Review
Immunology
Peng Ding, Zhiqiang Ma, Dong Liu, Minghong Pan, Huizi Li, Yingtong Feng, Yimeng Zhang, Changjian Shao, Menglong Jiang, Di Lu, Jing Han, Jinliang Wang, Xiaolong Yan
Summary: This review investigates the latest developments in lysine acetylation/deacetylation alteration in cancer immunotherapy, including the explanation of the acetylation/deacetylation process, relevant enzymes, immune molecules, and therapeutic strategies associated with lysine acetylation/deacetylation modification. In addition, prospective research fields related to cancer immunotherapy concepts are offered.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Alicia Tapias, David Lazaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Summary: The study reveals the importance of TRRAP for neuroprotection and the network connecting TRRAP, HAT, and SP1 in regulating microtubule dynamics.
Review
Biochemistry & Molecular Biology
Jie Wang, Feng Yun, Jiahui Sui, Wenpeng Liang, Dingding Shen, Qi Zhang
Summary: Epilepsy, a common and severe chronic neurological disorder, has been the subject of extensive research on post-translational modification (PTM) mechanisms, particularly protein acetylation modifications. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation, with HATs transferring acetyl groups to lysine residues and HDACs removing acetyl groups. Epilepsy is associated with the regulation of gene expression through histone acetylation and deacetylation, as well as the acetylation modification of non-histone substrates. HDAC inhibitors (HDACi) have been developed as potential antiepileptic drugs. This review summarizes the changes in acetylation modification during epileptogenesis, the application of HDACi in epilepsy treatment, and the underlying mechanisms. Further understanding of acetylation regulation will provide insights into the pathological mechanism of epilepsy and novel therapeutic ideas.
Article
Oncology
Sebastian Lunke, Scott Maxwell, Ishant Khurana, K. N. Harikrishnan, Jun Okabe, Keith Al-Hasani, Assam El-Osta
Summary: This study explores the impact of the anti-epileptic drug VPA and the HDAC inhibitor SAHA on histone modifications and gene expression. It reveals a broader regulatory role of VPA and SAHA on histone modifications, defining an acetylation/deacetylation (Ac/Dc) axis.
CLINICAL EPIGENETICS
(2021)
Article
Cell Biology
Zhenzhen Jiang, Xiaoli Zheng, Weijia Wang, Liqing Qiu, Lingrong Yang, Mingfeng Jiang, Yuhui Hua
Summary: The study found downregulation of CYP2C9 in human esophageal squamous cell carcinoma. The epigenetic analysis revealed that inhibition of HDAC8 and HDAC1 could increase the expression of CYP2C9. Overexpression of CYP2C9 reduces the invasion and migration ability of ESCC cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Maria Manou, Dimitrios S. Kanakoglou, Theodoros Loupis, Dimitrios M. Vrachnos, Stamatios Theocharis, Athanasios G. Papavassiliou, Christina Piperi
Summary: Salivary gland tumors (SGTs) are a rare and heterogeneous category of tumors with increasing understanding of their molecular mechanisms, poor prognosis, and potential therapeutic options. Genetic and epigenetic factors are involved in their heterogeneity and clinical phenotypes. Histone acetylation/deacetylation, through histone deacetylating factors (HDACs) and selective or pan-HDAC inhibitors (HDACis), plays an active role in the pathobiology of SGTs, suggesting potential treatment options. This article summarizes the molecular and epigenetic mechanisms of SGTs, focusing on the effects of histone acetylation/deacetylation on gene expression and the progress of HDACis in SGT therapy and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Geer Chen, Xiaoyu Zhu, Jiaqi Li, Yao Zhang, Xiaoxuan Wang, Ren Zhang, Xinchen Qin, Xi Chen, Junyi Wang, Weilin Liao, Zongjin Wu, Lu Lu, Weiyu Wu, Haijie Yu, Lijuan Ma
Summary: Alterations in histone modification have been shown to be related to cancer development and progression. Celastrol, a Chinese herbal compound, exhibits potent anti-tumor effects through multiple signaling pathways. This study demonstrates that histone modifications, especially histone acetylation associated with the NuA4 histone acetyltransferase complex, are involved in the anti-proliferation actions of celastrol. Combination therapy with celastrol and histone deacetylase inhibitors (HDACi) synergistically suppresses cancer cell proliferation. The results suggest that the combination of celastrol and HDACi could be a potential novel therapeutic approach for lung cancer patients.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Marina Barreto Felisbino, Mark Ziemann, Ishant Khurana, Jun Okabe, Keith Al-Hasani, Scott Maxwell, K. N. Harikrishnan, Camila Borges Martins de Oliveira, Maria Luiza S. Mello, Assam El-Osta
Summary: The study found that the histone deacetylase inhibitor valproic acid (VPA) can attenuate gene activation in hepatocytes under hyperglycaemia, and epigenetic regulation is involved in VPA action.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Chongyang Chen, Jingfang Liu
