Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Review
Clinical Neurology
Lingxin Cai, Hanhai Zeng, Xiaoxiao Tan, Xinyan Wu, Cong Qian, Gao Chen
Summary: Neuroinflammation plays a critical role in aneurysmal subarachnoid hemorrhage, with the neutrophil-to-lymphocyte ratio serving as an effective biomarker to predict clinical outcomes and complications. Increased NLR is valuable in predicting the clinical outcome of aSAH patients and is related to the risk of complications such as delayed cerebral ischemia or rebleeding, providing improved accuracy for predicting prognosis and stratifying patients into different risk categories.
FRONTIERS IN NEUROLOGY
(2021)
Review
Infectious Diseases
Tao Yu, Hongquan Wang, Shuhan Zheng, Liang Huo
Summary: This review analyzed literature on SARS-CoV-2-associated cerebrovascular disease (SCVD), highlighting the clinical features, mechanism, treatment, and outcomes. The review included 51 articles published between January 1, 2020, and June 20, 2020, reporting a total of 167 cerebrovascular events in COVID-19 patients, including ischemic stroke, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral venous thrombosis. The findings aim to assist clinicians in predicting SCVD outcomes and complications in their COVID-19 patients.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Clinical Neurology
Aaron M. Gusdon, Jude P. J. Savarraj, Eyad Shihabeddin, Atzhiry Paz, Andres Assing, Sang-Bae Ko, Louise D. McCullough, Huimahn Alex Choi
Summary: The study found that an early increase in monocytes is associated with poor outcomes after subarachnoid hemorrhage, while neutrophils and the neutrophil to lymphocyte ratio are related to infections. Elevated levels of monocytes in males are better predictors of cerebral ischemia and poor functional outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Yinghan Guo, Jiang Liu, Hanhai Zeng, Lingxin Cai, Tingting Wang, Xinyan Wu, Kaibo Yu, Yonghe Zheng, Huaijun Chen, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao, Gao Chen
Summary: This study demonstrated that elevated NLR on admission is associated with poor outcome in aSAH patients. Results are more reliable in studies with large sample sizes, low NLR cut-off value, multicenter, or prospective designs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xianjing Feng, Fang Yu, Minping Wei, Yunfang Luo, Tingting Zhao, Zeyu Liu, Qin Huang, Ruxin Tu, Jiaxin Li, Boxin Zhang, Liuyang Cheng, Jian Xia
Summary: This study found that neutrophil counts and neutrophil-to-lymphocyte ratio (NLR) are associated with stress hyperglycemia ratio (SHR) in patients with acute ischemic stroke (AIS). The correlation between neutrophil counts and NLR and different SHR levels varies according to TOAST classification and functional prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Sai Luo, Wen-Song Yang, Yi-Qing Shen, Ping Chen, Shu-Qiang Zhang, Zhen Jia, Qi Li, Jian-Ting Zhao, Peng Xie
Summary: This study aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and D-dimer-to-fibrinogen ratio (DFR) as predictors of pneumonia and poor outcomes in patients with acute intracerebral hemorrhage (ICH). The results showed that NLR and PLR were independent predictors of pneumonia, while NLR and DFR were independent predictors of poor 90-day outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Mengqi Lin, Ru Lin, Dongqin Zhu, Yuhuan Wu, Lufei Feng, Weizeng Su, Weilei He
Summary: This study aimed to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) levels and epilepsy in patients with primary intracerebral hemorrhage (ICH). The results showed that NLR levels were significantly correlated with the occurrence of post-stroke epilepsy (PSE), and high NLR was independently associated with an increased risk of PSE.
EPILEPSY & BEHAVIOR
(2023)
Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Julianne Kleitsch, Dominic A. Nistal, Natalia Romano Spica, Miryam Alkayyali, Rui Song, Deeksha Chada, Kaitlin Reilly, Cappi Lay, Alexandra S. Reynolds, Johanna T. Fifi, Joshua B. Bederson, J. Mocco, John W. Liang, Christopher P. Kellner, Neha S. Dangayach
Summary: This study found that a centralized approach to ICH management and the establishment of a dedicated ICH center in a New York City hospital system increased access to specialist services, including MIS. Most patients undergoing MIS were transferred from outside hospitals, highlighting the need for additional studies and descriptions of experiences to further elucidate the impact of and best protocols for the IHT of ICH patients.
