Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Yingfeng Shi, Min Tao, Hui Chen, Xiaoyan Ma, Yi Wang, Yan Hu, Xun Zhou, Jinqing Li, Binbin Cui, Andong Qiu, Shougang Zhuang, Na Liu
Summary: This study found that the aberrant expression of USP11 is related to tumor progression in kidney fibrosis. Inhibition of USP11 can attenuate pathological lesions and improve kidney function, suggesting its potential as a therapeutic strategy for patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Myeongjoo Son, Bomi Ryu, Jun-Geon Je, You-Jin Jeon, Dae Yu Kim
Summary: This study found that microgravity stimulation changes the morphology of human retinal pigment epithelial cells and increases the expression of VEGF and EMT markers. Treatment with ishophloroglucin A (IPA) reduces VEGF production and EMT marker expression, restoring excessive cell migration in microgravity-stimulated cells. These findings suggest that IPA could be a potential therapeutic candidate for angiogenesis-related eye diseases.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Geon-Ho Lee, Jayeon Cheon, Donghee Kim, Hee-Sook Jun
Summary: LPA promotes EMT and renal tubular fibrosis through LPAR1 signaling, downregulating E-cadherin and upregulating vimentin expression. This effect is mediated by regulation of KLF5 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Qi Wang, Fuqiang Wang, Xiangze Li, Zhi Ma, Dapeng Jiang
Summary: This study investigated the effect of quercetin treatment on renal fibrosis and its mechanism. The results showed that quercetin can alleviate fibrosis, inflammation, oxidative stress, and cell apoptosis. Quercetin alleviates fibrosis by inhibiting the activation of AREG/EGFR signaling.
PHYTOTHERAPY RESEARCH
(2023)
Article
Environmental Sciences
Dapeng Wang, Huifen Xu, Lili Fan, Wenli Ruan, Qian Song, Heng Diao, Rui He, Ying Jin
Summary: Chronic arsenic exposure induces liver fibrosis in rats, which is associated with activation of hepatic stellate cells, excessive extracellular matrix secretion, and hepatocytes epithelial-mesenchymal transformation. Additionally, arsenite exposure causes hyperphosphorylation of EGFR/ERK signaling in liver tissue, suggesting its involvement in arsenic-induced liver fibrosis. Treatment with erlotinib, a specific phosphorylation inhibitor of EGFR, reduces hyperphosphorylation of EGFR/ERK signaling, suppresses hepatocytes EMT, and alleviates liver fibrogenesis in arsenite-exposed rats.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Il-Ho Park
Summary: The pathogenesis of chronic rhinosinusitis is closely related to tissue remodeling, particularly epithelial-mesenchymal transition. Epigenetic mechanisms, such as DNA methylation, mediated by DNA methyltransferases, play key roles in this process. This study aimed to investigate the involvement of DNA methyltransferases in TGF-beta 1-induced epithelial-mesenchymal transition and explore the underlying mechanisms. The results showed that DNA methyltransferases were upregulated in chronic rhinosinusitis tissues and their expression was positively correlated with disease severity. Further experiments revealed that TGF-beta 1 induced the expression of DNA methyltransferases, which led to DNA methylation and epithelial-mesenchymal transition via the p38, JNK, Snail, and Slug signaling pathways. Inhibition of DNA methyltransferases suppressed the epithelial-mesenchymal transition process, suggesting its potential as a therapeutic strategy for chronic rhinosinusitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ananya Banerjee, Shurui Cai, Guozhen Xie, Na Li, Xuetao Bai, Kousalya Lavudi, Kevin Wang, Xiaoli Zhang, Junran Zhang, Srinivas Patnaik, Floor J. Backes, Chad Bennett, Qi-En Wang
Summary: The newly developed ERβ agonist OSU-ERb-12 can inhibit ovarian cancer cell expansion and tumor growth in an ERα-independent manner, as well as reduce the CSC population by blocking EMT process. It has the potential to hinder tumor progression and limit the CSC subpopulation, thus preventing tumor relapse and metastasis in ovarian cancer patients.
Correction
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: A correction to this paper has been published.
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Medicine, Research & Experimental
Yiwei Yin, Shikun Liu, Li Pu, Jing Luo, Hanhan Liu, Wenyi Wu
Summary: The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells induced by transforming growth factor beta 2 (TGF-02) is a key mechanism in the fibrosis pathogenesis of proliferative vitreoretinopathy (PVR). However, there are few medications that can inhibit proliferative membranes and cell proliferation in the clinic. In this study, nintedanib, a tyrosine kinase inhibitor, was found to inhibit TGF-02-induced EMT in ARPE-19 cells, suggesting its potential as a pharmacological treatment for PVR.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Medicinal
Jianqing Yu, George G. Chen, Paul B. S. Lai
Summary: Hepatocellular carcinoma is a major cause of cancer mortality worldwide, with current treatments showing unsatisfactory outcomes. The HGF/c-Met axis is considered crucial in regulating liver diseases and promoting HCC, and inhibiting this pathway may lead to the development of new and effective treatments for HCC.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Oncology
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter Ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas
Summary: TGF beta promotes sternness and invasiveness in breast cancer cells by inducing epithelial-mesenchymal transition (EMT) and metastatic colonization by inducing mesenchymal-epithelial transition (MET). However, whether TGF beta can promote both sternness and invasiveness simultaneously via EMT remains unclear.
