期刊
ONCOTARGET
卷 8, 期 37, 页码 62143-62153出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19121
关键词
laryngeal cancer; metastasis; mir-217; AEG-1; PD-L1
资金
- China Postdoctoral Science Foundation [2015M581470, 2015M581472]
- National Nature Science Foundation of China [81600539]
- Special Financial Grant from the China Postdoctoral Science Foundation [2016T90310]
- Heilongjiang Postdoctoral Foundation [LBH-Z15173, LBH-216097, LBH-TZ0616]
- Natural Science Foundation of Heilongjiang [H2016048, LC2016038]
- Technology Foundation for Selected Overseas Chinese Scholars
- Heilongjiang Human Resources and Social Security Bureau
- Youth elite training Foundation
- HaiYan scientific research Foundation of Harbin Medical University Cancer Hospital
- Harbin Special fund project for Science and technology innovation [2016RAQXJ203]
- Haiyan Foundation of the Tumor Hospital affiliated Harbin Medical University [TJMS2016-05]
- Youth elite training Foundation of Harbin Medical University Cancer Hospital [JY2016-06]
High incidences of laryngeal cancer have been reported recently. Increasing our understanding of the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating laryngeal cancer patients and so improve their prognoses. In this study, we explored the biological effects of miR-217 on laryngeal cancer. miR-217 potently inhibited multiple metastatic traits, including cell migration, invasion, proliferation, apoptosis, and EMT, as well as angiogensis. These effects were achieved through downregulation of the miR-217 target gene, AEG-1 and PD-L1. Clinical expression and animal model studies further confirmed our results. These findings provide new insight into the physiological effects of miR-217 in laryngeal cancer and its potential therapeutic use.
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