Review
Biochemistry & Molecular Biology
Zuzana Tothova, Jana Tomc, Natasa Debeljak, Peter Solar
Summary: Erythropoietin acts on multiple tissues through the receptor EPOR, triggering various signaling pathways such as JAK2/STAT5 and PI3K/AKT that regulate erythropoiesis and cell functions, with potential implications for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Feihong Liang, Huiting Guan, Wenhua Li, Xue Zhang, Tingting Liu, Yu Liu, Jie Mei, Cheng Jiang, Fengxue Zhang, Bangwei Luo, Zhiren Zhang
Summary: The research shows that erythropoietin (EPO) can promote resolution of infections caused by E. coli and S. aureus, while enhancing the actions of antibiotics. EPO increases macrophage clearance of bacteria, ameliorates inflammation, and reduces antibiotic requirements in resolving infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon
Summary: In this study, divergently modified peptide analogs derived from EPO showed potent neuroprotective effects against oxidative stress without inducing cell proliferation. One of the peptides, ML1-h3, exhibited unique binding potency to EPOR and inhibited neuronal death and brain injury under hypoxic stress.
Article
Biochemistry & Molecular Biology
Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Summary: This study demonstrates that EPOR in the monocytic lineage is at least partially responsible for the effect of EPO on bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
George Mpekoulis, Efseveia Frakolaki, Styliani Taka, Anastasios Ioannidis, Alice G. Vassiliou, Katerina Kalliampakou, Kostas Patas, Ioannis Karakasiliotis, Vassilis Aidinis, Stylianos Chatzipanagiotou, Emmanouil Angelakis, Dido Vassilacopoulou, Niki Vassilaki
Summary: In COVID-19 patients, there was a significant increase in the expression of L-Dopa decarboxylase (DDC) gene, while non-infected and influenza-infected individuals did not show the same. Short ACE2 (dACE2), ISG56, and EPO also showed significant increases in SARS-CoV-2 infected individuals.
Review
Pharmacology & Pharmacy
Soumyadeep Dey, Jeeyoung Lee, Constance T. Noguchi
Summary: EPO, through EPOR expression, exerts protective effects in non-hematopoietic tissues, influencing metabolism in the brain, fat, and bones, especially in regulating obesity and inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Yerin Chung, Suneetha Desiraju, Kopperuncholan Namachivayam, Pierre Guzman, Ling He, Krishnan MohanKumar
Summary: This study comprehensively investigated the hematological changes associated with anemia using a preclinical mouse model. The findings demonstrate that anemia may have an impact on neonatal diseases and provide insights for investigating anemia in preterm infants. The study emphasizes the importance of understanding the pathogenesis of anemia in premature infants.
PEDIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Daniela C. Vittori, Maria E. Chamorro, Yender V. Hernandez, Romina E. Maltaneri, Alcira B. Nesse
Summary: Erythropoietin, traditionally used to treat anemia, is now recognized for its cytoprotective effects on non-hematopoietic tissues. Clinical trials have shown that Epo treatment can stimulate neurogenesis, improve cognition, and activate anti-apoptotic, antioxidant, and anti-inflammatory pathways.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Zuzana Tothova, Martina Semelakova, Zuzana Solarova, Jana Tomc, Natasa Debeljak, Peter Solar
Summary: Erythropoietin (EPO) plays a crucial role in cell survival through triggering signaling cascades such as JAK2/STAT5, MAPK, and PI3K/AKT. This article describes the role of MAPK and PI3K/AKT pathways in red blood cell formation and non-hematopoietic tissues, highlighting the differences between erythroid and non-erythroid cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Elina J. Rancken, Marjo P. H. Metsaranta, Mika Gissler, Leena K. Rahkonen, Leena M. Haataja
Summary: The study found that high umbilical cord serum erythropoietin concentration at birth was associated with an increased risk of neurodevelopmental morbidity in early childhood, but the clinical value of erythropoietin determination appears to be minor.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yasuhiro Mochida, Akinori Hara, Machiko Oka, Kyoko Maesato, Kunihiro Ishioka, Hidekazu Moriya, Megumi Oshima, Tadashi Toyama, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Yoshitaka Koshino, Takayasu Ohtake, Sumi Hidaka, Shuzo Kobayashi, Takashi Wada
Summary: Anti-EPOR antibodies were found to be associated with left ventricular dysfunction in patients undergoing HD.
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: SGLT2 inhibitors reduce the risk of heart failure events by enhancing erythropoiesis. This enhancement is hypothesized to be due to increased oxygenation in the kidneys, increased oxygen consumption and localized hypoxia, increased iron mobilization, and direct activation of erythropoietin gene transcription. The liver may also contribute to erythropoietin production during SGLT2 inhibition. The mechanism linking erythropoiesis to cardioprotection may involve the upregulation of SIRT1 and its effects on HIF-2 alpha expression and erythropoietin synthesis.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Xiao-yu Wu, Yi-miao Zhu, Yang Qi, Wen-Wen Xu, Jing-Zhai
Summary: Tissue engineering aims to provide scaffolds mimicking native tissues, with erythropoietin (EPO) playing an increasingly significant role in regenerative medicine by preventing cell death and providing tissue protection. This review critically analyzes techniques for modifying scaffolds with EPO, as well as non-hematopoietic functions of EPO, discussing applications and future prospects in regenerative medicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Medicine, Research & Experimental
Liasmine Haine, Celine-Hivda Yegen, Dominique Marchant, Jean-Paul Richalet, Emilie Boncoeur, Nicolas Voituron
Summary: Erythropoietin (Epo) has cell-protective effects beyond its role in red blood cell synthesis, with potential applications in limiting symptoms of acute and chronic lung diseases. Research shows that Epo exhibits protective effects in multiple organs, particularly in the lung.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Dermatology
Hidehiko Fukushima, Yohei Iwata, Kenta Saito, Kazumitsu Sugiura
Summary: Combination therapy with BRAF and MEK inhibitors has greatly improved prognosis in patients with BRAF-mutant metastatic melanoma, however, resistance remains a challenge. Recent studies suggest that EphA2, p-EphA2, and EGFR may play critical roles in driving resistance to BRAF inhibitors in melanoma, providing potential targets for overcoming resistance and improving prognosis.
JOURNAL OF DERMATOLOGY
(2021)