Review
Oncology
Erna Jia, Na Ren, Xianquan Shi, Rongkui Zhang, Haixin Yu, Fan Yu, Shaoyou Qin, Jinru Xue
Summary: EV biomarkers show promising diagnostic potential for pancreatic cancer, especially in early-stage diagnosis. However, limitations in EV isolation and detection technologies exist.
Review
Oncology
Kui-Ying Jiang, Li-Li Qi, Xin-Bo Liu, Yong Wang, Ling Wang
Summary: Siglec-15 expression is significantly associated with poor outcomes in human solid tumors, but further studies are needed to determine its prognostic value.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Xin Zhang, Huiyu Liu, Yuanyuan Huang, Ruimin Wang
Summary: This meta-analysis identifies A beta 42, T-tau, and P-tau181 in neurogenic exosomes as reliable biomarkers for the early diagnosis of Alzheimer's disease (AD). The concentrations of these biomarkers are significantly higher in AD patients compared to healthy controls.
Review
Oncology
Yipeng Xu, Jianmin Lou, Mingke Yu, Yingjun Jiang, Han Xu, Yueyu Huang, Yun Gao, Hua Wang, Guorong Li, Zongping Wang, An Zhao
Summary: Urinary exosomes have great potential as non-invasive biomarkers for diagnosing urological tumors, with high sensitivity and specificity. Further clinical trials are needed to validate and explore their utility in treatment decision-making.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Amir Hossein Aalami, Hossein Abdeahad, Ali Shoghi, Mohammad Mesgari, Amir Amirabadi, Amirhossein Sahebkar
Summary: This meta-analysis aimed to evaluate the diagnostic accuracy of microRNAs in the blood for brain tumors. The results showed that microRNAs have high diagnostic accuracy in identifying brain tumors. Subgroup analyses were also performed to determine the influence of sample types, reference genes, and regions on the diagnostic power of microRNAs.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Review
Oncology
Maryam Koopaie, Sajad Kolahdooz, Mahnaz Fatahzadeh, Soheila Manifar
Summary: This study evaluates the diagnostic value of salivary biomarkers in breast cancer diagnosis through a meta-analysis and systematic review. The results suggest that saliva has the potential to accurately differentiate breast cancer patients from healthy controls.
Review
Cell Biology
Xi-Yi Zhao, Yu-Lu Gao, Dan-Feng Li, Hong-Chao Liu, Rui-Fang Zhu, Chang-Tai Zhu
Summary: The study found that miR-371a-3p has a high diagnostic value for TGCTs, with better performance compared to total miRNAs.
Review
Medicine, General & Internal
Ru-Dong Li, Min Guan, Zhe Zhou, Shu-Xiao Dong, Qian Liu
Summary: This study comprehensively reviewed evidence on using circRNAs as diagnostic indicators for colorectal cancer (CRC). The results showed that upregulated circRNAs in tissue or plasma had higher diagnostic values for CRC. Further prospective studies are needed to identify more representative circRNAs as diagnostic markers for CRC.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Yue Gao, Kai Gan, Kuangzheng Liu, Bin Xu, Ming Chen
Summary: SP1 has been shown to be up-regulated in various malignant tumors and is associated with lymph node metastasis, TNM stage, tumor infiltration, and poor clinical outcomes in patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Review
Medicine, General & Internal
Maryam Koopaie, Sajad Kolahdooz, Mahnaz Fatahzadeh, Zainab Abdulkareem Aleedawi
Summary: The systematic review and meta-analysis suggest that noncoding RNA biomarkers in stimulated saliva may be a promising approach for accurate diagnosis of pancreatic cancer in the early stages.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Linna Cheng, Shenzhen Huang, Lijuan Chen, Xiaoyan Dong, Lei Zhang, Chengye Wu, Kaihong Ye, Fengmin Shao, Zunmin Zhu, Rick F. Thorne
Summary: DCLK1 has emerged as a unique stem cell marker in gastrointestinal tissues, promoting tissue regeneration and serving as potential cancer stem cells. Targeting the expression or kinase activity of DCLK1, which is overexpressed in many cancers, has the potential to inhibit cancer cell growth. This review summarizes the evidence for DCLK1 as a prospective cancer target and discusses the challenges and progress in developing small molecule inhibitors of DCLK1.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Clinical Neurology
Mary Xylaki, Avika Chopra, Sandrina Weber, Michael Bartl, Tiago F. Outeiro, Brit Mollenhauer
Summary: Parkinson's disease (PD) biomarkers are important for diagnosis, study populations, and therapeutic response monitoring. Extracellular vesicles (EVs) have emerged as a promising material for biomarker development, containing proteins and molecular material from various organs. Meta-analysis reveals increased levels of alpha-synuclein (aSyn) and leucine-rich repeat kinase 2 (LRRK2) in EVs of PD patients, suggesting their potential as biomarkers for PD diagnosis and monitoring.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Amir Hossein Aalami, Farnoosh Aalami, Amirhossein Sahebkar
Summary: This meta-analysis examined the association between ApoA-I levels and human malignancies. The results suggest that urinary ApoA-I levels may serve as a favorable diagnostic marker for cancer, especially in East Asian countries.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Mingyu Chu, Yaqun Fang, Yucui Jin
Summary: The study systematically evaluated the diagnostic values of circRNAs in breast cancer, showing that circRNAs have a high diagnostic value for breast cancer and may serve as potential diagnostic biomarkers.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Medicine, General & Internal
Jian-Ming Zhou, Ting Wang, Kun-He Zhang
Summary: AFP-L3% has high specificity but low sensitivity for diagnosing early HCC, making it more suitable for excluding HCC in cases with elevated AFP levels. A hypersensitive detection method can improve the diagnostic accuracy of AFP-L3% for early HCC.
