期刊
ONCOTARGET
卷 8, 期 37, 页码 61927-61934出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18720
关键词
leptin receptor; Gln223Arg; polymorphism; type 2 diabetes mellitus
资金
- National Natural Science Foundation of China [NSFC 81100073]
- Excellent Young and Middle-Aged Teachers Assistance Program of Nanjing Medical University [JX2161015034]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Natural Science Foundation of Jiangsu Province [BK 2012648]
- six talent peaks project in Jiangsu Province [2015-WSN-033]
Background: The Leptin receptor (LEPR) Gln223Arg gene polymorphism has been associated with an increased susceptibility to Type 2 diabetes mellitus (T2DM). Results from various studies, however, are inconsistent. Objective and methods: To better elucidate the association of LEPR Gln223Arg gene polymorphism with T2DM in the Chinese population, a meta-analysis of 3,367 subjects from seven independent studies was performed. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) were evaluated by the fixed-effects model. Results: A significant relationship between LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population was found under allele (OR: 1.432, 95% CI: 1.211-1.694, P=2.67x10(-5)), dominant (OR: 1.466, 95% CI: 1.215-1.769, P=6.33x10(-5)), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06x10(-4)), and homozygous (OR: 0.472, 95% CI: 0.265-0.839, P=0.011) genetic models. Conclusions: LEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population. Therefore, Chinese carriers of the G allele of LEPR Gln223Arg gene polymorphism may be more susceptible to T2DM than the general population.
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