Review
Cell Biology
Rustem Uzbekov, Claude Prigent
Summary: All living organisms are composed of cells, which undergo cell division to reproduce and form a whole organism. Cell division is a highly regulated process that follows a sequence of events known as the cell cycle. The universality of the cell cycle is attributed to the shared genetic information encoded by the DNA double helix in all organisms.
Review
Oncology
Liguo Wang, Zhouli Yang, Guangchen Li, Yongbo Liu, Chao Ai, Yu Rao
Summary: This article summarizes the latest developments in CDK and cyclin protein degraders, covering their selectivity, application, validation, and the current state of development for CDK members lacking degraders. It provides a comprehensive overview for researchers in this field.
FRONTIERS OF MEDICINE
(2023)
Review
Oncology
Mitra Zabihi, Ramin Lotfi, Amir-Mohammad Yousefi, Davood Bashash
Summary: CDKs, cyclins, and CKIs play important roles in the cell cycle regulatory machinery, and dysregulation of their expression or function can contribute to tumorigenesis. While designing CDK inhibitors to target tumor cells shows promise, the non-canonical functions of CDKs pose challenges in their application. This review aims to explore the biology of CDKs and their contribution to tumorigenesis, and discuss the pros and cons of CDK inhibition in the treatment of human cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Xiao-Ru Liang, Yan-Fei Liu, Feng Chen, Zhi-Xia Zhou, Li-Jie Zhang, Zhi-Juan Lin
Summary: Long non-coding RNAs (lncRNAs) are involved in various biological processes and regulate key proteins in the cell cycle of cancer cells. Understanding their role in cell cycle regulation can lead to new therapeutic strategies for cancer treatment. This review article summarizes recent studies on lncRNA control of cell cycle-related proteins and discusses their emerging role in cancer diagnosis and therapy.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Rosa-Maria Ferraiuolo, Bre-Anne Fifield, Caroline Hamm, Lisa A. Porter
Summary: Understanding the relationship between protein expression level and response to treatment is crucial for developing novel treatment options for breast cancer patients. The data shows a correlation between Spy1 and c-Myc protein levels in more aggressive breast cancer cells and patient samples. Additionally, targeting Spy1 may confer an advantage to current chemotherapies, even when c-Myc levels are elevated.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Oncology
Alessandra Merlini, Valeria Pavese, Giulia Manessi, Martina Rabino, Francesco Tolomeo, Sandra Aliberti, Lorenzo D'Ambrosio, Giovanni Grignani
Summary: Effective treatment of advanced/metastatic bone and soft tissue sarcomas remains a medical challenge. CDK inhibitors have shown potential therapeutic effects in various cancer types, including sarcomas. This review explores the molecular basis and therapeutic implications of CDK inhibitors in sarcoma treatment and discusses the possibility of combination therapies with conventional treatments, targeted therapy, and immunotherapy to integrate CDK inhibition in sarcoma treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Aleksandra J. Pluta, Cecilia Studniarek, Shona Murphy, Chris J. Norbury
Summary: This article discusses the important roles of structurally related cyclin-dependent protein kinases (CDKs) in eukaryotic cell function, highlighting their roles in cell cycle regulation and transcriptional regulation, and the overlap between these processes.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Review
Plant Sciences
Aline Kohn Carneiro, Patricia da Fonseca Montessoro, Adriana Flores Fusaro, Bruna Gino Araujo, Adriana Silva Hemerly
Summary: In the face of climate change, plants have developed mechanisms to adapt by regulating cell division, with CDKs playing a crucial role in controlling the cell cycle. Understanding the roles of CDKs in responding to environmental stresses may be essential for increasing agricultural productivity in a changing climate.
Article
Biochemistry & Molecular Biology
Jonas Muhr, Daniel W. Hagey
Summary: The regulation of stem cell behavior is achieved through reciprocal regulation between the cell cycle machinery and differentiation factors. Activities of different cell cycle phases bias cells towards stem cell maintenance or differentiation, and direct mechanistic links between these processes have been established. Understanding the interconnections between these processes in pluripotent and neural stem cells can help explain their behavior in health and disease.
