Article
Immunology
Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy
Summary: This study investigated the expression levels of miR-210 in astrocytes under ischemic stroke and in vitro stress conditions, and found its association with the astrocytic response to disease and neuroprotection.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Immunology
Tineke Vanderhaeghen, Rudi Beyaert, Claude Libert
Summary: Glucocorticoid-induced and hypoxia-induced transcriptional responses play crucial roles in maintaining tissue homeostasis and regulating cellular stress and inflammatory responses. Cells respond rapidly to hypoxia to prevent metabolic shutdown and death through hypoxia inducible factors (HIFs). The crosstalk between the glucocorticoid receptor (GR) and HIFs has been investigated, and the therapeutic effects of GCs on HIF-mediated diseases have been discussed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma
Summary: The study showed that sevoflurane and desflurane enhanced ovarian cancer cell malignancy by deactivating miRNAs and increasing HIF-1 alpha expression. Further research is needed to determine the translational value of these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Andrology
Yi Ma, Yan Zhou, Qian Xiao, Sha-Sha Zou, Yin-Ci Zhu, Ping Ping, Xiang-Feng Chen
Summary: The study found that seminal exosomal miR-210-3p levels were positively correlated with the severity of varicocoele in patients, while negatively correlated with sperm count and seminal inhibin-B expression. Surgical treatment significantly reduced the level of miR-210-3p.
Article
Neurosciences
Michelle Watts, Gabrielle Williams, Jing Lu, Jess Nithianantharajah, Charles Claudianos
Summary: MiR-210 plays a critical role in neuroplasticity and cognitive function, with its loss in neurons leading to higher oxidative phosphorylation and ROS production, increased dendritic arbour density, and altered behavioral flexibility in cognitive tasks.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Qiqi Xue, Qianru Zhang, Zhenzhen Guo, Liping Wu, Yafen Chen, Zhongli Chen, Ke Yang, Jiumei Cao
Summary: This study aimed to explore the inhibitory effect of hypothermia-regulated microRNA-483-3p (miR-483-3p) on hypoxia-induced myocardial infarction. The results showed that therapeutic hypothermia recovered hypoxia-induced apoptosis and ATP level decreases, and increased miR-483-3p expression. Overexpression of miR-483-3p and downregulation of Cdk9 gene expression promoted cardiomyocyte survival and mitochondrial membrane potential stability. In animal experiments, miR-483-3p expression decreased and Cdk9 expression increased in the region of myocardial infarction. However, overexpression of miR-483-3p suppressed apoptosis, infarct size, and Cdk9 expression to improve cardiac contractility.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang
Summary: Prenatal dexamethasone exposure can have lasting adverse effects on bile acid metabolism in offspring by affecting placental BA transporters and inducing imbalanced fetal-placental-maternal BA circulation, leading to increased levels of primary BAs in fetal serum.
Article
Oncology
Mairah T. Khan, Joely J. Irlam-Jones, Ronnie Rodrigues Pereira, Brian Lane, Helen R. Valentine, Kai Aragaki, Lars Dyrskjot, David J. McConkey, Peter J. Hoskin, Ananya Choudhury, Catharine M. L. West
Summary: A 14-miRNA hypoxia signature was derived and found to be prognostic for overall survival in bladder cancer patients, showing similar performance to a 24-gene mRNA signature. Combining the miRNA and mRNA signatures improved performance and identified patients who benefitted most from carbogen and nicotinamide with radiotherapy. Interaction tests also showed significance for local relapse-free survival.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Bonita H. Powell, Andrey Turchinovich, Yongchun Wang, Olesia Gololobova, Dominik Buschmann, Martha A. Zeiger, Christopher B. Umbricht, Kenneth W. Witwer
Summary: Hypoxia, or low oxygen tension, is frequently found in highly proliferative solid tumors such as anaplastic thyroid carcinoma (ATC) and is believed to promote resistance to chemotherapy and radiation. Identifying hypoxic cells for targeted therapy may thus be an effective approach to treating aggressive cancers. In this study, miR-210-3p is explored as a potential cellular and extracellular biological marker of hypoxia in ATC cells, showing its association with low oxygen conditions and its presence in extracellular vesicles and Argonaute-2 as potential extracellular markers for hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Davide Marchi, Fredericus J. M. van Eeden
Summary: Glucocorticoids are essential for regulating physiological processes, but chronic steroid use may lead to limited therapeutic benefits. Understanding how to modulate glucocorticoid receptor activity is crucial for minimizing side effects and improving treatment outcomes.
