Article
Oncology
Maria Rosaria Ambrosio, Elisa Magli, Giuseppe Caliendo, Rosa Sparaco, Paola Massarelli, Vittoria D'Esposito, Teresa Migliaccio, Giusy Mosca, Ferdinando Fiorino, Pietro Formisano
Summary: The study identified serotoninergic receptor ligands that may be used in combination with Tamoxifen to improve its effectiveness on ER+ breast cancer patients. These ligands reduced viability of BC cells, particularly in MCF7 ER+ cells, and enhanced the effectiveness of Tamoxifen treatment, without affecting non-cancerous breast epithelial cells. SER68, in particular, showed potential in restoring drug effect in a Tamoxifen-resistant cell model.
Article
Biochemistry & Molecular Biology
Jeong Hee Lee, Jongsu Kim, Hong Sook Kim, Young Jin Kang
Summary: This study highlights the clinical significance of connective tissue growth factor (CTGF) as a prognostic marker in triple-negative breast cancer (TNBC) and explores the potential therapeutic effects of kahweol, a coffee diterpene molecule, in TNBC treatment. The findings demonstrate that CTGF is involved in migratory pathways relevant to TNBC treatment, and kahweol can regulate CTGF expression to suppress cell motility in TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jones Gyamfi, Joo Hye Yeo, Doru Kwon, Byung Soh Min, Yoon Jin Cha, Ja Seung Koo, Joon Jeong, Jinu Lee, Junjeong Choi
Summary: Adipocytes influence breast cancer behavior by releasing fatty acids into the tumor microenvironment. CD36 serves as a key mediator in the import and metabolism of fatty acids in cancer cells, interacting with STAT3 to drive tumor progression. Inhibition of CD36 and FABP4 induces apoptosis in tumor cells, indicating their potential as therapeutic targets in the tumor microenvironment.
Review
Endocrinology & Metabolism
Barbara Mensah Sankofi, Estefania Valencia-Rincon, Malika Sekhri, Adriana L. Ponton-Almodovar, Jamie J. Bernard, Elizabeth A. Wellberg
Summary: Obesity and type 2 diabetes are chronic metabolic diseases that have a significant impact on breast cancer risk and prognosis. Adipose tissue plays an important role in breast cancer progression, involving both adipocytes and fibroblasts. Fibroblast growth factor receptor signaling network may mediate the effects of adipose tissue on breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
En Cheng, Bette J. Caan, Wendy Y. Chen, Melinda L. Irwin, Carla M. Prado, Elizabeth M. Cespedes Feliciano
Summary: This study aimed to investigate the association between radiodensity of subcutaneous and visceral adipose tissue at diagnosis of breast cancer and patient prognosis. The results showed that high radiodensity of subcutaneous adipose tissue was significantly associated with increased risk of overall mortality, independent of other prognostic factors.
CLINICAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Marie Rebeaud, Caroline Bouche, Stephanie Dauvillier, Camille Attane, Carlo Arellano, Charlotte Vaysse, Frederique Fallone, Catherine Muller
Summary: Obesity is a negative prognostic factor for breast cancer, but the underlying biological mechanisms are largely unknown. This study suggests that altered transfer of free fatty acids (FFA) between adipocytes and tumor cells might contribute to tumor progression in obese conditions. A 3D model using a fibrin matrix is introduced as an alternative for studying the interaction between mammary adipocytes (M-Ads) and cancer cells, showing FFA transfer and its amplification by obesity.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Article
Multidisciplinary Sciences
Ryan Liu, Shyryn Ospanova, Rachel Perry
Summary: CPT1A is upregulated in high-risk breast cancer and its effect on patients' survival probability was explored using RNA sequencing data and positron emission tomography-computed tomography images. The study found that higher CPT1A expression is associated with lower breast cancer survivability, confirming a protective relationship between obesity and breast cancer in pre-menopausal patients.
Article
Oncology
Amy R. Dwyer, Thu H. Truong, Carlos Perez Kerkvliet, Kiran Paul, Peter Kabos, Carol A. Sartorius, Carol A. Lange
Summary: Phospho-PR-B collaborates with IRS-1 to promote the outgrowth of endocrine-resistant and stem-like breast cancer cells. Activation of p-PR can lead to tamoxifen insensitivity. Targeting the crosstalk between phospho-PR and IRS-1 may block the emergence of endocrine resistance.
BRITISH JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Su Hyun Lee, Myoung-jin Jang, Heera Yoen, Youkyoung Lee, Yeon Soo Kim, Ah Reum Park, Su Min Ha, Soo-Yeon Kim, Jung Min Chang, Nariya Cho, Woo Kyung Moon
Summary: Background parenchymal enhancement (BPE) at surveillance breast MRI is associated with future second breast cancer risk in women with a personal history of breast cancer.