WORLD NEUROSURGERY
(2021)
Article
Health Care Sciences & Services
Farzaneh Sadeghi, Ferenc Sarkady, Katalin S. Zsori, Istvan Szegedi, Rita Orban-Kalmandi, Edina G. Szekely, Nikolett Vasas, Ervin Berenyi, Laszlo Csiba, Zsuzsa Bagoly, Amir H. Shemirani
Summary: This study demonstrated for the first time that a high NLR-low LMR combination observed at 24 hours after thrombolysis can serve as an independent predictor of poor 3-months outcome in acute ischemic stroke patients. This simple and readily available data may help clinicians to improve the prognostic estimation of patients and may provide guidance in selecting patients for personalized and intensified care post-thrombolysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Jian Zhang, Chunlong Liu, Yaofeng Hu, Aoran Yang, Yonghui Zhang, Yang Hong
Summary: This study retrospectively collected baseline characteristics and laboratory findings of spontaneous intracerebral hemorrhage patients undergoing surgery, and found that high neutrophil-to-lymphocyte ratio (NLR) within 48 hours after surgery was an independent risk factor for poor prognosis at 30 days post-operation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jin Ma, Wenting Guo, Jiali Xu, Sijie Li, Changhong Ren, Longfei Wu, Chuanjie Wu, Chuanhui Li, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study found that platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were independently associated with unfavorable functional outcomes in patients with acute ischemic stroke (AIS) after successful recanalization.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Cuiping Chen, Lei Gu, Luyun Chen, Wangwang Hu, Xiaowen Feng, Fengzhen Qiu, Zijian Fan, Qitao Chen, Jiayou Qiu, Bei Shao
Summary: The study found that both NLR and PLR are independent predictors of functional outcomes after AIS, and may help to identify high-risk patients more effectively when used together.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Wenyuan Ma, Changmeng Cui, Song Feng, Genhua Li, Guangkui Han, Jilan Liu, Xianyun Qin, Yawei Hu, Mengjie Wang, Lu Zhang, Feng Jin
Summary: There appears to be a positive correlation between PLR and NLR in patients with MMD, suggesting a potential role of inflammation in the development and progression of the disease.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Marcello Scala, Amedeo Bianchi, Francesca Bisulli, Antonietta Coppola, Maurizio Elia, Marina Trivisano, Dario Pruna, Tommaso Pippucci, Laura Canafoglia, Simona Lattanzi, Silvana Franceschetti, Carlo Nobile, Antonio Gambardella, Roberto Michelucci, Federico Zara, Pasquale Striano
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2020)
Review
Cardiac & Cardiovascular Systems
Phillip J. Tully, Yuichiro Yano, Lenore J. Launer, Kazuomi Kario, Michiaki Nagai, Simon P. Mooijaart, Jurgen A. H. R. Claassen, Simona Lattanzi, Andrew D. Vincent, Christophe Tzourio
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Letter
Surgery
Anne L. Abbot, Alejandro M. Brunser, Athanasios Giannoukas, Robert E. Harbaugh, Timothy Kleinig, Simona Lattanzi, Holger Poppert, Tatjana Rundek, Saeid Shahidi, Mauro Silvestrini, Raffi Topakian
JOURNAL OF VASCULAR SURGERY
(2020)
Article
Clinical Neurology
Laura Buratti, Crizia Cruciani, Alessandra Pulcini, Chiara Rocchi, Viviana Totaro, Simona Lattanzi, Giovanna Viticchi, Lorenzo Falsetti, Mauro Silvestrini
Article
Clinical Neurology
Simona Lattanzi, Claudia Rinaldi, Alessandra Pulcini, Tommaso Corradetti, Stefania Angelocola, Maria Luisa Zedde, Giuseppe Ciliberti, Mauro Silvestrini
Summary: Distinct clinical phenotypes have been identified within the ESUS population, which are associated with different risk factors and vascular involvement; this may provide clues to the underlying pathogenic mechanisms of ESUS.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Simona Lattanzi, Claudia Rinaldi, Claudia Cagnetti, Nicoletta Foschi, Davide Norata, Serena Broggi, Chiara Rocchi, Mauro Silvestrini
Summary: The study found that approximately 20% of patients with post-stroke epilepsy develop pharmaco-resistance, which is associated with younger age at stroke onset, stroke type and severity, occurrence of status epilepticus, and seizure types.
