Article
Food Science & Technology
Sheung Yin San, Jennifer. M. F. Wan, Jimmy Chun Yu Louie
Summary: This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction. The results showed that salt reduction may still be the most effective strategy to improve vascular health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Pharmacology & Pharmacy
Giuditta Benincasa, Enrico Coscioni, Claudio Napoli
Summary: One major challenge in cardiovascular primary prevention is the lack of early biomarkers for endothelial dysfunction. Endothelial dysfunction can start in fetal life and may be reversed through smoking cessation, weight loss, physical exercise, and diet control.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Physiology
Andrea Tryfonos, Joseph Mills, Daniel J. Green, Anton J. M. Wagenmakers, Ellen A. Dawson, Matthew Cocks
Summary: This study examined the relationships between in vivo measures of vascular function and the expression of atherogenic risk-modulating proteins in endothelial cells (ECs) isolated from the radial artery of CAD patients. The results revealed a difference in the regulation of endothelium-dependent vasodilation measured in vivo between patients with CAD compared to previously reported data in subjects without a clinical diagnosis, suggesting that eNOS Ser(1177) phosphorylation may be the key to maintain vasodilation in CAD patients.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Celian Peyronnel, Perle Totoson, Helene Martin, Celine Demougeot
Summary: Rheumatoid arthritis (RA) is associated with excessive cardiovascular mortality due to premature atherosclerosis, with endothelial activation (EA) playing a key role. EA involves loss of vascular integrity, expression of leucocyte adhesion molecules, transition to a prothrombotic phenotype, cytokine production, shedding of membrane microparticles, and recruitment of endothelial progenitor cells. Circulating markers of EA may serve as potential biomarkers for vascular pathology and cardiovascular (CV) risk. This review presents the biology of EA, analyzes available data on EA markers in RA in relation to vascular pathology and CV events, discusses their relevance as biomarkers of CV risk, and proposes future directions.
Article
Cardiac & Cardiovascular Systems
Andrei C. Sposito, Ikaro Breder, Joaquim Barreto, Jessica Breder, Isabella Bonilha, Marcus Lima, Alessandra Oliveira, Vaneza Wolf, Beatriz Luchiari, Helison R. do Carmo, Daniel Munhoz, Daniela Oliveira, Otavio R. Coelho-Filho, Otavio R. Coelho, Jose Roberto Matos-Souza, Filipe A. Moura, Luiz Sergio F. de Carvalho, Wilson Nadruz, Thiago Quinaglia, Sheila T. Kimura-Medorima
Summary: The addition of evolocumab to empagliflozin in individuals with T2D improves endothelial function, leading to better vascular function.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Review
Immunology
George A. Karpouzas, Viet L. Bui, Nicoletta Ronda, Ivana Hollan, Sarah R. Ormseth
Summary: Biologic therapies have shown strong cardioprotective effects in rheumatoid arthritis patients, but the precise mechanistic effects are still not well characterized.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Review
Medicine, General & Internal
Bas Dijkshoorn, Reinder Raadsen, Michael T. Nurmohamed
Summary: RA patients have a 1.5 times higher risk of developing cardiovascular diseases compared to the general population. This is partly due to systemic inflammation causing increased atherogenesis, and an increased prevalence of traditional cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Enrique Garcia-Sayan, Miryoung Lee, James R. Stone, Danielle M. Stone, Beverly Smulevitz, David D. McPherson, Susan P. Fisher-Hoch, Joseph B. McCormick, Susan T. Laing
Summary: Endothelial dysfunction assessed by impaired brachial flow-mediated dilation (FMD) predicts incident cardiovascular disease (CVD). This study aimed to assess determinants of impaired FMD response (%FMD), an earlier marker of atherosclerosis, in a population-based sample of asymptomatic Mexican Americans. The results showed age-dependent associations between cardiometabolic biomarkers and an FMD response in a sample composed of Mexican Americans without previous CVD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Rheumatology
Tiago Pecanha, Daniel J. Bannell, Sofia Mendes Sieczkowska, Nicola Goodson, Hamilton Roschel, Victoria S. Sprung, David A. Low
Summary: Physical activity has a beneficial impact on microvascular and macrovascular function in patients with autoimmune rheumatic diseases, but does not show clear effects on macrovascular structure.
