Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Review
Biochemistry & Molecular Biology
Ombretta Repetto, Roberto Vettori, Agostino Steffan, Renato Cannizzaro, Valli De Re
Summary: Gastric cancer is a highly malignant disease with poor prognosis. Early detection and personalized treatment are important for improving patient survival. Recent advances in proteomics technologies have enabled the identification of novel biomarkers for gastric cancer, supporting the development of precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roberta Belli, Elisabetta Ferraro, Alessio Molfino, Raffaella Carletti, Federica Tambaro, Paola Costelli, Maurizio Muscaritoli
Summary: Cancer cachexia, characterized by unintentional weight loss due to systemic inflammation, impaired energy metabolism, and loss of muscle and adipose tissues, poses challenges in early diagnosis due to the lack of biomarkers. Liquid biopsy and circulating miRNAs have emerged as potential sources of easily accessible biomarkers for early detection, especially in the context of muscle atrophy related to cancer cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna M. Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola, Marcella Chiari
Summary: Assessing ctDNA in cancer patients' plasma is a promising noninvasive practice to evaluate somatic mutations. Recent studies suggest that isolation of extracellular vesicles improves the detection of mutant DNA from plasma in metastatic patients. The integration of ctDNA and sEV-associated DNA in patient management could offer a real-time assessment of cancer mutation status.
Article
Biochemistry & Molecular Biology
Maha M. Itani, Farah J. Nassar, Arafat H. Tfayli, Rabih S. Talhouk, Ghada K. Chamandi, Abdul Rahman S. Itani, Joelle Makoukji, Rose-Mary N. Boustany, Lifang Hou, Nathalie K. Zgheib, Rihab R. Nasr
Summary: The combination of miR-145/miR-425-5p/miR-139-5p/miR-130a as a panel of microRNAs shows the highest diagnostic accuracy for early-stage breast cancer detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Shuai Wang, Yanhan Dong, Anjing Gong, Huimin Kong, Jinning Gao, Xiaodan Hao, Yongmei Liu, Zibo Wang, Yuqiao Fan, Chengyu Liu, Wenhua Xu
Summary: Exosomal circRNAs have emerged as potential biomarkers in cancer diagnosis and prognosis, with the ability to influence target cells or organs by regulating tumor development and metastasis. The high stability of circRNAs in exosomes makes them promising candidates for early and minimally invasive cancer diagnosis and prognosis evaluation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Jose Pedro Sequeira, Vera Constancio, Joao Lobo, Rui Henrique, Carmen Jeronimo
Summary: Liquid biopsies have emerged as a new tool for early diagnosis, with circulating or exosome miRNAs showing great potential in renal cell carcinoma. The study of these miRNAs in liquid biopsies has experienced exponential growth, signaling a promising development in clinical applications.
Review
Biochemistry & Molecular Biology
Attila A. Seyhan
Summary: There is an urgent need for robust and reliable biomarkers for early diagnosis, prognosis, and prediction of response to specific treatments in aggressive and deadly cancers, such as pancreatic cancer. Liquid biopsy-based miRNA profiling shows potential for fulfilling this need. MiRNAs are non-coding RNAs that regulate gene expression and have emerged as potential diagnostic, prognostic, predictive, and therapeutic biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Wenqing Rong, Shiyun Shao, Yunzhou Pu, Qing Ji, Huirong Zhu
Summary: This study demonstrated that circulating extracellular vesicle-derived MARCKSL1 is significantly higher in patients with metastatic colorectal cancer compared to nonmetastatic colorectal cancer patients and healthy individuals. Combining MARCKSL1 with CA125 and lymphocyte levels achieved the best diagnostic efficacy, with an area under the ROC curve of 0.7480. These findings suggest that circulating extracellular vesicle-derived MARCKSL1 could be a potential new diagnostic biomarker for metastatic colorectal cancer.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Yunhe Yu, Wenfang Zheng, Changle Ji, Xuehui Wang, Mingkuan Chen, Kaiyao Hua, Xiaochong Deng, Lin Fang
Summary: Early diagnosis is crucial for improving the prognosis of breast cancer patients. This study identified three potential circulating biomarkers for breast cancer diagnosis using circRNA microarray analysis. One of these biomarkers, hsa_circ_0000091, was found to be associated with prognosis and axillary lymph node metastasis in breast cancer patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Karmele Valencia, Luis M. Montuenga
Summary: Exosomes, as a component of liquid biopsy, show great promise due to their presence in various biological fluids and ability to conduct multicomponent analyses. The content of exosomes mirrors the characteristics of their cell of origin, making them a valuable tool for capturing the complexity and heterogeneity of cancer.
Review
Biochemistry & Molecular Biology
Beata Soltesz, Gergely Buglyo, Nikolett Nemeth, Melinda Szilagyi, Ondrej Pos, Tomas Szemes, Istvan Balogh, Balint Nagy
Summary: Extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples have been found to play a crucial role in early detection and monitoring of cancer. They contribute to intercellular communication and have implications in tumor formation and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vera Mugoni, Yari Ciani, Caterina Nardella, Francesca Demichelis
Summary: The identification of prostate cancer biomarkers in patients' blood and urine can significantly improve PCa diagnosis and monitoring. Using EV-RNAs as biomarkers in PCa shows great potential, but faces challenges of EV heterogeneity and complexity.
Review
Medicine, General & Internal
E. Zhou, Yumei Li, Feng Wu, Mengfei Guo, Juanjuan Xu, Sufei Wang, Qi Tan, Pei Ma, Siwei Song, Yang Jin
Summary: Liquid biopsy, with the use of extracellular vesicles (EVs) and their cargos, shows promise in cancer diagnosis, prognosis, and guiding therapeutic strategies. EVs represent a minimally invasive method that provides real-time information with minimal damage to cancer patients. Their clinical significance in therapeutic response monitoring and prediction warrants further investigation in various cancers.
Review
Oncology
Barbara Cardinali, Roberta Tasso, Patrizia Piccioli, Maria Chiara Ciferri, Rodolfo Quarto, Lucia Del Mastro
Summary: This review discusses the potential application of circulating microRNAs (miRNAs) as diagnostic and monitoring biomarkers in breast cancer. It highlights the advantages and challenges that need to be addressed. Although further studies are needed to support their clinical utility, miRNAs could represent novel tools for breast cancer management.