Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Environmental Sciences
Tianzhu Sun, Dengyang Zhang, Zehao Wang, Bingyu Zhao, Yaping Li, Xiuli Sun, Jia Liu, Xuanjun Wang, Jun Sheng
Summary: Studies have shown that cervical cancer cells develop an EMT phenotype partly through activation of the Notch1 signaling pathway, leading to resistance to paclitaxel. Targeting the Notch1 signaling pathway may be a strategy to reverse the EMT phenotype and increase sensitivity of cervical cancer cells to paclitaxel treatment.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Oncology
Wenrong Mu, Zubang Zhou, Liping Shao, Qi Wang, Wanxue Feng, Yuling Tang, Yizong He, Yuanlin Wang
Summary: The study found that there is a close interaction between ferroptosis and EMT. The EMT process can promote the accumulation of iron ions, providing conditions for ferroptosis. Conversely, ferroptosis may impact the regulatory network of EMT by modulating transcription factors, signaling pathways, and cell adhesion molecules. Genes, signaling pathways, and oxidative homeostasis related to ferroptosis play important roles in the regulation of EMT.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Kaibo Guo, Yuqian Feng, Xueer Zheng, Leitao Sun, Harpreet S. Wasan, Shanming Ruan, Minhe Shen
Summary: Resveratrol and its analogs can reverse EMT through diverse mechanisms, inhibit tumor invasion and migration, potentially serving as novel anti-tumor agents. They can also reverse chemoresistance and improve the antiproliferative effects of conventional treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sepideh Mirzaei, Asal Jalal Abadi, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Kiavash Hushmandi, Ali Zarrabi, Maliheh Entezari, Amir Reza Aref, Haroon Khan, Milad Ashrafizadeh, Saeed Samarghandian
Summary: This article explores the issue of drug resistance in cancer cells, focusing on the role of the epithelial-to-mesenchymal transition (EMT) mechanism in enhancing cancer cell resistance to chemotherapy drug doxorubicin (DOX).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Review
Pharmacology & Pharmacy
Paula I. Escalante, Luis A. Quinones, Hector R. Contreras
Summary: The FOLFOX scheme is commonly used for metastatic colorectal cancer patients, but chemoresistance is a major challenge. EMT and overexpression of multiple genes may contribute to drug resistance.
Review
Oncology
Kostas Palamaris, Evangelos Felekouras, Stratigoula Sakellariou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by aggressive behavior and resistance to chemotherapy, with emerging evidence pointing to epithelial to mesenchymal transition (EMT) as a key driver of disease progression and drug resistance. EMT allows cancer cells to transition to a more mesenchymal state, contributing to tumor dissemination and chemoresistance in PDAC.
Article
Oncology
Yu Xie, Shuai Zhu, Jinglei Zang, Guanlin Wu, Yuheng Wen, Yu Liang, Ying Long, Weiming Guo, Chuanbing Zang, Xiang Hu, Gang Fan, Shuanglin Xiang, Jian Zhang
Summary: ADNP is overexpressed in BC tissues of patients with tumor progression, and high ADNP expression is associated with shorter tumor-free survival in BC patients. Downregulation of ADNP increases sensitivity to cisplatin in BC, while overexpression of ADNP has the opposite effect. ADNP promotes cell migration and EMT, leading to cisplatin resistance, possibly through the TGF-β/Smad signaling pathway.
Article
Oncology
Yu Tian, Peiwei Li, Zhaohua Xiao, Jie Zhou, Xia Xue, Ning Jiang, Chuanliang Peng, Licun Wu, Hui Tian, Helmut Popper, Mau-Ern Poh, Fabrizio Marcucci, Chengke Zhang, Xiaogang Zhao
Summary: The study demonstrates that triptolide can reverse epithelial-mesenchymal transition in taxol-resistant lung adenocarcinoma cells and inhibit tumor growth by suppressing the p70S6K/GSK3/β-catenin pathway, suggesting its potential as a new therapeutic agent for taxol-resistant lung adenocarcinoma.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Binshen Chen, Yiming Zhang, Chaoming Li, Peng Xu, Yubo Gao, Yawen Xu
Summary: The study revealed that downregulation of CNTN-1 can reverse multi-drug resistance to docetaxel in prostate cancer, reducing cell proliferation, migration, invasion, increasing apoptosis, and inhibiting the activity of the phosphoinositide 3-kinase signaling pathway.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Neurosciences
Ying Chen, Hui Xu, Pei Yu, Qing Wang, Shenggang Li, Fufu Ji, Chunwang Wu, Qing Lan
Summary: Previous studies have shown that high expression of IFI30 is associated with glioma and tumor grade. In this study, it was found that IFI30 promotes the epithelial-mesenchymal transition (EMT) process in glioma cells through the activation of the EGFR/AKT/GSK3 beta/beta-catenin pathway. Additionally, IFI30 regulates the chemoresistance of glioma cells to temozolomide by affecting the expression of the transcription factor Slug. These findings indicate that IFI30 may serve as a prognostic marker and a potential therapeutic target for temozolomide-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Tengteng Zou, Meng Lan, Fengjie Liu, Lihong Li, Tiange Cai, Huaqin Tian, Yu Cai
Summary: The study highlights the crucial role of EMT in breast cancer drug resistance, but inhibiting EMT with E-PLNs can enhance the sensitivity of breast cancer cells to chemotherapy drug DOX. This offers a new approach to prevent or delay clinical drug resistance in breast cancer.