Article
Biochemistry & Molecular Biology
Toshiya Fujisaki, Ken Saito, Toshiaki Kikuchi, Eisaku Kondo
Summary: OGFOD1 is an important factor that regulates the transcription and stabilization of cell cycle-related genes, and plays a role in maintaining the function of specific cell cycle regulators during cancer cell proliferation.
Review
Biochemistry & Molecular Biology
Ni Made Pitri Susanti, Daryono Hadi Tjahjono
Summary: The cell cycle is crucial in cell development, and its progression is controlled by endogenous CDK inhibitors, CDKs, and cyclins. Dysregulation of the cell cycle can lead to cancer, making CDK a natural target for anticancer therapy. Understanding CDK structures and complexes with drugs helps in developing CDK inhibitors, from non-selective to selective CDK4/CDK6 inhibitors applied in clinical cancer treatment.
Article
Cell Biology
Reema S. Wahdan-Alaswad, Susan M. Edgerton, Hyun Min Kim, Aik Choon Tan, Bryan R. Haugen, Bolin Liu, Ann D. Thor
Summary: Expression and signaling of estrogen receptor (ERα) play a major role in breast cancer development. Interactions with thyroid hormones and their receptors can lead to endocrine therapy resistance. A study found that thyroid hormone replacement therapy is significantly associated with higher rates of relapse and mortality in breast cancer patients, especially those who are steroid receptor positive and node-negative. In in vivo and in vitro experiments, researchers discovered that thyroid hormone in combination with estrogen and tamoxifen can enhance cell proliferation and resistance to tamoxifen in breast cancer cells.
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Irena Baranowska-Bosiacka, Katarzyna Kulczycka, Izabela Gutowska
Summary: Recent studies have shown that small molecule drugs targeting CDK inhibitors have become attractive options for treating cancer and neurodegenerative disorders. Most CDK inhibitors target the ATP binding pocket, but the similarity in structure among CDK kinases makes achieving selectivity challenging. Therefore, inhibitors binding outside the ATP binding site have attracted great interest for their potential applications in the biomedical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yen-Chia Chen, Hsiang-Ning Chang, Jong-Hwei Su Pang, Li-Ping Lin, Jing-Min Chen, Tung-Yang Yu, Wen-Chung Tsai
Summary: Lidocaine has toxic effects on tendon cells, inhibiting cell proliferation and mitosis, reducing the expression of collagens and promoting the expression of MMPs, leading to a decrease in extracellular matrix production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Sadia Perveen, Hanfa Ashfaq, Saira Ambreen, Isbah Ashfaq, Zakia Kanwal, Asima Tayyeb
Summary: Citrullus colocynthis extracts show significant anticancer activity in human breast cancer cells by regulating cyclin-CDK inhibitors to induce cell cycle arrest. Further research on therapeutic interventions is warranted.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Bre-Anne Fifield, John Talia, Carlee Stoyanovich, Mitchell J. Elliott, Martin K. Bakht, Amy Basilious, Joshua P. Samsoondar, Madison Curtis, Keith F. Stringer, Lisa A. Porter
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin K. Bakht, Jessica M. Lovnicki, Janice Tubman, Keith F. Stringer, Jonathan Chiaramonte, Michael R. Reynolds, Iulian Derecichei, Rosa-Maria Ferraiuolo, Bre-Anne Fifield, Dorota Lubanska, So Won Oh, Gi Jeong Cheon, Cheol Kwak, Chang Wook Jeong, Keon Wook Kang, John F. Trant, Colm Morrissey, Ilsa M. Coleman, Yuzhuo Wang, Hojjat Ahmadzadehfar, Xuesen Dong, Lisa A. Porter
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Medicine, Research & Experimental
Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie, Lisa A. Porter
Summary: This study surveyed clinicians and researchers in Windsor-Essex, identifying barriers to translational research such as managing competing interests, lack of time, funding, infrastructure, and networks. Physicians pointed out the lack of permanent post-graduate medical trainees as a major barrier. In terms of interdisciplinary collaboration, schedule incompatibility, funding issues, and finding interested collaborators with overlapping interests were highlighted as significant barriers by participants.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Caroline Hamm, Bre-Anne Fifield, Amin Kay, Swati Kulkarni, Rasna Gupta, John Mathews, Rosa-Maria Ferraiuolo, Huda Al-Wahsh, Emily Mailloux, Abdulkadir Hussein, Lisa A. Porter
Summary: A clinical trial was conducted to determine the optimal chemotherapy regimen for adding carboplatin to standard treatment for triple negative breast cancer (TNBC). The results showed that placing carboplatin on the second and final paclitaxel treatment had the best efficacy with reduced toxicities. Lower levels of androgen receptor and PD-L1 proteins may serve as indicators of treatment response and risk of relapse in TNBC patients.