Article
Endocrinology & Metabolism
Joshua I. Barzilay, Petra Buzkova, Howard A. Fink, Jane A. Cauley, Laura Carbone, Rachel Elam, John A. Robbins, Phyllis Stein, Kerry Sheets, Diana Jalal, Kenneth J. Mukamal
Summary: Endothelial dysfunction, which is associated with atherosclerotic vascular disease, was not found to have a significant association with hip fracture risk in older adults based on the examination of two markers of endothelial dysfunction.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Environmental Sciences
Szymon Mucka, Martyna Miodonska, Grzegorz K. Jakubiak, Monika Starzak, Grzegorz Cieslar, Agata Stanek
Summary: Assessment of endothelial function, particularly using the non-invasive method of flow-mediated dilation (FMD), is crucial in predicting the risk of cardiovascular diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Rheumatology
Anthony James Ocon, George Reed, Dimitrios A. Pappas, Jeffrey R. Curtis, Joel M. Kremer
Summary: The study found that initiating glucocorticoids in steroid-naive RA patients is associated with an increased risk of cardiovascular events, especially at daily doses of >= 5mg, cumulative doses exceeding 1100mg, and durations longer than 81 days. No increased risk was found at lower doses or shorter durations.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Cristina Santarcangelo, Alessandra Baldi, Roberto Ciampaglia, Marco Dacrema, Alessandro Di Minno, Valentina Pizzamiglio, Gian Carlo Tenore, Maria Daglia
Summary: This study measured the concentrations of four health-related trace elements in Parmigiano Reggiano cheese and found that 40-month ripened cheese is a good source of selenium and chromium, providing 15% of the nutrient reference intake values.
Review
Hematology
Matteo Nicola Dario Di Minno, Carlo Martinoli, Gianluigi Pasta, Hortensia De la Corte-Rodriguez, Islam Samy, David Stephensen, Merel A. Timmer, Ian Winburn
Summary: This review discusses the need for hemophilia teams to move beyond traditional outcomes in joint imaging and highlights the potential role of point-of-care ultrasound (POCUS) as an essential assessment tool for managing the care of patients with hemophilia. The review also provides evidence on assessing joint health for potential new treatment modalities, such as gene therapy, and emphasizes the importance of early detection of joint damage and monitoring disease progression through ultrasound.
Article
Medicine, General & Internal
Pasquale Ambrosino, Stefano Sanduzzi Zamparelli, Marco Mosella, Roberto Formisano, Antonio Molino, Giorgio Alfredo Spedicato, Antimo Papa, Andrea Motta, Matteo Nicola Dario Di Minno, Mauro Maniscalco
Summary: Impaired endothelial function can be documented in convalescent COVID-19 patients, especially when residual clinical manifestations persist. Targeting endothelial dysfunction through pharmacological and rehabilitation strategies may represent an attractive therapeutic option.
