Review
Endocrinology & Metabolism
Josie L. Fullerton, Josephine M. Thomas, Laura Gonzalez-Trueba, Cara Trivett, Josie C. van Kralingen, Stuart M. Allan, Terence J. Quinn, Lorraine M. Work
Summary: This systematic review aimed to assess the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs and their use in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. The findings highlighted specific microRNAs that consistently showed differential expression in both clinical and preclinical samples following stroke. However, further studies with larger populations and consistent methodologies are needed to confirm the clinical value of circulating microRNAs as biomarkers for stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Thais Borges Gally, Milena Magalhaes Aleluia, Grasiely Faccin Borges, Carla Martins Kaneto
Summary: Osteosarcoma is a fast-progressing bone tumor with high incidence in children and adolescents. Circulating microRNAs have been identified as potential non-invasive biomarkers for diagnosis, but the lack of consistency in results suggests the need for additional prospective studies to confirm their role in osteosarcoma.
Article
Infectious Diseases
Yicheng Huang, Yingsha Chen, Sheng Tu, Jiajie Zhang, Yunqing Qiu, Wei Yu
Summary: This meta-analysis assessed the diagnostic value of circulating miRNAs as promising biomarkers for HCV-associated hepatocellular carcinoma (HCV-HCC). The results showed that circulating miRNAs could distinguish HCC patients from chronic hepatitis C (CHC) and HCV-associated liver cirrhosis (HCV-LC) with relatively high accuracy. Combined use of miRNAs and AFP improved the diagnostic accuracy. Subgroup analysis revealed that miRNAs from plasma types, up-regulated miRNAs, and miRNA clusters had better diagnostic accuracy.
BMC INFECTIOUS DISEASES
(2022)
Review
Oncology
Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos, Carla Martins Kaneto
Summary: Cervical cancer is a preventable disease but remains a significant public health problem. The Pap smear has achieved great success, but has limitations, leading to the need for new approaches for early diagnosis and biomarker discovery. miRNAs have been identified as non-invasive biomarkers and have potential clinical value for early-stage cervical intraepithelial neoplasia screening. This study reviewed the expression of circulating miRNAs in the development of cervical cancer and identified potential biomarkers.
Review
Medicine, General & Internal
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: This article reviews the current research on the correlation between microRNAs (miRNAs) in extracellular bioliquids and subarachnoid hemorrhage (SAH) and its complications. It discusses the potential use of miRNAs as biomarkers in the treatment of SAH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Urology & Nephrology
Ricardo Leao, Maarten Albersen, Leendert H. J. Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J. Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J. Hamilton, Klaus-Peter Dieckmann
Summary: Circulating microRNA levels, especially miR-371a-3p, show promise for clinical use in testicular germ cell tumors, with high sensitivity and specificity in various clinical scenarios, potentially aiding in clinical decision-making.
Review
Oncology
I-Ping Yang, Kwan-Ling Yip, Yu-Tang Chang, Yen-Cheng Chen, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: It takes nearly two decades for a cancer lesion to develop from normal colon mucosa, but most colorectal cancer patients are at advanced stages at diagnosis. Chemotherapy, targeted therapy, and radiotherapy can improve the prognosis, but therapy resistance is common, and survival rates remain poor for patients with locally advanced or metastatic colorectal cancer. MicroRNAs (miRs) can regulate cancer pathways and serve as predictive biomarkers for detecting cancer or resistance to treatment. MiRNA-based therapeutics may reach clinical stages.
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amir Hossein Aalami, Farnoosh Aalami, Amirhossein Sahebkar
Summary: A meta-analysis was conducted to evaluate the diagnostic performance of circulating miRNAs in gastric cancer. The results suggest that circulating miRNAs can serve as diagnostic biomarkers for this malignancy.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Codrin-Constantin Burlacu, Daniela Ciobanu, Andrei-Vlad Badulescu, Vlad-Florin Chelaru, Andrei-Otto Mitre, Bogdan Capitanescu, Dirk M. Hermann, Aurel Popa-Wagner
Summary: Stroke is the second leading cause of death and disability, with limited therapeutic strategies. Blood-based biomarkers, such as microRNAs and exosomes, are recognized as useful tools to predict prognosis in patients with stroke. This systematic review identified 72 circulating biomarkers with prognostic value in stroke recovery, including 68 miRNAs predictive for motor recovery and seven biomarkers predictive for cognitive recovery. The most significant correlations were found with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. Serum miR-9 and neutrophil miR-29b were identified as promising biomarkers for further studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yunhui Xiang, Liuyun Zhang, Pinpin Xiang, Juan Zhang
Summary: This meta-analysis evaluates the potential of circulating miRNAs in diagnosing multiple myeloma (MM), demonstrating high accuracy and specificity. Factors such as miRNA clusters, detailed patient stage, and Ig isotypes have an impact on the diagnostic results, suggesting standardized recommendations for future studies. Additionally, circulating miRNAs show promise as valuable biomarkers for MM prognosis and treatment response prediction, expanding their clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Amir Hossein Aalami, Hossein Abdeahad, Ali Shoghi, Mohammad Mesgari, Amir Amirabadi, Amirhossein Sahebkar
Summary: This meta-analysis aimed to evaluate the diagnostic accuracy of microRNAs in the blood for brain tumors. The results showed that microRNAs have high diagnostic accuracy in identifying brain tumors. Subgroup analyses were also performed to determine the influence of sample types, reference genes, and regions on the diagnostic power of microRNAs.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Medicine, General & Internal
Yang Wang, Xianwei Su, Geoffrey Ho Duen Leung, Baohua Ren, Qiang Zhang, Zhiqiang Xiong, Jingye Zhou, Ling Yang, Gang Lu, Wai-Yee Chan, Lijie Ren
Summary: This study conducted comprehensive analysis and real-world validation to assess the association between circulating miRNAs and ischemic stroke (IS). The results showed that 4 miRNAs exhibited significant expression levels in IS patients, suggesting potential circulating diagnostic or therapeutic targets for IS patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Nan Wu, Hongyan Sun, Qian Sun, Fangqing Zhang, Lingli Ma, Yue Hu, Xianling Cong
Summary: This study evaluated the diagnostic value of circulating miRNAs for melanoma through a comprehensive literature search and analysis, and the results showed that circulating miRNAs have high accuracy. Subgroup analysis showed better diagnostic value in miRNA clusters, European population, plasma miRNAs, and upregulated miRNAs compared to other subgroups.