Article
Oncology
Changying Shi, Yong Li, Li Geng, Weifeng Shen, Chengjun Sui, Binghua Dai, Jiongjiong Lu, Mianshun Pan, Jiamei Yang
Summary: This study aimed to investigate the efficacy of SBRT targeting suboptimal resection margin as adjuvant therapy in MVI-positive HCC. The results showed that SBRT group had significantly better DFS and OS compared to the surgery alone group.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Joonho Jeong, Jung Gu Park, Kwang Ill Seo, Ji Hyun Ahn, Jae Chun Park, Byung Cheol Yun, Sang Uk Lee, Jin Wook Lee, Jong Hyouk Yun
Summary: This study aimed to investigate factors affecting tumor necrosis with TACE and evaluate factors associated with early hepatocellular carcinoma recurrence after curative hepatectomy. Microvascular invasion (MVI) was found to be the strongest factor influencing TACE-induced tumor necrosis and recurrence-free survival rate within 2 years. MVI could play a crucial role in determining TACE as an initial treatment for hepatocellular carcinoma and predicting recurrence after curative hepatic resection.
Article
Medicine, Research & Experimental
Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu, Weiqi Rong
Summary: This study successfully developed and validated a predictive model for early relapse after R0 resection in HCC patients with MVI, incorporating preoperative blood markers, hepatitis status, tumor characteristics, and other factors, with higher predictive accuracy in the validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Anwei Mo, Biquan Lin, Denglin Chen
Summary: This study aims to investigate the impact of sequential transcatheter arterial chemoembolization (TACE) on the prognosis of patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI) following radical resection. Thirteen articles were included in the study, and the results showed that TACE after radical hepatectomy resection (HR) significantly improved the recurrence-free survival (RFS) and overall survival (OS) rates at 1 year, 2 years, 3 years, and 5 years compared to HR alone. The findings suggest that postoperative sequential TACE treatment can benefit patients with HCC and MVI in terms of long-term survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Cyrille Feray, Loic Campion, Philippe Mathurin, Isabelle Archambreaud, Xavier Mirabel, Jean Pierre Bronowicki, Emmanuel Rio, Christophe Perret, Laurent Mineur, Frederic Oberti, Yann Touchefeu, Jerome Gournay, Helen Regnault, Julien Edeline, Agnes Rode, Patrick Hillion, Jean Frederic Blanc, Eric Nguyen Khac, Daniel Azoulay, Alain Luciani, Athena Galetto Preglisasco, Elodie Faurel-Paul, Helene Auble, Francoise Mornex, Philippe Merle
Summary: This study compared the efficacy and safety of the combination of a single TACE and external CRT vs. classical TACE. The results showed that the combination of TACE + CRT failed to improve liver PFS or overall survival and led to more frequent liver-related adverse effects.
Article
Gastroenterology & Hepatology
Hanyu Jiang, Jingwei Wei, Fangfang Fu, Hong Wei, Yun Qin, Ting Duan, Weixia Chen, Kunlin Xie, Jeong Min Lee, Mustafa R. Bashir, Meiyun Wang, Bin Song, Jie Tian
Summary: This study aimed to develop and validate a scoring system for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC). The results showed that the preoperative MVI score, which integrated five EOB-MRI features and serum alpha-fetoprotein level, accurately predicted MVI and postoperative survival in HCC. This score could be useful in making individualized treatment decisions.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Yun Yang, Kongying Lin, Lei Liu, Youwen Qian, Yuan Yang, Shengxian Yuan, Peng Zhu, Jian Huang, Fuchen Liu, Fangming Gu, Siyuan Fu, Beige Jiang, Hui Liu, Zeya Pan, Wan Yee Lau, Weiping Zhou
Summary: The study found that preoperative TACE did not impact the incidence of MVI and long-term survival outcomes in HCC patients undergoing curative liver resection. After propensity score matching, preoperative TACE was not associated with Disease-Free Survival (DFS) and Overall Survival (OS).
Article
Gastroenterology & Hepatology
Liming Wang, Yunhe Liu, Weiqi Rong, Fan Wu, Weibo Yu, Kan Liu, Shengtao Lin, Yiling Zheng, Kai Zhang, Tana Siqin, Changcheng Tao, Mei Liu, Bo Chen, Qinfu Feng, Jianxiong Wu
Summary: The study demonstrates that IOERT in combination with narrow-margin hepatectomy for centrally located HCCs is feasible and safe, with a significantly better recurrence-free survival rate observed in the IOERT group compared to the control group, particularly beneficial for patients with MVI (+).
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Xuqi Sun, Ziliang Yang, Jie Mei, Ning Lyu, Jinfa Lai, Minshan Chen, Ming Zhao
Summary: For HCC patients with MVI (+) and early small recurrence, TACE-RFA could achieve better prognosis than hepatectomy or RFA alone, while RFA alone provided comparable survival benefits compared with hepatectomy or TACE-RFA in other HCC patients with small recurrence.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Pharmacology & Pharmacy
Li Chen, Chen-Xi Yu, Bin-Yan Zhong, Hai-Dong Zhu, Zhi-Cheng Jin, Guang-Yu Zhu, Qi Zhang, Cai-Fang Ni, Gao-Jun Teng
Summary: This study aimed to identify the independent risk factors for transarterial embolization (TACE) refractoriness in hepatocellular carcinoma (HCC) patients. The study found that the number of tumors and bilobular invasion of HCC were independent risk factors for TACE refractoriness. The TACE refractoriness score was developed as an effective tool for predicting the risk of TACE refractoriness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhen-Hua Chen, Xiu-Ping Zhang, Jin-Kai Feng, Le-Qun Li, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jie Shi, Wei-Xing Guo, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: One-third of HCC patients with MVI achieved the long-term survival milestone of 5 years after resection. Anatomical hepatectomy, controlling intraoperative blood loss, a wide resection margin, and postoperative adjuvant TACE should be considered to improve long-term survival outcomes.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Yuling Xiong, Peng Cao, Xiaohua Lei, Weiping Tang, Chengming Ding, Shuo Qi, Guodong Chen
Summary: This study compared the clinical prognosis of HCC patients with or without tumor microvascular invasion (MVI) after radical surgical treatment and found that MVI is an independent risk factor for a poor prognosis after surgery. A prediction model based on preoperative AFP, tumor diameter, and TNM stage showed good predictive efficacy and clinical practicability.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Xubiao Wei, Yabo Jiang, Shuang Feng, Chongde Lu, Lei Huo, Bin Zhou, Yan Meng, Wan Yee Lau, Yaxin Zheng, Shuqun Cheng
Summary: For patients with a resectable single and small hepatitis B virus-related HCC predicted to have high risks of MVI, neoadjuvant RT gave a promising response rate with mild toxicity. Nevertheless, neoadjuvant RT yielded similar long-term DFS and OS rates compared with patients who underwent upfront surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, Research & Experimental
Yi Wang, Gui-Qi Zhu, Rui Yang, Cheng Wang, Wei-Feng Qu, Tian-Hao Chu, Zheng Tang, Chun Yang, Li Yang, Chang-Wu Zhou, Geng-Yun Miao, Wei-Ren Liu, Ying-Hong Shi, Meng-Su Zeng
Summary: This study revealed the interactions of cell subpopulations and distinct metabolism profiles in MVI+ HCC, and discovered the radiomics features related to the infiltration of APOE(+) macrophages and iCAFs. Furthermore, the study developed Radscore for predicting MVI and HCC prognostication, which could predict the level of infiltration of APOE(+) macrophages and iCAFs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
