期刊
ONCOTARGET
卷 8, 期 35, 页码 58654-58667出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17414
关键词
renal cell carcinoma; HOTAIR; hippo pathway; SAV1
资金
- National Natural Science Foundation of China [81370699, 81602216]
- National Science Foundation of Shanghai [16ZR1426500]
- Shanghai Pujiang Program [16PJD037]
The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth in vitro and in vivo. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation. Loss of function of SAV1 activated the Hippo pathway. HOTAIR could be a potential therapeutic target in RCC.
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