Article
Oncology
Bernard Fisher, John Bryant, Norman Wolmark, Eleftherios Mamounas, Ann Brown, Edwin R. Fisher, D. Lawrence Wickerham, Mirsada Begovic, Arthur DeCillis, Andre Robidoux, Richard G. Margolese, Anatolio B. Cruz Jr, James L. Hoehn, Alan W. Lees, Nikolay V. Dimitrov, Harry D. Bear
Summary: This study compares the efficacy of preoperative and postoperative chemotherapy in women with primary operable breast cancer, and explores the correlation between tumor response to preoperative chemotherapy and prognosis. The results showed no significant difference in DFS, DDFS, or survival between the preoperative and postoperative chemotherapy groups. Preoperative chemotherapy allows for more lumpectomies and tumor response is associated with prognosis.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Anette M. Skjervold, Marit Valla, Borgny Ytterhus, Anna Bofin
Summary: This study aimed to assess the association between PAK1 gene copy number and proliferation status, molecular subtype, and prognosis in breast cancer. The results showed that PAK1 copy number increase is associated with high proliferation and high histological grade, but not with prognosis. PAK1 copy number increase is most frequent in the HER2 type and Luminal B (HER2(-)) subtype and is associated with CCND1 copy number increase.
Article
Food Science & Technology
Duconseille Anne, Astruc Thierry, Sasaki Keisuke, Motoyama Michiyo
Summary: Cooking methods and temperatures have different effects on the structure of meat. Muscle fibers become more compact during cooking, but the cross-sectional area remains unchanged. Cooking meat to well-done significantly affects the structure of the meat's perimysium.
Article
Multidisciplinary Sciences
Xiangyue Meng, Michi Morita, Sayaka Kuba, Hiroko Hayashi, Ryota Otsubo, Megumi Matsumoto, Kosho Yamanouchi, Kazuma Kobayashi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Takeshi Nagayasu, Susumu Eguchi
Summary: Loss of E-cadherin expression is associated with adipose tissue invasion and poor prognosis in breast cancer patients. The study found that reduced E-cadherin expression was not only observed in the adipose tissue invasion area but also in the invasive front of the tumor. Decreased E-cadherin expression was correlated with lymph node metastasis and increased risk of recurrence.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Cell Biology
Mohammed K. Hankir, Annett Hoffmann, Florian Seyfried
Summary: This study reveals the potential of limiting glucose availability for cancer cells and slowing tumor growth by activating brown adipose tissue (BAT).
Review
Oncology
Marianna Aprile, Valerio Costa, Amelia Cimmino, George Adrian Calin
Summary: The view of long noncoding RNAs as nonfunctional garbage has been outdated, as evidence suggests their role as golden junk, particularly in precision oncology. They have potential use as diagnostic and/or prognostic biomarkers, and advancements in technology have made it easier to profile them in multiple tumors and large cohorts.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Rafael Franco, Joan Serrano-Marin
Summary: The tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, is essential for energy production and anabolic processes in cells. While not as tightly regulated as other key metabolic pathways, it plays a crucial role in understanding and addressing diseases related to mitochondrial dysfunction. This article suggests the need for better understanding and regulation of TCA cycle enzyme activity, including the possible direct regulation by G protein-coupled receptors (GPCRs) in mitochondrial membranes.
Article
Cell Biology
Rafael Rivas-Santisteban, Iu Raich, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro
Summary: The study discovered a direct interaction between PrPC and NMDAR, which alters the functionality of the receptor. Significant overexpression of NMDAR-PrPC complexes was observed in the AD model, and PrPC exacerbates the axonal transport of Tau and pTau proteins.
Article
Pathology
Andrea Ronchi, Marco Montella, Emma Carraturo, Eduardo Clery, Federica Zito Marino, Martina Amato, Giuseppe Argenziano, Elvira Moscarella, Gabriella Brancaccio, Teresa Troiani, Pasquale Alfano, Roberto Alfano, Renato Franco, Immacolata Cozzolino
Summary: BRAF molecular evaluation on cell suspension obtained from FNAC needle rinses is a time-saving and accurate technique for diagnostic and predictive purpose in the clinical practice.
