Article
Oncology
Jun-Qiang Du, Fan Zhang, Chao-Qun Wang, Ju-Fan Zhu, Li-Xia Xu, Yi-Heng Yang, Meng-Fei Han, Yan Hu
Summary: This study analyzed the levels of peripheral blood NLR in 203 patients with early cervical cancer and evaluated the relationship between NLR changes, clinicopathological characteristics, and patient prognosis. The study found that high preoperative NLR was associated with shorter overall survival and high postoperative NLR was associated with lower progression-free survival. Postmenopausal patients and those without vascular infiltration had higher rates of NLR increase. Further multicenter studies are needed to verify the effect of NLR changes on the prognosis of cervical cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mu Xu, Qibin Wu, Liangzhi Cai, Xiaoqi Sun, Xiaoyan Xie, Pengming Sun
Summary: The study demonstrates that preoperative SIS can serve as a simple and useful prognostic factor for postoperative survival in cervical cancer patients. The combination of SIS and FIGO stage shows superior prognostic impact compared to FIGO stage alone.
Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Gastroenterology & Hepatology
Liang Guo, Qi Wang, Kang Chen, Hai-Peng Liu, Xiao Chen
Summary: In this study, the combination of preoperative NLR and CA19-9 was found to independently predict the overall survival of patients with gastric cancer, providing a convenient, economical, and effective prognostic system for clinical practice. The NLR + CA19-9 score indicator showed better predictive ability than other combined or single score indicators, based on inflammation and tumor markers.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Mengli Zhao, Zhongrong Gao, Xiaowei Gu, Xiaojing Yang, Shanshan Wang, Jie Fu
Summary: The research focuses on analyzing the prognostic significance of minimum count of lymphocytes (LY) and the corresponding ratio of neutrophil-to-lymphocyte (NLR) in cervical cancer patients receiving radiotherapy. The study found that patients with higher LY levels and lower NLR values during radiotherapy had better survival prognosis. Factors such as FIGO stage I, absence of lymph node metastasis, and lower NLR values were associated with poorer overall survival and progression-free survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Qi Yu, Tian-Zhi An, Jun-Xiang Li, De-Hua Chang, Zi-Shu Zhang, Yu-Dong Xiao
Summary: ILIS is a powerful prognostic index for predicting the survival of patients with HCC after transarterial chemoembolization, outperforming other standard scoring systems and inflammatory indices. High ILIS, low lymphocyte count, beyond up-to-seven criteria, and nonresponse to the first transarterial chemoembolization session were identified as risk factors for poor prognosis after treatment. The predictive performances of ILIS for 1-, 2-, 3-, 4-, and 5-year survival were good, with higher area under the curve values than other scoring systems.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xinran Li, Lin Zhou, Yuxin Chen, Na Li, Jian Meng
Summary: This study retrospectively analyzed 71 patients with ACC and found that preoperative neutrophil-to-lymphocyte ratio (NLR) is an effective biomarker for the prognosis of ACC patients. High NLR is associated with lymph node metastasis and tumor stage, and it is correlated with overall survival but not disease-free survival in ACC patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Mingyu Wan, Yongfeng Ding, Chenyu Mao, Xiaolu Ma, Ning Li, Cheng Xiao, Jiong Qian, Haiping Jiang, Yulong Zheng, Luntao Wu, Lisong Teng, Nong Xu
Summary: This study aimed to investigate the prognostic significance of inflammatory markers in advanced gastric cancer patients receiving immunotherapy combined with chemotherapy. It was found that neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of progression-free survival and overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Daniel Balan, Mihai Dorin Vartolomei, Annamaria Magdas, Noemi Balan-Bernstein, Septimiu Toader Voidazan, Orsolya Martha
Summary: In this study, it was found that bladder cancer patients with IMPROVE score greater than 4 had higher NLR, LMR, and lymphocyte values. The IMPROVE score was significantly influenced by lymphocyte count and NLR value. Patients with NMIBC with low lymphocytes and NLR > 3 were at a higher risk of developing venous thromboembolic events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Lavinia Domenici, Alessandro Tonacci, Paolo Aretini, Silvia Garibaldi, Alessandra Perutelli, Pietro Bottone, Ludovico Muzii, Pierluigi Benedetti Panici
Summary: Inflammation plays a crucial role in cancer development, with IL-6 implicated in cervical cancer progression through platelet activation. This study evaluated the prognostic impact of platelet count, PLR, and IL-6 in cervical cancer patients. Higher platelet counts, PLR values, and IL-6 expression were associated with poorer prognosis.
Review
Biology
Deepak Ravindranathan, Viraj A. Master, Mehmet Asim Bilen
Summary: Inflammation is closely linked to tumor development, with inflammatory markers in the blood used to predict and assess tumor responses to chemotherapy and immunotherapy. Tumor-associated inflammation plays a crucial role in therapy, growth, and prognosis.
Article
Oncology
Shu-Bei Wang, Jia-Yi Chen, Cheng Xu, Wei-Guo Cao, Rong Cai, Lu Cao, Gang Cai
Summary: The study showed that pretreatment NLR can serve as a prognostic factor for survival in LAGC patients treated with adjuvant chemoradiotherapy after D2 dissection, especially for predicting locoregional recurrence rate and paraaortic lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Matteo Ferro, Gennaro Musi, Deliu Victor Matei, Alessandro Francesco Mistretta, Stefano Luzzago, Gabriele Cozzi, Roberto Bianchi, Ettore Di Trapani, Antonio Cioffi, Giuseppe Lucarelli, Gian Maria Busetto, Francesco Del Giudice, Giorgio Ivan Russo, Marina Di Mauro, Angelo Porreca, Giuseppe Renne, Michele Catellani, Danilo Bottero, Antonio Brescia, Giovanni Cordima, Ottavio de Cobelli
Summary: This study evaluated and validated the use of the Prostatic Systemic Inflammatory Markers (PSIM) score in predicting clinically significant prostate cancer and found a significant correlation between higher PSIM scores and increased pathological grade. PSIM was identified as the sole independent prognostic variable influencing adverse pathology in multivariate analysis.
Article
Gastroenterology & Hepatology
Da-Zhang Wu, Jing-Ming Zhong, Wei-Ping Jiang, Ze-Song Liao, Sheng-Hui Huang, Yan-Wu Sun, Yu Lin, Dao-Xiong Ye, Chi Pan, Wei-Zhong Jiang
Summary: The aim of this study is to investigate the prognostic value of baseline peripheral blood neutrophils, monocytes, and lymphocytes on locally advanced rectal cancer (LARC) patients. Results indicate that the peripheral blood immune score (PBIS) is an independent predictor of LARC prognosis. High PBIS and high lymphocyte count are favorable factors for survival.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
