Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, Mohammad Taheri, Peixin Dong
Summary: Pancreatic cancer is a deadly neoplasm with poor prognosis, and recent research has highlighted the impact of lncRNAs on its progression. Some lncRNAs are oncogenic while others act as tumor suppressors in pancreatic cancer. Dysregulated expression of specific lncRNAs may serve as prognostic markers in patients with this aggressive cancer.
Article
Oncology
Leonie Gebauer, Jan H. Moltz, Alexander Muehlberg, Julian W. Holch, Thomas Huber, Johanna Enke, Nils Jaeger, Michael Haas, Stephan Kruger, Stefan Boeck, Michael Suehling, Alexander Katzmann, Horst Hahn, Wolfgang G. Kunz, Volker Heinemann, Dominik Noerenberg, Stefan Maurus
Summary: Finding prognostic biomarkers with high accuracy in patients with pancreatic cancer remains a challenge. In this study, a combined model using quantitative imaging biomarkers and established clinical parameters showed significantly higher predictive performance in discriminating survival compared to clinical models alone. Integrating radiomics and geometric analysis of whole liver tumor burden enhanced the modeling of survival in patients with metastatic pancreatic cancer with liver metastases.
Review
Oncology
Chentao Jin, Xiaoyun Luo, Xiaoyi Li, Rui Zhou, Yan Zhong, Zhoujiao Xu, Chunyi Cui, Xiaoqing Xing, Hong Zhang, Mei Tian
Summary: This article reviews the current status of PET imaging in characterizing cancer hallmarks and discusses the future directions of PET imaging strategies for in vivo cancer phenotyping.
Article
Medicine, Research & Experimental
Mohadeseh Fathi, Soudeh Ghafouri-Fard, Atefe Abak, Mohammad Taheri
Summary: Pancreatic cancer is a deadly disease with genetic aberrations and epigenetic alterations playing a role in its development. Certain miRNAs act as oncomiRs, promoting cell proliferation, while others function as tumor suppressors, regulating cell growth and cycle transitions. The use of miRNAs as non-invasive markers for diagnosing and prognosticating pancreatic cancer shows promise in research.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Sanne A. Hoogenboom, Candice W. Bolan, Anthony Chuprin, Maria T. Raimondo, Jeanin E. van Hooft, Michael B. Wallace, Massimo Raimondo
Summary: This study suggests that pancreatic steatosis on CT imaging may serve as an early imaging feature for PDAC, independently associated with the disease up to three years prior to clinical diagnosis, especially in overweight individuals. If confirmed, this novel imaging feature could be valuable for identifying high-risk individuals and stratifying PDAC risk in those undergoing screening.
Article
Pharmacology & Pharmacy
S. Kannan, P. Shaik Syed Ali, A. Sheeza
Summary: This report discusses the development and characteristics of pancreatic ductal adenocarcinoma (PDAC), the most lethal and aggressive type of pancreatic cancer. The mutations in genes such as KRAS, CDKN2A, TP53, and SMAD4 play a role in the development of PDAC. However, there are currently no effective treatment options available. Research on biomarkers for early diagnosis and prognosis of PDAC is ongoing.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Natacha Jugniot, Rakesh Bam, Emmanuelle J. Meuillet, Evan C. Unger, Ramasamy Paulmurugan
Summary: PDAC is often diagnosed late with limited treatment options, highlighting the urgent need for new imaging technologies with high sensitivity and specificity. CETUS, a novel molecular imaging modality, shows promise for accurate detection of PDAC and has potential clinical translational applications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Tuan Trong Luu
Summary: Pancreatic cancer is a deadly cancer type with poor prognosis and high mortality rate, making early detection a focus of academic research. Immunohistochemistry biomarkers are believed to play a crucial role in improving diagnostic efficacy for pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xiangling Chen, Fangfang Liu, Qingping Xue, Xiechuan Weng, Fan Xu
Summary: Pancreatic cancer is a lethal malignancy with metastatic PC posing challenges in treatment, requiring further research on molecular mechanisms and therapeutic targets.