MOLECULAR ONCOLOGY
(2022)
Article
Fisheries
Chengyan Han, Hee-Jin Kim, Jae-Seong Lee, Yoshitaka Sakakura, Atsushi Hagiwara
Summary: This study investigates the tolerance, reproduction, behavior, and mitochondria-mediated stress and energy defenses of two species of rotifers, Brachionus plicatilis and Brachionus rotundiformis, following zinc chloride exposure. The results show that higher concentrations of zinc chloride inhibited reproductive processes in B. plicatilis but stimulated sexual reproduction in B. rotundiformis. The two species also exhibited different metabolic patterns and behavioral responses to zinc exposure.
Article
Marine & Freshwater Biology
Haksoo Jeong, Cheolho Yoon, Jae-Seong Lee, Eunjin Byeon
Summary: To examine the role of GST-O2 genes in biotransformation and detoxification in Daphnia magna, the study investigated various responses such as in vivo endpoints, arsenic speciation, enzymatic activities, and gene expression pathways. The results showed that MT fleas had higher sensitivity to arsenic and a lower rate of arsenate reduction, leading to higher accumulation of arsenic concentrations and decreased protection against toxicity. The mRNA expression of other GST genes increased but the enzymatic activity of GST decreased in the MT group compared to the WT group. The study highlights the important role of GST-O2 in arsenic biotransformation and detoxification in D. magna.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shweta B. Borkar, Manorma Negi, Neha Kaushik, Shaik Abdul Munnaf, Linh Nhat Nguyen, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: The proportion of resistant bacteria will increase over time, which is a major concern. Effective and biocompatible therapeutic strategies are urgently needed to combat these bacteria. Non-thermal plasma has been extensively studied for its antibacterial activity. This study investigates the inactivation efficiency and mechanisms of plasma-generated nitric oxide water (PG-NOW) on pathogenic Gram-negative and Gram-positive bacteria in water, air, soil, and food. Results showed that PG-NOW treatment effectively inhibits bacterial growth and accumulates nitric oxide within the cells. Gene expressions related to nitrosative stress and oxidative stress were also analyzed, supporting the nitrosative effect of PG-NOW. Additionally, changes in cell morphology were observed. These findings provide evidence for the further development of PG-NOW-based antibacterial treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
M. A. Yewale, R. A. Kadam, N. K. Kaushik, J. R. Koduru, N. B. Velhal, Umesh T. Nakate, A. A. Jadhavar, N. D. Sali, D. K. Shin
Summary: This study synthesized interconnected and porous microstructured NiCo2O4 material via a hydrothermal method and characterized its structure and electrochemical properties. The NiCo2O4 material exhibited a polycrystalline structure, interconnected plate-like microstructures, and high specific capacitance. It shows great potential for energy storage applications.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2023)
Article
Ecology
Deok-Seo Yoon, Hyuntae Choi, Alaa El -Din H. Sayed, Kyung-Hoon Shin, Joung Han Yim, Sanghee Kim, Min-Chul Lee, Jae-Seong Lee
Summary: Changes in temperature and starvation affect metabolism and fatty acid composition in zooplankton. However, little is known about fatty acid modulation in Antarctic zooplankton. This study investigated the changes in life history parameters and fatty acid profiles in the Antarctic copepod Tigriopus kingsejongensis under starvation at four different temperatures. The results showed that higher temperatures accelerated the development of T. kingsejongensis and increased overall offspring production. Starvation and higher temperatures led to a decrease in polyunsaturated fatty acids (PUFAs) and an increase in saturated fatty acids in T. kingsejongensis. However, specific PUFAs, such as docosahexaenoic acid and docosapentaenoic acid, increased under starvation and higher temperatures. This study provides valuable insights into fatty acid regulation in Antarctic copepods under environmental stressors.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Nagendra Kumar Kaushik, Eun Ha Choi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Young Hwan Lee, Min -Sub Kim, Yoseop Lee, Duck-Hyun Kim, Jae-Seong Lee
Summary: Ocean acidification (OA) and nanoplastics (NPs) have a synergistic negative effect on copepod reproduction across generations, potentially posing a significant threat to the sustainability of copepod populations. The intergenerational reproductive impairments observed are associated with differential methylation patterns of specific genes, indicating the role of epigenetic modifications. These findings contribute valuable insight into the intergenerational toxicity and underlying molecular mechanisms of responses to NPs under OA conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Physical
Shaina Joarder, Divyam Bansal, Harshvardhan Meena, Neha Kaushik, Jaya Tomar, Kamlesh Kumari, Indra Bahadur, Eun Ha Choi, Nagendra Kumar Kaushik, Prashant Singh
