Article
Medicine, Research & Experimental
Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li
Summary: CD45(+)EPCs play a role in promoting portal vein tumor thrombus (PVTT) formation in HCC by differentiating into erythroid-transdifferentiated myeloid cells (EDMCs) induced by HCC macrophages, which migrate from the circulation to the tumor microenvironment.
Review
Biology
Guoteng Qiu, Kunlin Xie, Zhaoxing Jin, Chuang Jiang, Hu Liu, Haifeng Wan, Jiwei Huang
Summary: Portal vein tumor thrombus (PVTT) is a common complication of hepatocellular carcinoma (HCC) indicating a poor prognosis. Monotherapy is ineffective for HCC-PVTT patients with high recurrence rates. Multidisciplinary management offers hope for improved survival benefits through accurate diagnosis, staging, and implementation of various treatment protocols in the absence of universal guidelines.
Review
Oncology
Fangzhou Luo, Mengxia Li, Jun Ding, Shusen Zheng
Summary: HCC with PVTT remains a challenging healthcare issue worldwide with no global consensus or standard guidelines for its management. In western countries, Sorafenib and Lenvatinib are recommended as first-line treatment options, but more aggressive approaches such as transarterial chemoembolization and radiotherapy have shown promise in improving prognosis and extending survival time for patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Nicole M. Nevarez, Adam C. Yopp
Summary: Partial hepatectomy with en bloc resection of PVTT can offer significant benefits in carefully selected patients with HCC, but the risks may outweigh the benefits when PVTT extends further.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Gastroenterology & Hepatology
Shohei Komatsu, Masahiro Kido, Kaori Kuramitsu, Daisuke Tsugawa, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
Summary: This study evaluated the impact of hepatectomy on HCC with macroscopic PVTT in 100 patients. The presence of Vp3/4 PVTT had a significant impact on survival, with hepatectomy being considered an effective treatment option.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Gastroenterology & Hepatology
Zhu-Jian Deng, Le Li, Yu-Xian Teng, Yu-Qi Zhang, Yu-Xin Zhang, Hao-Tian Liu, Jian-Li Huang, Zhen-Xiu Liu, Liang Ma, Jian-Hong Zhong
Summary: The proportions of HCC patients with PVTT vary greatly in different countries or regions, and the treatment regimens recommended also differ. In recent years, advancements in surgical concepts, radiotherapy techniques, and systematic therapies have provided more treatment options and improved prognoses for HCC patients with PVTT.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenkang Qiu, Chunpeng Yu, Xiaofei Qiu, Qun Li, Jian Li, Zhao Chen, Shuai Chang, Shuo Zhang, Gang Fan, Song Wang
Summary: This study evaluated the safety and efficacy of I-125 brachytherapy for treating PVTT in HCC patients. The results showed that this treatment is effective in controlling tumors with no severe adverse events. Patients younger than 60 years old with type I+II PVTT and a tumor diameter less than 5 cm have a better overall survival.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Xiao-Hui Zhao, Hai-Liang Li, Chen-Yang Guo, Quan-Jun Yao, Wei-Li Xia, Hong-Tao Hu
Summary: This study aimed to investigate the efficacy and safety of TACE in combination with 125I seed implantation and RFA for the treatment of HCC complicated by PVTT. The results showed that the combination of TACE and 125I seed implantation can effectively inactivate PVTT and achieve downstaging, and the addition of RFA can significantly improve patient survival.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Chemistry, Multidisciplinary
Xiu-Ping Zhang, Bozhao Li, Zefang Lu, Ming-Gen Hu, Guo-Dong Zhao, Shuai Xu, Zhouliang Wu, Tianjiao Chu, Feilong Qi, Suying Wu, Guangjun Nie, Suping Li, Rong Liu
Summary: In this study, an acid-responsive polymeric nanocarrier was developed to deliver anticoagulant and chemotherapeutic drugs into portal vein tumor thrombus (PVTT) for effective inhibition of hepatocellular carcinoma (HCC). The nanocarrier allowed continuous accumulation of the drugs at a constant ratio in the PVTT, leading to potent anti-tumor efficacy without side effects in mouse models. This work highlights the importance of PVTT modulation in advanced HCC treatment and presents a promising strategy for treating tumors accompanied by hypercoagulability and vascular invasion.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingqiang Zhang, Hongfei Miao, Wenlin Xie, Suxiang Jiang, Ze Song, Guihua Huang, Wenzhe Fan, Yu Wang, Jiaping Li, Yong Chen
Summary: This study identified clinical factors associated with overall survival in patients with hepatocellular carcinoma and portal vein tumor thrombus undergoing sorafenib plus transarterial chemoembolization. A prognostic score system was developed based on these factors, which accurately stratified patients into favorable, intermediate, and dismal groups with different survival outcomes. External validation confirmed the effectiveness of the prognostic scores in predicting patient outcomes.