ANNALS OF MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Pasquale Ambrosino, Pasquale Moretta, Anna Lanzillo, Roberto Formisano, Mauro Maniscalco
Review
Biochemistry & Molecular Biology
Mauro Mormile, Ilaria Mormile, Salvatore Fuschillo, Francesca Wanda Rossi, Laura Lamagna, Pasquale Ambrosino, Amato de Paulis, Mauro Maniscalco
Summary: Eosinophils play a significant role in airway inflammation in diseases like asthma, chronic rhinosinusitis, and chronic obstructive pulmonary disease. This review explores the immunological differences in eosinophilic airway inflammation and how it affects clinical presentation, emphasizing the need for accurate classification of patients based on phenotypes and endotypes to determine appropriate therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Giancarlo Castaman, Flora Peyvandi, Raimondo De Cristofaro, Berardino Pollio, Dario M. N. Di Minno
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Pasquale Ambrosino, Giuseppina Marcuccio, Roberto Formisano, Laura Marcuccio, Rosanna Filosa, Mauro Maniscalco
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Hammad Ullah, Alessandro Di Minno, Anna Di Filippis, Eduardo Sommella, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Hesham R. El-Seedi, Shaden A. M. Khalifa, Roberto Piccinocchi, Massimiliano Galdiero, Pietro Campiglia, Maria Daglia
Summary: Plant extracts from Cistus x incanus L. and Scutellaria lateriflora L. show potential for treating gingivitis due to their polyphenol content, which exhibit inhibitory effects against Porphyromonas gingivalis.
Review
Biochemistry & Molecular Biology
Fosca Quarti-Trevano, Raffaella Dell'Oro, Cesare Cuspidi, Pasquale Ambrosino, Guido Grassi
Summary: Vascular and sympathetic abnormalities are characteristic of chronic heart failure (CHF). These alterations have significant effects on disease prognosis and can promote disease progression and the development of cardiovascular complications. This review will discuss various therapeutic interventions targeting these vascular/sympathetic abnormalities in CHF, including non-pharmacological, pharmacological, and device-based treatments, and also address the unmet goals in treatment related to endothelial and adrenergic targets.
Article
Nutrition & Dietetics
Hammad Ullah, Eduardo Sommella, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Costanza Riccioni, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Pietro Campiglia, Roberto Sacchi, Maria Daglia
Summary: This study aimed to evaluate the efficacy of a new food supplement based on a chemically characterized pomegranate extract and hydro-soluble vitamins (B complex and C) in reducing prolonged fatigue in healthy subjects. The food supplement showed significant reductions in fatigue severity scores but had no considerable effect on psychological well-being.
Letter
Otorhinolaryngology
Pasquale Ambrosino, Andrea Motta, Mauro Maniscalco
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Medicine, General & Internal
Pasquale Ambrosino, Giuseppina Marcuccio, Carmen Lombardi, Silvestro Ennio D'Anna, Stefano Sanduzzi Zamparelli, Costantino Mancusi, Giorgio Alfredo Spedicato, Andrea Motta, Mauro Maniscalco
Summary: A meta-analysis showed that individuals with AATD have a significantly lower risk of ischemic heart disease and acute myocardial infarction compared to non-AATD controls. These findings are not influenced by AATD genotypes or prevalence of COPD, but are associated with differences in male sex, hypertension, and diabetes prevalence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Giuseppina Marcuccio, Pasquale Ambrosino, Claudia Merola, Fabio Manzo, Andrea Motta, Gaetano Rea, Elena Cantone, Mauro Maniscalco
Summary: Allergic rhinitis is a common allergic disease with a high occurrence between the ages of 20 and 40. It involves immune responses and nitric oxide has been identified as a potential biomarker for diagnosis and therapy monitoring. Measurement of nasal nitric oxide can help monitor airway obstruction and inflammation in various clinical conditions, including upper airways diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Biochemistry & Molecular Biology
Letizia Palomba, Debora Paris, Pasquale Ambrosino, Mauro Maniscalco, Andrea Motta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Health Care Sciences & Services
Pasquale Moretta, Pasquale Ambrosino, Anna Lanzillo, Laura Marcuccio, Salvatore Fuschillo, Antimo Papa, Gabriella Santangelo, Luigi Trojano, Mauro Maniscalco
Summary: This study investigated the association between cognitive impairment and clinical and functional variables in convalescent COVID-19 patients without pre-existing diseases potentially affecting cognition. The findings suggested a possible link between reduced cognitive efficiency and certain cardiological variables, such as altered blood pressure circadian rhythm.