Article
Gastroenterology & Hepatology
Johannes F. Fahrmann, C. Max Schmidt, Xiangying Mao, Ehsan Irajizad, Maureen Loftus, Jinming Zhang, Nikul Patel, Jody Vykoukal, Jennifer B. Dennison, James P. Long, Kim-Anh Do, Jianjun Zhang, John A. Chabot, Michael D. Kluger, Fay Kastrinos, Lauren Brais, Ana Babic, Kunal Jajoo, Linda S. Lee, Thomas E. Clancy, Kimmie Ng, Andrea Bullock, Jeanine Genkinger, Michele T. Yip-Schneider, Anirban Maitra, Brian M. Wolpin, Samir Hanash
Summary: CA19-9 serves as an anchor marker for pancreatic cancer early detection, especially with exponentially increasing levels starting 2 years before diagnosis, providing significant value for early diagnosis.
Article
Cardiac & Cardiovascular Systems
Hannah N. Marmor, Michael N. Kammer, Stephen A. Deppen, Maren Shipe, Valerie F. Welty, Khushbu Patel, Caroline Godfrey, Ehab Billatos, James G. Herman, David O. Wilson, Amanda K. Kussrow, Darryl J. Bornhop, Fabien Maldonado, Heidi Chen, Eric L. Grogan
Summary: The study aimed to compare different methods in diagnosing indeterminate pulmonary nodules, and the results showed that the integrated biomarker model had higher diagnostic accuracy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Oncology
Jenny Jing Li, Mojun Zhu, Purna C. Kashyap, Nicholas Chia, Nguyen H. Tran, Robert R. McWilliams, Tanios S. Bekaii-Saab, Wen Wee Ma
Summary: Recent studies have revealed the significant impact of the microbiome on cancer development and treatment, especially in pancreatic ductal adenocarcinoma. Utilizing microbiome analyses can lead to the development of new diagnostic and therapeutic strategies, such as fecal microbiota transplantation, probiotics, and dietary changes.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Article
Oncology
Edward Duckworth, Matthew Mortimer, Bilal Al-Sarireh, Venkateswarlu Kanamarlapudi, Debdulal Roy
Summary: In order to improve the low 5% survival rate of pancreatic cancer, a novel, affordable, and easily accessible cancer diagnostic tool has been developed. This method combines the accuracy of infrared spectroscopy with machine learning classification, achieving a diagnosis accuracy as high as 90%.
Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor M. Baart, Labrinus van Manen, Shadhvi S. Bhairosingh, Floris A. Vuijk, Luisa Iamele, Hugo de Jonge, Claudia Scotti, Massimo Resnati, Robert A. Cordfunke, Peter J. K. Kuppen, Andrew P. Mazar, Jacobus Burggraaf, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Summary: In this study, fluorescence-guided surgery using uPAR-targeting antibody fragments resulted in earlier tumor visualization compared to the parent IgG, but at the expense of peak fluorescence intensity.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Oncology
Fanny Boyaval, Hans Dalebout, Rene Van Zeijl, Wenjun Wang, Arantza Farina-Sarasqueta, Guinevere S. M. Lageveen-Kammeijer, Jurjen J. Boonstra, Liam A. McDonnell, Manfred Wuhrer, Hans Morreau, Bram Heijs
Summary: This study investigates the changes in sugar molecules during the progression of colorectal cancer (CRC) and finds that these sugar signatures can clearly differentiate different stages of CRC progression, especially between pre-cancerous and cancerous tissue. The study also observes the spreading of glycosylation signatures into the tumor microenvironment.