Summary: Thyroid cancer, particularly papillary thyroid cancer (PTC), is a common malignancy of the endocrine system. The incidence of PTC is increasing annually. Histone acetylation modification, an important epigenetic mechanism, plays a role in PTC cell proliferation, differentiation, and the treatment and prognosis of PTC patients.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Oncology
Oliver H. Kraemer, Gunter Schneider
Summary: In this commentary, we summarize and discuss recent evidence on the regulation and relevance of the transcription factor c-FOS in diffuse large B cell lymphoma cells treated with epigenetic erasers of the histone deacetylase inhibitor family.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel, Rossella Fioravanti, Beatrice Noce, Carola Castiello, Stefano Tomassi, Davide Corinti, Daniela Passeri, Roberto Pellicciari, Ciro Mercurio, Mario Varasi, Lucia Altucci, Marco Tripodi, Raffaele Strippoli, Angela Nebbioso, Sergio Valente, Antonello Mai
Summary: After years of research, HDAC inhibitors have been developed and approved by FDA/Chinese FDA for the treatment of cancer and non-cancer diseases. A series of novel compounds have been discovered to be effective anticancer agents, demonstrating selective inhibition of HDACs and inducing cell death and differentiation. These compounds also modulate gene and protein expression related to apoptosis and show potent antiproliferative activity in various cancer cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ukjin Kim, Kwang Seok Kim, Jong-Kuk Park, Hong -Duck Um
Summary: Based on previous findings, the interaction between p53 and p21 is essential for the tumor-suppressing functions of p53, and the acetylation of the C-terminal domain of p53 can affect this interaction. In this study, it was found that inhibiting the deacetylase SIRT1 or increasing the acetylation levels of lysine residues in the C-terminal domain reduced the interaction between p53 and p21. Additionally, substituting acetylation mimetics for the lysine residues in the C-terminal domain weakened the interaction. The degree of acetylation correlated with the extent of the inhibitory effect. Overall, these results suggest that cellular components involved in the acetylation or deacetylation of the C-terminal domain of p53 play a critical role in regulating the formation of the p53/p21 complex.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Irene Lo Cigno, Federica Calati, Carlo Girone, Cinzia Borgogna, Aldo Venuti, Renzo Boldorini, Marisa Gariglio
Summary: We evaluated the efficacy of a precision medicine approach targeting a novel SIRT1-dependent pathway in HPV-transformed cells, and found that SIRT1 plays a crucial role in HPV-driven oncogenesis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Xiao-Ling Liang, Lan Ouyang, Nan-Nan Yu, Zheng-Hua Sun, Zi-Kang Gui, Yu-Long Niu, Qing-Yu He, Jing Zhang, Yang Wang
Summary: This study identifies a potential anticancer therapy strategy by inducing cell death through shifting the scission position of mitochondria. The pan-HDAC inhibitor pracinostat is found to activate the CDK5-Drp1 signaling pathway, leading to mitochondrial fission and showing potential in CRC treatment.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Endocrinology & Metabolism
Jingru Yang, Cong Song, Xianquan Zhan
Summary: Protein acetylation is an important molecular event that is involved in various biological processes, including carcinogenesis. The modulation of protein acetylation levels can lead to the discovery of therapeutic drugs and lay the foundation for precision medicine in oncology.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Xin Wei, Kin-Sang Cho, Eric F. Thee, Martine J. Jager, Dong Feng Chen
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Lin Cheng, Lucy J. Wong, Naihong Yan, Richard C. Han, Honghua Yu, Chenying Guo, Khulan Batsuuri, Aniket Zinzuwadia, Ryan Guan, Kin-Sang Cho, Dong Feng Chen
Article
Multidisciplinary Sciences
Chenying Guo, Kin-Sang Cho, Yingqian Li, Kissauo Tchedre, Christian Antolik, Jie Ma, Justin Chew, Tor Paaske Utheim, Xizhong A. Huang, Honghua Yu, Muhammad Taimur A. Malik, Nada Anzak, Dong Feng Chen
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Cong Shi, Xuedong Yuan, Karen Chang, Kin-Sang Cho, Xinmin Simon Xie, Dong Feng Chen, Gang Luo
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ta-Ching Chen, Pin-Yi She, Dong Feng Chen, Jui-Hsien Lu, Chang-Hao Yang, Ding-Siang Huang, Pao-Yang Chen, Chen-Yu Lu, Kin-Sang Cho, Hsin-Fu Chen, Wei-Fang Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Sam Enayati, Karen Chang, Hamida Achour, Kin-Sang Cho, Fuyi Xu, Shuai Guo, Katarina Z. Enayati, Jia Xie, Eric Zhao, Tytteli Turunen, Amer Sehic, Lu Lu, Tor Paaske Utheim, Dong Feng Chen
Review
Cell Biology
Li Pan, Kin-Sang Cho, Irvin Yi, Chi-Ho To, Dong Feng Chen, Chi-Wai Do
Summary: This review focuses on the therapeutic potentials of three major active flavonoids extracted from Scutellaria baicalensis Georgi against ischemia-induced neurotoxicity and damage. These compounds have been shown to have promising pharmacological capabilities in preventing cell and tissue damage, and their bioactivity and bioavailability are also discussed. It is hoped that the therapeutic potential of these flavonoids can be utilized as natural treatments for ischemia-induced injuries of the central nervous system (CNS).