Summary: In the past decade, deep eutectic solvents (DESs) have been widely used as green solvents due to their advantages over traditional organic solvents and ionic liquids. DESs have been applied in various fields such as biotechnology, nanotechnology, synthesis, and catalysis. However, there is still uncertainty about their toxicity and conflicting reports on their biocompatibility. This review focuses on the catalytic potential of DESs and discusses their biocompatibility on different organisms.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Environmental Sciences
Paritosh Patel, Aditya Nandi, Suresh K. Verma, Neha Kaushik, Mrutyunjay Suar, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Emerging bio-contaminants, such as viruses, have had a significant impact on the health and environment of countries worldwide. Understanding the behavior of viruses is crucial in developing targeted therapeutic and vaccination treatments. Animal models, including non-human primates, rodents, and rabbits, offer advantages in assessing the risks of viral infections and chemical toxins, but their maintenance and experimental redundancy are issues. Therefore, exploring alternative animal models, such as zebrafish, is important. This review focuses on zebrafish traits and their potential in monitoring emerging bio-contaminants, particularly viruses like coronaviridae and poxviridae.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Panchanathan Manivasagan, Sekar Ashokkumar, Ala Manohar, Ara Joe, Hyo-Won Han, Sun-Hwa Seo, Thavasyappan Thambi, Hai-Sang Duong, Nagendra Kumar Kaushik, Ki Hyeon Kim, Eun Ha Choi, Eue-Soon Jang
Summary: Novel calcium ion-doped magnesium ferrite nanoparticles have been developed as efficient and biocompatible photothermal therapeutic materials for cancer treatment, with their high near-infrared absorption, short treatment period, strong cytotoxicity to cancer cells under laser irradiation, and minimal damage to healthy cells.
Article
Environmental Sciences
Ibrahim A. Mohamed, Hamdy A. M. Soliman, Mervat Hana, Jae-Seong Lee, Alaa El -Din H. Sayed
Summary: Acute toxicity experiments were conducted to determine the LC50 of UPGR 46% SL for Oreochromis niloticus, and the 96-h LC50 value was found to be 29.16 mg L-1. Hemato-biochemical effects were also studied, and it was discovered that UPGR exposure led to a significant decrease in various blood parameters, while sub-acute exposure resulted in an increase in certain parameters. The antagonistic toxic effects of UPGR and PE-MPs might be due to the sorption of UPGR onto PE-MPs.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Young Hwan Lee, Min-Sub Kim, Yoseop Lee, Chuxin Wang, Seong Chan Yun, Jae-Seong Lee
Summary: This study investigated the effects of interactions between microfibers and freshwater acidification (MFA) on individual Daphnia magna-microbiota interactions. The results showed that MFA interactions can have negative consequences on reproduction, growth, and sex ratio of D. magna, and can induce changes in immunity-and reproduction-related biological processes. The study also revealed that these adverse effects are closely related to changes in microbial communities, suggesting a causal link between D. magna fitness and the microbial community.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Marine & Freshwater Biology
Mohamed Hamed, Christopher J. Martyniuk, Jae-Seong Lee, Huahong Shi, Alaa El-Din H. Sayed
Summary: Marine environments in Egypt are facing a significant issue of microplastic pollution, which potentially harms aquatic organisms. This study evaluated the occurrence, abundance, and distribution of microplastics in marine fishes from the Mediterranean and Red seas in Egypt. The results showed that microplastics were present in the gastrointestinal system of fish at markets but not in muscle or liver. The size of the fish, its diet, and habitat were found to be key factors related to the bioaccumulation of microplastics in fish species. The study concludes that it is crucial to remove plastics from the sea, considering the risks they pose to fisheries and marine ecosystems.
JOURNAL OF SEA RESEARCH
(2023)
Article
Engineering, Environmental
Min-Sub Kim, Young Hwan Lee, Yoseop Lee, Eunjin Byeon, Duck-Hyun Kim, Minghua Wang, Atsushi Hagiwara, Manuel Aranda, Rudolf Shiu Sun Wu, Heum Gi Park, Jae-Seong Lee
Summary: The susceptibility of filter-feeding rotifers to high CO2 conditions and nanoplastic exposure depends on their adaptation history. Rotifers with different adaptation histories showed differences in ingestion and accumulation of nanoplastics, which may be related to microRNA-mediated epigenetic regulation.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Fisheries
Mi-Song Hong, Deok-Seo Yoon, Ji-Su Kim, Heum Gi Park, Jae-Seong Lee, Min-Chul Lee
Summary: We conducted a comprehensive analysis of the effects of increased salinity on Brachionus plicatilis, finding delays in maturation and potential disruptions in the reproductive process. High salinity also impedes growth and alters swimming behavior. Additionally, we discovered distinctive sequences of FABPs in three Brachionus species, contributing to our understanding of their evolutionary positioning.