevent adolescents from being greedy and examine the mediating role of adolescent core self-evaluations. The results indicated that mindful parenting had significant impacts on adolescent greed, partially mediated by adolescent core self-evaluations.
CURRENT PSYCHOLOGY
(2023)