Article
Clinical Neurology
Xiao-Bin Zhang, Yang Song, Yan-Ting Lai, Shao-Zhao Qiu, An-Ke Hu, Dai-Xi Li, Nai-Shan Zheng, Hui-Qing Zeng, Qi-Chang Lin
Summary: This study investigated the role of miR-210-3p in the relationship between intermittent hypoxia (IH) and tumor function. It was found that high levels of miR-210-3p were positively correlated with polysomnographic variables in patients with lung adenocarcinoma and obstructive sleep apnea (OSA). IH enhanced tumor viability, proliferation, migration, and invasion while downregulating E2F3 expression and increasing miR-210-3p levels. MiR-210-3p inhibition reversed these changes in vitro, and miR-210-3p antagomir injection reversed them in vivo. These findings suggest that miR-210-3p may be a potential therapeutic target for patients with concomitant cancer and OSA.
SLEEP AND BREATHING
(2023)
Article
Medical Laboratory Technology
Ahmed Ismaeel, Emma Fletcher, Dimitrios Miserlis, Marissa Wechsler, Evlampia Papoutsi, Gleb Haynatzki, Robert S. Smith, William T. Bohannon, Panagiotis Koutakis
Summary: Previous studies have shown that circulating microRNA (miR)-210 levels are elevated in patients with peripheral artery disease (PAD). This study aimed to investigate the relationship between miR-210 expression and mitochondrial function in PAD patients. The results revealed that miR-210 expression was significantly increased in skeletal muscle of PAD patients, and there were significant reductions in the respiratory function of certain mitochondrial complexes. These findings may contribute to a better understanding of the metabolic pathophysiology of PAD.
TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dingmei Zhang, Kexin Liu, Wen Hu, Xiaoqian Lu, Li Li, Qi Zhang, Hegui Huang, Hui Wang
Summary: This study confirmed that dexamethasone induces cell autophagy by activating the GR- FOXO1 pathway in utero, inhibiting hepatocyte proliferation and causing liver dysplasia in offspring rats.
Article
Cell Biology
Madelyn K. Logan, Katheryn E. Lett, Michael D. Hebert
Summary: The study demonstrates an increase in CB number and upregulation of CB marker protein coilin in WI-38 cells under hypoxia, suggesting a link to dysregulated miRNA expression.
JOURNAL OF CELL SCIENCE
(2021)
Article
Neurosciences
Jessica R. Ivy, Roderic N. Carter, Jin-Feng Zhao, Charlotte Buckley, Helena Urquijo, Eva A. Rog-Zielinska, Emma Panting, Lenka Hrabalkova, Cara Nicholson, Emma J. Agnew, Matthew W. Kemp, Nicholson N. Morton, Sarah J. Stock, Caitlin Wyrwoll, Ian G. Ganley, Karen E. Chapman
Summary: The late gestational increase in glucocorticoids helps in the maturation of the fetal heart, particularly in the switch from carbohydrate to fatty acid oxidation. Excessive use of exogenous glucocorticoids may interfere with normal fetal heart development and pose potential clinical risks.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Song, Xiang-Qun Hu, Monica Romero, Mark A. Holguin, Whitney Kagabo, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy increases the association of BKCa channel subunits and alters the localization of RyR subtypes in uterine arteries. Knockdown of RyR1 or RyR2 decreases Ca2+ sparks and STOCs frequency, increases myogenic tone, while RyR3 knockdown has no significant effect. This study provides new insights into the mechanisms of uterine vascular adaptation to pregnancy through RyR subtypes.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Angeliki Maria Nikolakopoulou, Yaoming Wang, Qingyi Ma, Abhay P. Sagare, Axel Montagne, Mikko T. Huuskonen, Sanket V. Rege, Kassandra Kisler, Zhonghua Dai, Jakob Korbelin, Joachim Herz, Zhen Zhao, Berislav V. Zlokovic
Summary: Loss of LRP1 in endothelial cells leads to blood-brain barrier breakdown, neuronal loss, and cognitive deficits, which can be reversed by endothelial-specific LRP1 gene therapy. This effect is mediated by inhibiting cyclophilin A.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xiang-Qun Hu, Lubo Zhang
Summary: Hypoxia during gestation has significant impacts on maternal complications and fetal development. Mitochondrial ROS play a key role in placental dysfunction and pregnancy complications. Therapeutic approaches targeting mitochondrial ROS in placental cells are discussed for potential treatment strategies.