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Li Pan, Ying Hon Sze, Menglu Yang, Jing Tang, Siming Zhao, Irvin Yi, Chi-Ho To, Chuen Lam, Dong Feng Chen, Kin-Sang Cho, Chi-Wai Do
Summary: Baicalein exhibits strong anti-inflammatory effects and inhibits activated microglia and immune responses both in vitro and in vivo. It attenuates neurodegeneration caused by retinal ischemia and shows neuroprotective effects, making it a potential therapeutic agent for degenerative retinal diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Yizhen Tang, Simran Shah, Kin-Sang Cho, Xinghuai Sun, Dong Feng Chen
Summary: In this article, a systematic meta-analysis of the current literature surrounding the metabolomics of patients with primary open angle glaucoma (POAG) was performed. Results suggest several specifically altered metabolites in patients with POAG, indicating potential generalizability and future research pathways.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ajay Ashok, Sarita Pooranawattanakul, Wai Lydia Tai, Kin-Sang Cho, Tor P. Utheim, Dean M. Cestari, Dong Feng Chen
Summary: This review article focuses on the influence of epigenetic factors on optic nerve development and homeostasis, as well as the associated molecular apparatus. Understanding the epigenetic regulation in the optic nerve can lead to the discovery of novel molecular pathways and contribute to the design of effective therapeutics for optic nerve protection, repair, and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daisy Y. Shu, Suman Chaudhary, Kin-Sang Cho, Anton Lennikov, William P. Miller, David C. Thorn, Menglu Yang, Tina B. McKay
Summary: Redox homeostasis is crucial for maintaining the balance between antioxidant defense mechanisms and reactive oxidizing species in the human eye. Disruption of this balance results in oxidative stress, which plays a key role in various ocular diseases. This review provides evidence for oxidative stress and mitochondrial dysfunction in both the anterior and posterior segments of the eye, and suggests that therapeutic interventions targeting redox balance may delay or prevent the progression of these major ocular pathologies.
Review
Pathology
Julie Chen, Dong Feng Chen, Kin-Sang Cho
Summary: Microbiota research offers new approaches to promote ocular health and treat retinal diseases. Changes in microbiota have been associated with specific diseases. This review summarizes the significant changes in microbial composition in glaucoma patients and identifies their relationship with disease progression.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Li Pan, Kin-Sang Cho, Xin Wei, Fuyi Xu, Anton Lennikov, Guangan Hu, Jing Tang, Shuai Guo, Julie Chen, Emil Kriukov, Robert Kyle, Farris Elzaridi, Shuhong Jiang, Pierre A. Dromel, Michael Young, Petr Baranov, Chi-Wai Do, Robert W. Williams, Jianzhu Chen, Lu Lu, Dong Feng Chen
Summary: Microglia shift toward an inflammatory phenotype during aging, exacerbating age-related neurodegeneration. IGFBPL1, expressed by mouse and human microglia, is identified as an upstream regulator of microglia-specific genes that switches off inflammation. Therapeutic administration of IGFBPL1 promotes pro-homeostatic microglia, preventing glaucomatous neurodegeneration and vision loss in mice.
Article
Immunology
Yizhen Tang, Zebin Xiao, Li Pan, Dongli Zhuang, Kin-Sang Cho, Kyle Robert, Xiaoxiao Chen, Lian Shu, Guangxian Tang, Jihong Wu, Xinghuai Sun, Dong F. Chen
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Ophthalmology
Jiaxin Xiao, Muhammed Yasin Adil, Karen Chang, Zicheng Yu, Lanbo Yang, Tor P. Utheim, Dong Feng Chen, Kin-Sang Cho
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)