Article
Pharmacology & Pharmacy
Yue Zhou, Tongjia Zhang, Shujie Wang, Ruixiang Yang, Zitao Jiao, Kejia Lu, Hui Li, Wei Jiang, Xiaowei Zhang
Summary: The transcription factor HBP1 plays a crucial role in inhibiting the tumorigenesis of breast cancer by enhancing TIMP3 activity and increasing PTEN protein levels. The HBP1/TIMP3 axis also inhibits MMP2/9 protein levels and promotes sensitivity to radiation therapy and hormone therapy. This study opens new perspectives for the treatment and prognosis of breast cancer.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Oncology
Viji Remadevi, Parvathy Muraleedharan, Sreeharshan Sreeja
Summary: This article examines the role of FOXO1 proteins in oral squamous cell carcinoma, including their regulation of cell cycle, apoptosis, oxidative stress, and their positive impact on tumor suppression, angiogenesis, and metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Baozhu Yi, Shuaibin Wang, Xinran Wang, Zhichao Liu, Chao Zhang, Ming Li, Song Gao, Shi Wei, Sejong Bae, Erica Stringer-Reasor, Lizhong Wang, Runhua Liu
Summary: MiR-3662 is minimally expressed in normal tissues but highly expressed in various cancers, especially in TNBC and African American breast cancer. Inhibition or knockout of miR-3662 suppresses proliferation and migration of TNBC cells by reducing Wnt/β-catenin signaling activation. HMG-box transcription factor 1 (HBP-1) is identified as a target of miR-3662 responsible for TNBC cell proliferation.
Article
Oncology
Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li, Xiaowei Zhang
Summary: The study found that HBP1 can repress the expression of AFP gene by directly binding to the AFP gene promoter, leading to attenuation of AFP effect on hepatoma cells, thereby inhibiting proliferation and migration, and inducing apoptosis. HBV-encoded protein HBx directly binding to HBP1 promotes malignancy in hepatoma cells, while icaritin can inhibit malignancy in hepatoma cells by enhancing HBP1 transrepression of AFP.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yu Gyung Kim, Chaeeun Seong, Kyoung-Ah Cho, Sang Min Lee, Tae-Jun Kim, Hyeon Ji Kim, Jin-Hwa Cho, Won Jung, Sungil Jang, Jae-Cheon Shin, Kyung-Ha Lee, Jin-Seok Byun, Do-Yeon Kim
Summary: Oral squamous cell carcinoma (OSCC) is a tumor with a poor prognosis and a high recurrence rate. The study found that Forkhead transcriptional factor O1 (FoxO1) can act as both a tumor suppressor and an oncogene in OSCC. FoxO1 exerts an anti-tumor effect by suppressing proliferation and migration/invasion but promoting oxidative stress-linked cell death in OSCC cells.
Article
Pharmacology & Pharmacy
Chenguang Zhao, Zhiling Zhang, Xiaohua Dai, Jinhui Wang, Hao Liu, Hongwei Ma
Summary: Actein demonstrated significant anti-OSCC effects by inducing cell cycle arrest and apoptosis, possibly through modulation of the Akt/FoxO1 pathway. Further evaluations are needed to confirm its potential as a candidate for clinical use.
Article
Oncology
Lixia Wang, Chuanlai Yang, Man Chu, Zhi-wei Wang, Boxin Xue
Summary: The study investigated the molecular mechanisms underlying radioresistance in bladder cancer, revealing elevated Cdc20 expression in IR cells and its role in governing IR-mediated EMT by regulating FoxO1 degradation. Therefore, inhibiting Cdc20 or activating FoxO1 may be potential strategies to overcome radioresistance in bladder cancer.
Article
Cell Biology
Yuning Cheng, Ruixiang Yang, Yue Zhou, Jiyin Wang, Tongjia Zhang, Shujie Wang, Hui Li, Wei Jiang, Xiaowei Zhang
Summary: This study found that HBP1 is involved in T2DM and it regulates blood glucose and insulin concentrations through a negative feedback regulatory loop. These findings provide a new theoretical basis and potential therapeutic target for T2DM.