Article
Neurosciences
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Summary: This study demonstrates that microvascular injury plays a key role in the pathogenesis of Alzheimer's disease after mild traumatic brain injury. Restoring vascular functions may be beneficial for patients with mild TBI and potentially reduce the risk of developing AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Guofang Shen, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma
Summary: CNP plays a vascular protective role in neonatal brain injury by reducing brain infarct size, decreasing brain edema and IgG extravasation, and protecting BMECs against oxygen-glucose deprivation. The vasculoprotective effect of CNP is mediated by its innate receptors NPR2 and NPR3, indicating a potential therapeutic target for neonatal brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Liansheng Zheng, Boshi Yan, Guoliang Jin, Weijie Han, Hailong Wang, Zhepeng Wang, Yongqiang Ma, Yuanyuan Nian, Xianmei Meng, Zhenyu Jiang
Summary: circ_0003159 inhibits the development of gastric cancer by binding to miR-221-3p/miR-222-3p and regulating the expression of LIFR.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Environmental Sciences
Jiayi Du, Ling Fu, Jiaxin Cui, Zifen An, Pei Fang, Lanhui Tan, Xianmei Meng, Liping Yu
Summary: The Heart to Heart Card Game improves psychological health outcomes in hospitalized patients with advanced cancer, and this randomized controlled study found that it is also effective for patients receiving home-based palliative care.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Yong Li, Yanyan Zhang, Andrew Walayat, Yingjie Fu, Bailin Liu, Lubo Zhang, Daliao Xiao
Summary: Nicotine exposure during the perinatal period can induce a sensitive phenotype to neonatal brain hypoxic-ischemic injury in offspring. The H19/miR-181a/ATG5 signaling pathway plays a regulatory role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Taiming Liu, Meijuan Zhang, Avoumia Mourkus, Hobe Schroeder, Lubo Zhang, Gordon G. Power, Arlin B. Blood
Summary: Chronic hypoxia at high altitude alters iron homeostasis and bioactive nitric oxide metabolites (NOx) levels in the fetal circulation. The fetus utilizes iron from non-hematopoietic tissues for erythropoiesis and shows increased bioavailability of NO in response to hypoxic stress at high altitude during gestation.
Article
Clinical Neurology
Yong Li, Rui Song, Guofang Shen, Lei Huang, DaLiao Xiao, Qingyi Ma, Lubo Zhang
Summary: In this study, it was discovered that miR210 regulates neuroinflammatory response induced by ischemic stroke through repression of TET2 in the adult mouse brain. Inhibition of miR210 reduced ischemic stroke-induced neuroinflammatory response, suggesting that miR210 is a potential treatment target for acute brain injury after ischemic stroke.
Article
Biochemistry & Molecular Biology
Eugenia Mata-Greenwood, Hans C. A. Westenburg, Stacy Zamudio, Nicholas P. Illsley, Lubo Zhang
Summary: High-altitude residence negatively impacts vitamin D levels, with Andeans having the lowest 25-OH-D levels and Europeans having the lowest 1 alpha,25-(OH)(2)-D levels. The ratio of 1 alpha,25-(OH)(2)-D to 25-OH-D is significantly lower in Europeans compared to Andeans. Placental gene expression plays a major role in circulating vitamin D levels, and high-altitude residents have a stronger correlation between vitamin D levels and placental gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Guofang Shen, Kayla Sanchez, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma
Summary: This study used a non-invasive 3D ultrasound imaging approach to evaluate the changes of cerebral blood flow (CBF) after hypoxic-ischemic encephalopathy (HIE) and explored its correlation with HI-induced brain infarct in mice. The results showed that CBF reduction is an indicator for neonatal HI brain injury, and 3D ultrasound imaging is a useful non-invasive approach for assessing HI brain injury in mice.
Article
Oncology
Zhiheng Chang, Tong Dang, Xianmei Meng, Jianyuan Chai
Summary: This article provides a summary of the laboratory work on the role of CCN1 in esophageal cancer and offers a new perspective on CCN1 biology. The study revealed that CCN1 induces TRAIL-mediated apoptosis in esophageal cancer cells, and antagonizes the effects of TNF. These findings suggest that CCN1 has the potential to be a candidate for the treatment of esophageal cancer.
Review
Oncology
Xianmei Meng, Tong Dang, Jianyuan Chai
Summary: DNA mutations are common in the human body, usually repaired by the DNA damage response program. Severe damages activate cell death, leading to genetic scars that can result in cancer. Apoptosis and necroptosis are the main strategies for optimal cell maintenance and cancer prevention, with apoptosis being the faster and cleaner option for cancer treatment.