Article
Engineering, Mechanical
Wenbo Shi, Zhousuo Zhang
Summary: This study presents a new contact characteristic parameters model for bolted joint interfaces, which overcomes the shortcomings of homogeneous distributions of contact stiffness and damping in previous models. By transforming the contact pressure distribution into normal contact load distribution, it is found that the interfacial contact stiffness and damping exhibit significant inhomogeneous distributions.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Xiao-lian Liu, Gui-ming Zhang, Si-si Huang, Wen-hui Shi, Lin-xuan Ye, Zhong-lu Ren, Jia-jie Zhang, Shu-wen Liu, Le Yu, Yi-lei Li
Summary: PTEN loss correlates with hypersensitivity to rapalogs in ccRCC cells and could be a marker for rapalog therapy selection in ccRCC patients.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Thermodynamics
Mengdi Cui, Baolong Wang, Falin Wei, Wenxing Shi
Summary: The study proposes a modified exergy analysis method to locate major imperfections and determine optimization directions for developing high-efficiency vapor compression systems, achieving significant improvements in coefficient of performance for air source heat pump water heaters and room air conditioners through improving energy efficiency of compressors and decreasing refrigerant exergy destruction.
APPLIED THERMAL ENGINEERING
(2022)
Article
Engineering, Environmental
Chuang Wang, Jinying Du, Zhijie Liang, Jialiang Liang, Zhiwei Zhao, Fuyi Cui, Wenxin Shi
Summary: The study investigated the removal efficiency and mechanism of fluoroquinolones using the VUV/Fe2+/PMS process, showing excellent performance at wide initial pH range. The degradation pathways of fluoroquinolones and main inorganic byproducts were thoroughly studied in this synergistic activation process.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Chemical
Bing Zhang, Xin Mao, Xiaomin Tang, Heli Tang, Bing Zhang, Yu Shen, Wenxin Shi
Summary: This study compares the application of modified microbial flocculants (MMFs) with conventional organic flocculants in mitigating membrane fouling. The results show that MMF has better performance in pollutant removal and membrane fouling control. The study also reveals that cake layer formation is the main mechanism of membrane fouling and MMF can reduce the accumulation of foulants on the membrane surface. Correlation analysis indicates that total phosphorus, polysaccharide, zeta potential, and particle size have the greatest correlation with fouling resistance.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Environmental Sciences
Zhanhua Zhou, Kim Yrjala, Junhui Chen, Chenliang Yu, Wenhui Shi, Hua Qin, Weiwu Yu, Wensheng Dai, Yuanyuan Hu, Jiasheng Wu
Summary: The combination of biochar and sheep manure significantly improved soil fertility and plant growth in a Torreya grandis plantation, demonstrating significant effects on plant quality and soil nutrients when compared to individual treatments with manure or rapeseed cake.
JOURNAL OF SOILS AND SEDIMENTS
(2022)
Article
Chemistry, Analytical
Tyler Chozinski, B. Scott Ferguson, William Fisher, Shencheng Ge, Qiang Gong, Hui Kang, John McDermott, Alexander Scott, Wentao Shi, Jeremiah J. Trausch, Thorsten Verch, Matthew Vukovich, Jinpeng Wang, J. Emma Wu, Qin Yang
Summary: This study aims to develop a portable device for affinity assays of viral particles in viral vaccines by combining aptamers, microfluidic devices, and electrochemical detection. By generating and characterizing aptamers and designing/fabricating electrochemical microfluidic devices, CMV concentrations were successfully measured. This work represents a critical first step towards developing simple, affordable, and robust affinity assays for global deployment.