Article
Genetics & Heredity
Line J. Manceau, Julien E. Richard Albert, Pier-Luigi J. Lollini, Maxim V. C. E. Greenberg, Pascale J. Gilardi-Hebenstreit, Vanessa E. Ribes
Summary: The chimeric proteins PAX3-FOXO1 and PAX7-FOXO1, derived from chromosomal translocations, exhibit distinct genomic occupancy and transcriptional activity, leading to different pathological manifestations in alveolar rhabdomyosarcoma.
Article
Oncology
Mengke Zhu, Chao Wei, Haijiang Wang, Shangning Han, Lindi Cai, Xiaowen Li, Xinhua Liao, Xiangming Che, Xuqi Li, Lin Fan, Guanglin Qiu
Summary: This study investigates the effects and underlying mechanism of SIRT1 on autophagy and malignant biological behavior of gastric cancer cells under conditions of glucose deprivation. Results show that SIRT1 regulates the activity of FoxO1 and upregulates the expression of Rab7 through deacetylation, thereby affecting autophagy in gastric cancer cells. Decreasing the expression of SIRT1, FoxO1 or Rab7 significantly inhibits autophagy levels, increases sensitivity to glucose deprivation, and enhances the inhibition of proliferation, migration, and invasion, as well as apoptosis in gastric cancer cells induced by glucose deprivation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jiyin Wang, Ruixiang Yang, Yuning Cheng, Yue Zhou, Tongjia Zhang, Shujie Wang, Hui Li, Wei Jiang, Xiaowei Zhang
Summary: This study demonstrates that PRMT1-mediated methylation of HBP1 at R378 decreases its protein stability, promoting tumor metastasis and growth. Additionally, GSN is identified as a novel target gene of HBP1. Methylation of HBP1 downregulates GSN levels, leading to actin cytoskeleton remodeling and tumor progression.
Article
Biochemistry & Molecular Biology
Wei-liang Sun, Ling-yan He, Li Liang, Si-yu Liu, Jie Luo, Mei-ling Lv, Zheng-wen Cai
Summary: This study identifies a novel pathway, Ambra1-Akt-FoxO1-Bim, which regulates apoptosis and chemosensitivity in breast cancer cells by modulating the expression of the key protein Bim.
Article
Biochemistry & Molecular Biology
Chao Chen, Yu'e Liu, Hongxiang Wang, Xu Zhang, Yufeng Shi, Juxiang Chen
Summary: We investigated the role of FOXO1 and miR-506 in the progression and drug resistance of GBM. Through in vitro and in vivo experiments, we found that the FOXO1-miR-506 axis suppresses GBM cell invasion and migration and promotes chemosensitivity to TMZ, mediated by autophagy. We also discovered a negative feedback loop of FOXO1/miR-506/ETS1/FOXO1 in regulating invasiveness and chemosensitivity in GBM.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Medicine, General & Internal
Veronique Bouvard, Suzanne T. Nethan, Deependra Singh, Saman Warnakulasuriya, Ravi Mehrotra, Anil K. Chaturvedi, Tony Hsiu-Hsi Chen, Olalekan A. Ayo-Yusuf, Prakash C. Gupta, Alexander R. Kerr, Wanninayake M. Tilakaratne, Devasena Anantharaman, David Conway, Ann Gillenwater, Newell W. Johnson, Luiz P. Kowalski, Maria E. Leon, Olena Mandrik, Toru Nagao, Vinayak M. Prasad, Kunnambath Ramadas, Felipe Roitberg, Pierre Saintigny, Rengaswamy Sankaranarayanan, Alan R. Santos-Silva, Dhirendra N. Sinha, Patravoot Vatanasapt, Rosnah B. Zain, Beatrice Lauby-Secretan
Summary: An expert panel review by the International Agency for Research on Cancer (IARC) suggests that smoking, smokeless tobacco use, areca nut exposure, and heavy alcohol consumption are major contributors to oral cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Lijuan Yu, Bingdong Sui, Xin Zhang, Jiayun Liu, Xiaoke Hao, Lei Zheng
Summary: This study demonstrates that miR-92a-1-5p enriched EVs regulate osteoclast function by reducing MAPK1 and FoxO1 expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Letter
Allergy
Yu-Hsin Wang, Shih-Yi Huang, Han-Pin Kuo, Hsien-Yu Fan, Andre Moreira, Maria Michelle Papamichael, Yang-Ching Chen
Article
Biochemistry & Molecular Biology
Wen-De Lai, Te-Hsuan Tung, Chu-Yun Teng, Chia-Hsuan Chang, Yang-Ching Chen, Hui-Yu Huang, Hsin-Chien Lee, Shih-Yi Huang
Summary: Sleep deprivation can lead to neuropsychiatric behaviors, but fish oil supplementation can reverse these behaviors and improve gut barrier injury and dysbiosis of the microbiota.