Article
Multidisciplinary Sciences
Martin K. Bakht, John J. Hayward, Farsheed Shahbazi-Raz, Magdalena Skubal, Ryo Tamura, Keith F. Stringer, Daniel Meister, Varadha Balaji Venkadakrishnan, Hui Xue, Adam Pillon, Mathew Stover, Adam Tronchin, Bre-Anne Fifield, Lavleen Mader, Sheng-Yu Ku, Gi Jeong Cheon, Keon Wook Kang, Yuzhuo Wang, Xuesen Dong, Himisha Beltran, Jan Grimm, Lisa A. Porter, John F. Trant
Summary: PSMA is highly overexpressed in most prostate cancers, but effectively absent from certain high-mortality, treatment-resistant subsets such as NEPC. However, GUL-based PSMA tracers still have the potential to identify NEPC metastatic tumors and may bind unknown proteins associated with PSMA-suppressed cancers. We identified the up-regulation of NAALADaseL and mGluRs in PSMA-suppressed prostate cancers, which inversely correlate with PSMA expression and are associated with GUL-based radiotracer uptake. NAALADaseL and mGluR expression also correlates with a unique cell cycle signature.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell & Tissue Engineering
Dorota Lubanska, Ingrid Qemo, Megan Byrne, Kaitlyn N. Matthews, Bre-Anne Fifield, Jillian Brown, Elizabeth Fidalgo da Silva, Lisa A. Porter
Summary: Fully differentiated cells can be reprogrammed through ectopic expression of key transcription factors to create induced pluripotent stem cells, which have great potential in disease modeling and regenerative medicine. However, this process has limitations due to the upregulation of antiproliferative genes, resulting in low efficiency. Our data reveals a unique cell cycle mechanism where mouse fibroblasts are able to repress cyclin dependent kinase inhibitors through the activation of the epigenetic regulator EZH2 by a cyclin-like protein SPY1, thus increasing reprogramming efficiency.
Review
Cell Biology
E. Fidalgo da Silva, J. Fong, A. Roye-Azar, A. Nadi, C. Drouillard, A. Pillon, L. A. Porter
Summary: The ability of cells to sense environmental signals and integrate them with the cell cycle machinery is critical for cellular function. The Tuberous Sclerosis Complex (TSC) protein complex plays a key role in integrating diverse environmental signals to regulate protein synthesis, cell cycle progression, and other important cell biology events.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Ryland Corchis-Scott, Qiudi Geng, Rajesh Seth, Rajan Ray, Mohsan Beg, Nihar Biswas, Lynn Charron, Kenneth D. Drouillard, Ramsey D'Souza, Daniel D. Heath, Chris Houser, Felicia Lawal, James McGinlay, Sherri Lynne Menard, Lisa A. Porter, Diane Rawlings, Matthew L. Scholl, K. W. Michael Siu, Yufeng Tong, Christopher G. Weisener, Steven W. Wilhelm, R. Michael L. McKay
Summary: A wastewater surveillance program targeting a university residence hall successfully detected cases of Alpha variant COVID-19 and triggered a public health response to prevent an outbreak on campus.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Ken G. Drouillard, Amanda Tomkins, Sharon Lackie, Scott Laengert, Allison Baker, Catherine M. Clase, Charles F. De Lannoy, Dora Cavallo-Medved, Lisa A. Porter, Rebecca S. Rudman
Summary: The objective of this study was to assess commercially-available cotton fabrics for the construction of cloth masks. The study found that certain cotton fabrics can produce breathable masks with filtration efficiencies comparable to medical masks.