Article
Neurosciences
Simona Lattanzi, Davide Norata, Afshin A. Divani, Mario Di Napoli, Serena Broggi, Chiara Rocchi, Santiago Ortega-Gutierrez, Gelsomina Mansueto, Mauro Silvestrini
Summary: This study aimed to evaluate the relationship between systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. The study found that older age, higher admission National Institutes of Health stroke scale score, and higher admission SIRI increased the risk of poor outcomes at 3 months despite complete or near-complete recanalization.
Article
Genetics & Heredity
Matteo Paolucci, Chiara Vincenzi, Michele Romoli, Giulia Amico, Isabella Ceccherini, Simona Lattanzi, Anna Bersano, Marco Longoni, Simona Sacco, Fabrizio Vernieri, Rosario Pascarella, Franco Valzania, Marialuisa Zedde
Summary: PFO is a common postnatal defect of cardiac atrial septation with potential familial aggregation. However, no genetic variants associated with PFO have been identified so far. Despite the need for further research, existing evidence from animal and other studies suggest a strong genetic background for PFO.
Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Article
Medicine, General & Internal
Giovanni Falcicchio, Simona Lattanzi, Francesco Negri, Marina de Tommaso, Angela La Neve, Nicola Specchio
Summary: This retrospective study examined the 12-month effectiveness and tolerability of Cenobamate (CNB) in patients with Lennox-Gastaut syndrome (LGS) in real-world practice. The results showed a reduction in seizure frequency and minimal side effects after CNB treatment. These findings suggest that CNB may be a promising therapeutic option for drug-resistant epilepsy associated with LGS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Iga Kwiatkowska, Ewa Zekanowska, Simona Lattanzi, Andrea M. Alexandre, Agata Kister-Kowalska, Artur Slomka
Summary: Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago, and its biological properties and role in hemostasis have been extensively studied. The structure of FSAP and its interactions with other proteins and compounds that modulate its activity have been elucidated. This review summarizes the current knowledge on FSAP, including its structure, the processes regulating its activity, and its role in hemostasis and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Simona Lattanzi, Stefano Meletti, Eugen Trinka, Francesco Brigo, Gianni Turcato, Claudia Rinaldi, Claudia Cagnetti, Nicoletta Foschi, Serena Broggi, Davide Norata, Mauro Silvestrini
Summary: This study aimed to develop a model and nomogram to predict drug resistance in patients with post-stroke epilepsy (PSE). The study identified age, intracerebral hemorrhage, stroke severity, latency of PSE, and status epilepticus as independent predictors of drug resistance. The nomogram showed good predictive accuracy and may serve as a practical tool for personalized prediction of drug-resistant PSE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Payam Tabaee Damavandi, Francesco Pasini, Gaia Fanella, Giulia Sofia Cereda, Gabriele Mainini, Jacopo C. DiFrancesco, Eugen Trinka, Simona Lattanzi
Summary: Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms. Glutamate receptors antagonist Perampanel (PER) may have therapeutic potential in reducing tumor growth and controlling epileptiform activity. Both pre-clinical and clinical studies suggest that PER can be an effective and well-tolerated option for patients with BTRE, but more research is needed for further understanding of its effects on tumor progression.
Review
Behavioral Sciences
Bruna Nucera, Fabrizio Rinaldi, Raffaele Nardone, Simona Lattanzi, Francesco Brigo
EPILEPSY & BEHAVIOR
(2020)
Article
Clinical Neurology
S. Bonifazi, C. Passamonti, S. Vecchioni, R. Trignani, P. P. Martorano, V Durazzi, S. Lattanzi, F. Mancini, R. A. Ricciuti
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)