Article
Multidisciplinary Sciences
Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study found that the immunomodulatory effects of Lactobacillus casei Shirota fermented beverage (LcSFB) depend on the mode of antigen presentation, enhancing immune response in mice injected with OVA, but attenuating it in mice treated with injection plus intranasal administration.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ngan Thi Kim Nguyen, Nguyen-Phong Vo, Shih-Yi Huang, Weu Wang
Summary: This study found that laparoscopic sleeve gastrectomy leads to significant increases in fat-free mass and skeletal muscle mass in males with type 2 diabetes, resulting in diabetes remission. However, there is a lack of similar evidence in female patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Quynh Thi Vu Huynh, Ban Tran Ho, Nguyen Quoc Khanh Le, Tung Huu Trinh, Luu Ho Thanh Lam, Ngan Thi Kim Nguyen, Shih-Yi Huang
Summary: This study aimed to analyze the prevalence of brain lesions in girls with central precocious puberty (CPP) stratified by age group (0-2, 2-6, and 6-8 years). The results showed that most girls had no brain lesions, and the prevalence of brain lesions decreased with age. Clinicians should cautiously use cranial MRI for girls aged 6-8 years with CPP.
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Chih-Wei Chiu, Cheng-Ying Hsieh, Chih-Hao Yang, Jie-Heng Tsai, Shih-Yi Huang, Joen-Rong Sheu
Summary: Yohimbine (YOH) inhibits the proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated by PDGF-BB through downregulating the α2B-adrenergic receptor-independent PLC gamma 1 pathway, and reduces neointimal formation in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Te-Hsuan Tung, Yang-Ching Chen, Ya-Tin Lin, Shih-Yi Huang
Summary: This study investigated the effects of fish oil intake on gut microbiota, bile acid profiles, and behavior in rats. The results suggest that fish oil intake can increase the abundance of certain microbial species and bile acid concentrations, thereby alleviating emotional symptoms.
Article
Nutrition & Dietetics
Liang-Yu Su, Wen-Ching Huang, Nai-Wen Kan, Te-Hsuan Tung, Linh Ba Phuong Huynh, Shih-Yi Huang
Summary: Eccentric contraction can lead to muscle damage and inflammation, reducing muscle efficiency. Resveratrol has anti-inflammatory effects in muscles, promotes muscle repair, and improves exercise performance after contusion recovery. However, its effects on sports injuries caused by eccentric contraction are unknown. Thus, this study investigated the effects of resveratrol on inflammation and energy metabolism.