Article
Multidisciplinary Sciences
Adam Pillon, Jessica Dare-Shih, Jackie Fong, Elizabeth Fidalgo da Silva, Lisa A. A. Porter
Summary: Tuberin, a component of the Tuberous Sclerosis Complex, plays a crucial role in cell cycle progression. Mutations in the Tuberin gene can lead to the formation of benign tumors. A study on a truncation of the Tuberin protein shows that it alters the subcellular localization of Cyclin B1 and increases cell proliferation.
Article
Multidisciplinary Sciences
Dorota Lubanska, Sami Alrashed, Gage T. Mason, Fatima Nadeem, Angela Awada, Mitchell DiPasquale, Alexandra Sorge, Aleena Malik, Monika Kojic, Mohamed A. R. Soliman, Ana C. DeCarvalho, Abdalla Shamisa, Swati Kulkarni, Drew Marquardt, Lisa A. Porter, Simon Rondeau-Gagne
Summary: This study investigates the selective targeting of tumor initiating cells (TICs) in brain cancer by synthesizing conjugated polymer nanoparticles (CPNs) and studying their permeability through the blood-brain barrier and selective uptake by CD44 positive GBM-patient derived cultures. The findings show that uptake of CPNs can regulate the levels and signaling activity of the CD44 receptor, reducing stemness, invasive properties, and proliferation of the CD44-TIC populations.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Rosa-Maria Ferraiuolo, Bre-Anne Fifield, Caroline Hamm, Lisa A. Porter
Summary: Understanding the relationship between protein expression level and response to treatment is crucial for developing novel treatment options for breast cancer patients. The data shows a correlation between Spy1 and c-Myc protein levels in more aggressive breast cancer cells and patient samples. Additionally, targeting Spy1 may confer an advantage to current chemotherapies, even when c-Myc levels are elevated.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Martin Crozier, Janice Tubman, Bre-Anne Fifield, Rosa-Maria Ferraiuolo, Jenna Ritchie, Katie Zuccato, Emily Mailloux, Indrajit Sinha, Caroline Hamm, Lisa A. Porter
Summary: Dex treatment exacerbates the metastatic potential of ER- breast cancer cells, highlighting the adverse role of glucocorticoids in breast cancer biology.
Article
Cell Biology
Elizabeth Fidalgo da Silva, Bashaer Abu Khatir, Christopher Drouillard, Isabelle Hinch, Gordon Omar Davis, Mariam Sameem, Rutu Patel, Jackie Fong, Dorota Lubanska, Lisa A. Porter
Summary: Tuberin, a member of the Tuberous Sclerosis Complex (TSC) protein complex, acts as a nutrient sensor and regulates protein synthesis and cell cycle progression. Mutations in the Tuberin gene, TSC2, can lead to tumor formation and developmental defects in multiple organ systems, including the central nervous system. Our study investigates the regulation of Tuberin levels during embryonic brain development in vivo and in immortalized cell lines in vitro. The results show that Tuberin levels are tightly regulated during different developmental stages and play a role in stemness and functional differentiation in the central nervous system.
Article
Chemistry, Multidisciplinary
Lavleen Mader, John J. Hayward, Lisa A. Porter, John F. Trant
Summary: This study reports an improved and refocused synthesis method for CDK2 inhibitors, allowing for effective exploration of substituents at the O-6 position.
NEW JOURNAL OF CHEMISTRY
(2022)