EUROPEAN RADIOLOGY
(2021)
Article
Cell Biology
Tong Lin, Zhimei Lin, Peipei Mai, E. Zhang, Lisheng Peng
Summary: This study identified 12 commonly down-expressed DEGs in PVTT tissues, with up-regulation associated with favorable outcomes in HCC patients. Genetic alterations and DNA methylation of DEGs were frequent and correlated with patient prognosis. DEGs and co-expressive genes participated in ECM organization and focal adhesion biological processes.
Article
Gastroenterology & Hepatology
Wan Yee Lau, Kang Wang, Xiu-Ping Zhang, Le-Qun Li, Tian-Fu Wen, Min-Shan Chen, Wei-Dong Jia, Li Xu, Jie Shi, Wei-Xing Guo, Ju-Xian Sun, Zhen-Hua Chen, Lei Guo, Xu-Biao Wei, Chong-De Lu, Jie Xue, Li-Ping Zhou, Ya-Xing Zheng, Meng Wang, Meng-Chao Wu, Shu-Qun Cheng
Summary: A new staging system for hepatocellular carcinoma (HCC) associated with portal vein tumor thrombus (PVTT) was developed, incorporating various factors and showing good discriminatory ability to separate patients into different stages and substages.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Hong-Tao Hu, Jun-Peng Luo, Guang-Shao Cao, Zhen Li, Ming Jiang, Chen-Yang Guo, Hang Yuan, Quan-Jun Yao, Xiang Geng, Jung-Hoon Park, Hong-Tao Cheng, Li Jiang, Jun-Li Ma, Yan Zhao, Hai-Liang Li
Summary: The study demonstrated the significant survival improvement of HCC patients with PVTT, especially in subtype IIa, when treated with TACE-(125)iodine, with minimal adverse events.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Juxian Sun, Rongping Guo, Xinyu Bi, Mengchao Wu, Zhaoyou Tang, Wan Yee Lau, Shusen Zheng, Xuehao Wang, Jinming Yu, Xiaoping Chen, Jia Fan, Jiahong Dong, Yongjun Chen, Yunfu Cui, Chaoliu Dai, Chihua Fang, Shuang Feng, Zhili Ji, Weidong Jia, Ningyang Jia, Gong Li, Jing Li, Qiu Li, Jiangtao Li, Tingbo Liang, Lianxin Liu, Shichun Lu, Yi Lv, Yilei Mao, Yan Meng, Zhiqiang Meng, Feng Shen, Jie Shi, Huichuan Sun, Kaishan Tao, Gaojun Teng, Xuying Wan, Tianfu Wen, Liqun Wu, Jinglin Xia, Mingang Ying, Jian Zhai, Leida Zhang, Xuewen Zhang, Zhiwei Zhang, Haiping Zhao, Donghai Zheng, Xuting Zhi, Jie Zhou, Cuncai Zhou, Jian Zhou, Zhaochong Zeng, Kangshun Zhu, Minshan Chen, Jianqiang Cai, Shuqun Cheng
Summary: Portal vein tumor thrombus (PVTT) is a common factor affecting the prognosis and staging of hepatocellular carcinoma (HCC). The guidelines have been revised to incorporate new treatment options for PVTT, and further research is needed for future strategies in China.
Review
Medicine, General & Internal
Giuseppe Sena, Daniele Paglione, Gaetano Gallo, Marta Goglia, Mariasara Osso, Bruno Nardo
Summary: This paper presents a case of a patient with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) who underwent surgical resection. A systematic literature review comparing the outcomes of surgical resection with other non-surgical treatments for HCC patients with PVTT was conducted. The results showed that surgical resection can be an effective first-line treatment option.
JOURNAL OF CLINICAL MEDICINE
(2022)