Article
Medicine, General & Internal
Hua-Chien Wu, Yin-Ru Hsieh, Weu Wang, Ching-Wen Chang, I-Wei Chang, Chi-Long Chen, Chun-Chao Chang, Chia-Hsuan Chang, Wei-Yu Kao, Shih-Yi Huang
Summary: This study investigated the differences in lipidomic profile features between mild and significant liver fibrosis cases in patients with morbid obesity and NASH. The results showed that the concentrations of triglycerides, cholesterol esters, phosphatidylcholine, phosphatidic acid, phosphatidylinositol, phosphatidylglycerol, and sphingomyelin were significantly lower in patients with significant fibrosis compared to those with mild fibrosis. However, the concentration of phosphatidylcholine was relatively higher in patients with stage 2-4 fibrosis. Moreover, predictive models incorporating specific lipid components showed a potential correlation between NASH fibrosis stages and liver lipid accumulation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Hsien-Feng Liao, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly in individuals over 40 years old. Mood disorders are frequently comorbid with COPD, but often overlooked or undiagnosed, leading to poor treatment outcomes and increased mortality. The exact link between COPD and mood disorders is still uncertain, but it is believed that inflammation in the lungs, blood, and brain may contribute to the development of mood disorders in COPD. Antidepressants are commonly used to manage mood disorders in COPD, but their efficacy is limited due to tolerability issues. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which regulate inflammatory responses, may offer promising alternatives for managing mood disorders in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Te-Hsuan Tung, Wen-De Lai, Hsiu-Chuan Lee, Kuan-Pin Su, Binar Panunggal, Shih-Yi Huang
Summary: The prevalence of depression is increasing, and it is particularly difficult to recognize and treat geriatric depression. This study found that fish oil supplementation can improve depressive symptoms and neuroinflammation in older adults, while also increasing serotonin levels in the brain.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Yi-Ting Hsu, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a common lung disease that is associated with pulmonary inflammation and cognitive impairment. The exact mechanisms of cognitive impairment in COPD patients are still unclear, but hypoxia, oxidative stress, systemic inflammation, and cerebral manifestations of these conditions are believed to play crucial roles. Current medications for cognitive impairment in COPD patients may have life-threatening adverse effects, indicating the need for alternative medications. This review discusses the potential role of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in improving cognitive deficits in COPD patients and highlights the importance of clinical studies to evaluate the efficacy of omega-3 PUFAs in managing cognitive impairment in COPD patients.
Article
Biochemistry & Molecular Biology
Chia-Hsuan Chang, Hua-Chien Wu, Yin-Ru Hsieh, Wen-De Lai, Te-Hsuan Tung, Jun-Jie Huang, Wei-Yu Kao, Shih-Yi Huang
Summary: Clinical evidence suggests a bidirectional relationship exists between sleep loss and psychiatric disorders. The study investigated the add-on effects and mechanisms of melatonin receptor agonist ramelteon (RMT) and n-3 polyunsaturated fatty acids (n-3 PUFAs) in ameliorating neuropsychiatric behaviors in sleep-deprived rats. The findings revealed that RMT plus EPA alleviated depressive-like behavior, while RMT plus DHA alleviated anxiety-like behavior. Lipidomic analysis suggested aberrant lipid metabolism may be involved.
Article
Biochemistry & Molecular Biology
Bingcong Li, Yin-Ru Hsieh, Wen-De Lai, Te-Hsuan Tung, Yu-Xuan Chen, Chia-Hui Yang, Yu-Chiao Fang, Shih-Yi Huang
Summary: The study found that melatonin intervention can improve neuropsychiatric behaviors caused by chronic sleep deprivation, possibly by influencing the production of gut microbiota and lipid metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Quynh Thi Vu Huynh, Nguyen Quoc Khanh Le, Shih-Yi Huang, Ban Tran Ho, Tru Huy Vu, Hong Thi Minh Pham, An Le Pham, Jia-Woei Hou, Ngan Thi Kim Nguyen, Yang Ching Chen
Summary: A machine learning-based diagnostic model was developed to rapidly identify CPP in girls using CPP-related variables and a brief GnRHa stimulation test within 30 minutes.