期刊
ONCOTARGET
卷 8, 期 41, 页码 69874-69887出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19434
关键词
Bisphenol A; iodine excess; thyroid carcinoma; estrogen receptor a; PCNA
资金
- National Natural Science Foundation of China [81272181]
- Science and Technology Development Project of Shandong Province [2012GSF11851]
Thyroid carcinoma (TC) is the most common endocrine neoplasm. The risk of TC as a second primary malignancy (SPM) of breast cancer is significantly increased. Bisphenol A (BPA) is a widely contacted xenoestrogen and increases susceptibility to breast cancer through binding to estrogen receptor alpha (ER alpha). However, the effect of BPA on thyroid carcinogenesis has not been fully demonstrated. This present study aimed to characterize the effects of BPA on the development of TC using a Fischer 344 (F344) rat model. In this study, we established a TC model using female F344 rats pretreated with N-Bis (2-hydroxypropyl) nitrosamine (DHPN) at a single dose of 2800 mg/kg (the DA group) or without DHPN (the DN group), followed by stimulation with BPA at the level of 250 mu g/kg (BPA250) or 1000 mu g/kg (BPA1000) and a basic diet containing potassium iodine (KI, 1000 mu g/L) for 64 weeks. We demonstrated that the incidence of TC in the BPA250 + KI of DA groups reached the highest at 50%, the incidence of thyroid hyperplasia lesions (including both tumors and focal hyperplasia lesions) in the BPA1000 + KI of DA groups reached 100% (P < 0.05). ER alpha protein and immunochemistry expression was upregulated in the BPA-exposed groups and the immunochemistry scores were positively correlated with PCNA. Thus, the present results indicate that BPA could enhance the susceptibility to TC stimulated by DHPN and iodine excess. ERa is probably involved in the proliferation effect of BPA. BPA or KI alone could not increase TC incidence.
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