ANALYTICAL CHEMISTRY
(2022)
Article
Acoustics
Wentao Shi, Xiangshui Li, Weidong Wang, Weijie Tan, Hui Li
Summary: In this article, a sparse alternating iterative minimization (SAIM) method is proposed to address the direction-of-arrival (DOA) estimation problem via a non-ideal acoustic vector hydrophone (AVH) array. The method establishes a non-ideal AVH array model and formulates a new cost function to provide accurate DOA estimation. Extensive numerical simulation and experimental results demonstrate the superior DOA estimation performance of the proposed method.
Article
Engineering, Environmental
Bijiang Geng, Shirui Zhang, Xue Yang, Wenyan Shi, Ping Li, Dengyu Pan, Longxiang Shen
Summary: This study developed a novel heterojunction nanosonosensitizer with enhanced production of singlet oxygen and hydroxyl radicals for sonodynamic therapy. The nanosonosensitizer effectively separated the electron-hole pairs generated by ultrasound through a direct Z-scheme charge transfer mechanism. The experiments demonstrated complete tumor eradication in osteosarcoma models using a single drug injection and single ultrasound irradiation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Wentao Shi, Manali Singha, Gopal Srivastava, Limeng Pu, J. Ramanujam, Michal Brylinski
Summary: Computational modeling is crucial in modern drug discovery, particularly in predicting binding molecules. Pocket2Drug is a promising computational approach that uses data mining and machine learning to predict binding molecules for a given ligand binding site.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Crystallography
Shuai Yue, Yushuai Bai, Zhonghua Du, Huaiwu Zou, Wenhui Shi, Guang Zheng
Summary: This study aims to investigate the dynamic response associated with the impact of a kinetic projectile on the internal structure of an artificial satellite. Through ground damage testing and finite element dynamic simulation, we determined the lateral effect and penetration performance of the projectile, and studied its dynamic behavior when penetrating a honeycomb sandwich panel and multi-layer plates. The ballistic limit velocity of the projectile was found to be 150 m/s, and the deformation of the opening had little relationship with the projectile velocity. Additionally, it was observed that the launch velocity required to meet the damage requirements of the multi-layer plates was within 325 +/- 25 m/s, with higher initial velocities resulting in reduced damage area.
Article
Immunology
Mingyue Cai, Wensou Huang, Jingjun Huang, Wenbo Shi, Yongjian Guo, Licong Liang, Jingwen Zhou, Liteng Lin, Bihui Cao, Ye Chen, Juan Zhou, Kangshun Zhu
Summary: TACE-L-P significantly improves survival in advanced HCC patients with acceptable safety, especially in those without main portal vein invasion but with extrahepatic metastasis or tumor number >3.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Haifeng Wang, Wei Xue, Weigang Yan, Lei Yin, Baijun Dong, Biming He, Yongwei Yu, Wentao Shi, Zhien Zhou, Hengzhi Lin, Yi Zhou, Yanqing Wang, Zhenkai Shi, Shancheng Ren, Xu Gao, Linhui Wang, Chuanliang Xu
Summary: High-frequency irreversible electroporation (H-FIRE) is a promising treatment for localized prostate cancer. It can selectively destroy cancer cells while preserving surrounding nerves and blood vessels. The study showed that H-FIRE had a lower rate of clinically significant prostate cancer at 6 months compared to other energy platforms.
Article
Materials Science, Multidisciplinary
Yaxi Tian, Dongyun Que, Rongfeng Guan, WenYan Shi
Summary: Cu-BiVO4 photocatalysts with excellent visible light response were successfully fabricated by modification with a SiO2 template and Cu doping. Cu doping can reduce carrier recombination rate and greatly improve the ability of BiVO4 to degrade RhB. The crystal phase and photocatalytic activity of Cu-BiVO4 are influenced by doping amount. The mechanism of Cu doping was investigated using first-principles calculations.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Business, Finance
Wen Shi, Xiaogang Bi
Summary: This research examines the impact of Buddhism on mergers & acquisitions (M&As) performance using data from 4622 M&A transactions of Chinese public firms between 2004 and 2018. The findings provide ample evidence that acquirers located in regions with a higher intensity of Buddhism achieve better short-term and long-term performance after the merger. Furthermore, the study reveals that state ownership plays a crucial role in mitigating this effect, and the value creation is driven by higher deal completion rates and fewer violation cases for acquiring firms. Finally, the study addresses the issue of endogeneity, and the results remain unchanged.
ACCOUNTING AND FINANCE
(2023)