CANCER NANOTECHNOLOGY
(2021)
Review
Veterinary Sciences
Federico Armando, Federico Mazzola, Luca Ferrari, Attilio Corradi
Summary: This review discusses the general concept of epithelial-mesenchymal transition (EMT) and its regulation by various factors. It covers the role of transcription factors, microRNAs, reactive oxygen species, exosomes, microvesicles, and viruses in EMT. The review also examines EMT in embryonic development, fibrosis, and cancer metastasis, including discussions on the tumor microenvironment, pre-metastatic niches, and cancer stem cells. Additionally, it explores the use of EMT as a prognostic marker and provides insights into mesenchymal-epithelial transition (MET) in sarcomas. Therapeutic approaches for targeting EMT and MET are also addressed.
VETERINARY SCIENCES
(2023)
Review
Cell Biology
Jozsef Dudas, Andrea Ladanyi, Julia Ingruber, Teresa Bernadette Steinbichler, Herbert Riechelmann
Article
Oncology
Barbara Kofler, Johannes Laimer, Emanuel Bruckmoser, Teresa B. Steinbichler, Annette Runge, Volker H. Schartinger, Dorothee von Laer, Wegene Borena
Article
Oncology
Barbara Kofler, Wegene Borena, Jozsef Dudas, Veronika Innerhofer, Daniel Dejaco, Teresa B. Steinbichler, Gerlig Widmann, Dorothee von Laer, Herbert Riechelmann
Article
Engineering, Biomedical
Rene Fischlechner, Barbara Kofler, Volker Hans Schartinger, Jozsef Dudas, Herbert Riechelmann
Summary: Using fuzzy matching, the study found no significant difference in overall survival between HNC patients who received LLLT and those who did not. There was no increased risk of death observed in HNC patients who received LLLT covering the tumor region.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Alexandra Fullar, Katalin Karaszi, Peter Hollosi, Gabor Lendvai, Laszlone Olah, Andrea Reszegi, Zoltan Papp, Gabor Sobel, Jozsef Dudas, Ilona Kovalszky
Article
Psychiatry
D. Riedl, D. Dejaco, T. B. Steinbichler, V. Innerhofer, T. Gottfried, L. Bektic-Tadic, A. I. Giotakis, G. Rumpold, H. Riechelmann
Summary: The SNOT-22 questionnaire is a validated tool for assessing symptoms, health-related quality-of-life, and treatment response in patients with chronic rhinosinusitis. The German version of SNOT-22 demonstrated good reliability, validity, and responsiveness in German patients with CRS.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Oncology
Herbert Riechelmann, Teresa Bernadette Steinbichler, Susanne Sprung, Matthias Santer, Annette Runge, Ute Ganswindt, Gabriele Gamerith, Jozsef Dudas
Summary: Slug is identified as a predictive biomarker for treatment failure in HNSCC patients and shows significant value for patients undergoing upfront surgery.
Article
Cell Biology
Julia Ingruber, Dragana Savic, Teresa Bernadette Steinbichler, Susanne Sprung, Felix Fleischer, Rudolf Glueckert, Gabriele Schweigl, Ira-Ida Skvortsova, Herbert Riechelmann, Jozsef Dudas
Summary: The study found that in head and neck squamous cell carcinoma, Slug gene expression was significantly higher while KLF4 gene expression was significantly lower. There was a significant negative correlation between KLF4 and Slug gene expression in the majority of HNSCC samples. TGF-β1 contributed to the downregulation of KLF4 and the upregulation of Slug.
Review
Otorhinolaryngology
Teresa Bernadette Steinbichler, Dolores Wolfram, Annette Runge, Roland Hartl, Daniel Dejaco, Tina Rauchenwald, Claus Pototschnig, Herbert Riechelmann, Volker Hans Schartinger
Summary: EndoVAC therapy is an easy-to-perform, safe procedure for the treatment of pharyngocutaneous fistulas. In a case series of six male patients, it was successful in five patients (83.3%), with a median duration of therapy of 18.5 days and a median number of sponge changes of 4. One patient required additional reconstructive surgery with no treatment-related complications observed.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Biochemistry & Molecular Biology
Lejo Johnson Chacko, Hanae Lahlou, Claudia Steinacher, Said Assou, Yassine Messat, Jozsef Dudas, Albert Edge, Berta Crespo, Moira Crosier, Consolato Sergi, Anneliese Schrott-Fischer, Azel Zine
Summary: By analyzing transcriptomic data from otic sensory cells differentiated from human induced pluripotent stem cells, we identified novel genes and biological networks in the human otic sensory developmental cell lineage. The study suggests a critical role of ECM-ITG interactions with otic neurosensory lineage genes in early neurosensory development and cell fate determination in the human fetal inner ear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Julia Ingruber, Jozsef Dudas, Susanne Sprung, Bianca Lungu, Felicitas Mungenast
Summary: This study reveals the important role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC), and suggests that stable KLF4-overexpression may enhance the sensitivity of HNSCC tumor cells to Cisplatin treatment.
Article
Cell Biology
Dragana Savic, Teresa Bernadette Steinbichler, Julia Ingruber, Giulia Negro, Bertram Aschenbrenner, Herbert Riechelmann, Ute Ganswindt, Sergej Skvortsov, Jozsef Dudas, Ira-Ida Skvortsova
Summary: Unfavorable clinical outcomes in HNSCC necessitate the development of new therapeutic strategies. This study demonstrates that Erk1/2 activation in HNSCC cells increases vulnerability to ferroptosis induction. Overexpression of xCT (SLC7A11) in malignant tissues suggests its potential as a druggable target.