Article
Oncology
Thomas P. Brouwer, Natasja L. de Vries, Tamim Abdelaal, Ricki T. Krog, Zheng Li, Dina Ruano, Arantza Farina, Boudewijn P. F. Lelieveldt, Hans Morreau, Bert A. Bonsing, Alexander L. Vahrmeijer, Frits Koning, Noel F. C. C. de Miranda
Summary: This study reveals an immunosuppressive landscape in PDAC tissues, with a depletion of cytotoxic T cells and an enrichment of regulatory T cells and B cells. The potential of ILC1-like cells in PDAC to act against tumors may be explored in therapeutic settings. Moreover, the immune cell composition of the PDAC microenvironment can be reflected in blood samples isolated from the portal vein.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Thomas Brouwer, Marieke Ijsselsteijn, Jan Oosting, Dina Ruano, Manon van der Ploeg, Frederike Dijk, Bert Bonsing, Arantza Farina, Hans Morreau, Alexander Vahrmeijer, Noel de Miranda
Summary: The infiltration of regulatory T cells (Tregs) in pancreatic ductal adenocarcinomas (PDAC) is associated with better overall survival of patients, independent of cytotoxic T cell infiltration and the transcriptomic profiles of their respective tumors.
Article
Oncology
Myrte Gorris, Nadine C. M. van Huijgevoort, Arantza Farina, Lodewijk A. A. Brosens, Hjalmar C. van Santvoort, Bas Groot Koerkamp, Marco J. Bruno, Marc G. Besselink, Jeanin E. van Hooft
Summary: Patients with pancreatic cancer associated with pancreatic cystic neoplasms (PCN) have better overall survival compared to those without PCN. Further prospective studies are needed to investigate the impact of these findings on treatment regimens for this specific patient group.
Article
Oncology
Floris A. Vuijk, Fleur Kleiburg, Wyanne A. Noortman, Linda Heijmen, Shirin Feshtali Shahbazi, Floris H. P. van Velden, Victor M. Baart, Shadhvi S. Bhairosingh, Bert D. Windhorst, Lukas J. A. C. Hawinkels, Petra Dibbets-Schneider, Neanke Bouwman, Stijn A. L. P. Crobach, Arantza Farina-Sarasqueta, Andreas W. K. S. Marinelli, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg, Frits Smit, Alexander L. Vahrmeijer, Lioe-Fee De Geus-Oei, Denise E. Hilling, Marije Slingerland
Summary: PSMA-targeted PET/CT imaging shows potential in detecting gastrointestinal cancers, but challenges include low tumor expression and high physiological uptake in surrounding organs/tissues. Additionally, [F-18]FDG PET/CT may be more effective in detecting colon, gastric, and pancreatic cancers compared to [F-18]DCFPyL PET/CT.
Review
Oncology
Bertram J. de Kleijn, Gijs T. N. Heldens, Jasmijn M. Herruer, Cornelis F. M. Sier, Cesare Piazza, Remco de Bree, Orlando Guntinas-Lichius, Luiz P. Kowalski, Vincent Vander Poorten, Juan P. Rodrigo, Nina Zidar, Cherie-Ann Nathan, Raymond K. Tsang, Pawel Golusinski, Ashok R. Shaha, Alfio Ferlito, Robert P. Takes
Summary: In head and neck cancer surgery, complete removal of the tumor is necessary for optimal therapy, but this is challenging in vulnerable areas with potential functional limitations. Various imaging techniques can assist in distinguishing tumor from healthy tissue and aid in achieving complete tumor removal. This paper provides an overview of imaging techniques for oropharyngeal squamous cell carcinoma and discusses the potential for optimizing surgical outcomes.
Article
Biochemistry & Molecular Biology
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F. C. C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A. E. M. Tollenaar, Francesco M. Marincola, Jerome Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Summary: The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, comprehensive genomic analyses were performed on fresh-frozen samples from 348 patients with primary colon cancer. The study revealed a gene expression signature called Immunologic Constant of Rejection that outperformed conventional prognostic molecular biomarkers. Additionally, a favorable outcome was associated with a microbiome signature driven by Ruminococcus bromii.