Article
Cell Biology
Simona Cataldi, Marianna Aprile, Caterina Perfetto, Brice Angot, Mireille Cormont, Alfredo Ciccodicola, Jean-Francois Tanti, Valerio Costa
Summary: Adipose tissue dysfunctions are associated with insulin resistance and type 2 diabetes mellitus. Targeting GIP receptor is a valid option for improving the efficacy of GLP-1 receptor agonists in diabetes treatment. However, the therapeutic potential and impact of targeting the GIP/GIPR axis on adipose tissue are controversial.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Oncology
Emanuela Esposito, Valeria Varone, Claudio Siani, Maurizio Di Bonito, Maria Teresa Melucci, Ivana Donzelli, Raimondo di Giacomo, Ugo Marone, Ruggero Saponara, Francesca Collina, Alfredo Fucito, Franca Avino
Summary: This case report describes a 60-year-old female with a personal and familial history of monoclonal gammopathy of undetermined significance (MGUS) and a lump in her right breast. Biopsy revealed lymphoplasmacytic lymphoma (LPL) of the breast, leading to a diagnosis of Waldenstrom's Macroglobulinemia (WM). Breast lymphoma is a rare disease often misdiagnosed due to lack of specific features on mammogram and ultrasound, making core biopsy crucial for diagnosis.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Oncology
Stefano Luca, Renato Franco, Antonella Napolitano, Valeria Soria, Andrea Ronchi, Federica Zito Marino, Carminia Maria Della Corte, Floriana Morgillo, Alfonso Fiorelli, Antonio Luciano, Giuseppe Palma, Claudio Arra, Sabrina Battista, Laura Cerchia, Monica Fedele
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), has a high mortality rate and lacks effective therapies. Immunotherapy shows promise, but predicting success is challenging. This study investigated the relationship between PATZ1 and PD-L1 expression in NSCLC and found that they are negatively associated. PATZ1 overexpression downregulates PD-L1 expression and inhibits NSCLC cell proliferation, migration, and invasion, suggesting it may act as a tumor suppressor in NSCLC.
Article
Biochemistry & Molecular Biology
Gianluca Fasciolo, Gaetana Napolitano, Marianna Aprile, Simona Cataldi, Valerio Costa, Maria Teresa Muscari Tomajoli, Assunta Lombardi, Sergio Di Meo, Paola Venditti
Summary: This study aims to explore the correlation between oxidative stress and insulin resistance (IR) in skeletal muscle, using hyperthyroid rats as a model. The results suggest that hyperthyroidism-induced oxidative stress plays a role in the development of IR in muscle, and vitamin E supplementation can mitigate the effects of oxidative stress on IR.
Article
Medicine, General & Internal
Giuseppa Zannini, Ilaria Tedesco, Immacolata Cozzolino, Marco Montella, Eduardo Clery, Carminia Maria Della Corte, Floriana Morgillo, Marina Accardo, Renato Franco, Federica Zito Marino
Summary: This study aimed to evaluate the quantity and quality of nucleic acids extracted from mixed stained slides (MSSs) compared to unstained slides (USs). It was found that DNA extracted from MSSs showed satisfactory results while RNA extraction was not successful.
Article
Pathology
Federica Zito Marino, Simona Buono, Marco Montella, Rosa Giannatiempo, Francesco Messina, Giovanni Casaretta, Grazia Arpino, Giulia Vita, Francesco Fiorentino, Luigi Insabato, Alessandro Sgambato, Michele Orditura, Renato Franco, Marina Accardo
Summary: TNBC is an aggressive disease with limited treatment options. This study aimed to investigate the frequency of NTRK aberrations in TNBC. Analysis of 83 TNBC cases showed high false-positive rate in IHC for detecting fusions, suggesting the necessity of molecular testing.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alejandro Lillo, Joan Serrano-Marin, Jaume Lillo, Iu Raich, Gemma Navarro, Rafael Franco
Summary: Microglial activation is often seen in patients with neurodegenerative diseases. A study investigated the effect of adenosine receptor ligands on microglial activation and identified potential biomarkers associated with immune system-related events.
Review
Biochemistry & Molecular Biology
Rafael Franco, Joan Serrano-Marin, Gemma Navarro, Rafael Rivas-Santisteban
Summary: This review discusses the potential role of the renin angiotensin system (RAS) in the central nervous system, particularly in the treatment of Parkinson's disease. The expression of RAS in dopaminergic neurons may impact dopamine synthesis and oxidative stress detoxification, and the regulation of glucose-6-phosphate dehydrogenase activity may involve the activation of protein kinase A and/or protein kinase C.
Article
Biochemistry & Molecular Biology
Niklas Rosier, Denise Moennich, Martin Nagl, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes-Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes
Summary: Dopamine D-1-like receptors are the most abundant type of dopamine receptors in the central nervous system. The synthesis of new fluorescent ligands derived from D1R antagonist SCH-23390 was described, which can be used as tools for the visualization of D-1-like receptors. The high-affinity ligand UR-NR435 (25) showed excellent selectivity towards D-1-like receptors and proved to be a neutral antagonist in binding studies. This fluorescent ligand is a useful tool for studying native D-1 receptors in various experimental setups.
Article
Biochemistry & Molecular Biology
Martin Nagl, Denise Moennich, Niklas Rosier, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes-Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes
Summary: This study describes the synthesis of a set of new fluorescent ligands for visualization of dopamine D-2-like receptors. The ligand UR-MN212 (20) showed high affinity for D-2-like receptors and moderate selectivity towards D-1-like receptors. It displayed rapid association with D2longR and can be used for fluorescence microscopy studies. The ligand's binding affinity was determined in a single-digit nanomolar range, consistent with radioligand binding data.