Article
Gastroenterology & Hepatology
Quisette P. Janssen, Rutger Quispel, Marc G. Besselink, Bert A. Bonsing, Marco J. Bruno, Michael Doukas, Arantza F. Sarasqueta, Marjolein Y. V. Homs, Jeanin E. van Hooft, Geertjan van Tienhoven, Marie-Louise F. van Velthuysen, Joanne Verheij, Rogier P. Voermans, Johanna W. Wilmink, Bas Groot Koerkamp, Casper H. J. van Eijck, Lydi M. J. W. van Driel
Summary: This study evaluates the performance of endoscopic tissue acquisition procedures for borderline resectable and resectable pancreatic ductal adenocarcinoma (PDAC). The results show that EUS-guided tissue acquisition had a sensitivity of over 85% for both initial and repeat procedures, meeting international standards.
Article
Oncology
Luogen Peng, Yuchan Li, Sha Yao, Jochen Gaedcke, Victor M. Baart, Cornelis F. M. Sier, Albrecht Neesse, Volker Ellenrieder, Hanibal Bohnenberger, Frieder Fuchs, Julia Kitz, Philipp Stroebel, Stefan Kueffer
Summary: Pancreatic ductal adenocarcinomas (PDACs) with urokinase-type plasminogen activator receptor (uPAR) gene amplification or overexpression have a poor prognosis. uPAR reinforces the MEK/ERK signaling pathway and suppresses FAK and CDC42 signaling in tumor cells with a KRAS mutation, promoting cell migration and proliferation, and sensitizing them towards gemcitabine. However, targeting KRAS or uPAR could induce cellular dormancy and make the tumor more resistant to chemotherapy.
Article
Biochemistry & Molecular Biology
Zeger Rijs, Esther Belt, Gijsbert M. M. Kalisvaart, Cornelis F. M. Sier, Peter J. K. Kuppen, Arjen H. G. Cleven, Alexander L. L. Vahrmeijer, Michiel A. J. van de Sande, Pieter B. A. A. van Driel
Summary: This study aims to evaluate the expression of eight promising biomarkers for FGS in MFS tissue samples and adjacent healthy tissue. The results show that TEM-1 is the most suitable biomarker for FGS in MFS and should be further investigated to optimize MFS treatment.
Article
Surgery
Jose Annelie Suurmeijer, Eline Christine Soer, Mark Pui Gien Dings, Yongsoo Kim, Marin Strijker, Bert Anne Bonsing, Lodewijk Adriaan Anton Brosens, Olivier Robert Busch, Jesse Vincent Groen, Johannes Berend Gerardus Halfwerk, Robbert Alexander Eduard Slooff, Hanneke Wilma Marlies van Laarhoven, Isaac Quintus Molenaar, George Johan Arnold Offerhaus, Johannes Morreau, Marc Jone van de Vijver, Arantza Farina Sarasqueta, Joanne Verheij, Marc Gerard Besselink, Maarten Fokke Bijlsma, Frederike Dijk
Summary: This study found that the molecular subtypes of pancreatic adenocarcinoma have prognostic value in clinical practice, particularly in the preoperative setting. However, the prognostic value of these subtypes decreases when histopathological parameters are available in the postoperative setting.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Hematology
Rayna J. S. Anijs, El Houari Laghmani, Betul Unlu, Szymon M. Kielbasa, Hailiang Mei, Suzanne C. Cannegieter, Frederikus A. Klok, Peter J. K. Kuppen, Henri H. Versteeg, Jeroen T. Buijs
Summary: This study aimed to identify novel tumor-expressed miRNAs associated with VTE in colorectal cancer. Through sequencing analysis, 19 differentially regulated tumor-expressed miRNAs were identified, which may provide insights into the biological mechanism and serve as potential predictive biomarkers.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)